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2018 Vol. 15, No. 6
Published: 2018-02-25
 
 
4 Curative effect of new nanocrystalline silver-zinc dressing on deep partial-thickness scald burn infection in rats
HUAN Ke1,2 BAI Bo1 BAI Xiaozhi3 SU Fei1 CHEN Xiao4 SANG Hongxun1,5
Objective To study the therapeutic effect of the new nanocrystalline silver-zinc dressing on deep partial-thickness scald burn infection. Methods 90 male SD rats were divided into three groups by random number table, with 30 rats in each group. Two deep partial-thickness scald wounds infected with Pseudomonas aeruginosa were established in the back of rats with consistent area and depth. Group A was treated with nano-silver dressing, group B was treated with nanocrystalline silver-zinc dressing, and group C was treated with ordinary sterile dressings when dressing change. The concentrations of interleukin -1 (IL-1), tumor necrosis factor alpha (TNF-α), interleukin -10 (IL-10) and transforming growth factor beta (TGF-β) in the tissues were detected by ELISA at 3, 6, 10 and 14 days after injury. Immunohistochemistry staining was used to observe the expression of inflammatory cytokines in group B, and the wound healing time of each group was recorded. Results At 3, 6, 10 and 14 days after injury, the levels of inflammatory factors IL-1 and TNF-α in group B were lower than those in group A and C, and the trend decreased with time prolonged, with statistically significant difference (P < 0.05). The concentration of IL-10 and TGF-β in group B was higher than those in group A and C, and the trend increased with time prolonged, with statistically significant difference (P < 0.05). Immunohistochemical staining was showed that the expression of inflammatory factor TNF-α in group B decreased with the prolongation of treatment time, and the expression of IL-10 increased gradually. The wound healing time of group B was shorter than those of group A and C, with statistically significant difference (P < 0.05). Conclusion The new nanocrystalline silver-zinc dressing has a better anti-infection and healing effect on deep partial-thickness scald burn infection.
2018 Vol. 15 (6): 4-7 [Abstract] ( 238 ) HTML (1 KB)  PDF (676 KB)  ( 132 )
8 Study on the anti-inflammatory effects of Turkish galls extract in vivo and in vitro
Meireguli·Yimiti1 DOU Qin2,3 LI Zhijian2,3 Silafu·Aibai2,3
Objective To study the anti-inflammatory effects of Turkish galls extract in vivo and in vitro. Methods The anti-inflammatory effects in vivo were observed through the experiments of mice ear swelling induced by xylene and rats toe swelling induced by carrageenan; the effects of Turkish galls extract for the growth curve and vitality of RAW264.7 cells and phagocytosis of neutral red were observed in vitro; the effects of Turkish galls extract for the secretion of tumor necrosis factor α (TNF-α) in RAW264.7 cells stimulated by lipopolysaccharide (LPS) were detected by enzyme linked immunosorbent assay (ELISA). Results Compared with model group, Turkish galls extract could significantly reduce the degree of ear swelling and toe swelling (P ＜ 0.05 or P ＜ 0.01). 20, 40 μg/mL of Turkish galls extract could activate RAW264.7 macrophages, the proliferation of RAW264.7 cells was promoted and their phagocytosis was enhanced. 25, 50 μg/mL of Turkish galls extract had significant inhibitory effects for the secretion of TNF-α in RAW264.7 cells stimulated by LPS (P ＜ 0.01). Conclusion Turkish galls extract has certain anti-inflammatory effects, which may be related to the inhibition of secretion of pro-inflammatory mediator TNF-α.
2018 Vol. 15 (6): 8-12,23 [Abstract] ( 229 ) HTML (1 KB)  PDF (897 KB)  ( 80 )
13 Study on the mechanism of Cisplatin chemosensitivity in cervical cancer cells based on miR21
YUE Xiaoxue MIAO Jinwei LU Pan
Objective To detect the mechanism of miR21 gene on the sensitivity of Hela and Cisplatin-resistant Hela/DDP cells to Cisplatin. Methods Mature miR21 mimic and negative control (NC) miRNA were transfected into Hela cells, while miR21 inhibitor and negative control (NC) miRNA were transfected into Hela/DDP cells by riboFECTTM  CP. Therefore, Hela cells were divided into mimic group, inhibitor group, NC group and blank group. Real-time PCR was used to measure the expression of PTEN mRNA in each group. The cell cycle was measured through PI method and apoptosis rate of cells after Cisplatin treatment was detected through AnnexinⅤ/PI by fluorescene activated cell sorter. Results Real-time PCR results showed that the expression of PTEN mRNA was an average of (0.410±0.046) fold higher in Hela/DDP than in Hela (P ＜ 0.01). The expression of PTEN mRNA in mimic group was obviously lower than those in NC group and blank group (P ＜ 0.01). The expression of PTEN mRNA in inhibitor group was significantly higher than those in NC group and blank group (P ＜ 0.01). There was no statistical difference between NC group and blank group (P ＞ 0.05) in Hela and Hela/DDP cells. The results of Annexin Ⅴ/PI showed that the apoptosis rate of mimic group was lower than NC group and blank group (P ＜ 0.05), while the inhibitor group showed that the apoptosis rate was more than NC group and blank group (P ＜ 0.05). The of cell proportion of S period in mimic group was higher than those of NC group and blank group (P ＜ 0.05), and there was no significant difference between NC group and blank group (P ＞ 0.05). In the meantime, the cell proportion of S period in inhibitor group was less than those of NC group and blank group (P ＜ 0.05), and there was no significant difference between NC group and blank group (P ＞ 0.05). Conclusion PTEN mRNA is low expressed in Hela/DDP cells and highly expressed in Hela cells. The up-regulated expression of miR21 in Hela can significantly reduce the expression of PTEN mRNA, reduce apoptosis and increase the proportion of S phase in the cell cycle, thereby resulting in Cisplatin resistance. The down-regulated expression of miR21 in Hela/DDP can increase the expression of PTEN mRNA, increase the apoptosis rate and reduce the proportion of S phase in the cell cycle, so as to increase the chemosensitivity of Cisplatin.
2018 Vol. 15 (6): 13-18 [Abstract] ( 254 ) HTML (1 KB)  PDF (1308 KB)  ( 95 )
19 Determination of drug content in entecavir-loaded orodispersible film by a reverse phase high performace liqiud chromatography
WEI Teng1 GAO Ying2 CAO Qingri1
Objective To establish a reverse phase high performance liquid chromatography (RP-HPLC) method for the determination of drug content in entecavir-loaded orodispersible films (ODFs). Methods The entecavir-loaded ODFs were prepared by using a solvent casting method with polyvinyl alcohol/polyethylene glycol graft copolymer as a film-forming agent. The RP-HPLC analysis was performed on an Inertsil ODS-3 C18 (4.6 mm×150 mm, 5 μm) column with mobile phases composed of acetonitrile-water (3∶97) and acetonitrile. The flow rate of mobile phase was 1.0 mL/min. The wavelength of UV detector was set at 254 nm and the injection volume was 20 μL. The column temparature was mantained at 25℃. The drug content of entecavir-loaded ODFs was analyzed by a gradient elution mode. Results The linear regression equation of entecavir standard solution was A=52548.1316C-639.5153 (R2=0.9999). The intra-day precision was 0.15%-0.56%, the inter-day precision was 0.35%-1.36%, and the accuracy was 99.70%. The limit of detection was 0.31 ng and the limit of quantitation was 0.28 ng. The drug solution was stable within 24 h. The drug content of entecavir-loaded ODFs was (98.93±0.55)%. Conclusion The RP-HPLC method of entecavir shows high specificity, good precision, accuracy, and stability. This method is suitable for the detemination of drug content in entecavir-loaded ODFs.
2018 Vol. 15 (6): 19-23 [Abstract] ( 219 ) HTML (1 KB)  PDF (769 KB)  ( 127 )
24 Research progress and mechanism of sepsis-induced acute kidney injury
ZHENG Ting YANG Dingping▲
Acute kidney injury is one of the most common and serious complications of severe sepsis. And the incidence and mortality of patients with sepsis-induced acute kidney injury (SAKI) remained high. In recent years, more and more studies have shown that the mechanism of mitochondrial dynamics, autophagy, oxidative stress and inflammatory response plays an extremely important role in the formation of SAKI. Therefore, understanding the development mechanism of SAKI is helpful for better prevention and control, and effectively reduce morbidity and mortality. In this paper, the mechanism of occurrence and development of SAKI is reviewed.
