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2023 Vol. 20, No. 36 Published: 2023-12-25

	4	Effect of electro-acupuncture intervention on mitochondrial fission in diabetic mice with postoperative cognitive dysfunction
		YAN Ruyu DING Lingling CHEN Mengjie LUO Jiansheng NING Jiaqi ZHOU Ruiling YU Bo
		DOI: 10.20047/j.issn1673-7210.2023.36.01
		Objective To observe the effect of electro-acupuncture intervention on mitochondrial fission in diabetic mice with postoperative cognitive dysfunction (POCD). Methods Thirty-nine SPF-grade C57BL/6 male mice of body weight(20±2) g aged four to six weeks injected intraperitoneally with streptozotocin after 16 weeks of high-fat and high-sugar diet with fasting blood glucose≥11.1 mmol/L after one week, that is, they were experimental animals with diabetes mellitus type 2 (no mice died). Then they were divided into the control group, the model group, and the electro-acupuncture group by random number table method, 13 mice in each group. The control group did not do any other intervention except grasp and fixation. POCD model was established by tibial fracture intra- medullary fixation between model group and electroacupu- ncture group (no mice death). Compared with the control group, the cognitive ability of the model group decreased and the model was considered successful. In the electro-acupuncture group, shéntíng, bǎihuì, nèiguān, and zúsānlǐ were treated with electro-acupuncture intervention two weeks before surgery, and the needles were retained for 30 min each time for five consecutive days every week. The cognitive function of mice was evaluated by open field test and fear conditioning test one day after operation. Hematoxylin-eosin staining was used to observe the pathology of hippocampal CA1 region. The number of neurons was observed by Nissl staining. The content of adenosine triphosphate (ATP) was detected by chemiluminescence. Mitochondrial membrane potential (MMP) was detected by flow cytometry. Western blot analysis was performed to detect the protein expression levels of dynamin-related protein 1(Drp1), p-Drp1 Ser616, and p-Drp1 Ser637 in the hippocampus of mice. Results Compared with the control group, the freezing time of the context test in the model group was reduced (P＜0.05). Compared with the model group, the freezing time of the context test in the electro-acupuncture group was increased (P＜0.05). Compared with the control group, the damage of neurons in CA1 region of the model group was aggravated and the number of neurons was decreased (P＜0.05). Compared with the model group, the damage of neurons in CA1 region was reduced and the number of neurons was increased in electro-acupuncture group (P＜0.05). Compared with the control group, ATP content and MMP in the model group were decreased (P＜0.05). Compared with the model group, ATP content and MMP in electro-acupuncture group were increased (P＜0.05). Compared with the control group, the expression level of p-Drp1 Ser616 protein in hippocampus of model group was increased, while the expression level of p-Drp1 Ser616 protein was decreased (P＜0.05). Compared with the the model group, the expression level of p-Drp1 Ser616 protein in hippocampus of the electro-acupuncture group was decreased, and the expression level of p-Drp1 Ser616 protein was increased (P＜0.05). Conclusion Electro-acupuncture can improve the learning and memory ability of POCD in diabetic mice and reduce the neuronal damage. The mechanism may be related to the reduction of Drp1-mediated mitochondrial hyperfission and the improvement of hippocampal mitochondrial function.
		2023 Vol. 20 (36): 4-9 [Abstract] ( 22 ) HTML (1 KB) PDF (1222 KB) ( 599 )

	10	Effects of Mashe Anjin Pills on airway inflammation and expression levels of mucin 5AC and γ-aminobutyric acid A receptor α subunit in rat model with hypersecretion of airway mucus in chronic obstructive pulmonary disease
		SHANG Yanhua DENG Jinghua ZHANG Xiaoyang MA Zhen WANG Yudong
		DOI: 10.20047/j.issn1673-7210.2023.36.02
		Objective To investigate the effects of Mashe Anjin Pills on airway inflammation and the expression levels of mucin 5AC (MUC5AC) and γ-aminobutyric acid A receptor α subunit (GABAARα) in rat model with hypersecretion of airway mucus in chronic obstructive pulmonary disease (COPD). Methods A total of 102 7-week-old male SD rats with body weight of (195±20) g were divided into normal group, model group, Ambroxol positive control group, and Chinese medicine low-dose, medium-dose, high-dose groups by random number table method, with 17 rats in each group. Except for the normal group, the other groups were treated with lipopolysaccharide drops combined with cigarette smoke exposure to establish COPD airway mucus hypersecretion rat model. After successful modeling, Ambroxol positive control group was given Ambroxol solution (54 mg/[kg·d]), Chinese medicine low-dose, medium-dose, high-dose groups were given 4.375, 8.750, and 17.500 g/(kg·d) Mashe Anjin Pills (decoction), respectively, normal group and model group were given equal volume of normal saline, and all six groups were given continuous gavage for 28 days. After the experiment, hematoxylin-eosin staining and periodic acid Schiff stain were used to observe the pathological changes of lung tissue in each group. Serum inflammatory factors and alveolar lavage fluid cytokine levels were detected by enzyme-linked immunosorbent assay. The contents of MUC5AC and GABAARα in lung tissue were detected by Western blot. Results The pathological changes of airway and lung tissues in the model group were more serious. The levels of interleukin-1β (IL-1β), neutrophil elastase (NE), tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), tissue metalloproteinase-1 (TIMP-1), matrix metalloproteinase-9 (MMP-9), MUC5AC, GABAARα of model group were higher than those of normal group, the differences were statistically significant (P＜0.05). The pathological changes of airway and lung tissues in Chinese medicine low-dose, medium-dose, high-dose groups were less than those in model group, and the levels of IL-1β, NE, TNF-α, TGF-β1, TIMP-1, MMP-9, MUC5AC, and GABAARα were lower than those in model group, the differences were statistically significant (P＜0.05). The levels of IL-1β, NE, MMP-9, and GABAARα in Chinese medicine medium-dose group were lower than those in Chinese medicine low-dose group. The levels of IL-1β, NE, TNF-α, TGF-β1, TIMP-1, MMP-9, MUC5AC, and GABAARα in Chinese medicine high-dose group were lower than those in Chinese medicine low-dose and medium-dose groups, and the differences were statistically significant (P＜0.05). Conclusion Mashe Anjin Pills can improve airway mucus hypersecretion and inhibit airway remodeling in COPD, which may be related to reducing inflammatory injury and inhibiting the expression of MUC5AC and GABAARα.
		2023 Vol. 20 (36): 10-15 [Abstract] ( 14 ) HTML (1 KB) PDF (1926 KB) ( 193 )

