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2018 Vol. 15, No. 16
Published: 2018-06-05
 
 
4 The variation of rats′ physiological indices after different time of simulated weightlessness
ZHAO Jun1 LI Yongzhi2 GAO Jianyi2 ZHANG Ruitao1 YU Jiaoyan1 XU Yuan1 ZHANG Yang1 QIAO Yuan3 WANG Qingwei1
Objective To study the variation of rats′ physiological indices on different time of simulated weightlessness. Methods Sixty-four SD rats were divided into 8 groups randomly, with 8 rats in each group. The model of simulated weightlessness was established by hindlimb unloading respectively for 1, 2, 3 weeks and 4 weeks, the body weight, liver function, kidney function and myocardial enzyme spectrum were measured, the body weight growth rate and organ coefficient were calculated. And then, the data was statistically analyzed. Results Compared with the control group, the body weight growth rate of simulated weightlessness rat gradually decreased, the changes were significant after 2 weeks(P < 0.05), the changes were more significant after 3 weeks(P < 0.01); the ratio of heart to body weight and kidney to body weight were increased (P < 0.01 or P < 0.05); while the ratio of gastric to body weight showed a trend of decrease, and the changes were significant (P < 0.05) after 2 weeks, the ratio of heart to brain weight and kidney to brain weight were increased (P < 0.01 or P < 0.05); ALT (P < 0.05), AST, BUN, CK, CK-MB (P < 0.01) significantly increased after 1 week, the GLB (P < 0.05), UA (P < 0.01) increased significantly after 3 weeks. On the contrary, ALP, ALB, CHE (P < 0.01) and DBIL (P < 0.05) were significantly reduced after 1 week, TBA, AMY (P < 0.01) after 2 weeks and TP(P < 0.05) after 3 weeks significantly reduced. Conclusion Simulated weightlessness can induce a variety of effects on the physical function of rats, weight growth is inhibited, liver, kidney and myocardial function are severely injuried, prolong simulated weightlessness can increase the damage. 
2018 Vol. 15 (16): 4-7,12 [Abstract] ( 238 ) HTML (1 KB)  PDF (602 KB)  ( 81 )
8 Expression of lncRNA MEG3 in the osteoarthritis and its correlation with VEGF
LIU Zhenfeng LIANG Zhiquan DENG Yingjie FANG Rui MENG Qingcai
Objective To determine the expressions of long non-coding RNA MEG3 (lncRNA MEG3) and vascular endothelial growth factor (VEGF) in the articular cartilage tissues of osteoarthritis (OA), and to analyze the correlation between the lncRNA MEG3 and VEGF. Methods The knee articular cartilage tissues from 40 cases of primary OA and 20 healthy volunteers were collected from January 2014 to December 2015 in Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region. After the safranin O staining, the OA patients were grouped according to the improved score criterion of Mankin. Real-time PCR assay was applied to detect the expressions of lncRNA MEG3 and VEGF mRNA in the knee articular cartilage tissues, and the ELISA assay was utilized to determine the protein level of VEGF. The correlation between the lncRNA MEG3 and VEGF was analyzed by the Pearson. Results The real-time PCR results showed that compared to the normal articular cartilage tissues, the lncRNA MEG3 was significantly downregulated in the OA articular cartilage tissues (P < 0.05), and the higher degree of degradation, the lower of lncRNA MEG3 (P < 0.05). Moreover, the mRNA and protein levels of VEGF were significantly upregulated in the OA articular cartilage tissues (P < 0.05), and the higher degree of degradation, the higher of VEGF (P < 0.05). The Pearson results showed that there was a negative relationship between the lncRNA MEG3 and VEGF (r = -0.466, P < 0.05). Conclusion lncRNA MEG3 was decreased in the articular cartilage tissues of OA, and lncRNA MEG3 was negatively correlated with the VEGF. lncRNA MEG3 may be involved in primary OA development through the regulation of angiogenesis.
2018 Vol. 15 (16): 8-12 [Abstract] ( 211 ) HTML (1 KB)  PDF (648 KB)  ( 70 )
13 The effect of CD151 on the changes of Wnt signaling pathway in the combined targeting therapy of colorectal cancer
LIU Xuegang1 LIU Yancai2 WU Chunping2 LI Jingguang2 ZHAO Lingling2 ZHANG Zhenya3▲
Objective To explore the effect of CD151 on the changes of Wnt signaling pathway in colon cancer. Methods Western blot method was used to detect colon cancer cells (HT29) and CD151 gene knockout colon cancer cells (CD151--HT29) in CD151, LRG-1 and LGR-5 protein expression; the expression of LRG-1 HT29, CD151--HT29 cells and LGR-5 gene were detected by real-time quantitative PCR technique; the invasion ability of HT29, CD151--HT29 cells was inspected. Results The results showed that there was CD151, LRG-1 and LGR-5 protein expression in HT29 cells, but no CD151 protein expression in CD151--HT29 cells, and significantly decrease could be observed in the expression of LRG-1 and LGR-5 protein; real-time quantitative PCR results showe that, compared with HT29 cells, the expression of LRG-1 and LGR-5 gene in CD151--HT29 cells decreased significantly (P < 0.05). Cell invasion assay showed that HT29 cell invasion ability was stronger than that in CD151--HT29 cells (P < 0.05). Conclusion The expression of CD151 gene deletion can inhibit Wnt signaling initiation protein LRG-1 and LGR-5, and decrease the cancer cell invasion, which indicates that the CD151 gene has some role in the regulation of Wnt signaling pathway, to provide some scientific guidance for the colorectal cancer combined with targeted therapy.

 
2018 Vol. 15 (16): 13-16 [Abstract] ( 229 ) HTML (1 KB)  PDF (694 KB)  ( 57 )
17 Study on the role and mechanism of lncRNA ANRIL in breast cancer cells
TANG Hongping1 ZHONG Lin2 JIANG Hui1 GAO HuiJun1 CHEN Yingying1
Objective To explore the role and mechanism of long noncoding RNA-ANRIL (lncRNA ANRIL) in proliferation, invasion and apoptosis of breast cancer cells. Methods Breast cancer cells were transiently transfected with si-ANRIL. Real-time PCR was used to confirm the interfere effect of si-ANRIL, MTT assay was used to detect cell proliferation, transwell method was used to detect cell invasion, flow cytometer (FCM) was used to detect cell apoptosis, Western blot was used to detect the protein expression level of p53. Breast cancer cells were co-transfected with si-ANRIL and si-p53, MTT assay, transwell method and FCM were used to detect cell proliferation, invasion and apoptosis. Results ANRIL knockdown decreased cell proliferation, invasion, and increased cell apoptosis (P < 0.05). ANRIL knockdown activated p53 signal pathway. Simultaneous p53 knockdown partially reversed the effect of ANRIL knockdown. Conclusion LncRNA ANRIL can promote the proliferation, invasion and inhibit apoptosis of breast cancer cells by inhibiting p53 pathway, thus promoting the occurrence and development of breast cancer.
2018 Vol. 15 (16): 17-20 [Abstract] ( 222 ) HTML (1 KB)  PDF (590 KB)  ( 85 )
21 Expression of PIK3CA and GST-π in human osteosarcoma and its clinical significance
DING Wanjun1 HUANG Li2 ZENG Tao3 GE Wei1 ZHANG Yukun1 GUO Weichun4 YU Ling4

Objective To detect the expression of phosphatidylinositol 3-kinase (PIK3CA) and glutathione-S transferase-π (GST-π) in osteosarcoma tissues and to explore its effect on the multidrug resistance of osteosarcoma. Methods Thirty-three cases of pathological tissue specimens of osteosarcoma from Renmin Hospital of Wuhan University from January 2009 to June 2017 were collected. The expression of PIK3CA and GST-π of 33 cases of osteosarcoma specimens was detected by immunohistochemistry (Envision method) and Western blot method. The differences between the chemotherapy-resistant group (7 cases) and the chemotherapy-effective group (26 cases) were compared. The results were analyzed combined with clinicopathological factors. Results The average optical density of PIK3CA in the chemotherapy-resistant group and chemotherapy-effective group was (11.089±2.147) and (6.938±2.065) respectively, and there was a significant difference between the two groups (P ＜ 0.05); the average optical density of GST-π in the chemotherapy-resistant group and chemotherapy-effective group was (15.871±2.678) and (7.693±2.443), and there was a significant difference between the two groups (P ＜ 0.05). The average optical density of PIK3CA and GST-π by Western blot method had significant differences between the two groups (P ＜ 0.05). The expression of PIK3CA and GST-π in osteosarcoma was correlated (r = 0.68, P ＜ 0.01). Conclusion PIK3CA and GST-π are over expressed in osteosarcoma chemotherapy-resistant group, and the expression of PIK3CA and GST-π is positively correlated with each other, which may be one of the mechanisms of drug resistance in osteosarcoma.