2018 Vol. 15 (6): 24-27 [Abstract] ( 207 ) HTML (1 KB)  PDF (533 KB)  ( 160 )
28 Research progress of incretin-based therapies on nonalcoholic fatty liver disease
PANG Baoying KUANG Hongyu▲
Type 2 diabetes mellitus is closely associated with non-alcoholic fatty liver disease (NAFLD), which is the most prevalent chronic liver disease worldwide. Currently, the only validated treatment for NAFLD is lifestyle intervention. Glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, collectively termed incretin-based therapies, represent two of the most widely used classes of novel antidiabetic drugs. A number of studies of human trials have evaluated the effects of incretins on liver fat content and suggest that the treatment could represent a new alternative for NAFLD management. In this paper, the main clinical studies regarding the effects of incretins on NAFLD are reviewed.
2018 Vol. 15 (6): 28-30,34 [Abstract] ( 192 ) HTML (1 KB)  PDF (547 KB)  ( 82 )
31 Research progress in application of heart rate variability in pregnancy disease
ZHU Meilin ZHENG Wenhui CHENG Lili DONG Youjing
Particular physical and psychological changes in the maternal body during pregnancy can lead to the occurrence of certain diseases, such as gestational hypertension, gestational diabetes, gestational sleep apnea syndrome, etc. The development of pregnancy disease is closely related to the change of maternal autonomic nervous function during pregnancy, for example, the very low frequency (VLF) and low frequency (LF) of pregnant women with preeclampsia increased significantly. The high frequency (HF) of pregnant women with gestational diabetes decreased significantly at night. The LF/HF of pregnant women with sleep apnea syndrome increased. The 24 hours standard deviation of NN intervals, HF and LF of the patients with congenital heart disease were significantly decreased, and the Heart rate variability (HRV) variation of the mothers with arrhythmia was controversial. HRV connected by safe noninvasive means can monitor the change of autonomic nerve and it has important clinical value in the evaluation and prediction of pregnancy maternal system disease.
2018 Vol. 15 (6): 31-34 [Abstract] ( 237 ) HTML (1 KB)  PDF (534 KB)  ( 128 )
35 Advances in the treatment of knee osteoarthritis with integrated traditional Chinese and western medicine
WANG Jing1* XIANG Fusheng1* LIU Li1 ZHONG Minlan2
Knee osteoarthritis is a very common chronic degenerative disease in clinic. For a long time, the morbidity of elderly patients has been kept up, the nonreversibility of disease process make it extremely difficult to treat the disease clinically. The Chinese scholars have made a lot of researches and clinical practice in the prevention and treatment of knee osteoarthritis. According to different fundamentals of medical theory, there are mainly traditional Chinese medicine, western medicine and combined treatment with multiple methods, which can be mainly divided into two aspects of invasive treatment and noninvasive treatment, such as oral medicine, external used medicines, joint injection, arthroscopic minimally invasive surgery, surgical operation, and so on. This paper makes a review of the current basic treatment conditions of knee osteoarthritis, so as to provide certain guiding effects for the majority of clinical workers.
2018 Vol. 15 (6): 35-38,48 [Abstract] ( 202 ) HTML (1 KB)  PDF (844 KB)  ( 132 )
39 Roles of various components in tumor microenvironment in the occurrence and development of tumor
TANG Yan ZHANG Mengmei WANG Fei YANG Ze WEI Xiangyao WANG Yuanyan BAI Yuju
Tumor microenvironment (TME), which is an extremely complex network of the internal environment composed of cancer-associated fibroblasts, neuroendocrine cells, adipose cells, immunocytes, vascular and lymphatic network, extracellular matrix and physical factors such as pH value, hypoxia, interstitial fluid pressure, etc., is closely related to every step in the onset, progression and metastasis of tumors. Based on current researches on TME at the cellular level, this study summarizes the main roles of the changes in the levels of each cell component and various factors in the onset, progression and invasion of tumors, providing a basis for exploring novel targets for the prevention and treatment of tumors.
2018 Vol. 15 (6): 39-43 [Abstract] ( 833 ) HTML (1 KB)  PDF (547 KB)  ( 611 )
44 Investigation and countermeasures of the present conditions of the quality of the hospital venous treatment in some districts and counties in Chongqing
LI Yuanjing1 ZHENG Huiyuan2▲ XIONG Chengmin2 ZHAO Hong2 DING Yi3 FU Hong4
Objective To discuss the present situation of the quality of venous treatment in the county hospitals of Chongqing, in order to provide the basis for the clinical training and quality improvement. Methods On March 21, 2016, through a cross-sectional survey, the current level and problems of intravenous infusion treatment for all hospitalized patients in Jiangjin Central Hospital of Chongqing, Three Gorges Central Hospital, and Liangping County People′s Hospital were investigated. In this study, the investigation focuses on the selection of infusion tools, selection of infusion puncture site, maintenance of various catheters, fixation and complications of catheter. Results ①Among a total number of 3232 patients in hospital, 2680 patients have been treated with infusion, accounting for 82.9%, among which, 1954 patients were chosen and recorded in research database. ②The use of the puncture tool was as follows: scalp needles accounted for 46.0%, the retention needle accounted for 49.0%, CVC accounted for 3.7%, and PICC accounted for 1.3%. ③The selection of puncture sites was as follows: 61.0% were conducted on the back of hands, 24.0% were in the forearm, and 15.0% were in other parts. ④The choice of dressing and fixation: 98.9% were transparent dressings, 1.1% were gauze dressings. There were 384 cases of nonstandard fixation and maintenance of dressings, including 183 nonstandard cases, accounting for 47.6%; 81 improper cases, accounted for 21.1%; 72 cases of hematocele or leakage in the wound dressing, account ing for 18.8%; 48 cases of edge curl, which accounted for 12.5%. ⑤Catheter maintenance: hematocele in catheter or joint, accounted for 15.0%. ⑥Related complications of infusion: 126 cases on complications where red points were mostly occurred in puncture sites, accounted for 51.6%. Conclusion According to the investigation, the surveyed hospitals operate quite well in choosing puncture sites and fixation, but there exist many defects in the selection and maintenance of catheter infusion tools. Nursing staff should analyze the current situations and carry out the relevant training and guidance to further standardize the operation behaviors so as to ensure the safety of transfusion and to prevent the occurrence of transfusion complications.
2018 Vol. 15 (6): 44-48 [Abstract] ( 251 ) HTML (1 KB)  PDF (487 KB)  ( 139 )
49 Investigation of the risk factors for functional dyspepsia of coal miners
ZHANG Xiujing MA Lizhuan LI Zhiting ZHANG Guoshun HOU Bingxu
Objective To investigate the possible risk factors for functional dyspepsia (FD) of coal miners in Tangshan. Methods A total of 1796 coal miners were selected randomly based on the Rome Ⅲ diagnosed questionnaire for adult functional gastrointestinal disease from April to August in 2016. They were interviewed by face-to-face and data were collected. FD was diagnosed according to the Rome Ⅲ criteria. The prevalence of FD was calculated. Multivariate logistic regression analysis was performed to determine the significant factors related to FD. These factors contained smoking, alcohol drinking, drinking tea, spicy food intake, water consumption, family income, underground work, work time and so on. Results At last, 1721 effective questionnaires were collected. And 398 miners with FD were enrolled in FD group while 1323 miners belonged to non-FD group. The overall prevalence of FD was 23.23%. In FD group, the rates of alcohol drinking, spicy or acidity food intake, skipping breakfast and irregular diet were higher than those in non-FD group (P ＜ 0.05). In FD group, the occurrence rates of underground work, long work time, low family income and contracted workers were higher than those in non-FD group (P ＜ 0.05). Multivariate Logistic indicated that spicy food intake, underground work, long work time and low family income were the influence factors of FD (P ＜ 0.05). Conclusion FD is a common disease in coal miners. Spicy food intake, underground work, long work time and low family income are risk factors of FD. Living habits educations, a pay raise, improving the working environment and increasing the labor and social security maybe will help to reduce the happening of FD in the coal mine workers.
2018 Vol. 15 (6): 49-52,57 [Abstract] ( 213 ) HTML (1 KB)  PDF (748 KB)  ( 161 )
53 Comparison of the effects of different ways of giving Bicalutamide combined with Goserelin in the treatment of advanced prostate cancer and influence on the expression of serum PSA, VEGF and miR-34a
LI Xiunan QIN Jie ZHANG Junpeng MA Chuanyu WANG Xingli WU Dongjun CHEN Xiaochi
Objective To analyze the effects of different ways of giving Bicalutamide combined with Goserelin in the treatment of advanced prostate cancer and influence on the expression of serum prostate-specific antigen (PSA), vascular endothelial growth factor (VEGF) and miRNA-34a (miR-34a). Methods From February 2015 to December 2016, 80 patients with advanced prostate cancer in the First Affiliated Hospital of Dalian Medical University were selected as research objects, and divided into study group and control group by random number table, with 40 cases in each group. The study group was treated with oral Bicarbonide and subcutaneous injection of Goserelin, when PSA< 0.2 ng/mL, stop taking these two drugs, and when PSA>4 ng/mL, continue to take these two drugs. The control group was given continuous medication. The serum PSA, VEGF, mir-34a and the incidence of urinary tract obstruction were detected and recorded before and after treatment, and the treatment effect, the incictence of adverse effects, the average treatment cost between two groups were compared. Results The serum PSA, VEGF, mir-34a and urinary obstruction of patients in the two groups after treatment for 3, 6, 9 months and 12 months were all lower than those before treatment, the differences were statistically significant (P < 0.05), and the two groups were compared, the differences were not statistically significant (P > 0.05). After treatment, the overall response rate in the study group was higher than control group, the difference was statistically significant (P < 0.05), the average treatment cost in the study group was lower than control group, the difference was statistically significant (P < 0.05), both groups had different levels of adverse reactions, but they were compared, the difference was not statistically significant (P > 0.05). Conclusion Bicalutamide combined with Goserelin intermittent and continuous administration all can improve the serum PSA, VEGF and miR-34a in patients with advanced prostate cancer, while the effect of intermittent administration is more obvious, and the effect is good.
