阻塞性睡眠呼吸暂停低通气综合征患者血清25-羟维生素D的水平变化及临床意义

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Abstract Objective To investigate the changes and clinical significance of serum 25-hydroxyvitamin D[25-(OH)D] in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total of 100 OSAHS patients admitted to the Third People′s Hospital of Chengdu (hereinafter referred to as “our hospital”) from July 2017 to January 2019 were selected as the observation group. According to the apnea hypopnea index (AHI) level, they were divided into 23 cases with mild (5 times/h＜AHI≤15 times/h), 48 cases with moderate (15 times/h＜AHI≤30 times/h), and 29 cases with severe (AHI＞30 times/h). A total of 90 healthy patients in our hospital during the same period were selected as the control group. After enrollment, all patients were examined by polysomnography, and the lowest blood oxygen saturation (L-SpO2) was recorded. Serum levels of 25-(OH)D and vitamin D (VitD) deficiency were measured. The L-SpO2 and serum 25-(OH)D levels of patients with different severity of OSAHS were evaluated. The correlation between AHI, L-SpO2 and 25-(OH)D of patients with OSAHS was analyzed. Results Serum L-SpO2 and 25-(OH)D levels in the observation group were lower than those in the control group, with statistically significant differences (all P ＜ 0.05); the degree of serum VitD deficiency in the observation group was significantly higher than that in the control group, with statistically significant difference (P ＜ 0.05); L-SpO2 and 25-(OH)D in severe and moderate OSAHS patients were lower than those in mild patients, and L-SpO2 and 25-(OH)D in severe OSAHS patients were lower than those in moderate patients, with statistically significant differences (all P ＜ 0.05). Pearson correlation analysis showed that serum 25-(OH)D level was negatively correlated with AHI in OSAHS patients (r = -0.634, P = 0.003) and positively correlated with L-SpO2 (r = 0.660, P = 0.002). Conclusion The serum level of 25-(OH)D in OSAHS patients is significantly decreased, and 25-(OH)D is negatively correlated with the severity of OSAHS. VitD may be involved in the occurrence and development of OSAHS.

Key words： Obstructive sleep apnea hypopnea syndrome Vitamin D 25-hydroxyvitamin D Clinical significance

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	DAI Hongmei1 ZHU Yifang2

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DAI Hongmei1 ZHU Yifang2. Changes of serum 25-hydroxyvitamin D levels in patients with obstructive sleep apnea hypopnea syndrome and its clinical significance[J]. 中国医药导报, 2020, 17(7): 164-167.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I7/164

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