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| Comparative study on red blood cell parameters of different renal function stages in patients with Type Ⅱ cardio-renal syndrome |
| JIANG Yuchen1 WANG Huan1▲ DU Bai1 CHU Yuguang1 QIU Zhiling2 |
1.Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
2.Graduate School, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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Abstract Objective To investigate the levels of inflammation and anemia in patients of TypeⅡ cardio-renal syndrome. Methods Two hundred and nine cases of Type Ⅱ cardio-renal syndrome patients were divided into Chronic kidney disease CKD3 period group (129 cases), CKD4 period group (59 cases) and CKD5 period group (21 cases), 88 cases of chronic heart failure (CHF) patients as CHF group, enrolled in Department of Cardiology, Guang′ anmen Hospital from January 2009 to December 2009, and a total of 152 healthy people as healthy group were selected. The levels of red blood cell parameters in each group were examined. Results The comparison of levels of red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT): CKD3, CKD4, CKD5 groups were lower than healthy group, and CKD4, CKD5 groups were lower than CHF group, and CKD5 group was lower than CKD3 group, and the difference was significant (P < 0.01).The levels of RBC and HCT in CHF group were lower than those of healthy group, and the difference was significant (P < 0.01 or P< 0.05).The comparison of levels of red blood cell volume distribution width (RDW-CV): CHF, CKD3, CKD4, CKD5 groups werehigherthan healthy group, and CKD4 group washigher than CHF group, and the difference was significant (P < 0.01 or P < 0.05). Mean corpuscular hemoglobin concentration (MCHC), RDW-CV were positively correlated with Type Ⅱ cardio-renal syndrome (P ＜ 0.05). RBC, Hb, HCT, mean corpuscular volume （MCV), mean corpuscular hemoglobin (MCH) were negatively correlated with the Type Ⅱ cardio-renal syndrome （P ＜ 0.05). Conclusion The levels of inflammation and anemia in Type Ⅱ cardio-renal syndromepatientsare associated with red blood cell parameters, and may increase according to the reduction of cardiacfunction and renal function.
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