	16	Effects of amentoflame on proliferation and proliferation-related protein expression of neuroblastoma cells in mice
		ZHU Pingping1 YUAN Wei2 WANG Pengzhen3
		DOI: 10.20047/j.issn1673-7210.2023.36.03
		Objective To investigate the effects of amentoflame (AF) on proliferation and proliferation-related protein expression of neuroblastoma cells (Neuro-2a) in mice. Methods Neuro-2a cells were resuscitated, cultured, and selected for this study. The CCK-8 assay was divided into five groups: 0, 25, 50, 75 and 125 μmol/L groups, the cells were treated for 24 h. The effect of AF (75 μmol/L AF) on the percentage of G1 phase and S phase in the cell cycle of Neuro-2a was determined by cytometry. The effects of AF (75 μmol/L AF group) on the expression of proliferation-related mRNA and proteins in Neuro- 2a cells were detected by fluorescence quantitative PCR and Western blot. Results The results of CCK-8 showed that 25 and 50 μmol/L AF group had no significant effect on the activity of Neuro-2a cells (P＞0.05), while 75 μmol/L group AF significantly decreased the activity of Neuro-2a cells, and the difference was statistically significant (P＜0.05). Compared with the control group, the percentage of Neu-2A cells in G1 phase in 75 μmol/L AF group was significantly increased, and the difference was statistically significant (P＜0.05); compared with the control group, the percentage of S-phase cells of Neuro-2a cells in 75 μmol/L AF group was significantly decreased, and the difference was statistically significant (P＜0.05); however, 75 μmol/L AF group had no significant effect on the cell distribution in G2 phase of Neuro-2a cells. Quantitative PCR and Western blot results showed that 75 μmol/L AF inhibited the expression of β-catenin, CyclinD1, CyclinE, and Survivin mRNA and protein in Neuro-2a cells, and promote expression of p21 and p16 mRNA and protein (P＜0.05). Conclusion 75 μmol/L AF inhibited the proliferation of Neuro-2a cells by inhibiting the expression of β-catenin, CyclinD1, CyclinE, and Survivin, promoting the expression of proliferation-related proteins such as p21 and p16.
		2023 Vol. 20 (36): 16-20 [Abstract] ( 15 ) HTML (1 KB) PDF (995 KB) ( 120 )

	21	Study on quality standard of Qijing Fanggan Capsules for medical institution
		ZHAO Yan1 YE Xin1 NIU Tong1 ZHAO Min1 REN Qingliang2
		DOI: 10.20047/j.issn1673-7210.2023.36.04
		Objective To establish the quality control method of Qijing Fanggan Capsules for medical institution. Methods The main microscopic features of Radix Astragali, Rhodiolae Crenulatae Radix et Rhizoma, and Atractylodis Rhizoma in Qijing Fanggan Capsules were identified by microscopic identification; thin layer chromatography (TLC) was used to identify Radix Astragali and Rhodiolae Crenulatae Radix et Rhizoma in Qijing Fanggan Capsules; the contents of salidroside and phillyrin were determined by high performance liquid chromatography (HPLC). The chromatographic column type was Agilent ZORBAX Eclipse XDB-C18(250 mm×4.6 mm，5 μm); acetonitrile∶water(8:92) was used as the initial mobile phase for gradient elution, the column temperature was 20 ℃, the flow rate of mobile phase was 1 ml/min, the injection volume was 5 μl, and the detection wavelength was 223 nm. Results The main microscopic features such as fiber bundle (Radix Astragali), threaded catheter (Rhodiolae Crenulatae Radix et Rhizoma), inulin and stone cell (Atractylodis Rhizoma) were obviously observed in the microscopic identification method. The spots were fairly clear, well separated, and the negative samples showed no interference in the TLC map. The linearity of salidroside and phillyrin were good in the range of 5.0-50.0, 3.0-30.0 μg/ml, the linear regression equations were Y=11.343X-11.967 (r=0.999 7), Y=8.648X+0.334 (r=0.999 6), respectively, and RSD values of simple recovery rate were 2.34%, 1.81% respectively. The mean content of salidroside and phillyrin in three batches of Qijing Fanggan Capsules were 1.371 5, 0.682 8 mg/g, respectively. Conclusion This research method has strong specificity, high precision， and good repeatability, which can provide a basis for establishing the quality control of Qijing Fanggan Capsules.
		2023 Vol. 20 (36): 21-25 [Abstract] ( 22 ) HTML (1 KB) PDF (1257 KB) ( 60 )

	26	Determination of four sugar components in Fuzilizhong Pills preparation
		WU Hongna1 YAO Chen1 ZHANG Shengtan2 ZHAO Qinglin1 SONG Zhongqiang1 HAN Xu2 JIA Ruiqi1▲
		DOI: 10.20047/j.issn1673-7210.2023.36.05
		Objective To establish a method for simultaneous determination of four sugar components in honey of Fuzilizhong Pills preparation. Methods High-performance liquid chromatography was performanced and the column was Prevail Carbohyrate ES and acetonitrile-water at a flow rate of 1.0 ml/min in a gradient elution, the column temperature was 30 ℃. Results Fructose, glucose, sucrose, and maltose had a good linearity in the ranges of 75.055 0-375.275 0, 80.006 5- 400.032 5, 10.009 5-50.047 5, 10.003 5-50.017 5 μg (r＞0.999), whose recoveries were 94.7%-100.1% (RSD＜2.0%, n=9). Conclusion The method is scientific and accurate, and can be used for the quality control of honey in Fuzilizhong Pills preparation.
		2023 Vol. 20 (36): 26-31 [Abstract] ( 21 ) HTML (1 KB) PDF (1024 KB) ( 32 )