2018 Vol. 15 (16): 21-24 [Abstract] ( 264 ) HTML (1 KB)  PDF (613 KB)  ( 103 )
25 Preliminary study on the quality standard of rose petals in Hetian, Xinjiang Uygur Autonomous Region
CHEN Changchun1 CHEN Jiayuan2 PANG Zhan3 HUO Shixia4
Objective To establish a quality standard for rose petals of Hetian, and provide experimental basis for the quality control of the medicinal materials. Methods According to the general principles of Chinese pharmacopoeia in 2015 the total ash content, acid insoluble ash and extract were determined. TLC method was used to identify the crude drug with quercetin as the reference. The content of quercetin in rose petals was determined by RT-HPLC with methanol-0.1% phosphoric acid (56∶44) as the mobile phase. Results The method of TLC had specificity, the total ash was 4.9% in average, the acid insoluble ash was 0.19% in average, and the extract was 45.8% in average. The average content of quercetin was 0.21%. Conclusion According to the experimental results, a quality standard for rose petals is established preliminarily, and the quality standard of the medicinal plants can be used for the quality control of rose petals of Hetian.
2018 Vol. 15 (16): 25-29 [Abstract] ( 239 ) HTML (1 KB)  PDF (480 KB)  ( 96 )
30 Research progress of motivational interviewing in self-management of patients after percutaneous coronary intervention
YUE Weiwei1 SHI Yan2 JIANG Jinxia3
The status of self management in patients after percutaneous coronary intervention was reviewed in this article, and it was essential to adopt effective methods of health education to help patients improve their level of self-management. The effect of motivational interviewing was reviewed to improve bad eating habits and life style, medication and exercise compliance in patients after percutaneous coronary intervention. The existing problems was analyzed and summarized. It was pointed out that the implementers were lack of standardized training before intervention, which had not unified standard for each intervention, and the forms were not variaus enough, etc. It was suggested that in order to improve the self-management level of postoperative patients, the intervention time and times of motivational interviews should be increased, and the effect evaluation should be carried out scientifically and reasonably, and experience should be accumulated in the continuous implementation to provide reference for further promotion and application.
2018 Vol. 15 (16): 30-33 [Abstract] ( 180 ) HTML (1 KB)  PDF (509 KB)  ( 124 )
34 Advance of the diagnosis and treatment of anal abscess and anal fistula of infants
ZHANG Qiang LU Jingen LIANG Hongtao
More and more infants (0-3 years old) with diseases of anal abscess and anal fistula are identified, and the incidence is increasing year by year. There are two opposite viewpoints about the treatment: conservative treatment and operation. The unwisely pursuits of conservative treatment by some doctors and the infants′ parents directly causes the infants′ suffering from repeated attacks of the disease for a long time, even the enlargement of the focus, the aggravation of the disease, and more pain, what′s more, and brought physical, work, psychological and economic pressure on parents, which can not be ignored either. Operation will relieve symptoms and improve physical stress quickly, but cutting and draining alone, not seeking a cure method would also increase the pain of children. Therefore, there is an urgent need for effective treatment of perianal abscess and anal fistula in infants. This article reviews the literature about the diseases last decade, studying the commonly clinical characteristics, the etiology, the treatment and the prognosis of these diseases, looking forward to find a better treatment to treat them.
2018 Vol. 15 (16): 34-37 [Abstract] ( 212 ) HTML (1 KB)  PDF (539 KB)  ( 100 )
38 Advances of PD-1/PD-L1 inhibitors in tumor immunotherapy
LIU Yongjun▲ XU Wen
Programmed cell death-1(PD-1) and its ligand PD-L1 inhibitors can inhibit PD-1 and PD-L1 combination to block negative control signals, leading to activity of T cells and enhancement of immune responses. Targeted PD-1/PD-L1 drugs currently approved for marketing include Nivolumab, Pembrolizumab, Atezolizumab, etc. Clinical studies have shown that PD-1/PD-L1 inhibitors have a definite effect on monotherapy or combined with ipilimumab for the treatment of melanoma and second-line treatment PD-L1 positive advanced non-small cell lung cancer. At the same time, clinical trials for the treatment of breast cancer, head and neck cancer, gastric cancer, urothelial cancer, lymphoma and other malignancies are actively underway. At present, PD-1/PD-L1 inhibitors have some problems such as potential serious adverse reactions, uncertain treatment model, difficult to evaluate efficacy and expensive price. This article mainly reviews the action mechanism and current situation of PD-1 and PD-L1 inhibitors as well as their application in the treatment of various tumors, points out the problems existing in the current research, and provides some ideas and basis for follow-up research and government related policy formulation.
2018 Vol. 15 (16): 38-41 [Abstract] ( 236 ) HTML (1 KB)  PDF (553 KB)  ( 110 )
42 Endoplasmic reticulum stress related reactive oxygen species and its mechanism
SUN Jing1 WANG Wei2 TIAN Ye2 TIAN Zhen1▲
Endoplasmic reticulum(ER) is the major site of calcium storage and protein folding. Alterations in the oxidative environment of ER and also intra-ER Ca2+ can cause the production of ERS-induced ROS. PDI, ERO-1, GSH, Nox4, CYP, Ca2+ and mitochondrial electron transport chain proteins play crucial roles in ERS-induced production of ROS. Here, persistent ERS and protein misfolding-initiated ROS cascades and their related mechanisms will be reviewed.
2018 Vol. 15 (16): 42-44,54 [Abstract] ( 248 ) HTML (1 KB)  PDF (916 KB)  ( 286 )
45 Preventive effect of different monitoring methods on ischemic brain injury in beach chair arthroscopy
PAN Chuanlong CHEN Jingxia LIU Zhiheng
Objective To explore the preventive effect of different monitoring methods on ischemic brain injury in beach chair arthroscopy. Methods A total of 60 patients underwent elective arthroscopic shoulder arthroscopy in the Second People's Hospital of Shenzhen were selected and divided into routine monitoring group, SjvO2 monitoring group, NIRS monitoring group and TCD monitoring group according to the random number table, with 15 cases in each group. The mini mental state examination(MMSE) and the repeatable battery for the assessment of neuropsychological status (RBANS) were used to evaluate the congnitive function and neuropsychological function of the patients. Results Before operation for 1 d, there were no statistically significant differences in the scores of MMSE among the four groups (P ＞ 0.05). After operation for 1 d, the scores of MMSE in the routine monitoring group, SjvO2 monitoring group and TCD monitoring group were all lower those before operation for 1 d, SjvO2 monitoring group, NIRS monitoring group and TCD monitoring group were all higher than that of routine monitoring group, with statistically significant differences (P ＜ 0.05). After operation for 3 d, the score of MMSE in the routine monitoring group was lower than that before operation for 1 d, and the scores in SjvO2 monitoring group and TCD monitoring group were all significantly higher than that of routine monitoring group, with statistically significant differences(P ＜ 0.05); After operation for 5 d, there were no statistically significant differences in the score of MMSE among the four groups and compared with 1 d before operation (P ＞ 0.05). Before operation for 1 d, there were no statistically significant differences in the scores of RBANS among the four groups (P ＞ 0.05). After operation for 1 d, the scores of RBANS in the four groups were all lower than those before operation for 1 d, and the sores in SjvO2 monitoring group, NIRS monitoring group and TCD monitoring group were all higher than that of routine monitoring group, with statistically significant differences (P ＜ 0.05). After operation for 3 d, the scores of RBANS in the routine monitoring group, SjvO2 monitoring group and NIRS monitoring group were all lower than that of 1 d before operation, with statistically significant differences (P ＜ 0.05). After operation for 5 d, there were no statistically significant differences in the score of RBANS among the four groups and compared with 1 d operation (P ＞ 0.05). Conclusion TCD monitoring is the best way to prevent ischemic brain injury in arthroscopic surgery of beach chair shoulder. If TCD monitoring can not be carried out, NIRS is recommended to instead of SjvO2.