2018 Vol. 15 (6): 53-57 [Abstract] ( 291 ) HTML (1 KB)  PDF (458 KB)  ( 179 )
58 Comparison of the treatment of minimally invasive percutaneous nephro?鄄lithotomy and flexible ureteroscope lithotripsy for solitary kidney subrenal calyx calculus 2-3 cm
ZHANG Yu1,2 JIANG Youtao3 LI Jiuzhi3 CHEN Lezhong1 WU Yue2
Objective To compare the effects of minimally invasive percutaneous nephrolithotomy (MPCNL) and flexible ureteroscope lithotripsy (FURL) for the treatment of solitary kidney subrenal calyx calculus 2-3 cm. Methods The clinical data of 96 cases of isolated kidney stone and treated in Baoan Central Hospital of Shenzhen from April 2013 to February 2017 were analyzed retrospectively. According to the different treatment methods, they were divided into MPCNL group (52 cases) and FURL group (44 cases), and the stone clearance rate, operation time, intraoperative bleeding, length of hospital stay, 24 hours postoperatively hemoglobin drop value and 24 hours postoperatively serum creatinine elevation value, surgical complications, and calculi composition were compared between the two groups. Results The phase 1 calculi clearance rate of MPCNL group was higher than that of FURL group (P < 0.05), but the total stone clearance rate of both groups were compared, the difference was not statistically significant (P > 0.05). The operation time of MPCNL group was shorter than that of FURL group (P < 0.01), but the intraoperative bleeding of MPCNL group higher than that of FURL group (P < 0.01), the length of hospital stay of MPCNL group was longer than that of FURL group (P < 0.01). The 24 hours postoperatively  hemoglobin drop value of MPCNL group was higher than that of FURL group (P < 0.01), the 24 hours postoperativedy serum creatinine elevation value of both groups were compared, the difference was not statistically significant (P > 0.05). The surgical complications of MPCNL group and FURL group were compared, the difference was not statistically significant (P < 0.05). The calculi composition of both groups were compared, the difference was not statistically significant (P > 0.05). Conclusion In the treatment of solitary kidney subrenal calyx calculus 2-3 cm, although the phase 1 calculi clearance rate of MPCNL is higher than FURL, FURL is less bleeding, and the length of hospital stay is shorter, which could be used as an alternative treatment to some extent.
2018 Vol. 15 (6): 58-62 [Abstract] ( 225 ) HTML (1 KB)  PDF (463 KB)  ( 184 )
63 Clinical effect of closed reduction combined with external fixaton in the treatment of intertrochanteric fracture of femur in high risk elderly
TIAN Yafeng1 LIU Shizhao2 YAO Xingbao1 YU Jian1 REN Weiliang3 LI Yanli4 WANG Jinbang3 QI Liqing3
Objective To explore the clinical effect of the closed reduction combined with external fixaton in the treatment of intertrochanteric fracture of femur in high risk elderly. Methods From May 2012 to May 2016, 92 patients with femoral intertrochanteric fracture over 60 years old treated in Hebei Provincial Hospital of Traditional Chinese Medicine were divided into the treatment group and the control group by random number table, with 46 cases in each group. The treatment group was given closed reduction combined with external fixaton and the control group was given skeletal traction, both of them were followed up for 6 months after operation. The Harris score and the incidence of complications were compared between the two groups. Results The Harris score in the treatment group was higher than that of control group, the incidence of complications in the treatment group was lower than that of control group, with statistically significant differences (P ＜ 0.05). Conclusion The clinical effect of the closed reduction combined with external fixaton in the treatment of intertrochanteric fracture of femur in high risk elderly is good. It can reduce the incidence of complications. The advantages are appropriate for elderly patients who are poor tolerance for surgery and with more internal medical diseases. It is worthy of clinical promotion and application.
2018 Vol. 15 (6): 63-66 [Abstract] ( 295 ) HTML (1 KB)  PDF (591 KB)  ( 84 )
67 Minimally invasive with cannulated compression screw combined with medial support plate in young adults with Garden Ⅲ and Ⅳ femoral neck fractures
WEN Yangyang1 LYV Jing1 SUN Hanrui1 FAN Ya′nan1 LI Wenlong2 JIA Yudong2 LIU Youwen2
Objective To observe the clinical effect of open reduction with cannulated compression screw combined with medial support plate via direct anterior approach (DAA) in the treatment of Garden Ⅲ and Ⅳ femoral neck fractures in young adults. Methods Clinical data of 37 young patients with femoral neck fractures treated by cannulated compression screw combined with medial support plate via DAA approach in He′nan Luoyang Orthopedic Traumatological Hospita from November 2014 to September 2015 were enrolled in this retrospective study. Fracture healing and complications were followed up and observed. The hip function was evaluated by hip Harris score and the fracture reduction was evaluated by Garden reset index. Results In this study, 37 patients were followed up for more than 2 years. All patients achieved bone healing in 3-6 months after operation, the average healing time was (4.40±0.96) months. No loosening of internal fixation or displacement of fracture occurred. Two years after operation, one patient had osteonecrosis of the femoral head, then the conservative treatment was performed, the activity of the hip joint was not significantly affected. One patient experienced a decrease in sensation of the skin outside the thigh, which was considered to be caused by injury of the lateral femoral cutaneous nerve and was given the drug symptomatic treatment, and recovered after 5 months. The final follow-up of the Harris hip score was (89.66±4.52), which was significantly higher than the preoperative score (40.41 ± 6.98) (P ＜ 0.05). There was no significant difference in the Garden reset index between 3 d after operation and 2 years after the operation (P ＞ 0.05). Conclusion By using open reduction with hollow compression screw combined with medial support plate via DAA approach in the treatment of Garden Ⅲ and Ⅳ femoral neck fracture in young adults, the injury is small, the reduction is accurate and the internal fixation is firm, which is beneficial to early active rehabilitation after operation and to reduce the incidence of nonunion and necrosis of the femoral head. It is worth popularizing in clinic.
2018 Vol. 15 (6): 67-70,79 [Abstract] ( 207 ) HTML (1 KB)  PDF (808 KB)  ( 167 )
71 Clinical study of percutaneous vertebroplasty combined with hypothermia plasma ablation in the treatment of thoracolumbar metastasis
LENG Yankui HOU Liqiang CAO Zhiqiang WANG Qiang WANG Haomin
Objective To explore the clinical effect of percutaneous vertebroplasty combined with hypothermia plasma ablation in the treatment of thoracolumbar metastasis. Methods A total of 20 patients with malignant tumor thoracolumbar metastasis diagnosed by clinical imaging and pathology in Department of Orthopedics, Zhejiang Jinhua Guangfu Hospital from January 2010 to June 2015 were selected, and they were treated with percutaneous minimally invasive vertebroplasty combined with hypothermia plasma ablation under local anesthesia. The visual analogue scale (VAS) before and after operation was compared, and the results of CT and X-ray were observed. Results All 20 cases gained successfull operation, they could move around by wearing a waist belt after operation for 2 h. They were followed-up for 12-30 months, with an average of 18 months. Postoperative thoracic waist pain was significantly reduced. The VAS score was reduced from (6.9±0.9) points before operation to (1.6±0.8) points after operation (P ＜ 0.05). The quality of life was improved significantly. The reexamination of CT and X-ray showed that the bone cement was filled satisfactorily, with no leakage. Conclusion Percutaneous vertebroplasty combined with hypothermia plasma ablation is a micro-invasive, effective palliative operation method for the malignant tumor patients with osteolytic metastatic lesion confined to the vertebral body, which can relieve pain, improve the quality of life, and reduce the recurrence of local lesions.