	32	Discussing the medication rule of Professor Zhou Shaohua in treating of insomnia based on data mining
		GONG Xiao WANG Muren GUO Chunli
		DOI: 10.20047/j.issn1673-7210.2023.36.06
		Objective Based on data mining analysis of Professor Zhou Shaohua’s clinical medication for insomnia. Methods Prescription information of insomnia patients in Professor Zhou Shaohua’s outpatient department of Xiyuan Hospital from January 2016 to December 2022 was collected, and statistical analysis, rule analysis, and cluster analysis of traditional Chinese medicine inheritance computing platform were used to analyze drug frequency, drug class, drug properties, channel normalization, and core drugs. Results A total of 177 prescriptions were involved in this article, included 207 traditional Chinese medicine flavors. The top three drugs used most were stir-frying Semtnziziphi Spinosae, Fuzhuan, and Rodix Angelicae Sinensis. The main drugs were deficiency tonic, heat clearing, and tranquilizing drugs. The four nature of drugs were cold, warm, and calm, and the five flavours were sweet, bitter and pungent. Conclusion Professor Zhou’s treatment of insomnia is based on the principle of calming the heart and calming the spirit, regulating qi and tonifying deficiency, clearing heat and nourishing blood, treating the five viscera together, supplementing Qi and blood, paying attention to drug safety, and the effect is remarkable, which can provide reference for traditional Chinese medicine treatment of insomnia.
		2023 Vol. 20 (36): 32-36 [Abstract] ( 19 ) HTML (1 KB) PDF (1111 KB) ( 145 )

	37	Research progress in non-invasive continuous blood pressure prediction based on pulse wave
		ZHUANG Liyuan1 WANG Xinkang2
		DOI: 10.20047/j.issn1673-7210.2023.36.07
		Blood pressure is an important physiological index of the human body， in recent years, there has been an increasing demand for non-invasive, cuffless, and continuous blood pressure monitoring devices. A suitable model based on the characteristic parameters of pulse wave can be used to continuously estimate arterial blood pressure by measuring a series of characteristics of pulse such as pulse transmission time of arterial pulse wave. This paper first introduces the principle of blood pressure measurement based on the characteristic parameters of pulse wave, and summarizes the relevant measurement models, such as linear regression model, non-linear regression model, and neural network model, summarizes the research results, introduces the research status of the application of pulse wave technology in cardiovascular diseases, and finally analyzes its future development trend.
		2023 Vol. 20 (36): 37-40,45 [Abstract] ( 19 ) HTML (1 KB) PDF (616 KB) ( 458 )

	41	Research progress of Rhei Radix Et Rhizoma in the treatment of sepsis based on intestinal flora regulation
		DAI Xuan1 CHEN Shaoyu2 LI Jingxin2 ZHANG Mengying2 SUN Yanni3 CHENG Jiwei1
		DOI: 10.20047/j.issn1673-7210.2023.36.08
		A lot of studies have shown that Rhei Radix Et Rhizoma has good efficacy in the treatment of sepsis. In order to further clarify the related role and mechanism of Rhei Radix Et Rhizoma in the treatment of sepsis, this paper reviews the understanding of sepsis in traditional Chinese medicine, the negative effect of sepsis on intestinal flora, the significance of intestinal flora regulation in the treatment of sepsis, and the effect of Rhei Radix Et Rhizoma on sepsis by regulating intestinal flora. Studies have found that the occurrence and development of sepsis is closely related to the changes of intestinal flora. Single drug Rhei Radix Et Rhizoma, Rhei Radix Et Rhizoma compound and Rhei Radix Et Rhizoma monomer can effectively treat sepsis, and its mechanism may be related to improving intestinal flora imbalance, protecting gastrointestinal mucosal barrier, preventing intestinal bacterial translocation, and endotoxin absorption into the blood, and reducing inflammatory response. This review further clarified the therapeutic effect of Rhei Radix Et Rhizoma on sepsis and its related mechanism, and provided a theoretical basis for the clinical prevention and treatment of sepsis.
		2023 Vol. 20 (36): 41-45 [Abstract] ( 20 ) HTML (1 KB) PDF (618 KB) ( 260 )

	46	Research progress on the mechanism of damage of asymptomatic hyperuricemia to vascular endothelial function
		WU Xiaowen1 ZHU Xiaolin2 YANG Yali2 YIN Liping2
		DOI: 10.20047/j.issn1673-7210.2023.36.09
		Asymptomatic hyperuricemia is a metabolic disorder characterized by elevated levels of serum uric acid. Elevated uric acid stimulates the inflammatory process, promotes oxidative stress, reduces nitric oxide bioavailability, activates the renin-angiotensin system, induces changes in mitochondrial function, and causes endothelial dysfunction, accelerating the progression of chronic kidney disease, cardiovascular system disease, metabolic disease, and other chronic diseases. This article elaborates on the mechanism of high-level uric acid damage to vascular endothelium, in order to provide new ideas for clinical diagnosis and treatment.
		2023 Vol. 20 (36): 46-49 [Abstract] ( 15 ) HTML (1 KB) PDF (605 KB) ( 110 )

	50	Research progress on new mechanisms of insulin resistance
		LIU Yaqin1 CHEN Yan1 MA Luyao2 ZHAO Shujie1
		DOI: 10.20047/j.issn1673-7210.2023.36.10
		Insulin resistance is related to the occurrence and development of various metabolic diseases such as polycystic ovary syndrome, non-alcoholic fatty liver disease, and type two diabetes mellitus. With the improvement of living standards, the probability of obesity and insulin resistance is increasing. The research on insulin sensitivity has received increasing attention, with a focus on the mechanism of insulin resistance. At present, the mechanism of insulin resistance is not only lipid overload and inflammation, but also a series of stress reactions, molecular level mutations of substances in the insulin signaling pathway, autophagy, and intestinal microbiota imbalance. The published articles on the mechanism of insulin resistance are not comprehensive enough, therefore, this article reviews the existing mechanisms of insulin resistance from multiple aspects mentioned above.
		2023 Vol. 20 (36): 50-53,57 [Abstract] ( 17 ) HTML (1 KB) PDF (646 KB) ( 270 )