2018 Vol. 15 (16): 45-49 [Abstract] ( 282 ) HTML (1 KB)  PDF (679 KB)  ( 92 )
50 A comparative study of the diagnostic value of T-SPOT.TB in cerebrospinal fluid and peripheral blood for tuberculous meningitis
SONG Tao1 FU Hongyi1 LI Lijuan2
Objective To evaluate the diagnostic value of T-SPOT.TB in cerebrospinal fluid for tuberculous meningitis. Methods A total of 147 inpatients of suspected tuberculous meningitis in the Department of TB Medicine of Hebei Chest Hospital from January 2012 to June 2016 were selected. Based on final diagnosis, 133 patients were divided into two groups: tuberculous meningitis group and non tuberculous meningitis group. The positive and the negative rates of T-SPOT.TB in cerebrospinal fluid and peripheral blood were compared. Results Among the patients, there were  76 cases of diagnosed tuberculous meningitis, and 57 cases of non tuberculous meningitis. The sensitivity of T-SPOT.TB in peripheral blood was 77.63%, compared with 63.16% of T-SPOT.TB in cerebrospinal fluid, there was no statistically significant difference (P > 0.05). The specificity of T-SPOT.TB in cerebrospinal fluid was 98.25%, significantly higher than 84.21% of T-SPOT.TB in peripheral blood, the difference was statistically significant (P < 0.05). The positive predictive value of T-SPOT.TB in cerebrospinal fluid was 97.96%, higher than 86.76% of T-SPOT.TB in peripheral blood, the difference was statistically significant (P < 0.05). The negative predictive value of T-SPOT.TB in peripheral blood was 73.85%, compared with 66.67% of T-SPOT.TB in cerebrospinal fluid, there was no statistically significant difference between the results (P > 0.05). Taking 96 SFCs/106PEMC as the cut-off value, the sensitivity, specificity, PPV, NPV and AUROC of T-SPOT.TB in cerebrospinal fluid in diagnosis of tuberculous meningitis were 90.79%, 98.25%, 98.57%, 88.89% and 0.993 (95%CI: 0.982-1.000), respectively. Conclusion Compared with T-SPOT.TB in peripheral blood, the T-SPOT.TB in cerebrospinal fluid can significantly improve the specificity and PPV, and accurate diagnosis level of tuberculous meningitis.
2018 Vol. 15 (16): 50-54 [Abstract] ( 235 ) HTML (1 KB)  PDF (707 KB)  ( 78 )
55 Diagnostic value of multi-factorial combination for bone metastasis of lung cancer
WU Qiong MA Haiying ZHANG Mingming WANG Zhiwu▲ WANG Xuechen CUI Zejun
Objective To investigate the diagnostic value of multi-factorial combination in bone metastasis of lung cancer. Methods From January 2013 to December 2015, 126 newly diagnosed lung cancer patients from Department of Chemoradiotherapy in Tangshan People′s Hospital were selected in this study. The serum levels of NTx and ALP were measured and the information of clinical characteristics such as sex, age and the Karnofsky's index of performance status (KPS) score were collected. The bone metastasis was diagnosed by ECT combined with CT and MRI. Patients were grouped according to the presence or absence of bone metastasis. ROC curves were used to examine the diagnostic value of NTx, ALP and KPS and determine the best cutoff value. The correlation between bone metastasis and aforementioned factors was analyzed by logistic regression analysis. The multi-factorial combination which was produced though Logistic regression analysis was valued by ROC test again. Results The rate of bone metastasis was 34.1%. After being grouped, ROC analysis indicated that the optimal cutoff value of NTx, ALP and KPS were 21.5 nmol/L, 94 U/L and 80. The areas under the ROC curve of NTx, ALP and KPS were 0.792, 0.641 and 0.644. The sensitivities were 65.1%, 46.5% and 74.4% and the specificities were 84.3%, 81.9% and 44.6% respectively. Univariate and multivariate analysis showed NTx, ALP and KPS were significantly correlated with bone metastasis（P < 0.05）. Further ROC test demonstrated that the multi-factorial combination got a better diagnostic result (area under the ROC curve 0.861, sensitivity 74.4% and specificities 86.7%). Conclusion Serum NTx, Serum ALP and KPS were independent factors corrected with bone metastasis. Multi-factorial combination has a higher diagnostic result than single factor. Further multi-center studies with large sample should be conducted to confirm the result.
2018 Vol. 15 (16): 55-58 [Abstract] ( 232 ) HTML (1 KB)  PDF (685 KB)  ( 47 )
59 Correlation analysis of carotid plaque characteristics and smoking in patients with diabetics
CAI Senquan1 SHEN Qijun2▲
Objective To explore the correlation between carotid plaque characteristics and smoking in patients with diabetics. Methods From July 2015 to May 2017, 275 patients with diabetics in the endocrinology clinic of Deqing Traditional Chinese Medicine Hospital were selected as the research objects and divided into the smoking group (150 cases) and the non-smoking group (125 cases). Carotid doppler ultrasound examination was performed for all patients. The clinical data， characteristics of carotid plaque and the hemodynamic indicators [peak systolic velocity (PSV), end-diastolic velocity (EDV), pulse index (PI), resistance index (RI) and PSV/EDV] between the two groups were analyzed. The correlation between carotid plaque and smoking was analyzed. Results The maximum thickness, number, echo, carotid artery stenosis rate and hemodynamic parameters of PSV, EDV, PI, RI and PSV/EDV in the non-smoking group were better than those of smoking group, with statistically significant differences (P ＜ 0.05). The patch echo, PSV/EDV and the maximum thickness of plaque had high diagnostic value in diabetes, and the area under the curve was 0.877, 0.875 and 0.841. In smoking groups, the total amount of smoking had no effect on the stability of carotid plaque (P ＞ 0.05). Conclusion There is a close correlation between carotid plaque characteristics and smoking in patients with diabetics. Carotid doppler ultrasound examination can be a valuable tool for screening high-risk population of diabetes. It is an important guiding role in early diagnosis and treatment of carotid atherosclerotic disease.
2018 Vol. 15 (16): 59-62 [Abstract] ( 208 ) HTML (1 KB)  PDF (845 KB)  ( 152 )
63 The predictive value of serum amyloid A and neutrophilto-lymphocyte rate for the severity of acute pancreatitis
GU Xiaoyu HUANG Shangshu LIANG Weixin LIU Xiaozhen FENG Weizhao LAI Yongqiang ZHU Mingzhang LI Zhihong
Objective To investigate the predictive value of serum amyloid A (SAA), neutrophilto-lymphocyte rate (NLR) for the severity of acute pancreatitis. Methods The clinical data of 116 patients with acute pancreatitis admitted to Gaoming People's Hospital of Foshan City from January 2015 to May 2017 were retrospectively analyzed and divided into SAP group (34 cases), MSAP group (47 cases) and MAP group (35 cases) according to the severity of the disease. The general information of patients, SAA, white blood cell count (WBC) and NLR were analyzed. Results There were statistically significant differences in NLR and SAA among the three groups (P ＜ 0.05). Further comparision showed that  the indicators above in SAP group were higher than that of MSAP group, both SAP group and MSAP group were higher than that of MAP group, with statistically significant differences (P ＜ 0.05). The areas of SAA, WBC and NLR under the ROC curve predicted by SAP were 0.912, 0.776 and 0.842 respectively. The areas of SAA, WBC and NLR under ROC curve were 0.839, 0.799 and 0.811 for MSAP+SAP. Conclusion SAA and NLR have a certain value in predicting the severity of acute pancreatitis.
2018 Vol. 15 (16): 63-66 [Abstract] ( 203 ) HTML (1 KB)  PDF (681 KB)  ( 159 )
67 A Meta-analysis of the association between interleukin-10 -1082A>G polymorphism and cervical cancer risk
GUO Chong1 ZHU Jie2
Objective To investigate the association between interleukin-10 -1082A>G polymorphism and cervical cancer risk with a Meta-analysis. Methods The databases of PubMed, Embase, Web of SCI, CNKI and Wanfang databases were searched for the relevant literatures about the association between interleukin-10 -1082A>G polymorphism and cervical cancer risk from their inception to December 31st, 2017. The data of genotype distributions and other information were extracted in the selected studies. Odds ratio (OR) and 95% confidence interval (CI) were calculated with STATA 14.0 software. Publication bias, sensitivity and cumulative analyses were also applied. Results Thirteen published case-control studies including 2311 patients with cervical cancer and 2491 controls were selected. Overall, significant elevate association between IL-10 -1082A>G polymorphism and cervical cancer risk were found in this Meta-analysis (G vs. A: OR = 1.60, 95%CI = 1.12-2.29, P = 0.01, I2 = 92.3%; AG vs. AA: OR = 1.34, 95%CI = 1.04-1.74, P = 0.03, I2 = 65.9%; AG+GG vs. AA: OR = 1.58, 95%CI = 1.11-2.25, P = 0.01, I2 = 84.4%), and the same results were obtained in the subgroup analysis based on ethnicity and control design. Conclusion This Meta-analysis demonstrates that IL-10 -1082A>G polymorphism may be a risk factor for cervical cancer development.