2018 Vol. 15 (6): 71-74 [Abstract] ( 199 ) HTML (1 KB)  PDF (712 KB)  ( 124 )
75 The efficacy of different surgical methods on the complicated tibial plateau fracture combined with soft tissue injury around the knee joint in the optimal time
MIAO Benkuan YU Runze
Objective To investigate the efficacy of different surgical methods on the complicated tibial plateau fracture combined with soft tissue injury around the knee joint in the optimal time. Methods From October 2013 to September 2017, clinical data of 60 patients with complicated tibial plateau fracture combined with soft tissue injury around the knee joint treated in the Second People's Hospital of Anhui Province were retrospectively analyzed and divided into group A and group B by different surgical methods, with 30 cases in each group. Group A was treated with anteromedial incision and group B was treated with anterolateral combined with posterior medial incision, both performed 6-7 d after the fracture within the optimal timing. The operation time, average bleeding volume, incidence of postoperative infection, drainage volume, the incidences of the delayed healing, the skin necrosis and the postoperative soft tissue injury around the knee joint in the two groups were compared. Results There was no statistically significant difference in the operation time between the two groups(P ＞ 0.05); The average bleeding volume and postoperative drainage volume in group A were lower than those of group B, with statistically significant differences (P ＜ 0.05); the incidences of the delayed healing, postoperative infection and skin necrosis in group B were lower than those of group A, with statistically significant differences(P ＜ 0.05). There were no statistically significant differences in the postoperative fracture healing time, incidence of internal fixation failure and recovery of ligaments around the knee between the two groups (P ＞ 0.05). The effective rate of knee joint scoring systom in group B was higher than that of group A, with statistically significant differences (P ＜ 0.05). Conclusion The anterolateral combined with posterior medial incisionin the optimal time can promote the recovery in patients with complicated tibial plateau fracture combined with soft tissue injury around the knee joint and reduce the incidence of postoperative complications, which is worthy of further clinical application.
2018 Vol. 15 (6): 75-79 [Abstract] ( 200 ) HTML (1 KB)  PDF (567 KB)  ( 244 )
80 Clinical effect comparison of Endobutton plates and clavicular hook plates for treatment of NeerⅡ distal clavicle fractures
LUO Yuancheng HUA Xianzhang Wang Kui WU Meiping WANG Lizuo YANG Wei ZHU Bing
Objective To compare and analyze the clinical efficacy of Endobutton plates and clavicular hook plates in treating NeerⅡ distal clavicle fractures. Methods The clinical data of 61 patients with NeerⅡ distal clavicle fractures in the National Hospital of Enshi Atonomous Prefecture from July 2012 to September 2016 were collected and divided into Group A (27 cases, adopted Endobutton plates fixation) and Group B (34 cases, adopted clavicular hook plates fixation). The intraoperative blood loss, the duration of surgery, total cost for treatment, surgery-related complications, visual analogue scale (VAS) scores and constant scores before and after surgery were compared between the two groups. Results All patients were followed-up for 12 months. The operation time in Group A was slightly longer than that in group B, while the intraoperative blood loss, the length of the wound and complications in Group A were lower than those in Group B (P ＜ 0.05). The comparison of average cost between the two groups had no statistical significance (P ＞ 0.05). The comparison of the excellent and good rate of VAS and Constant scores between the two groups of patients before and 12 months after surgery had no statistical significance (P ＞ 0.05). However, the excellent and good rate in Group A was obviously higher than that in Group B at 1, 3, and 6 months after surgery, the difference was statistically significant (P ＜ 0.05). Conclusion Endobutton plates are characterized by low incidence of surgery-related complications, more beautiful after surgery, rapid recovery, small pain and without the need of a second surgery, which is more worthy for clinical application.
2018 Vol. 15 (6): 80-83 [Abstract] ( 265 ) HTML (1 KB)  PDF (594 KB)  ( 119 )
84 Effect of growth hormone in the treatment of patients with severe intrauterine adhesions and its effect on the outcome of pregnancy and the level of inflammatory cytokines
YANG Li WU Huizhen GAN Haisi
Objective To investigate the effect of growth hormone on the treatment of patients with severe intrauterine adhesions and its effect on the outcome of pregnancy and the level of inflammatory cytokines. Methods Sixty-six patients with severe intrauterine adhesions treated in Obstetrics and Gynecology of Affiliated Hospital of Youjiang Medical University for Nationalities from June 2014 to March 2017 were selected as study subjects, and all patients were divided into control group (intrauterine adhesions separation surgery + estrogen therapy) + observation group (intrauterine adhesions separation + estrogen + growth hormone intervention) according to whether usedgrowth hormone, each group had 33 cases. The clinical treatment effect and pregnancy outcomes were compared between two groups, the levels of inflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were measured by enzyme linked immunosorbent assay. Results The improvement rate of menstruation in the observation group was significantly higher than that in the control group (χ2=4.232, P=0.039), and the intrauterine readhesion rate was also significantly lower than that in the control group (χ2=3.995, P=0.046). The pregnancy success rate was significantly higher than that of the control group (χ2=3.986, P=0.046), but there was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.733, P=0.392). The endometrial thickness of the observation group was significantly higher than that of the control group (P < 0.05). However, there was no significant difference in endometrial volume, resistance index and pulsatility index between the two groups (P > 0.05). In addition, the levels of IL-6, IL-8 and TNF-α in the observation group were significantly lower than those in the control group after the treatment (P < 0.05). Conclusion Growth hormone can significantly improve the treatment of patients with intrauterine adhesions, improve pregnancy outcomes, reduce the level of inflammatory cytokines.
2018 Vol. 15 (6): 84-87 [Abstract] ( 187 ) HTML (1 KB)  PDF (630 KB)  ( 112 )
88 Meta analysis of the efficacy of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in treatment of adenomyosis
GU Zijuan1 LU Ruling2 YUAN Shuo2 DENG Gaopi2
Objective To evaluate the clinical efficacy and safety of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in the treatment of adenomyosis. Methods Published papers about randomized controlled trials (RCTs) of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in the treatment of adenomyosis from the establishment of the database till December 10, 2017 with language restriction of Chinese and English were searched from various databases, which included PubMed, the Cochrane Library, Web of Science, CBM, Wanfang Data, CNKI, VIP. The subjects were divided into two groups, including Sanjie Zhentong capsules combined with Levonorgestrel Intrauterine System group and mere Levonorgestrel Intrauterine System group. Moreover, the observations including the total efficiency and the indexes of Lesion reduction rate and dysmenorrhea score and endometrial thickness and serum CA125 levels. In addition, a Meta-analysis was conducted with Review Manager 5.3 software. Results Six articles involving 602 patients were included. The Meta-analysis showed that there was a significantly positive effect of San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System in the treatment of adenomyosis. Conclusion San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System can improve not only the indexes of Lesion reduction rate (OR=17.94, 95%CI: [7.47, 43.10], P ＜ 0.000 01), Dysmenorrhea score (MD=-1.72, 95%CI: [-3.37, -0.07], P=0.04), Endometrial thickness (MD =-1.52, 95%CI: [-1.77, -1.27], P ＜ 0.000 01), Serum CA125 levels (MD =-5.74, 95%CI: [-8.12, -3.35], P ＜ 0.000 01), but also the total efficiency (OR=5.38, 95%CI: [3.01, 9.63], P ＜ 0.000 01) and it seems to have no obvious adverse reactions. Conclusion The evidences support that San Jie Zhen Tong Capsules combined with Levonorgestrel Intrauterine System have potential advantages compared to mere Levonorgestrel Intrauterine System therapy in the treatment of adenomyosis.
2018 Vol. 15 (6): 88-93 [Abstract] ( 605 ) HTML (1 KB)  PDF (1199 KB)  ( 330 )
94 The safety and efficacy of the whole stage electrical stimulation combined with epidural labor analgesia
LYU Ning LYU Yan LI Li
Objective To compare the safety and efficacy of the whole stage epidural labor analgesia and whole stage electrical stimulation combined with epidural labor analgesia. Methods From December 2016 to December 2017, a total of 200 cases of puerperas in Tianjin Central Obstetrics and Gynecology Hospital were selected as the research objects and divided into the whole stage epidural labor analgesia group (group B) and the whole stage electrical stimulation combined with epidural labor analgesia group (group C) by the random number table, with 100 cases in each group. The puerperas who received caesarean section were eliminated, with 85 cases in group B and 93 cases in group C. Group B was given epidural labor analgesia in the latent phase (after uterine contractions regularly), group C was given electrical stimulation in incubation period of first production process and epidural labor analgesia after uterine contractions regularly as in group B (when the uterus cervix was 3 cm). The time for the first stage of labor and the scores of visual analogue scale (VAS) at the uterus cervix 2, 4, 6, 8 cm and 10 cm were recorded. The blood gas analysis of umbilical artery of neonates (includes pH value, carbon dioxide partial pressure, oxygen partial pressure, lactic acid, residual alkali.) and the Apgar score after 1 min of delivery were recorded. Results The cesarean section rate in group B was higher than that of group C, the first stage of labor time in group B was longer than that of group C, with statistically significant differences (P ＜ 0.05). At the uterine cervix 2 cm, the VAS score in group B was lower than that of group C, with statistically significant difference (P ＜ 0.05). There were no statistically significant differences at the uterine cervix 4 cm and 6 cm between the two groups(P ＞ 0.05). At the uterine cervix 8 cm and 10 cm, the VAS scores in group B were higher than those of group C, with statistically significant differences (P ＜ 0.01). There were no statistically significant differences between the two groups in the blood gas analysis of umbilical artery and the 1 min Apgar score after birth (P ＞ 0.05). Conclusion The whole stage electrical stimulation combined with epidural labor analgesia is safe and effective for puerperas with natural labor.