	54	Research progress on mechanism of acupuncture treatment for chronic migraine
		ZHAO Chengqi1 ZOU Wei2
		DOI: 10.20047/j.issn1673-7210.2023.36.11
		Chronic migraine is a highly disabling neurological disease that has serious adverse effects on the quality of life of patients. Acupuncture can intervene and treat chronic migraine through many ways, with definite clinical effect and good preventive effect. This paper analyzes and summarizes the relevant literatures on the mechanism of acupuncture intervention in chronic migraine in recent years, and reviewes the mechanism of acupuncture treatment of chronic migraine from the perspectives of benign adjustment of brain functional connectivity, inhibition of neurogenic inflammation, correction of central sensitization, improvement of descending pain regulation system, and autonomic nervous system, so as to provide theoretical support for the clinical application of acupuncture treatment of chronic migraine. It also provides reference for further research.
		2023 Vol. 20 (36): 54-57 [Abstract] ( 27 ) HTML (1 KB) PDF (606 KB) ( 141 )

	58	Research progress on psychological characteristics and psychological intervention of children and their parents with giant congenital melanocytic nevus
		MAO Xiaoyue1 GAN Cheng1 XIE Zhongyao2 WANG Dafang1
		DOI: 10.20047/j.issn1673-7210.2023.36.12
		In the perioperative period of patients with giant congenital melanocytic nevus, children and their parents will face psychological pain, which will lead to bad mood, cognition, and behavior, and have adverse effects on body and mind. Therefore, it is of great clinical significance to pay attention to the psychological characteristics of children with giant congenital melanocytic nevus and their parents and carry out psychological nursing intervention. At present, the nursing research on the children and their parents with giant congenital melanocytic nevus is limited and lack of systematic psychological nursing research. This article reviews the current research progress on the psychological characteristics and psychological intervention of children and their parents with giant congenital melanocytic nevus, the aim of this study is to provide reference for psychological nursing intervention of children and their parents with giant congenital melanocytic nevus.
		2023 Vol. 20 (36): 58-61,66 [Abstract] ( 21 ) HTML (1 KB) PDF (920 KB) ( 166 )

	62	Correlation between self-efficacy and health literacy and discharge readiness in young and middle-aged patients with acute myocardial infarction after percutaneous coronary intervention
		DING Liping1 ZHANG Rong2 FAN Xinrong1 LIU Feng1 XU Fen1 ZHANG Lianghui1▲
		DOI: 10.20047/j.issn1673-7210.2023.36.13
		Objective To investigate the relationship between hospital discharge readiness and health literacy and the mediating role of self-efficacy in young and middle-aged patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods From January 2021 to January 2022, a total of 296 inpatients who underwent PCI in the Department of Cardiovascular Medicine, Affiliated Hospital of Southwest Medical University were selected as the study objects. Patients who met the exclusion criteria were investigated by using the scale of general data, discharge readiness, general self-efficacy, and health literacy of chronic patients. The relationship between the three was analyzed by statistical method, and the mediating effect was discussed. Results The scores of discharge readiness, general self-efficacy, and health literacy of chronic disease in patients after PCI were (95.79±10.27), (26.78±3.97) points and (93.58±9.10) points, respectively. There were positive correlations between self-efficacy and health literacy, and between health literacy, self-efficacy and hospital discharge readiness (r=0.501, 0.539, 0.432, P＜0.05). Self-efficacy had a partial mediating effect between health literacy and hospital discharge readiness, with a contribution rate of 18.89%. Conclusion Health literacy can directly affect hospital discharge readiness of young and middle-aged AMI patients after PCI, and can also indirectly affect hospital discharge readiness through self-efficacy. According to positive psychology, nurses take improving health literacy and improving self-efficacy as the entry point to improve patients’ readiness for discharge.
		2023 Vol. 20 (36): 62-66 [Abstract] ( 15 ) HTML (1 KB) PDF (491 KB) ( 226 )

	67	Analysis of cognitive function characteristics and related influencing factors in middle-aged patients with obstructive hypopnea sleep apnea syndrome
		WANG Hongyu1 GAO Qian1 ZHU Qilin1 WANG Meilan2▲
		DOI: 10.20047/j.issn1673-7210.2023.36.14
		Objective To analyze the cognitive function characteristics and related influencing factors of middle-aged patients with obstructive hypopnea sleep apnea syndrome (OSAHS). Methods A total of 98 middle-aged patients with OSAHS admitted to the Third People’s Hospital of Nantong City from January to November 2022 were included in the observation group, and 98 middle-aged healthy subjects were included in the control group during the same period. Baseline data of the two groups were collected, and Montreal cognitive assessment and polysomnography monitoring were performed to analyze the cognitive function characteristics and related influencing factors of OSAHS patients. Results The frequency of apnea in the observation group was higher than that in the control group, the longest apnea time and the average apnea time were longer than that in the control group, and the minimum oxygen saturation in arterial blood (SaO2) and the average level of SaO2 were lower than that in the control group, and the differences were statistically significant (P＜0.05). The scores of attention, delayed memory, visual space, and executive dimension of the Montreal cognitive assessment scale in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Logistic analysis showed that SaO2 level was an independent risk factor for cognitive impairment in OSAHS patients (OR＞1, P＜0.05). Conclusion OSAHS can lead to cognitive impairment in patients, and the concentrated manifestations are attention, delayed memory, visuospatial and executive dysfunction. SaO2 level is an independent risk factor for cognitive impairment in patients with OSAHS. Targeted intervention measures can be taken to reduce the risk of cognitive impairment in patients.
		2023 Vol. 20 (36): 67-70 [Abstract] ( 14 ) HTML (1 KB) PDF (477 KB) ( 140 )

