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| Roles of various components in tumor microenvironment in the occurrence and development of tumor |
| TANG Yan ZHANG Mengmei WANG Fei YANG Ze WEI Xiangyao WANG Yuanyan BAI Yuju |
| Department of Oncology, Affiliated Hospital of Zunyi Medical University, Guizhou Province, Zunyi 563000, China |
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Abstract Tumor microenvironment (TME), which is an extremely complex network of the internal environment composed of cancer-associated fibroblasts, neuroendocrine cells, adipose cells, immunocytes, vascular and lymphatic network, extracellular matrix and physical factors such as pH value, hypoxia, interstitial fluid pressure, etc., is closely related to every step in the onset, progression and metastasis of tumors. Based on current researches on TME at the cellular level, this study summarizes the main roles of the changes in the levels of each cell component and various factors in the onset, progression and invasion of tumors, providing a basis for exploring novel targets for the prevention and treatment of tumors.
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