2018 Vol. 15 (6): 94-97 [Abstract] ( 265 ) HTML (1 KB)  PDF (632 KB)  ( 148 )
98 Difference on the levels of Nesfatin-1, C-reactive protein and serum ferritin in different gestational periods in patiens with gestational diabetes mellitus and their relationship
JIANG Haiying ZUO Jinling SANG Xuemei WANG Qian ZHAO Jing
Objective To investigate the levels of Nesfatin-1, C-reactive protein (CRP) and serum ferritin (SF) of different gestational periods in patients with gestational diabetes mellitus (GDM) and their relationship. Methods From June 2015 to January 2017, 103 patients in early pregnancy built profile and examined in Maternal and Child Health Hospital of Tangshan were selected as research objects and divided into the test group (47 cases) and the control group (56 cases) by the oral glucose tolerance test. The general conditions (includes age, gestational weeks, BMI, fasting blood glucose and fasting insulin) in middle pregnancy between the two groups were compared and the levels of Nesfatin-1, CRP and SF in the early and middle pregnancy between the two groups were compared. The logistic regression analysis was used to analyze the related factors of GDM. Results There were no statistically significant differences in the age, gestational weeks and BMI between the two groups in the middle pregnancy (P ＞ 0.05). The fasting blood glucose and fasting insulin in the test group were higher than those of control group, with statistically significant differences(P ＜ 0.05). In the early and middle pregnancy, the levels of Nesfatin-1, CRP and SF in the test group were higher than those of control group, with statistically significant differences (P ＜ 0.05). In the test group, the indicators above in the middle pregnany were higher than those of early pregnany, with statistically significant differences (P ＜ 0.05); in the control group, there were no statistically significant differences in the above indicators between the early and middle pregnany (P ＜ 0.05). The Logistic regressive analysis showed that the fasting blood glucose, fasting insulin, Nesfatin-1,CRP and SF were the risk factors of GDM (P ＜ 0.05). Conclusion Serum Nesfatin-1, CRP and SF are the risk factors of GDM. In early pregnancy of GDM patients, Nesfatin-1, CRP and SF are higher than those in normal pregnant women and it is helpful for early detection of GDM, so as to control the patients′ blood glucose effectively, which is of great significance to improve the pregnancy outcome.
2018 Vol. 15 (6): 98-101,105 [Abstract] ( 273 ) HTML (1 KB)  PDF (703 KB)  ( 122 )
102 Analysis of nasopharyngeal bacteria carrying and risk factors in preschool children with respiratory infection
XU Jing1,2 YAN Dan2▲
Objective To analyse the nasopharyngeal bacterial carrying and risk factors of respiratory tract infection in preschool children. Methods From August 2016 to June 2017, 115 cases of preschool children with respiratory tract infection in Huangshi Aikang Hospital (“our hospital” for short) were selected, divided it into observation group. In the same period, another 115 preschool children who went to our hospital for physical examination were selected as the control group. All the children received 1 nasopharyngeal secretory specimens for bacterial isolation and culture. The bacterial infection types of nasopharyngeal bacteria were analyzed, and the risk factors were analyzed according to the age, sex and activities of daily living. Results After the testing, preschool children with respiratory tract infections of nasopharyngeal bacteria mainly Haemophilus Influenzae, Staphylococcus Aureus, Klebsiella Pneumoniae. The premature delivery, antibacterial drugs were used more frequently, the family members had respiratory diseases, partial eclipse or picky eaters, family smoking, poor family hygiene were related to respiratory tract infections in preschool children (P < 0.05). Logistic regression analysis showed that the premature delivery, antibacterial drugs were used more frequently, the family members had respiratory diseases, partial eclipse or picky eaters, family smoking were all high risk factors of respiratory tract infection in preschool children (P < 0.05). Conclusion The main types of nasopharyngeal bacteria carrying by respiratory tract infection in preschool children are haemophilus influenzae, staphylococcus aureus, klebsiella pneumoniae, and there are many risk factors for the disease, clinic should select appropriate treatment according to bacterial resistance methods, at the same time for the risk factors for the disease to take targeted preventive measures to reduce the risk of respiratory infection in preschool children.
2018 Vol. 15 (6): 102-105 [Abstract] ( 272 ) HTML (1 KB)  PDF (635 KB)  ( 142 )
106 Effects of low-frequency repetitive transcranial magnetic stimulation of different frequency on bone metabolism, lipid metabolism and quality of life of children with epilepsy
XU Bei1 WANG Guilan2
Objective To observe the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) of different frequency on bone metabolism, lipid metabolism and quality of life of children with epilepsy. Methods From March 2014 to March 2017, 156 children with epilepsy in the First Central Hospital of Baoding City were selected, and randomly divided into the control group (50 cases), 0.5 Hz group (53 cases) and 1.0 Hz group (53 cases). On the basis of the original antiepileptic treatment scheme， the control group was treated with sham stimulation, 0.5 Hz group was treated with rTMS of 0.5 Hz, and 1.0 Hz group was treated with rTMS of 1.0 Hz, all three groups were treated for 3 months. The seizure frequency of epilepsy and incidence of headache, bone metabolism indexes [calcium (Ca), phosphorus (P), alkaline phosphatase (ALP)], lipid metabolism indexes [total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C)], and scores of the pediatric quality of life inventory measurement models (PedsQL4.0) before and after treatment in the three groups were compared. Results After treatment, the seizure frequency of epilepsy in the three groups was all lower than before treatment (P < 0.05), and the seizure frequency of epilepsy in the 1.0 Hz group was lower than those in the control group and 0.5 Hz group (P < 0.05), the incidence of headache in the three groups was compared, the difference was not statistically significant (P > 0.05). In levels of Ca, P, ALP, TC, TG and LDL-C in the three groups before and after treatment and between groups after treatment were compared, the difference were not statistically significant (P > 0.05). After treatment, The PedsQL4.0 each dimension score in three groups were higher than those before treatment (P < 0.05), and the 1.0 Hz group was higher than those of the control group and 0.5 Hz group(P < 0.05). Conclusion The rTMS of 1.0 Hz can reduce the seizure frequency of epilepsy and improve the quality of life of children. It has no obvious effect on lipid metabolism and bone metabolism in short term.
2018 Vol. 15 (6): 106-109 [Abstract] ( 237 ) HTML (1 KB)  PDF (634 KB)  ( 140 )
110 Significance of detection of cervical epithelial cell stability free ferrous protoporphyrin in the diagnosis of cervical cancer in different ages
ZHAO Ying ZHOU Xunhua CHEN Yanhui
Objective To investigate the significance of detection of cervical epithelial cell stability free ferrous protoporphyrin (FH) in the diagnosis of cervical cancer in different ages. Methods The clinical data of 213 cases of patients with cervical tumor admitted to Hu'nan Brain Hospital from October 2014 to October 2017 was retrospectively analyzed. They were divided into 6 age groups of ≤30 years old, >30-40 years old, ＞40-50 years old, ＞50-60 years old, ＞60-70 years old, and ＞70 years old by age, and all the patients were treated with surgical treatment and diagnosed by pathological examination, also they were detected by cervical epithelial cells stability FH. The results of FH detection at different ages were compared, and the sensitivity, specificity and accuracy of FH test in different age groups were analyzed, then the receiver operating curves (ROC) of patients with high-risk cervical cancer in different age groups based on uterine epithelial cells stability FH were made, and the area under curves (AUC) were obtained. Results The total positive rates of people at age of ＞40-50 years old and ＞60-70 years old were significantly higher than those of ≤30 years old, ＞30-40 years old, ＞50-60 years old and ＞70 years old (P ＜ 0.05), but there were no significant differences between the other age groups (P ＞ 0.05). There were respectively 10, 25, 56, 9, 50 cases and 11 cases of ≤30 years old, ＞30-40 years old, ＞40-50 years old, ＞50-60 years old, ＞60-70 years old and ＞70 years old by cervical epithelial cells stability FH, while there were respectively 7, 21, 55, 7, 49 cases and 8 cases of ≤30 years old, ＞30-40 years old, ＞40-50 years old, ＞50-60 years old, ＞60-70 years old and ＞70 years old by immunocytochemistry examination. Epithelial cells stability FH detection had higher sensitivity, specificity and accuracy in different age groups, which of ＞40-50 years old and ＞60-70 years old were higher than other age groups. The AUC of the uterine epithelial cells stability FH for the detection of people at age of ＞40-50 years old, ＞60-70 years old, ＞30-40 years old, ＞70 years old, ＞50-60 years old, and ≤30 years old were 0.956, 0.949, 0.819, 0.763, 0.727 and 0.727 respectively. Conclusion Cervical epithelial cells stability FH staining are reliable in the diagnosis of cervical cancer at different ages, but the sensitivity, specificity and accuracy of ＞40-50 years old and ＞60-70 years old are relatively higher other ages, which can be used to guide clinical screening and diagnosis of cervical cancer.