	71	Effects of general practitioner group services on blood glucose and lipid control, negative emotions, and self-management in patients with type 2 diabetes mellitus
		ZHANG Xiaolin LI Zhongmei WANG Jing SHI Wenli FANG Ziqiao
		DOI: 10.20047/j.issn1673-7210.2023.36.15
		Objective To investigate the effects of general practitioner group services on blood glucose and lipid control, negative emotions, and self-management in patients with type 2 diabetes mellitus (T2DM). Methods A total of 200 T2DM patients treated in Fukuang General Hospital, Liaoning Health Industry Group from January 2020 to July 2022 were selected as the study objects. According to random number table method, they were divided into signed group and unsigned group, with 100 cases in each group. The unsigned group was administered by the general community, while the signed group was administered by the general practitioner group. Both groups were treated for six months. The knowledge awareness rate, blood glucose control, blood lipid control, negative emotion, and self-management ability of the two groups were compared before and after the intervention. Results After intervention, the awareness rate of diabetes related knowledge in both groups was higher than that before intervention, and that of signed group was higher than that of unsigned group, the differences were statistically significant (P＜0.05). After intervention, the levels of fasting blood glucose, postprandial 2h blood glucose, glycated hemoglobin, triglyceride, total cholesterol, low density lipoprotein cholesterol, and scores of self-rating anxiety scale, self-rating depression scale in the two groups were lower than those before intervention, and those of signed group were lower than those of unsigned group, the differences were statistically significant (P＜0.05). After intervention, the scores of Chinese version scale of the diabetes self-care activities of the two groups were higher than those before intervention, and those of signed group were lower than those of unsigned group, the differences were statistically significant (P＜0.05). Conclusion General practitioner group service can significantly improve T2DM patients’ cognition of disease-related knowledge, improve negative emotions, improve self-management ability, and further promote patients’ active control of blood sugar and blood lipids, which has high promotion value.
		2023 Vol. 20 (36): 71-74,83 [Abstract] ( 24 ) HTML (1 KB) PDF (702 KB) ( 148 )

	75	Analysis of hot spots and trends of thyroid disease omics research based on CiteSpace
		QIAO Xue1 MU Silin1 CHEN Hanhan2 CHEN Hongzhi3 LI Jingwei2
		DOI: 10.20047/j.issn1673-7210.2023.36.16
		Objective To analyze the hotspots and trends of thyroid disease omics research based on CiteSpace. Methods The “thyroid” and “omics” were used as keywords, the relevant literatures on thyroid disease omics included in CNKI from January 2006 to July 2023 were retrieved. CiteSpace 5.7.R5 software was used to analyze the authors, institutional cooperation, and keyword co-occurrence, clustering, emergence of the included literatures, and corresponding visual knowledge maps were drawn. Results A total of 96 literatures were included, of which six were published by Liu Shumin, the author with the most papers. Heilongjiang University of Chinese Medicine and Union Hospital Affiliated to Fujian Medical University were the institutions with the largest number of publications, with four each. There were eight keyword co-occurrence clusters and 14 keywords emergent. The research focuses mainly on thyroid cancer, Graves disease, thyroid nodules, imaging, proteomics, metabolomics, and Chinese medicine. Conclusion Thyroid cancer, Hashimoto thyroiditis, and imaging may be the research trends in the future.
		2023 Vol. 20 (36): 75-78 [Abstract] ( 21 ) HTML (1 KB) PDF (2007 KB) ( 65 )

	79	Effects of Rituximab on renal function, anti-M-type phospholipase A2 receptor antibody, and angiopoietin-like protein-4 in patients with membranous nephropathy
		GAI Wei GU Xianghao ZHOU Yun
		DOI: 10.20047/j.issn1673-7210.2023.36.17
		Objective To explore the effects of Olmesartan combined with Rituximab on renal function, anti-M-type phospholipase A2 receptor (PLA2R) antibody, and angiopoietin-like protein-4 levels in patients with membrane-induced nephropathy. Methods A total of 72 patients with membranous nephropathy treated in Department of Rheumatology and Nephrology of Xuzhou Hospital of Traditional Chinese Medicine, Jiangsu Province from May 2019 to May 2022 were selected and divided into control group and observation group by random number table method, with 36 cases in each group. The control group was treated with Prednisone Acetate Tablets combined with Olmesartan, and the observation group was treated with Olmesartan Medoxomil Tablets combined with Rituximab. After six months of treatment, the therapeutic effect, renal function index, anti-M-type PLA2R antibody, angiopoietin-like protein-4, and helper T (Th) cell levels were compared between the two groups. The patients were followed up for three months and the adverse reactions were recorded in both groups. Results After six months of treatment, the efficacy of observation group was better than that of control group, and the difference was statistically significant (P＜0.05). After six months of treatment, the levels of blood urea nitrogen, creatinine, uric acid, anti-M-type PLA2R antibody, angiopoietin-like protein-4, Th17 cells, Th1 cells, and Th2 cells in two groups were lower than those before treatment, and those of observation group were lower than those of control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Olmesartan combined with Rituximab in the treatment of membrane nephropathy can improve the renal function of patients, reduce the levels of anti-M-type PLA2R antibody and angiopoietin-like protein-4, and improve the therapeutic effect of patients.
		2023 Vol. 20 (36): 79-83 [Abstract] ( 22 ) HTML (1 KB) PDF (400 KB) ( 202 )