2018 Vol. 15 (16): 67-71 [Abstract] ( 245 ) HTML (1 KB)  PDF (862 KB)  ( 60 )
72 Association between cough strength and the efficacy of noninvasive mechanical ventilation in patients with respiratory failure
XIAO Meiling DUAN Jun▲
Objective To explore the association between cough strength and the efficacy of noninvasive mechanical ventilation. Methods This study was performed in Respiratory Intensive Care Unit of the First Affiliated Hospital of Chongqing Medical University from January to December 2016. Patients required noninvasive mechanical ventilation due to acute respiratory failure were enrolled. Before the use of noninvasive mechanical ventilation, cough strength was assessed, and it was classified to strong, moderate and weak cough. Results A total of 370 patients were enrolled. Among them, 308 patients were strong cough, 43 patients were moderate cough and 19 patients were weak cough. The noninvasive mechanical ventilation failure rate was 16.9% in patients with strong cough; but it was 23.3% and 78.9% in patients with moderate and weak cough, respectively (P < 0.01). The hospital mortality was 19.5% in patients with strong cough, but it increased to 32.6% and 84.2% in patients with moderate and weak cough, respectively (P < 0.01). Weak cough was an independent risk factor for noninvasive mechanical ventilation failure (OR = 20.99, 95%CI: 5.10-86.50, P < 0.01) and death in hospital (OR = 17.15, 95%CI: 4.28-68.66, P < 0.01) respectively analyzed by multivariable logistic regression analysis. Conclusion Weak cough is associated with increased noninvasive mechanical ventilation failure and hospital mortality.
2018 Vol. 15 (16): 72-75 [Abstract] ( 286 ) HTML (1 KB)  PDF (618 KB)  ( 66 )
76 The influence of the choice of proper time of brain radiotherapy on the curative effect and survival time of non-small cell lung cancer with brain metastases
WANG Zhe YUAN Na ZHU Yanping
Objective To explore the best time of brain radiotherapy in patients of non-small cell lung cancer with brain metastases and its influence on the curative effect and survival time. Methods The clinical data of 106 patients diagnosed as non-small cell lung cancer accompanied by brain metastases in the First Affiliated Hospital of Hebei North University from July 2013 to January 2015 were analyzed retrospectively and they divided into the observation group (n = 54) and the control group (n = 52) according to the clinical symptoms. The observation group was carried out brain radiation after non-small cell lung cancer accompanied by brain metastases, while the control group was given brain radiotherapy after the clinical symptoms of brain metastasis. The initial progress parts of the patients were observed, the curative effect and prognosis were compared between the two groups. Results After the treatment of patients with brain metastases, there was statistically significant difference in the initial progress parts between the two groups (P ＜ 0.05). There were no statistically significant differences in the short term efficacy such as objective response rate and total effective rate (P ＞ 0.05). During the treatment period, the adverse reactions in the two groups were mainly hematological toxicity, gastrointestinal reaction and fatigue. The grade of adverse reactions was mostly in grade Ⅰ/Ⅱ level, Ⅲ/Ⅳ level was less, and there were no statistically significant differences between the two groups in Ⅰ/Ⅱ and Ⅲ/Ⅳ level (P ＞ 0.05). The patients were all followed up and the follow up time was 3-24 months, the median follow-up time was 13.5 months. Before treatment, there was no statistically significant difference in score of life quality between the two groups (P ＞ 0.05), after treatment for 1 year and 2 years, the score of life quality in the observation group were significantly higher than those in the control group, with statistically significant differences (P ＜ 0.05). Conclusion Early whole brain radiotherapy helps to prolong the survival time of patients with non-small cell lung cancer accompanied by brain metastases, delayed brain radiotherapy will have a negative impact on the prognosis of the patients, clinical attention should be focused on.
2018 Vol. 15 (16): 76-79 [Abstract] ( 234 ) HTML (1 KB)  PDF (617 KB)  ( 106 )
80 The application of Dexmedetomidine combined with Sulfentanyl for postoperative analgesia in children's inguinal area
ZHANG Jie1 LI Jianling2 CUI Yan3
Objective To explore the value of Dexmedetomidine combined with Sulfentanyl for postoperative analgesia in children's inguinal area. Methods From June 2016 to June 2017, 100 cases of inguinal area operation and general anesthesia for children were studied in Chengde Hospital of Traditional Chinese Medicine and Affiliated Hospital of Chengde Medical University. According to the random number table method, they were randomly divided into observation group (n = 50, using Dexmedetomidine combined with Sulfentanyl for postoperative analgesia) and control group (n = 50, conventional analgesics for postoperative analgesia). HR, MAP, Ramsay score, Wong-Baker facial expression scale and adverse reactions were compared at different times after operation (i.e. T1: immediately after operation; T2: postoperative 2 h; T3: postoperative 4 h; T4: postoperative 8 h) between two groups. Results At T2, HR and MAP of children in the two groups were lower than T1, the differences were statistically significant (P < 0.05), while in T1, T2, T3 and T4 time, there was no significant difference in HR and MAP between the two groups and the differences were not statistically significant (P > 0.05). The Ramsay scores at T2, T3 and T4 in two groups were all higher than those at T1, the scores at T2, T3 and T4 in the observation group were higher than those in the control group(P < 0.05). At T2, Wong-Baker facial expression scale scores of two groups were higher than those at T1, Wong-Baker facial expression scale scores of the observation group at T2, T3, T4 were lower than those of the control group, and the differences were all statistically significant (P < 0.05). The incidence of adverse reactions in the observation group was 14.00%, and the incidence of adverse reactions in the control group was 10.00%. There was no statistical significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Dexmedetomidine combined with Sulfentanyl has good analgesic effect in children after inguinal surgery. It has little influence on hemodynamics and safety, and it is worthy of clinical application.
2018 Vol. 15 (16): 80-84 [Abstract] ( 235 ) HTML (1 KB)  PDF (490 KB)  ( 70 )
85 The application of Dexmedetomidine combined with Ropivacaine unilateral paravertebral block in thoracic surgery
WANG Wei1 LIN Dawei2▲ ZHANG Chengzuo3 GENG Baochun1
Objective To observe the application effect of Dexmedetomidine combined with Ropivacaine unilateral paravertebral block in thoracic surgery. Methods A total of 94 patients in Fushun Central Hospital from February 2015 to April 2017 were divided into control group (n=47) and observation group (n=47) according to the random number table method. The patients in the control group were treated with Ropivacaine, and the patients in the observation group were treated with Dexmedetomidine combined with Ropivacaine. The differences of analgesic effect, paravertebral block, awakening and adverse reaction were observed between the two groups. Results The onset time of sensory block, the fixed time of block, the range of spinal nerve block, the duration of operation, the time of tracheal catheter extraction and the time to leave recovery room were compared between the two groups, and the differences were not statistically significant (P > 0.05). The postoperative VAS score in the observation group was lower than the control group, the difference was statistically significant(P < 0.05). There were no statistically significant differences in the Ramsay scores and the adverse effects between two groups (P > 0.05). Conclusion Compared with Ropivacaine alone, Dexmedetomidine combined with Ropivacaine unilateral paravertebral block has better analgesic effect in thoracic surgery, which reduce postoperative pain intensity, and it is safety, reliability, in favor of postoperative recovery and worthy of clinical promotion.
2018 Vol. 15 (16): 85-88 [Abstract] ( 262 ) HTML (1 KB)  PDF (478 KB)  ( 76 )
89 The introduction of professor Yang Hua′s academic thought and experience in treating spleen and stomach diseases
HONG Dan1,2 CHENG Yawei2 YANG Hua2
This paper introduces the academic thought and experience of professor Yang Hua in treating the spleen and stomach disease. It proposes that "the spleen and stomach are the pivot of the qi functional movements in body and curing disease shall comply with the nature of qi's ascending and descending", "the spleen and stomach shall be cured separately and the qi and blood shall be regulated simultaneously", "the representation of symptom on the upper and lower body shall be cured from the middle body" and "the discrimination and differentiation of disease shall be combined". The clinical experiences such as "the principal syndrome shall be grasped and the pathogenesis shall be discriminated", "the physical health shall be discriminated, different measures shall be adopted to different persons" and "the treatment rules shall be clear, as well as the prescription shall be selected, and the therapy shall be based on the classical theory" have been summarized.
2018 Vol. 15 (16): 89-92,96 [Abstract] ( 294 ) HTML (1 KB)  PDF (649 KB)  ( 148 )
93 Experience on the clinical effects of Modified Huangqi Guizhi Wuwu Decoction in the treatment of rhabdomyolysis caused by crayfish
CHE Yueni SHENG Meixiao
Rhabdomyolysis (RM) is a series of clinical syndromes, the dissolution of muscle cells caused by striated muscle injury releases plenty of myoglobin, creatine phosphokinase and lactate dehydrogenase, which enter the peripheral blood and give rise to organic biochemical disorder and injury of organ function. RM caused by eating crayfish is also called as Haff disease, which belongs to Chinese medicine “muscle bi-disease”, muscle bi-disease is caused by improper diet, dysfunction of spleen in transportation, dampness blocking channel. Huangqi Guizhi Wuwu Decoction is from Synopsis of Golden Chamber, which is made up of Radix Astragali seu Hedysari, Ramulus Cinnamomi, Radix Paeoniae Alba, Fructus Jujubae. The author uses Modified Huangqi Guizhi Wuwu Decoction in the treatment of RM caused by crayfish on basis of conventional treatment of western medicine, which has achieved satisfactory effects.