2018 Vol. 15 (6): 110-113,123 [Abstract] ( 284 ) HTML (1 KB)  PDF (1092 KB)  ( 107 )
114 A clinical study of the serum content of copper iron and zinc iron in patients with minor recurrent aphthous ulcer
ZHANG Zichuan1 WANG Hongyan2 CHEN Guang1 WU Zhongyin1 FANG Huiqing1
Objective To compare the serum content of iron and Copper Zinc in patients with minor recurrent aphthous ulcer (MiRAU) and healthy individuals, and then to analyze that whether there is a possible relationship between them and recurrent aphthous ulcer. Methods Ninty-seven patients with minor recurrent aphthous ulcer (MiRAU) confirmed in Department of Stomatology of Bethune International Peace Hospital (hereinafter referred to as "our hospital") from March 2015 to December 2016 and 102 healthy persons without MiRAU in our hospital were enrolled. The patients with MiRAU (group A) and healthy persons (group B) were extracted 5 mL fasting venous blood respectively, and then the chromaticity method was used to detect the serum concentration of Copper and Zinc irons in subjects. Results The serum content of  Copper iron in those subjects of group A and group B were (16.77±3.89) μmol/L and (17.62±3.05) μmol/L, and there was no significant difference between the two groups (P ＞ 0.05). The serum content of Zinc iron in those subjects of group A [(14.39±1.86)μmol/L] was significantly lower than that of group B [(16.18±2.46) μmol/L](P ＜ 0.05). Conclusion The decrease of serum content of Zinc iron may be associated with recurrent aphthous ulcer.
2018 Vol. 15 (6): 114-117 [Abstract] ( 225 ) HTML (1 KB)  PDF (482 KB)  ( 66 )
118 Study of the walking line of mandibular canal by CBCT
ZHONG Fei
Objective To study the location in the mandible of mandibular canal by cone-beam computed tomography (CBCT). Methods Fifty healthy volunteers examined in the Stomatology Department of the Third People' Hospital of Zhenjiang City in Jiangsu Province from January 2014 to January 2015 were selected. The following data were collected: the distance from the inner contour of the canal to alveolar crest, the distance from the inner contour of the canal to the buccal and lingual surface of mandible, the distance from the superior border of the mandibular canal to alveolar crest and the distance from the inferior border of the mandibular canal to the inferior border of mandible. Results The mean distance from the inner contour of the canal to alveolar crest in the third molar section, the second molar section, the first molar section, the second premolar section, the first premolar section was (18.14±1.13) mm, (15.63±1.42) mm, (17.55±1.70) mm, (18.16±1.57) mm and (17.13±1.36) mm respectively. The distance from the inner contour of the canal to the buccal surface of mandible in the third molar section, the second molar section, the first molar section,the second premolar section and the first premolar section was (7.40±1.43) mm, (7.78±1.49) mm, (5.92±1.57) mm, (4.08±1.23) mm and (4.23±1.45) mm respectively. The distance from the inner contour of the canal to the lingual surface of mandible in the third molar section, the second molar section, the first molar section, the second premolar section and the first premolar section was (2.74±1.21) mm, (4.40±1.31) mm, (4.84±1.16) mm, (5.81±1.28) mm and (4.86±1.11) mm. The mandibular canal walking in the mandible went downward for a distance at first, and then went up. The distance from the inner contour of the canal to alveolar crest was shortest in the second molar section and was farthest in the second premolar section (P ＜ 0.01). There were statistical significances in every section between the buccal bone width and the lingual width. The lingual bone width was thinnest in the third molar section, and was thickest in the second premolar section (P ＜ 0.01). The mandibular canal was more close to the edge of mandible than alveolar crest (P ＜ 0.01). Conclusion The mandibular canal starts from the mandible foramen, walks forward and downward first, then turns to move upward and moves toward the buccal side in the second molar section. Finally it moves up to the mental foramen and walks out of the mandible.
2018 Vol. 15 (6): 118-123 [Abstract] ( 190 ) HTML (1 KB)  PDF (679 KB)  ( 90 )
124 Study on critical value of child intermittent exotropia questionnaire in preoperative quality of life assessment for strabismus children
TAN Mingqiong BIAN Wei XU Yan WAN Junli LIU Yang
Objective To identify the optimal critical value of the child intermittent exotropia questionnaire (Child-IXTQ) in preoperative quality of life assessment for strabismus children. Methods A prospective cohort of 106 strabismus children were recruited to complete the Child-IXTQ and PedsQL4.0 questionnaire, and the PedsQL4.0 was used as the criterion for evaluating Child-IXTQ. Through the sensitivity and specificity calculation of each score corresponding to Child-IXTQ, we draw the receiver working characteristic curve (ROC curve) to get the application of Child-IXTQ in evaluating the quality of life of strabismus children before operation so as to determine the best critical value. Results The score of Child - IXTQ was positively correlated with the score of PedsQL4.0 (r = 0.609, P ＜ 0.01). The optimal critical value for Child-IXTQ was 67 scores, the subject's operating characteristic (ROC) curves is the farthest from the standard reference line in the upper left. The sensitivity and specificity were 0.929 and 0.893 respectively, the areas under the curve was 0.902 (P ＜ 0.01), and the standard error was 0.052. Conclusion The optimal critical value of Child-IXTQ for the strabismus children is 67 scores, and it is an effective tool for preoperative assessment for quality of life of strabismus children.
2018 Vol. 15 (6): 124-127 [Abstract] ( 668 ) HTML (1 KB)  PDF (524 KB)  ( 95 )
128 Extraction and content determination of total saponins from Astragali Radix and Ophiopogonis Radix in Tingli Shengmai Decoction
LI Jiajia1 ZHENG Wenli2 ZHANG Huatan3 LI Chunhua4
Objective To study the content determination method of total saponins from Astragali Radix and Ophiopogonis Radix in Tingli Shengmai Decoction, and to optimize the optimum extraction process of Astragali Radix and Ophiopogonis Radix taking the contents as indices. Methods The vanillic aldehyde-glacial acetic acid-perchloric acid was selected as color developing agent, and the contents of total saponins were detected by ultraviolet spectrophotometry. By using orthogonal experiment, taking the contents of total saponins as indices, the effects of ethanol concentration, solid-liquid ratio and extraction duration for the extraction process were investigated, so as to optimize the optimum extraction process of Astragali Radix and Ophiopogonis Radix. Results In this study, astragaloside Ⅳ showed a good linear relationship within the range of 8.88-44.40 μg, all the RSD values of degree of precision, stability and repeatability experiments were ≤1.19%, the average recovery rate was 101.78%, RSD was 1.85% (n = 9). The optimum extraction process: reflux extraction of 8 times amount of 80% ethanol was taken for 2 times, once 2 h. Conclusion The method is simple, accurate and reproducible, which can be used as a method for the quality control of Astragali Radix and Ophiopogonis Radix in Tingli Shengmai Decoction
2018 Vol. 15 (6): 128-131 [Abstract] ( 204 ) HTML (1 KB)  PDF (539 KB)  ( 162 )
132 Effects of Dexmetomidine hydrochloride on hemodynamics and stress response in patients with pseudomyxoma peritonei
LU Liangyuan XUE Yanyan ZHANG Guyue YANG Zhanmin
Objactive To study the effects of Dexmedetomidine hydrochloride on hemodynamics and stress response in patients with pseudomyxoma peritonei. Methods Forty-six patients with pseudomyxoma peritonei in Beijing Aerospace Center Hospital from June 2015 to October 2017 were selected and devided into Dexmedetomidine group (24 cases) and control group (22 cases) by randomly number table method. After entered the operating room, patients of two groups were given the 0.5 μg/kg·h Dexmedetomidine or the same dose of normal saline, after 10 minutes, anesthesia induction. The blood samples were extracted and tested at the time before anesthesia induction (T1), 3 minutes after endotracheal intubation (T2), before intraperitoneal hyperthermic perfusion chemotherapy (T3), after thermal perfusion (T4), end of the surgery (T5). The heart rate (HR), MAP, cardiac output (CO), stroke volume variation (SVV), Tnose, blood glucose (Glu), plasma norepinephrine (NE) and epinephrine (E) were recorded. Results Hormone levels: the plasma E and NE levels in Dexmedetomidine group were lower than control group at T2-T5 (P ＜ 0.05). Hemodynamics: In Dexmedetomidine group of T3, T4 and T5, the change of CO and SVV was better than that of normal saline control group (P ＜ 0.05). The average MAP in Dexmedetomidine group was higher than the control group, the dosage of Propofol was lower than that of control group, the differences were statistically significant (P ＜ 0.05). There was no  statistical significance between the two groups in preoperative, postoperative PCI index, CVP, Glu, time of operation, blood volume, urine volume and liquid amount (P ＞ 0.05). Conclusion Dexmedetomidine hydrochloride can reduce the reaction of injury in patients with pseudomyxoma peritonei, which is beneficial to reduce the hemodynamic fluctuation during the operation.