	84	Analysis of hot spots and frontiers of thoracolumbar fracture treatment and rehabilitation based on CiteSpace
		ZOU Qiping1 ZHOU Binbin2 LIN Chunting1 CHEN Dingcong1 JI Xiaofeng1 YAO Xinyu1 ZHANG Jie1
		DOI: 10.20047/j.issn1673-7210.2023.36.18
		Objective To analyze research trends in thoracolumbar fracture treatment and rehabilitation over the last 20 years. Methods Literature on thoracolumbar fracture treatment and rehabilitation in the core databases of CNKI, Wanfang data, VIP, and Web of Science from January 2002 to December 2022 was searched, and CiteSpace software was used to map, author, institution, and keywords. Results A total of 1 125 Chinese and 547 English literatures were included. The author with the highest number of Chinese papers was Xu Jianwen, and the institution with the highest number of Chinese papers was Yuxi People’s Hospital of Yunnan Province. Gelu Onose was the author with the highest number of international publications, and Harvard University was the highest number of publications; domestic and international high-frequency keywords were thoracolumbar fracture, rehabilitation, surgical treatment; the highest domestic outburst intensity was lumbar compression fracture, and the highest international outburst intensity was spinal cord injury. Conclusion Domestic and international research focus on determining the clear indication of surgical treatment and postoperative rehabilitation and nursing. Domestic research focuses on personalized surgical programs and rehabilitation nursing means, while international research focuses on the basis of thoracolumbar fracture.
		2023 Vol. 20 (36): 84-88,94 [Abstract] ( 20 ) HTML (1 KB) PDF (1467 KB) ( 61 )

	89	Application of “internet+” based three subjects and two tracks follow-up intervention in screening of neonatal inherited metabolic diseases
		LUO Fuyu XIE Xinxing TU Xiangwen LAI Guihua CHEN Junkun YANG Yichen
		DOI: 10.20047/j.issn1673-7210.2023.36.19
		Objective To explore the application of “internet+” based three subjects and two tracks follow-up intervention in screening of neonatal inherited metabolic diseases(IMD). Methods A total of 4 915 IMD positive newborns from January 2020 to December 2021 in Ganzhou Maternal and Child Health Hospital of Jiangxi Province were selected as the observation group, and three subjects and two tracks follow-up intervention based on “internet +” was implemented; 5 048 newborns with positive IMD screening were selected as the control group from January 2018 to December 2019, and routine follow-up intervention was carried out. The recall situation, non-recall reasons, IMD detection situation, and recall time were compared between the two groups. The actual recalled newborns and the main guardians were included in the recall group, and the rest were included in the non-recall group, the relationship between the main guardians and the newborns, the gender of the newborns, the household registration and education background of the main guardians were compared between the recall group and the non-recall group. The contribution of telephone (including text message), WeChat group, hospital website, and hospital WeChat public number to recall in observation group were compared. Results There was significant difference in follow-up between the two groups (P＜0.05); there was no significant difference in the rate of IMD detected between the two groups (P＞0.05). There was no significant difference between the two groups in the reasons for no recall of IMD positive neonates (P＞0.05). The recall time of the observation group was shorter than that of the control group (P＜0.05). There were significant differences in household registration and education background between the recall group and the non-recall group (P＜0.05); there were no significant differences in the relationship between the main guardian and the newborn, and the newborn sex between the recalled group and the non-recalled group (P＞0.05). In the observation group, more people were recalled through ≥2 channels (phone including [text message], WeChat group, hospital website, and hospital WeChat public account). Conclusion In newborn IMD screening, the implementation of three subjects and two tracks follow-up intervention based on “internet +” can improve the recall rate, shorten the recall time, improve the efficiency of newborn IMD screening, and help early diagnosis and treatment of children. Rural household registration and low educational background are the factors affecting the recall of newborns, and multi-channel recall can be used.
		2023 Vol. 20 (36): 89-94 [Abstract] ( 19 ) HTML (1 KB) PDF (472 KB) ( 18 )

	95	Correlation analysis of serum 25 hydroxyvitamin D3, antimicrobial peptide LL-37, and interleukin-6 with disease severity in children with bronchiolitis
		LYU Yanguan1 ZHANG Qigang1 LIN Xiaofei2 ZANG Xiaojuan3
		DOI: 10.20047/j.issn1673-7210.2023.36.20
		Objective To investigate the correlation of serum 25-hydroxyvitamin D3 (25-[OH]D3), antimicrobial peptide LL-37, and interleukin-6 (IL-6) with disease severity in children with bronchiolitis. Methods Sixty cases with bronchiolitis admitted to Huaian Maternal and Child Health Hospital Affiliated to Yangzhou University from October 2021 to October 2022 were selected as the experimental group, the control group was selected from 60 healthy children who underwent physical examination in the same period. According to the diagnostic criteria of bronchiolitis, they were divided into mild group and severe group, with thirty cases in each group. The serum levels of 25-[OH]D3, LL-37, and IL-6 in all groups were compared; the correlation between the levels of serum 25-[OH]D3, LL-37, and IL-6 and the severity of bronchiolitis in children with bronchiolitis were analyzed. Results The levels of serum 25-[OH]D3 and LL-37 in experimental group were lower than those in control group, while the level of IL-6 was higher than that in control group (P＜0.05). The serum levels of 25-[OH]D3 and LL-37 in severe group were lower than those in mild group (P＜0.05); there was no statistical significance in the level of IL-6 between severe group and mild group (P＞0.05). The levels of serum 25-[OH]D3 and LL-37 were negatively correlated with the severity of bronchiolitis in children (r=-0.563, -0.681, P＜0.05); the level of serum IL-6 was positively correlated with the severity of bronchiolitis in children (r=0.645, P＜0.05). Conclusion The levels of serum 25-[OH]D3, LL-37, and IL-6 are related to the occurrence of bronchiolitis. The levels of serum 25-[OH]D3, LL-37, and IL-6 can indicate the degree of bronchiolitis, this study can provide new ideas for the diagnosis and treatment of children with bronchiolitis.
		2023 Vol. 20 (36): 95-98 [Abstract] ( 20 ) HTML (1 KB) PDF (460 KB) ( 117 )