2018 Vol. 15 (16): 93-96 [Abstract] ( 214 ) HTML (1 KB)  PDF (618 KB)  ( 176 )
97 Clinical study of Modified Shenqi Dihuang Decoction in the treatment of refractory primary nephrotic syndrome
YU Xiaoyu1 ZHOU Min2 LU Dan1 QIU Xiaoling3
Objective To observe the clinical efficacy of Modified Shenqi Dihuang Decoction in the treatment of refractory primary nephrotic syndrome. Methods Sixty-eight patients with refractory primary nephrotic syndrome treated and hospitalized in Huludao Central Hospital from January 2015 to July 2017 were selected as research objects, and they were divided into control group and experimental group according to the random number table. The control group was given the basic treatment of western medicine, on basis of which, the experimental group was treated with Modified Shenqi Dihuang Decoction. The total course of both groups was 8 weeks. The urine protein, serum albumin, creatinine and urea nitrogen levels were compared between the two groups before and after treatment, and the differences of renal function indices and TCM syndrome scores were recorded. The data of the study was analyzed by SPSS 17.0. Results The levels of urinary protein quantitation for 24 hours, serum albumin, creatinine, urea nitrogen and TCM syndrome scores of the two groups after treatment were all significantly improved compared with those before treatment, the differences were statistically significant (P ＜ 0.05). Compared with the control group, the renal function index and TCM syndrome score of the experimental group improved more significantly, the differences were statistically significant (P ＜ 0.05). After treatment, the recurrence rate of the experimental group and the control group was 8.82% and 17.65% respectively, the difference was statistically significant (P ＜ 0.05). Conclusion Modified Shenqi Dihuang Decoction can effectively improve renal function indices, reduce proteinuria and improve the clinical symptoms in patients with refractory primary nephrotic syndrome. The clinical value is worthy of in-depth exploration.
2018 Vol. 15 (16): 97-100 [Abstract] ( 211 ) HTML (1 KB)  PDF (623 KB)  ( 76 )
101 Effects of Guishao Zuogui Yin in treating vulvar dystrophy with syndrome of yin deficiency of liver and kidney and the influence on immune function
LIU Yi DENG Linwen
Objective To explore clinical effects of Guishao Zuogui Yin in treating vulvar dystrophy with syndrome of yin deficiency of liver and kidney and the influence on immune function. Methods According to the random number table, 104 cases of patients with vulvar dystrophy with syndrome of yin deficiency of liver and kidney admitted to Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January 2014 to January 2017 were selected, and they were divided into treatment group and control group, with 52 cases in each group. The control group was treated with conventional treatment, while the treatment group was treated with conventional medicine combined with Guishao Zuogui Yin. The two groups were treated for 1 month. The clinical curative effect was evaluated after treatment. The TCM symptom scores, vulvar skin pigment loss scores, CD3+, CD4+, CD8+ and CD4+/CD8+ of the two groups were compared before and after treatment. The adverse reactions of the two groups during the treatment were recorded and compared. Results The total effective rate of observation group was 96.15% (50/52), which of control group was 69.23% (36/52), the difference was statistically significant (χ2=13.168, P ＜ 0.01). After treatment, the TCM symptom scores, vulvar skin pigment loss scores, CD3+, CD4+ and CD4+/CD8+ of the treatment group were lower than those of the control group (P ＜ 0.01), the CD8+ of the treatment group was higher than that of the control group (P ＜ 0.01). There were no serious adverse reactions of the two groups during treatment. Conclusion Guishao Zuogui Yin in the treatment of vulvar dystrophy with syndrome of yin deficiency of liver and kidney has a good efficacy and few adverse reactions, which can reduce the clinical symptoms, improve the immune function, and it is worthy of clinical promotion and application.
2018 Vol. 15 (16): 101-104 [Abstract] ( 155 ) HTML (1 KB)  PDF (662 KB)  ( 43 )
105 Evaluation of clinical efficacy and safety of external application of Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction for knee osteoarthritis syndrome of cold-dampness due to kidney deficiency
ZHANG Yanzhen1 LU Cong2 ZHANG Chen1 SUN Songge1 QIU Xinping1▲
Objective To evaluate the clinical efficacy and safety of external application of Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction for knee osteoarthritis of syndrome of cold-dampness due to kidney deficiency. Methods Sixty-eight patients with knee osteoarthritis of syndrome of cold-dampness due to kidney deficiency admitted to Outpatient Department of Rheumatology, Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital from January to October 2017 were selected as research objects. They were divided into treatment group and control group by random number table method. The treatment group was treated with Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction, the control group was treated with external application of Diclofenac Diethylamine Emulsion, the course of the two groups was 2 weeks. The scores of joint pain (patient evaluation and doctor evaluation), Michel Lequesne index of severity for knee joint osteoarthritis (ISOA), WOMAC osteoarthritis index, and TCM syndrome integral, security indices were observed before and after treatment, so as to evaluate the effect and safety. Results After treatment, the scores of joint pain (patient evaluation) in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of joint pain (patient evaluation) after treatment in the treatment group was lower than the control group (P ＜ 0.05). After treatment, the scores of joint pain (physician evaluation) in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of joint pain (physician evaluation) after treatment in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the scores of ISOA in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of ISOA after treatment in the treatment group were lower than the control group (P ＜ 0.05). After treatment, the scores of WOMAC osteoarthritis index in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the scores of WOMAC osteoarthritis index in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the total scores of TCM syndromes in the two groups were significantly lower than those before treatment (P ＜ 0.01), and the total score of TCM syndromes in the treatment group after treatment was lower than the control group (P ＜ 0.05). After treatment, the clinical efficacy of the treatment group was better than that of control group, the difference was significant (P ＜ 0.05). The efficacy of TCM syndrome of the treatment group was better than that of control group, the difference was statistically different (P ＜ 0.05). No adverse reactions occurred in either group. Conclusion The treatment of Chinese herbal medicine fumigation with Eliminating Dampness and Dispelling Cold Decoction has the effects of relieving symptoms and improving joint function and clinical signs in patients with knee osteoarthritis syndrome of cold-dampness due to kidney deficiency. Its curative effect is more significant than that of external application of Diclofenac Diethylamine Emulsion, and no adverse reactions are found. It is a safe and effective method.
2018 Vol. 15 (16): 105-109 [Abstract] ( 249 ) HTML (1 KB)  PDF (680 KB)  ( 48 )
110 Ultrasonography imaging characteristics analysis of the phyllodes tumor of the breast
XUE Shanshan1 LI Ning1 SHENG Wei2 ZHAO Qiaoling1▲
Objective To analyze the sonographic features of phyllodes tumors of the breast (PTB) and explore the diagnostic value of ultrasonography in the PTB. Methods A retrospective analysis was performed on the patients with PTBs in the First Affiliated Hospital of Xi 'an Jiaotong University from June 2015 to June 2017, including 36 masses with complete ultrasound and pathological data. Results Among the 36 PTBs, 19 PTBs were benign, 11 PTBs were borderline and 6 were malignant tumors according to the pathologic diagnosis. The ultrasonic image feature of the masses were commonly observed to have more a clear-cut boundary, and inhomogeneous internal echo, the rarely calcification and more blood flows. The clear boundary was more commonly detected in the benign phyllodes tumors (χ2=6.597, P =  0.037). The inhomogeneous internal echo was more commonly observed in the malignant, with high echo separation and a cystic echo-free area was more commonly observed in these malignant tumor (χ2=6.840, P = 0.033; χ2=7.049, P = 0.029). Conclusion The ultrasonic imaging of PTB exhibits definite characteristics, and the border with high echo separation and cystic areas in the tumors can be used to differentiate between benign and malignant PTBs.