2018 Vol. 15 (6): 132-136 [Abstract] ( 198 ) HTML (1 KB)  PDF (458 KB)  ( 67 )
137 The effect of Qiliqiangxin Capsules on cardiac function and prognosis of patients with ST-segment elevation acute myocardial infarction after PCI
LI Ying ZHAO Lihong
Objective To study the effect of Qiliqiangxin Capsules on cardiac function and prognosis of patients with ST-segment elevation acute myocardial infarction after percutaneous coronary intervention (PCI). Methods From January 2016 to May 2017, 60 patients with ST-segment elevation acute myocardial infarction after PCI in the Second Policlinic Directly under the Authority of Hebei Province were selected and divided into observation group and control group according to treatment, with 30 cases in each group. All patients were treated with conventional western medicine treatment after PCI. In addition to standard therapy, the observation group was treated by Qiliqiangxin Capsules, and the control group were treated by placebo. Before and 6 months after treatment, the matrix metalloproteinase-9 (MMP-9), tumor necrosis factor alpha (TNF-α) and nitric oxide (NO) concentration were compared. And the left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWD), interventricular septal thickness (IVSd), and cardiac events were also compared. Results After treatment, the levels of MMP-9, TNF-α in the observation group were lower than those in the control group, and the leud of NO was higher than that in the control group, with statistically significant difference (P < 0.05). After treatment, the level of LVEF in the observation group was higher than that in the control group, and the levels of LVEDD, LVPWD, IVSd in the observation group were lower than those in the control group, with statistically significant difference (P < 0.05). The incidence of cardiac events in the control group was lower than that in the control group (P < 0.05). Conclusion Qiliqiangxin Capsules is beneficial to the repair of damaged myocardial cells. Besides, it can improve the ability of myocardium contraction, promote myocardial microcirculation andinhibit ventricular remodeling after myocardial infarction.
2018 Vol. 15 (6): 137-140 [Abstract] ( 209 ) HTML (1 KB)  PDF (374 KB)  ( 100 )
141 Analysis on the characteristics of dynamic electrocardiogram of premature ventricular contractions with syndromes of stirring wind due to yin deficiency
CHEN Jin1,2 ZHANG Limei1 SONG Qingqiao1 DU Bai1
Objective To observe the characteristic changes of dynamic electrocardiogram in patients who were diagnosed as premature ventricular contractions with syndromes of stirring wind due to yin deficiency. Methods From November 2011 to August 2016, 90 patients who were diagnosed as premature ventricular contractions with syndromes of stirring wind due to yin deficiency in Guang'anmen Hospital, China Academy of Chinese Medical Sciences (“our hospital” for short) were selected as the premature ventricular contraction group, and 30 healthy subjects in our hospital were selected as the control group. All subjects underwent 24 hours dynamic electrocardiogram. The average heart rate, slowest heart rate, heart rate variability (HRV) of the two groups and the number of premature ventricular contraction in morning and night of premature ventricular contraction group, the correlation between TCM syndrome classification and HRV index in the premature ventricular contraction group were observed and analyzed. Results The levels of the average heart rate and the slowest heart rate in premature ventricular contraction group were all higher than those in control group (P ＜ 0.05). The levels of standard deviation of NN intervals (SDNN), standard deviation of average 5 min NN intervals (SDANN), percentage of differences exceeding 50 ms between adjacent normal number of intervals (PNN50), square root of the mean squared differences of successive RR interval (RMSSD) and HRV trigonometric index in premature ventricular contraction group were lower than those in control group (P ＜ 0.05). The premature ventricular contraction frequency of premature ventricular contraction group in the night was more than that in the morning (P ＜ 0.05). The syndrome classification of traditional Chinese medicine in premature ventricular contraction group was positively correlated with age, which was negatively correlated with SDNN, SDANN, PNN50, RMSSD, HRV triangular index. Conclusion The premature ventricular contraction frequency of patients in premature ventricular contraction group in the night is more than that in the morning, and the HRV is lower than control group. It is speculated that the occurrence of premature ventricular contraction with syndrome of stirring wind due to yin deficiency is positively related to autonomic nerve dysfunction, mainly vagus function decline.
2018 Vol. 15 (6): 141-144 [Abstract] ( 190 ) HTML (1 KB)  PDF (548 KB)  ( 210 )
145 Clinical efficacy of impulse IQ in the treatment of temporomandibular joint disorder with syndrome of blockade of cold-dampness
CHEN Jianchong LI Lifu YAO Zhichuan WANG Wei QIU Lilu
Objective To observe the clinical efficacy of impulse IQ in the treatment of temporomandibular joint disorder with syndrome of blockade of cold-dampness. Methods Fifty-six cases of patients with temporomandibular joint disorder with syndrome of blockade of cold-dampness treated in Outpatient Department of Rehabilitation, Cixi Sixth People′s Hospital from October 2016 to April 2017 were randomly divided into observation group (28 cases) and control group (28 cases) by random number table method. The observation group was treated with SIT6000 impulse IQ, while the control group was treated with acupuncture with the main points of SI19, ST7 and ST6. After treatment for 7 days, the visual analogue scale (VAS), temporomandibular joint dysfunction index (DI), palpation index (PI), and Fricton index (CMI) of the two groups were used to evaluate efficacy. Results After treatment, the VAS scores of the two groups were all significantly lower than those before treatment (P ＜ 0.05), the scores of DI, PI and CMI in the observation group were all significantly lower than those before treatment (P ＜ 0.05). After treatment, the scores of VAS, DI, PI and CMI in the observation group were all lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Impulse IQ can significantly improve the function of temporomandibular joint and relieve the pain of temporomandibular joint disorder in patients with temporomandibular joint disorder with syndrome of blockade of cold-dampness.
2018 Vol. 15 (6): 145-148 [Abstract] ( 231 ) HTML (1 KB)  PDF (543 KB)  ( 100 )
149 Professor Wang Guohua's experience in treating acne caused by polycystic ovary syndrome
PANG Ying WANG Guohua ZHAO Xiuping GAO Yue
In recent years, the incidence of polycystic ovary syndrome (PCOS) was increased year by year, among which, acne is the most distressing and concerned problem for most patients, while there are only few related reports. Professor Wang Guohua believes that as the changes of lifestyle, the main Chinese etiology and pathogenesis of acne caused by PCOS are qi depression and deficient fire. The main etiology are the disorder of qi movement caused by stagnation of liver qi and blood stasis and stagnated fire in lung meridian, and the flaring up of deficient fire caused by upper heat and lower cold and disharmony between heart and kidney. Professor Wang Guohua pays attention to “treatment aiming at its root causes” in clinical treatment, and focuses on the regulation of health education and lifestyle, she is also good at using modified classic prescriptions, which has received good clinical effects. It is worthy of learning and promotion.
2018 Vol. 15 (6): 149-152 [Abstract] ( 219 ) HTML (1 KB)  PDF (524 KB)  ( 134 )
153 Application of feedback and inten sive health education pathway in patients with total knee arthroplasty
ZHANG Guiran GAO Li ZHANG Li
Objective To investigate the effect of feedback and intensive health education pathway in patients with total knee arthroplasty. Methods From September 2016 to August 2017, 140 patients with total knee arthroplasty in the Bone and Joint Surgery Department of Beijing Luhe Hospital were selected as the research subjects and divided into the control group and the observation group by random number table, with 70 cases in each group. The control group was given traditional indoctrination education and the observation group was given feedback and intensive health education. The education effect before and after admission, pre-operation, post-operation and 2 weeks after discharge were compared between the two groups. The compliance and the nursing satisfaction were compared between the two groups. Results There was no statistically significant difference in the effect of education between the two groups before admission (P ＞ 0.05). After admission, pre-operation, post-operation and 2 weeks after discharge, the education effects in the observation group were better than those of control group, with statistically significant differences (P ＜ 0.05). The compliance and the nursing satisfaction in the observation group were higher than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion The effect of feedback and intensive health education in patients with total knee arthroplasty is good. It is worthy of clinical promotion and application.