	99	Comparison of clinical effect of digital impression and traditional impression on complete denture restoration
		ZOU Lei YAN Rongzeng LI Lelan WANG Boxin
		DOI: 10.20047/j.issn1673-7210.2023.36.21
		Objective To compare the clinical effect of digital impression and traditional impression on complete denture restoration for patients with edentulous. Methods Sixty patients with edentulous admitted to Fuzhou Fuyi Stomatological Hospital of Jiangxi Province from January to December 2022 were selected as the study subjects. They were divided into digital group and traditional group by random number table method, with 30 cases in each group. Patients in digital group wore complete dentures made using digital impressions, while patients in traditional group wore complete dentures made using secondary impressions. The impression comfort score and impression time of two groups were compared; the clinical effect of denture restoration was compared between two groups; the overall satisfaction of dentures before restoration and at one, two, and three months after restoration was compared between two groups; and the mastication efficiency and total grinding times were compared between two groups. Results The impression comfort score of digital group was higher than that of traditional group, and impression time was shorter than that of traditional group, and the differences were statistically significant (P＜0.05). There were no significant differences in aesthetics and pronunciation scores between two groups (P＞0.05); while the tenderness, retention stability, and denture comfort scores of digital group were lower than those of traditional group, and the differences were statistically significant (P＜0.05). The overall analysis showed that there were statistically significant differences between groups, time, and interaction in the overall satisfaction score after denture restoration between two groups (P＜0.05). Further pound-to-group comparison and intra-group comparison: the overall satisfaction scores after denture restoration of two groups were compared at different time points, and the differences were statistically significant (P＜0.05). Inter-group comparison: at two and three months after restoration, the overall satisfaction scores of the digital group were lower than those of traditional group, and the differences were statistically significant (P＜0.05). The masticatory efficiency of digital group was lower than that of traditional group, and the total grinding times were higher than those of traditional group, and the differences were statistically significant (P＜0.05). Conclusion The two impression methods have their own advantages in the process of making full denture. The digital impression method has better impression comfort and shorter time, while the traditional impression method has more obvious advantages in the aspects of denture comfort, tenderness, retention stability and chewing efficiency.
		2023 Vol. 20 (36): 99-103 [Abstract] ( 18 ) HTML (1 KB) PDF (1185 KB) ( 57 )

	104	Diagnostic value of electrophysiological visual evoked potential detection combined with serum visceral adipose-specific serine protease inhibitor expression in diabetic optic neuropathy
		ZHANG Suya WANG Jing
		DOI: 10.20047/j.issn1673-7210.2023.36.22
		Objective To investigate the diagnostic value of electrophysiological visual evoked potential (VEP) detection combined with serum visceral adipose-specific serine protease inhibitor (Vaspin) expression in diabetic optic neuropathy (DON). Methods Clinical data of 259 patients (518 eyes) with type 2 diabetes mellitus admitted to Sir Run Run Hospital Nanjing Medical University from January 2020 to July 2022 were retrospectively analyzed, and they were divided into non-DON group (238 cases, 476 eyes) and DON group (21 cases, 42 eyes) according to whether they had DON or not. The factors affecting the occurrence of DON in diabetic mellitus patients were analyzed, and the diagnostic value of electrophysiological VEP detection and serum Vaspin expression for DON was analyzed. Results Duration of diabetes mellitus, P100 latent time in DON group were longer than those in non-DON group, serum Vaspin level was higher than that in non-DON group, and P100 amplitude was lower than that in non-DON group (P＜0.05). Duration of diabetes mellitus (OR=4.289), P100 latent time (OR=2.838), P100 amplitude (OR=0.328), and serum Vaspin (OR=3.466) were influencing factors for the occurrence of DON in diabetic mellitus patients (P＜0.05). The area under the curve of P100 latent time and P100 amplitude combined with serum Vaspin level in diagnosis of DON was higher than that in each single prediction (P＜0.05). Conclusion Electrophysiological VEP detection (P100 latent time, P100 amplitude) and serum Vaspin level have important value in the diagnosis of DON, and the combination of the three has higher diagnostic value.
		2023 Vol. 20 (36): 104-107 [Abstract] ( 17 ) HTML (1 KB) PDF (564 KB) ( 16 )

	108	Lü Peiwen’s experience of using Furong Ointment in the treatment of acute mastitis during lactation
		LI Yuwei1 ZHANG Dongxiao2 LYU Peiwen2
		DOI: 10.20047/j.issn1673-7210.2023.36.23
		This paper summarizes the clinical experience of Professor Lü Peiwen in the treatment of acute mastitis during lactation using Furong Ointment. The incidence of acute mastitis during lactation has increased significantly in recent years, and the probability of progression from mastitis to breast abscess increases greatly if the treatment is untimely and incorrect. Professor Lü Peiwen believes that this disease is mostly caused by the accumulation of breast milk, and the feeling of external evils, and the treatment is to clear away heat, remove toxins and dissipate lumps. Furong Ointment, as a classic prescription of yanjing school of surgery, has been used clinically for more than 50 years, which is based on the traditional formula and skillfully adds drugs to enhance the effectiveness and prevent therapeutic side effects, and is highly effective in treating acute mastitis during lactation, and it has the advantages of being easy to use, affordable, and with fewer adverse reactions. Professor Lü Peiwen emphasizes syndrome differentiation, focusing on the treatment modalities as well as the timing of entry, the use of Furong Ointment in the early stage of the disease is simple but specialized to reduce the patient’s symptoms and control the development of the disease effectively, reflecting the traditional Chinese medicine thinking of “people oriented and preventing transform when sickness”. And with one experimental case.
		2023 Vol. 20 (36): 108-111 [Abstract] ( 19 ) HTML (1 KB) PDF (457 KB) ( 67 )

