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| Effect of Sevoflurane combined with Propofol on immune function and liver and kidney function in patients with liver cirrhosis after operation |
| ZHANG Kun1 KE Shan2 |
1.Department of Anesthesiology, West District of Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China;
2.Department of Hepatobiliary, West District of Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China |
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Abstract Objective To investigate the effect of Sevoflurane combined with Propofol on immune function and liver and kidney function in patients with liver cirrhosis after operation. Methods From August 2016 to July 2019, 102 patients with liver cirrhosis who were to undergo splenectomy in West District of Beijing Chaoyang Hospital, Capital Medical University were selected. The patients were randomly divided into study group (n = 51, Sevoflurane combined with Propofol anesthesia) and control group (n = 51, Sevoflurane anesthesia) according to the randorm number table method. The recovery time of spontaneous respiration, orientation, speech response, eye opening and extubation, CD3+, CD4+, CD8+, CD4+/CD8+, glutamate amino transferase (ALT), total bilirubin (TBil), blood urea nitrogen (BUN), creatinine (CR) and adverse reactions were recorded and compared between the two groups. Results There was no significant difference in preoperative CD3+, CD4+/CD8+, CD8+ and CD4+ between the two groups (P > 0.05). In the third day after operation, CD3+, CD4+/CD8+ and CD4+ in both groups were lower than those before operation, and study group was higher than control group, the differences were statistically significant (all P < 0.05); CD8+ was higher than that before operation, and study group was lower than control group, the differences were statistically significant (all P < 0.05). The recovery time of spontaneous respiration, orientation, speech response, eye opening and extubation in study group were shorter than those in control group, the differences were statistically significant (all P < 0.05). There were no significant differences in serum levels of ALT, TBil, BUN and Cr between the two groups (P > 0.05). The serum levels of ALT, TBil, BUN and Cr in study group were higher than those in control group on the third day after operation, study group was lower than control group, the differences were statistically significant (all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Sevoflurane combined with Propofol can effectively improve the perioperative indexes, reduce the damage of liver and kidney function, reduce the immunosuppression, and the drug safety is good, which has high clinical application value.
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