2018 Vol. 15 (16): 110-113 [Abstract] ( 213 ) HTML (1 KB)  PDF (652 KB)  ( 125 )
114 Application of ultrasound elastography and contrast-enhanced ultrasonography in the evaluation of neoadjuvant chemotherapy for breast cancer
HAN Yanfeng1 ZOU Shuwei2 WANG Baohua3▲
Objective To discuss the comparison of ultrasound elastography and contrast-enhanced ultrasonography in the evaluation of neoadjuvant chemotherapy for breast cancer. Methods A total of 55 patients with breast cancer in Chinese and Western Medicine Hospital of Taizhou City from January 2015 to January 2017 were selected, all patients underwent neoadjuvant chemotherapy, ultrasound elastic imaging and ultrasound angiography were used in patients before and after the chemotherapy cycle, the differences between the imaging results and pathological results were compared, and the application of two kinds of examination regimen in the evaluation of neoadjuvant chemotherapy for breast cancer were determined. Results There were not significant differences in ultrasound elastography, ultrasonography, and pathological results after 4 cycles of chemotherapy (P > 0.05). Compared with ultrasound elastography, there was no significant difference in the sensitivity and accuracy of CEUS (P > 0.05). Conclusion There is a high sensitivity and accuracy in the evaluation of neoadjuvant chemotherapy in breast cancer with ultrasound elastography and contrast-enhanced ultrasound, and it is different in the evaluation of the direction and content. Combined with elastic imaging and ultrasound angiography in the clinical can improve the accuracy assessment of neoadjuvant chemotherapy in breast cancer.
2018 Vol. 15 (16): 114-117 [Abstract] ( 742 ) HTML (1 KB)  PDF (630 KB)  ( 151 )
118 Feasibility of low - dose HRCT in the diagnosis of pulmonary - ground - glass - density nodules using iterative reconstruction
LIU Wenhui1 CAO Liming1 LI Liangshan2▲ LI Bin2
Objective To evaluate the feasibility of diagnosing pulmonary grinded glass nodule (pGGN) by different levels of iDose4 iterative reconstruction technology under low HRCT conditions. Methods Selected 40 cases of patients who was diagnosed as a glass-polluted nodule by conventional chest CT examination in Traditional Chinese Medicine Hospital of Pinghu City, from October 1 2014 to April 1 2016. 16-slice spiral CT was performed on 40 pulmonary nodular nodules whose diameter were 5 to 13 mm, took four different dose conditions (tube voltage 120 kV; tube current 100, 50, 25, 10 mAs), reconstructed all the data by iDose4 iteration reconstruction techniques and traditional filtered backprojection (FBP). Two experienced physicians were asked to evaluate images at different dose levels and different reconstruction techniques. Consistency assessment was conducted by Kappa analysis, and the image noise (MSD) and effective radiation dose (ED) was measured for each examination. Results The difference was statistically significant (P < 0.05) in SD values under different tube currents and image reconstruction techniques. The difference was statistically significant (P < 0.05) in SD values under the same tube current conditions and different reconstruction techniques. There was no significant difference(P > 0.05) in CT values of lung parenchyma under different tube currents and image reconstruction techniques. The consistency was good(Kappa=0.601, P = 0.000) between the two doctors, under traditional FBP and iDose4 technology, there was a statistically significant difference (P < 0.05) in the comparison of the visibility of pGGN at 100, 50, 25, 10 mAs. Under the condition of 50, 25, 10 mAs, there was a statistically significant difference (P < 0.05) in the number of nodules on the high score under the iDose4-4/7 reconstruction technique. Conclusion 16-slice spiral CT can be used to detect lung-dense glass nodules at 10 mAs, it can ensure images in the clinical combine with iDose4 iterative reconstruction technology. The radiation dose to the patient can be further reduced, and it is worthy of clinical promotion in early lung cancer screening.
2018 Vol. 15 (16): 118-121,129 [Abstract] ( 199 ) HTML (1 KB)  PDF (602 KB)  ( 177 )
122 Application of high frequency color ultrasonography in the diagnosis of long head bicep tendinitis
JING Chaolong1 MA Yong2 SUN Yousheng1 ZHANG Jun1 ZHANG Jianyong1 ZHANG Hui1
Objective To evaluate the diagnostic value of high frequency color ultrasonography in tendinitis of caput longum musculi bicipitis brachii. Methods A total of 60 patients who were diagnosed with scapulohumeral periarthritis and long head bicep tendinitis by high frequency color ultrasonography at Orthopedic Clinic of Yangzhou Traditional Chinese Medicine Hospital from March 2016 to February 2018 were selected. Thickness, internal echo, calcification and blood flow distribution sonogram of both affected and unaffected long head bicep tendons were observed from cross section and longitudinal section. In order to compare differences between affected and unaffected long head bicep tendons, those 60 patients were divided into the acute period and the chronic period. Results Of the 36 acute patients, the thickness of tendon, echo reduction, and blood flow increase of the affected side were higher than those of the unaffected side, the differences were statistically significant (P < 0.05). Of the 24 chronic period patients, echo clutter, internal calcification, and blood flow increase of the affected side were higher than those of the unaffected side, the differences were statistically significant (P < 0.05). Conclusion High frequency color ultrasonography is clear, fast, cheap and repeatable in positioning and qualitatively diagnosing tendinitis of caput longum musculi bicipitis brachii. Therefore, it can be regarded as the preferred method of examination.
2018 Vol. 15 (16): 122-125 [Abstract] ( 215 ) HTML (1 KB)  PDF (666 KB)  ( 72 )
126 Analysis of factors influencing image quality of chest 18F-fluorodexxyglucose SPECT coincidence images
CAO Baoxia LI Duo LYU Pingxin▲
Objective To discuss the method that can improve the image quality of chest 18F-FDG SPECT coincidence imaging through analysis of the factors that affect the image quality. Methods The chest coincidence imaging of 100 patients in Beijing Chest Hospital， Capital Medical University from December 2016 to February 2017 were obtained. The imaging quality was classified as excellent in 12 cases, good in 72 cases and poor in 16 cases. The radioactivity counting and the standard deviation (SD) value of lung, chest wall, main vessel and liver were recorded. The relationship of subjective image quality and the objective value was analyzed. The patients' age, gender, height, body weight, blood glucose, injected FDG dose, check order, probe 1 and 2 of the radioactivity counting and coincidence rate, injection and scanning time interval were also recorded. The influences of above factors on image quality were analyzed. Results There was a significant difference of BMI, injected FDG dose of per kilogram body weight and the time interval between the injections and scan among the three groups (all P < 0.01). There was a significant difference in the radioactivity count of lung, chest wall, and liver among the three groups (all P < 0.01). There was a significant difference in SD value of the chest wall, large vessels and liver among the three groups (all P < 0.05). There was moderate correlation of the image quality and the coincidence rate (r = 0.505, P < 0.01), BMI was negatively correlated with image quality (r = -0.473, P < 0.01), while the injected FDG dose of per kilogram body weight was positively correlated with image quality (r = 0.343, P < 0.01). Conclusion The subjective image quality evaluation is in good agreement with the objective measured values. BMI is the most important factor that affects the image quality. The best dose of injected FDG and the appropriate injection and scanning time interval are beneficial to obtain the good quality image.
2018 Vol. 15 (16): 126-129 [Abstract] ( 197 ) HTML (1 KB)  PDF (542 KB)  ( 69 )
130 The effect of Venlafaxine and Escitalopram in patients with depression and its influence on heart rate variability and autonomic nervous function
HUANG Minfang LIU Jimeng LIU Lingjiang LI Xingxing ZHOU Qi ZHOU Dongsheng
Objective To research the curative effect of Venlafaxine and Escitalopram in patients with depression and its influence on heart rate variability and autonomic nerve function. Methods From December 2016 to December 2017, 100 patients with depression admitted to Ningbo Kangning Hospital were selected and divided into Venlafaxine group and Escitalopram group by random envelope method, with 50 cases in each group. All patients were treated for 4 weeks. The Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were applied to evaluate the clinical efficacy before and after treatment. The heart rate variability was measured by dynamic electrocardiogram. The sympathetic skin response (SSR) was used to assess the autonomic nerve function. Results After treatment, the scores of HAMD and HAMA in the two groups were all lower than those of before treatment, with statistically significant differences (P ＜ 0.05), but there were no statistically significant differences between the two groups after treatment (P ＞ 0.05). There was no statistically significant difference between the two groups in the total effective rate (P ＞ 0.05). After treatment, the standard deviation of normal to normal R wave (SDNN), standard deviation of the averages of NN intervals in all 5-minute segments of the entire recording (SDANN), total power (TP), low frequency (LF) and high frequency (HF) were all significantly higher than those of before treatment, the percentage of intervals 50 ms different from preceding interval was significantly lower than that of before treatment, and the indicators above in the Venlafaxine group improved much more remarkably, with statistically significant differences (P ＜ 0.05). After treatment, the latency of SSR in the two groups was lower than that of before treatment, the amplitude of SSR was significantly higher than that of before treatment, and the indicators above in the Venlafaxine group improved much more remarkably, with statistically significant differences (P ＜ 0.05). Conclusion Venlafaxine and Escitalopram have equivalent effects on depression. The Venlafaxine is better than Escitalopram on heart rate variability and autonomic nerve function in depression patients.