2018 Vol. 15 (6): 153-157 [Abstract] ( 256 ) HTML (1 KB)  PDF (626 KB)  ( 203 )
158 Design and research of traditional Chinese medicine big data platform infrastructure based on Hadoop
WANG Li WANG Ping SHEN Junhui
Big data technology has been widely concerned in the present and building a big data platform for traditional Chinese medicine is a powerful weapon to strengthen the competitiveness of traditional Chinese medicine in the future. In this paper, through the analysis of traditional Chinese medicine data characteristics, architecture design and research of traditional Chinese medicine data platform, through reasonable design and deployment of cluster, server and network environment, so as to provide a stable and reliable traditional Chinese medicine data base platform.
2018 Vol. 15 (6): 158-162 [Abstract] ( 245 ) HTML (1 KB)  PDF (1080 KB)  ( 319 )
163 Comparative study on red blood cell parameters of different renal function stages in patients with Type Ⅱ cardio-renal syndrome
JIANG Yuchen1 WANG Huan1▲ DU Bai1 CHU Yuguang1 QIU Zhiling2
Objective To investigate the levels of inflammation and anemia in patients of TypeⅡ cardio-renal syndrome. Methods Two hundred and nine cases of Type Ⅱ cardio-renal syndrome patients were divided into Chronic kidney disease CKD3 period group (129 cases), CKD4 period group (59 cases) and CKD5 period group (21 cases), 88 cases of chronic heart failure (CHF) patients as CHF group, enrolled in Department of Cardiology, Guang′ anmen Hospital from January 2009 to December 2009, and a total of 152 healthy people as healthy group were selected. The levels of red blood cell parameters in each group were examined. Results The comparison of levels of red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT): CKD3, CKD4, CKD5 groups were lower than healthy group, and CKD4, CKD5 groups were lower than CHF group, and CKD5 group was lower than CKD3 group, and the difference was significant (P < 0.01).The levels of RBC and HCT in CHF group were lower than those of healthy group, and the difference was significant (P < 0.01 or P< 0.05).The comparison of levels of red blood cell volume distribution width (RDW-CV): CHF, CKD3, CKD4, CKD5 groups werehigherthan healthy group, and CKD4 group washigher than CHF group, and the difference was significant (P < 0.01 or P < 0.05). Mean corpuscular hemoglobin concentration (MCHC), RDW-CV were positively correlated with Type Ⅱ cardio-renal syndrome (P ＜ 0.05). RBC, Hb, HCT, mean corpuscular volume （MCV), mean corpuscular hemoglobin (MCH) were negatively correlated with the Type Ⅱ cardio-renal syndrome （P ＜ 0.05). Conclusion The levels of inflammation and anemia in Type Ⅱ cardio-renal syndromepatientsare associated with red blood cell parameters, and may increase according to the reduction of cardiacfunction and renal function.
2018 Vol. 15 (6): 163-166 [Abstract] ( 185 ) HTML (1 KB)  PDF (641 KB)  ( 139 )
167 The effect of systematic nursing intervention on the quality of life in children with severe viral encephalitis combined with dysphagia
XIE Li′na LI Jie▲
Objective To explore the effect of systematic nursing intervention on the quality of life in children with severe viral encephalitis combined with dysphagia. Methods From January 2016 to May 2017, 60 patients with severe viral encephalitis combined with dysphagia treated in Shenyang Children′s Hospital were selected as the research subjects and divided into the control group and observation group by random number table, with 30 cases in each group. The control group was given routine nursing intervention and the observation group was given systematic nursing intervention. Both groups were all intervened for 14 d. The dysphagia disorders survey (DDS) and the Chinese version of the pediatria quality of life inventory 3.0 healthcare satisfaction hematology/oncology module were applied to evaluate the dysphagia and the quality of life before and after nursing intervention. Results Before intervention, there were no statistically significant differences in the scores of DDS and quality of life between the two groups (P ＞ 0.05). After intervention, the scores of DDS in the two groups were all lower than those of before intervention, and that in the observation group was significantly lower than that of control group, with statistically significant differences (P ＜ 0.05). After intervention, the scores of life quality in each item in the two groups were all higher than those of before intervention, and the scores above in the observation group were all significantly higher than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion Systematic nursing intervention can improve the clinical symptoms and enhance the quality of life in children with severe viral encephalitis combined with dysphagia. It is worthy of promotion and application.
2018 Vol. 15 (6): 167-170 [Abstract] ( 227 ) HTML (1 KB)  PDF (655 KB)  ( 99 )
171 Effect of CHPPC combined with intravenous chemotherapy on the expression of serum OPN and nm23H1 protein in elderly patients with advanced gastric cancer
YANG Benxin DU Yuan NIE Shuangfa LI Lei FEI Jiandong▲
Objective To analyze the effect of continuous hyperthermic peritoneal perfusion chemotherapy (CHPPC) combined with intravenous chemotherapy on the treatment of elderly patients with gastric cancer and the influence of expression of OPN and nm23H1 protein in the serum of the patients. Methods From January 2016 to January 2017, 80 elderly patients with gastric cancer in the First Affiliated Hospital of Hebei North University were selected, and divided into observation group and control group by random envelope method, with 40 cases in each group. The control group was treated with conventional intravenous chemotherapy, observation group was treated with CHPPC combined with intravenous chemotherapy, and the short-term efficacy of the treatment was evaluated 8 weeks after treatment, the serum CEA CA242, CA199, OPN, nm23H1 protein expression level between two groups were compared. Results After treatment, the total effective rate in observation group was higher than control group, the difference was highly statistically significant (P < 0.01). After treatment, the serum CEA CA242, CA199 level of patients in both groups were lower than those before treatment (P < 0.05), and observation group were lower than those control group (P < 0.05). After treatment, the serum OPN level of patients in both groups was lower than before treatment (P < 0.05), nm23H1 protein expression level was higher than before treatment (P < 0.05), and the serum OPN level in the observation group was lower than control group (P < 0.05), nm23H1 protein expression level was higher than control group (P < 0.05). Conclusion Elderly patients with gastric cancer treated with CHPPC combined with intravenous chemotherapy can effectively improve the clinical efficacy and improve serum OPN and nm23H1 levels, and it has extensive clinical significance.
2018 Vol. 15 (6): 171-174 [Abstract] ( 641 ) HTML (1 KB)  PDF (621 KB)  ( 132 )
175 Repair of rabbit steroid-induced avascular necrosis of femoral head by ADSCs injection through the joint puncture
TAN Weiyuan AN Rongze QI Xinwen XIE Jiaqing
Objective To investigate the effect of adipose derived stem cells (ADSCs) injection through the joint puncture on the repair of steroid-induced avascular necrosis of femoral head in rabbits. Methods ADSCs were isolated and passaged from the neck adipose tissue of adult New Zealand white rabbits. Thirty-six New Zealand white rabbits were used to establish the model of steroid-induced avascular necrosis of femoral head by horse serum combined with hormone. These rabbits were randomly divided into control group, core decompression group and ADSCs group (12 rabbits in each group), and all for bone density detection. Control group:no intervention; core decompression group: femoral head drilling decompression; ADSCs group:by intra-articular injection of ADSCs. At 4 weeks and 8 weeks after intervention, 6 rabbits in each group were examined with bone mineral density (BMD) and X-ray examination. After the death, their femur samples were collected for gross observation, HE staining and PCR were used for the measurement of BMP-2 mRNA. Through the comparison of each group to explore the effect of ADSCs repairing steroid-induced avascular necrosis of the femoral head by joint puncture injection. Results 4 weeks and 8 weeks after intervention three groups of BMD, but the control group decreased, compared with core decompression group and ADSCs group were statistically significant (P < 0.05), but there was no significant difference between the core decompression group and the ADSCs group (P > 0.05). General observation, imaging and histological findings at 4 weeks and 8 weeks after intervention, compared with the control group, ADSCs treatment by joint puncture injection and core decompression both can delay the progress of femoral head necrosis. There had a repair effect on femoral head necrosis, and the effects in ADSCs group were better than those in core decompression group; at 4 weeks and 8 weeks after intervention, the expression of BMP-2 mRNA in the ADSCs group and the core decompression group were both higher than those in the control group, the differences were statistically significant (P < 0.05), while there was no significant difference between the core decompression group and the ADSCs group (P > 0.05). Conclusion ADSCs injected through the joint puncture can repair the steroid induced avascular necrosis of the femoral head in rabbits.
2018 Vol. 15 (6): 175-180 [Abstract] ( 204 ) HTML (1 KB)  PDF (1084 KB)  ( 101 )
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