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| Effect of CHPPC combined with intravenous chemotherapy on the expression of serum OPN and nm23H1 protein in elderly patients with advanced gastric cancer |
| YANG Benxin DU Yuan NIE Shuangfa LI Lei FEI Jiandong▲ |
| Graduate School of Hebei North University, Hebei Province, Zhangjiakou 075000, China |
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Abstract Objective To analyze the effect of continuous hyperthermic peritoneal perfusion chemotherapy (CHPPC) combined with intravenous chemotherapy on the treatment of elderly patients with gastric cancer and the influence of expression of OPN and nm23H1 protein in the serum of the patients. Methods From January 2016 to January 2017, 80 elderly patients with gastric cancer in the First Affiliated Hospital of Hebei North University were selected, and divided into observation group and control group by random envelope method, with 40 cases in each group. The control group was treated with conventional intravenous chemotherapy, observation group was treated with CHPPC combined with intravenous chemotherapy, and the short-term efficacy of the treatment was evaluated 8 weeks after treatment, the serum CEA CA242, CA199, OPN, nm23H1 protein expression level between two groups were compared. Results After treatment, the total effective rate in observation group was higher than control group, the difference was highly statistically significant (P < 0.01). After treatment, the serum CEA CA242, CA199 level of patients in both groups were lower than those before treatment (P < 0.05), and observation group were lower than those control group (P < 0.05). After treatment, the serum OPN level of patients in both groups was lower than before treatment (P < 0.05), nm23H1 protein expression level was higher than before treatment (P < 0.05), and the serum OPN level in the observation group was lower than control group (P < 0.05), nm23H1 protein expression level was higher than control group (P < 0.05). Conclusion Elderly patients with gastric cancer treated with CHPPC combined with intravenous chemotherapy can effectively improve the clinical efficacy and improve serum OPN and nm23H1 levels, and it has extensive clinical significance.
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