2018 Vol. 15 (16): 130-133 [Abstract] ( 721 ) HTML (1 KB)  PDF (438 KB)  ( 268 )
134 Clinical effect of Shugan Jieyu Capsules combined with Mesalazin in the treatment of patients with ulcerative colitis
XU Xiaohong
Objective To investigate curative effect of Shugan Jieyu Capsules combined with Mesalazin in the treatment of patients with ulcerative colitis. Methods Clinical data of 150 patients with ulcerative colitis admitted to Ganzi Tibetan Autonomous Prefecture People′s Hospital from June 2015 to January 2017 was analyzed retrospectively and divided into the observation group and the control group according to the method of administration, with 75 cases in each group. The control group was treated with oral Mesalazin, while the observation group was treated with Shugan Jieyu Capsules on the basis of the control group. The course of treatment was 3 months in both groups. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were applied to compare the levels of anxiety and depression between the two groups before and after treatment. The modified Mayo scoring system was used to evaluate the degree of disease activity and the curative effect. The inflammatory bowel disease questionnaire (IBDQ) was used to evaluate the quality of life after treatment in both groups. The changes of blood inflammatory markers in the both groups were compared before and after treatment, and the adverse reactions were recorded. Results The total effective rate in the observation group was significantly higher than that of control group, with statistically significant difference (P ＜ 0.05). After treatment, the scores of SAS and SDS in the observation group were much lower than those of before treatment and those of control group, with statistically significant differences (P ＜ 0.05); the score of IBDQ was higher than that of before treatment and the score of Mayo was lower than that of before treatment, and the scores in the observation group improved much more remarkably, with statistically significant differences(P ＜ 0.05). After treatment, the levels of platelet count and C-reactive protein were significantly lower than those of before treatment, and the indicators above in the observation group were much more lower than those of control group, with statistically significant differences (P ＜ 0.05). There was no statistically significant difference in the level of platelet volume before and after treatment in the two groups (P ＞ 0.05). There was no statistically significant difference in incidence of adverse reactions between the groups (P ＞ 0.05). Conclusion Mesalazin combined with Shugan Jieyu Capsules can significantly reduce the level of inflammation in ulcerative colitis patients, thereby helping to relieve the extent of disease activity, improve the curative effect. It can effectively alleviate the anxiety and depression, improve the life quality of ulcerative colitis patients.
2018 Vol. 15 (16): 134-137,141 [Abstract] ( 176 ) HTML (1 KB)  PDF (672 KB)  ( 69 )
138 Evaluation of the laboratory results of patients with syphilis
GUO Jie* JIAO Bingxin* LIU Ying QU Pei XU Xinmin LI Juan
Objective To investigate the value of different combinations of serological tests in the diagnosis of syphilis. Methods The serum of 20 325 patients visited Beijing Ditan Hospital from September 2016 to August 2017 were collected. Three methods including toluene red unheated serum test (TRUST), treponema pallidum gelatin agglutination test (TPPA) and fluorescent treponema pallidum antibody absorption test (FTA) were used to test the syphilis antibodies in the serum sample. Results Among the 20 325 patients, 4480 were diagnosed with treponema pallidum (TP) infection and among these patients with TPPA-positive, 3342 cases were positive for TRUST, accounted for 74.6%; 1138 cases were negative for TRUST, accounted for 25.4%. Among 3342 cases of TPPA-positive and TP-positive patients, 979 cases were positive for FTA-ABS-IgM, accounted for 29.3%. Among 1138 cases of TPPA-positive and TRUST-negative patients, 12 cases were positive for FTA-ABS-IgM, accounted for 1.05%. The positive rate of IgM antibody in 979 patients with syphilis was logarithmically correlated with different dilutions of the TRUST (R2 = 0.9351). Conclusion For laboratories that carried out syphilis serological tests, TPPA and TRUST should be carried out simultaneously. FTA-ABS-IgM was an effective complement for two other methods with TRUST-negative and TRUST persistent positive after treatment.
2018 Vol. 15 (16): 138-141 [Abstract] ( 197 ) HTML (1 KB)  PDF (438 KB)  ( 152 )
142 Exploration on pharmacy major practical teaching system of pharmaceutical specialty in higher vocational education melt into the “craftsmanship spirit”
YANG Wenhao
“Craftsmanship spirit” is a kind of attitude of skilled talents to the occupation, which is an important content of professional spirit. Under the background of new normal of domestic economy and adjustment of pharmaceutical industry structure at present, the pharmaceutical companies pay more and more attention to the professional spirit of graduates in higher vocational colleges besides professional skills, especially to the professional attitude in work. In the higher vocational education, especially the practical teaching system of pharmaceutical specialty, the “craftsmanship spirit” complies with the development trend of domestic pharmaceutical industry, which is also conducive to the improvement of the overall quality of students and the sustainable development of their future careers. This study starts from the necessity of “craftsmanship spirit” melt into the teaching system of pharmaceutical specialty in higher vocational education, and constructs the practical teaching system of pharmaceutical specialty melt into the spirit of “craftsmanship spirit”, thus, the “craftsmanship spirit” of students are cultivated from three aspects: setting up the practical teaching team of pharmaceutical specialty, building campus practical training base, optimizing off-campus training base, and so on. Significant achievements have been obtained in the practical teaching system of past six years.
2018 Vol. 15 (16): 142-145 [Abstract] ( 175 ) HTML (1 KB)  PDF (546 KB)  ( 185 )
146 Research on the application of multi virtual machine collaborative computing in virtual drug screening
LI Xiaoyan LI Jianzhi LI Jingzhong
The virtual screening method based on molecular docking has become an important technology in the field of computer aided drug research, which plays a very important role in revealing the mechanism of drug and the target of the body and in the process of pharmaceutical research and development. The traditional molecular docking method used in virtual drug screening is complex in the operation process, which cannot realize automatic docking and automatic collection of calculated results. Through dynamic task scheduling and script control technology and using distributed architecture design, the collaborative computing virtual drug screening platform based on multi virtual institutions introduced in this paper realizes automatic manipulation of docking software and automatic collection of calculated results, which reduces the screening time remarkably, and improve the screening efficiency greatly.
2018 Vol. 15 (16): 146-149 [Abstract] ( 200 ) HTML (1 KB)  PDF (899 KB)  ( 105 )
150 SWOT analysis of the network open courses on the medical education reform in China
XU Ting1 LI Shufeng2
With the popularization of internet and the introduction of sharing education concept, the internet has become an important approach for the knowledge seekers to acquire knowledge. The abundant network open courses on the internet provide convenient learning conditions for medical students and medical workers, meanwhile, the courses have great influences on traditional medical education. Through summarizing the medical network open courses on the internet, this paper introduces websites and contents of excellent medical open course resources at home and abroad, analyzes the existing strengths and weaknesses, opportunities and threats of medical network open courses by the method of SWOT, and then put forward four strategies and proposals of strengths-opportunities (SO), strengths-threats (ST), weaknesses-opportunities (WO), weaknesses-threats (WT), so as to provide reference for the development of medical network open courses in our country and the reform of medical education.
2018 Vol. 15 (16): 150-153 [Abstract] ( 209 ) HTML (1 KB)  PDF (536 KB)  ( 98 )
154 Research on the improvement in outpatient department procedure based on the theory of industrial engineering
LIU Jie
The outpatient department procedure is one of the core procedures of hospital administration. The essay made the research that the improvement in the procedure of outpatient department from an angle of industrial engineering. Firstly, based on the procedure analysis method of motion study in the theory of industrial engineering, the author selected the medical process of obstetrics and gynecology, a department receiving the most patients in hospital, as a sample. Through investigation and research, the author found that it took patients many times to queue for paying costs and for a long time to queue inefficiently, significantly reducing the efficiency of treatment. Next, the author asked the subjects questions by using the “5W1H” method, in order to find the way of improving the outpatient procedure, including establishing the information system as integrate bank cards with medical cards, optimizing the layouts of type-B ultrasonic and medical examination, and balancing the distribution of patients receiving treatment based on the line balance theory, etc. In addition, the author used ECRS to cancel, merge, reorder or simple those nodes in the procedure, to save patients′ waiting time, reduce the non-effective actions and enhance patients′ satisfaction. Finally, the writer discussed that applying the industrial engineering theory can make more distributions to hospital administration, and expected to promote service efficiency, to improve service quality and to save the cost under the application of the key techniques of industrial engineering.
