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| The variation of rats′ physiological indices after different time of simulated weightlessness |
| ZHAO Jun1 LI Yongzhi2 GAO Jianyi2 ZHANG Ruitao1 YU Jiaoyan1 XU Yuan1 ZHANG Yang1 QIAO Yuan3 WANG Qingwei1 |
1.Department of Pharmacy, the Second Affiliated Hospital of Airforce Medical University, Shaanxi Province, Xi＇an 710038, China;
2.China Astronaut Research and Training Center, Beijing 100094, China;
3.Department of Pharmacy, Affiliated Hospital of Yan＇an University, Shaanxi Province, Yan′an 716000, China |
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Abstract Objective To study the variation of rats′ physiological indices on different time of simulated weightlessness. Methods Sixty-four SD rats were divided into 8 groups randomly, with 8 rats in each group. The model of simulated weightlessness was established by hindlimb unloading respectively for 1, 2, 3 weeks and 4 weeks, the body weight, liver function, kidney function and myocardial enzyme spectrum were measured, the body weight growth rate and organ coefficient were calculated. And then, the data was statistically analyzed. Results Compared with the control group, the body weight growth rate of simulated weightlessness rat gradually decreased, the changes were significant after 2 weeks(P < 0.05), the changes were more significant after 3 weeks(P < 0.01); the ratio of heart to body weight and kidney to body weight were increased (P < 0.01 or P < 0.05); while the ratio of gastric to body weight showed a trend of decrease, and the changes were significant (P < 0.05) after 2 weeks, the ratio of heart to brain weight and kidney to brain weight were increased (P < 0.01 or P < 0.05); ALT (P < 0.05), AST, BUN, CK, CK-MB (P < 0.01) significantly increased after 1 week, the GLB (P < 0.05), UA (P < 0.01) increased significantly after 3 weeks. On the contrary, ALP, ALB, CHE (P < 0.01) and DBIL (P < 0.05) were significantly reduced after 1 week, TBA, AMY (P < 0.01) after 2 weeks and TP(P < 0.05) after 3 weeks significantly reduced. Conclusion Simulated weightlessness can induce a variety of effects on the physical function of rats, weight growth is inhibited, liver, kidney and myocardial function are severely injuried, prolong simulated weightlessness can increase the damage.
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