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| Endoplasmic reticulum stress related reactive oxygen species and its mechanism |
| SUN Jing1 WANG Wei2 TIAN Ye2 TIAN Zhen1▲ |
1.Department of Pathophysiology, Harbin Medical University, Heilongjiang Province, Harbin 150081, China;
2.Department of Cardiovascular Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150001, China |
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Abstract Endoplasmic reticulum(ER) is the major site of calcium storage and protein folding. Alterations in the oxidative environment of ER and also intra-ER Ca2+ can cause the production of ERS-induced ROS. PDI, ERO-1, GSH, Nox4, CYP, Ca2+ and mitochondrial electron transport chain proteins play crucial roles in ERS-induced production of ROS. Here, persistent ERS and protein misfolding-initiated ROS cascades and their related mechanisms will be reviewed.
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