2018 Vol. 15 (16): 154-157 [Abstract] ( 209 ) HTML (1 KB)  PDF (372 KB)  ( 226 )
158 The development of standard physical restraint assessment scale for critically ill patients and its reliability and validity
YU Mingdi1 ZHANG Jingping2 ZHOU Yixia1
Objective To design standard physical restraint assessment scale for critically ill patients and test the reliability and validity, which provide a standard data for the nurses to follow, and help the nurses to regularize their behavior based on this scale. Methods Sixteen experts were consulted by using Delphi method to develop scale evaluation items, and 80 patients in ICU of the Affiliated Hospital of Guizhou Medical University were assessed to examine the reliability and validity. Results Physical restraint assessment scale consisted of 3 dimensions and 8 items: attack risk assessment (sedation agitation degree, communication skills, pain, aggressive behavior), fall-bed risk (activity ability, the number of drug) and tube risk (tube risk degree, the number of tube). The correlation coefficients between each item and total score ranged from 0.61 to 0.83. The exploratory factor analysis extracted 3 common factors, and the cumulative contribution rate was 87.215%. Internal consistency reliability Cronbach's alpha coefficient was 0.889, and inter rater reliability was 0.946 (P ＜ 0.05). Conclusion Standard physical restraint assessment scale for critically ill patients can be used to assess patients comprehensively, and it has good reliability and validity, which can guide nurses to regularize its restraint behaviors.
2018 Vol. 15 (16): 158-161 [Abstract] ( 279 ) HTML (1 KB)  PDF (611 KB)  ( 84 )
162 Application value of MEWS scoring assessment system in severe acute pancreatitis patients
LU Junhong NIU Yuying ZHANG Ying YANG Qian ZHAO Fengqun WANG Yan
Objective To explore the effect of MEWS in the nursing of patients with acute pancreatitis in emergency department. Methods Totally 94 patients admitted in the Emergency Department of Beijing Friendship Hospital, Capital Medical University from January 2014 to March 2017 were evaluated by MEWS, and corresponding measures were taken according to the MEWS scores. Then, the relationship between MEWS scores and admission time, prognosis were analyzed, the satisfaction of nursing job before and after MEWS were compared. Results 6 patients died after treatment among 94 patients, with mortality rate of 6.38%. The average MEWS score of death group was higher than that of survival group, the difference was statistically significant (P ＜ 0.05). The mortality gradually elevated with the increase of MEWS score, and there were statistically significant differences in cure rate and improvement rate of the patients with different MEWS score (P ＜ 0.05). The cure rate of the patients with 0 point in MEWS score was the highest (100.00%), and the improvement rate of the patients with MEWS score ≥6 was the highest (75.00%). Through effective treatment measures, overall MEWS scores gradually declined, especially after 6 hours of admission, the decline was most pronounced. Conclusion MEWS score has the characteristics of convenient, quick and easy to master, can accurately reflect the state of illness and evaluate prognosis of the patients with SAP, also can obviously improve the nursing quality.
2018 Vol. 15 (16): 162-165 [Abstract] ( 207 ) HTML (1 KB)  PDF (623 KB)  ( 53 )
166 Study on the effects of health education combined with psychotherapy on the mental disorders after thoracic aorta aneurysm surgery
LI Xinxing WANG Jia SONG Mowei
Objective To explore the impact of health education combined with psychological nursing on the mental disorder after thoracic aorta aneurysm surgery. Methods Ninety cases of patients with thoracic aortic aneurysm from July 2015 to July 2017 treated in Qunli Hospital, the First Affiliated Hospital of Harbin Medical University were selected as clinical research objects, and divided into two groups by random number table, each group had 45 cases. The  patients in the control group were given routine health education, and the patients in the observation group were given health education in combination with psychological nursing. Anxiety depression, self-efficacy and comfort score changes before and after nursing intervention of two groups were compared. Results Compared with those before nursing intervention, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of each group after nursing intervention were significantly decreased (P < 0.05), and SAS and SDS scores of the patients in the observation group were significantly lower than those of the control group (P < 0.05). Compared with before nursing intervention, self-efficacy of the two groups after nursing intervention was significantly enhanced (P < 0.05), whereas, comfort score was significantly decreased (P < 0.05). Self-efficacy of the patients in the observation group was significantly improved than that of control group (P < 0.05), and its comfort score was significantly lower than that of the control group (P < 0.05). Conclusion Health education in combination with psychological nursing can effectively improve stress disorder in patients with poor psychological mood after thoracic aorta aneurysm surgery, which help to alleviate the mental disorders, increase their self-efficacy, improve patients daily comfort at the same time, which plays an important role in improving the prognosis of patients.
2018 Vol. 15 (16): 166-169 [Abstract] ( 192 ) HTML (1 KB)  PDF (607 KB)  ( 93 )
170 The effects of one-to-one tutoring education method on the nursing behavior of patients with high risk of type 2 diabetes
CHI Zhongqiu LIU Huan GAO Xue
Objective To explore the effect of one-to-one tutoring education method on the nursing behavior of patients with high risk of type 2 diabetes. Methods One hundred and ten cases of patients with high risk of type 2 diabetic foot treated in the Second Endocrine Ward, the Fourth Affiliated Hospital of Harbin Medical University from August 2015 to August 2017 were selected. All the patients were divided into the control group and the experimental group by random number table, each group had 55 cases. The control group was given the routine health education. The experimental group was given one-to-one tutoring education. All patients were given 12 months health education intervention. The basic knowledge, diabetic foot health behavior and the change of the protection act in accordance with the doctor's advice of patients with diabetic foot before and after health education were compared between the two groups. Results Compared with before health education, after intervention, the basic knowledge scores of diabetic foot, diabetic foot health behavior scores and self-care behavior scores were significantly enhanced in the two groups (P < 0.05); and after intervention, the basic knowledge scores, diabetes foot health behavior scores and compliance doctor self-care behavior scores of the experimental group were higher than those of the control group, the differences were statistically significant (P < 0.05). Conclusion One-to-one tutoring type health education can effectively improve diabetic foot high-risk patients' knowledge about their disease and foot care, help to establish a healthy lifestyle, improve patients' self-protection consciousness, reduce the occurrence of diabetic foot injury.
2018 Vol. 15 (16): 170-173 [Abstract] ( 137 ) HTML (1 KB)  PDF (567 KB)  ( 81 )
174 Clinical study of the prevention of galactostasis after cesarean section by 5P manual massage
TANG Lizhen
Objective To study the influence of 5P manual massage on breasts to eliminate postoperative galactostasis after cesarean section. Methods From January to November 2016, 200 cases of patients underwent cesarean section in Liutie Central Hospital of Liuzhou City were selected and divided into massage group (n = 100) and control group (n = 100). The control group was received routine breast care, and the massage group was implemented 5P manual massage on the basis of breast massage. The lactation yield, deposition rate and breast-feeding situation were compared between the two groups. Results Postpartum 48, 72, 96 h, the lactation yield of massage group were significantly higher than the control group, with statistically significant differences (P < 0.05). Postpartum 72 h and 96 h, the incidence of breast deposition in massage group were significantly lower than the control group, with statistically significant differences (P < 0.05). 5 days postpartum, the rate of breast feeding adequacy of the parturient in the massage group was obviously higher than that of the control group, with statistically significant difference (P < 0.05). Conclusion 5P manual massage can effectively improve the amount of lactation yield, prevent the incidence of galactostasis, and improve breast feeding in cesarean section. It is worthy of clinical promotion.
2018 Vol. 15 (16): 174-176 [Abstract] ( 186 ) HTML (1 KB)  PDF (609 KB)  ( 63 )
177 Application effect of Roy adaptive nursing intervention in family members of children with congenital heart disease
LIU Zhengwei1 ZHOU Wanxing2▲
Objective To investigate the effect of Roy adaptive nursing intervention on family intervention in children with congenital heart disease. Methods A total of 150 children with congenital heart disease who were treated in Department of Cardiac Surgery, Guangzhou Women and Children Medical Center from June to September 2017 were selected and randomly divided into study group and control group according to random number table, with 75 cases in each group. The relatives of children in the control group were given routine nursing intervention, including observation of the disease, basic nursing, and health guidance for the family members of the children. On the basis of the control group, the study group was given Roy adaptive nursing intervention during perioperative period. Both the two groups were intervened for 1 month. The satisfaction degree of nursing service was evaluated by the questionnaire of hospital nursing satisfaction. SDS and SAS were used to investigate the mental health status of the two groups. Results 85.45% of the children′s family members in the control group was satisfied with the nursing work, which was 98.18% in the study group, the difference was statistically significant (P < 0.05). The scores of SDS and SAS after intervention were significantly decreased compared with before intervention in the two groups (P < 0.05). The scores of SDS and SAS after intervention in the study group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Implementing Roy adaptive nursing model in children with cardiac surgery can not only create favorable conditions for surgery, but also improve the satisfaction of nursing services for children and their families, and make them feel safe during the medical treatment, reduce the anxiety for surgery of the relatives of children, thus improve the quality of care.
2018 Vol. 15 (16): 177-180 [Abstract] ( 173 ) HTML (1 KB)  PDF (613 KB)  ( 55 )
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