	112	Predictive value of preoperative multimodal ultrasound for postoperative recurrence risk of breast cancer
		JI Donglu
		DOI: 10.20047/j.issn1673-7210.2023.36.24
		Objective To analyze the correlation between preoperative multimodal ultrasound features and recurrence risk of breast cancer and to explore its value. Methods A total of 286 cases (286 lesions) with breast cancer patients who underwent surgery in Mudan People’s Hospital of Heze City, Shandong Province from January 2020 to January 2023 were selected. They were divided into training set (200 cases) and validation set (86 cases) according to the ratio of 7∶3. The training set was divided into high risk group (68 cases) and a low-medium risk group (132 cases) according to the Guidelines and Norms for Diagnosis and Treatment of Breast Cancer of the Chinese Anti-Cancer Association 2021 Edition. The factors influencing the risk of breast cancer recurrence after surgery were analyzed and the prediction model of nomogram was established. The performance of the model was evaluated by receiver operating characteristic curve and calibration curve. Results There was no significant difference in general data between the training set and verification set (P＞0.05). TNM stage, pathological grade, lymph node metastasis, tumor diameter, boundary, hyperechoic halo, internal echo, blood flow grade, and elastic score were significantly different between high risk group and low-medium risk group (P＜0.05). Tumor diameter (OR=1.428), boundary (OR=3.425), hyperechoic halo (OR=3.300), internal echo (OR=9.631), and blood flow grade (OR=1.725) were independent risk factors for postoperative recurrence of breast cancer patients (P＜0.05). Based on this, a nomogram prediction model was constructed. The area under the curve (AUC) in the training set was 0.832, and the AUC in verification set was 0.800, which showed good performance. Calibration curve consistency was high. Conclusion It is of high practical value to construct a nomogram model for predicting the recurrence risk of breast cancer based on preoperative multimodal ultrasound.
		2023 Vol. 20 (36): 112-116 [Abstract] ( 22 ) HTML (1 KB) PDF (658 KB) ( 80 )

	117	Literature Identification of the treatment of moxibustion to cure cholera after death in the Zhouhou Beiji Fang
		FENG Jialei XIAO Yongzhi
		DOI: 10.20047/j.issn1673-7210.2023.36.25
		Ge Hong, a physician of the Jin Dynasty, discussed in detail the moxibustion treatment of cholera in Zhouhou Beiji Fang, and Beiji Qianjin Yao Fang and Waitai Miyao quoted the text a lot. By studying the content of moxibustion to cure cholera after death in the three books, it was found that there were textual differences in the descriptions of the “moxibustion therapy for resurrecting cholera” and “Hua Tuo’s treatment for cholera after death”. Referring to the Yixin Fang, it was believed that the acupoints measurement in the “moxibustion therapy for resurrecting cholera” should be based on the “renkou” standard. The positioning for moxibustion in “Hua Tuo’s treatment for cholera after death” should be more accurately based on the recorded information in Beiji Qianjin Yao Fang and Waitai Miyao. Moreover, the measurement of the jiaji should be one cun, which is more reasonable. By examining the relationship between Zhouhou Beiji Fang, Beiji Qianjin Yao Fang, Waitai Miyao, and Yixin Fang, this paper aims to analyze the accuracy of the texts, explore the reasons for the differences, and provide references for clinical applications.
		2023 Vol. 20 (36): 117-120 [Abstract] ( 19 ) HTML (1 KB) PDF (792 KB) ( 27 )

	121	Visual analysis of traditional Chinese medicine in treatment of cervical spondylotic radiculopathy based on CiteSpace
		LI Zhi CHEN Feng YANG Yuanque LIU Tao LIU Qin
		DOI: 10.20047/j.issn1673-7210.2023.36.26
		Objective To analyze the hot spots and current situation of traditional Chinese medicine in treatment of cervical spondylotic radiculopathy based on CiteSpace. Methods The relevant literatures on the treatment of cervical spondylotic radiculopathy with traditional Chinese medicine of CNKI and Web of Science core collection database from inception to December 2022 were searched by computer, and the scientific knowledge map of the authors, institutions, and keywords of the included literatures were drawn by CiteSpace 6.1.R6 software. Results A total of 3 285 and 124 Chinese and English literatures were included. The annual number of published documents showed a rapid rising trend. The high-yield author of CNKI was Zhu Liguo, and the high-yield institution was Guangxi University of Chinese Medicine; the high-yield author of Web of Science core collection database was Piva, and the high-yield institution was Shanghai University of Traditional Chinese Medicine. There were 640 keywords in Chinese literatures, which could be grouped into ten categories, and 342 keywords in English literatures, which could be grouped into nine categories. Traction, massage, acupuncture and moxibustion, manipulation, internal and external application of traditional Chinese medicine, and cupping were widely used. Qi stagnation and blood stasis syndrome was a common type of syndrome differentiation. Gegen Decoction, Juanbi Decoction, and Shengyu Decoction were commonly used. Clinical efficacy and functional range were the observational indicators of intervention. Randomized controlled experiment, systematic review, and meta were commonly used research methods. Emergent words pain, cervical function, and acupuncture have increased explosively in recent years. Conclusion This study shows the overall situation in the field of traditional Chinese medicine treatment of cervical spondylotic radiculopathy, and provides references for future scholars to predict the research direction and scientific research topics.
		2023 Vol. 20 (36): 121-126 [Abstract] ( 22 ) HTML (1 KB) PDF (2776 KB) ( 23 )

	127	Professor Guo Jun’s experience in the treatment of benign prostatic hyperplasia with Guiyi Tonglong Formula based on the “brain-heart-kidney-essence chamber” axis theory
		YANG Jiutian1 GUO Jun2 ZHAO Ziwei2 MA Dongyue2 REN Kai2 WANG Fu2
		DOI: 10.20047/j.issn1673-7210.2023.36.27
		Traditional Chinese medicine believes that benign prostatic hyperplasia is often caused by kidney deficiency and instability, as well as bladder disturbance in functioning of qi. Professor Guo Jun proposes the “brain-heart-kidney-essence chamber” axis theory based on this and combined with modern psychological factors such as high work pressure, emphasizing the differentiation and treatment of both body and mind, as well as the combination of overall and local factors. Professor Guo Jun believes that the kidneys and seminal chambers reside together in the lower jiao, which is responsible for water and regulates urine metabolism locally. The heart and brain reside together in the upper jiao, which hides the mind and regulates the physiological functions of the kidneys and seminal chambers as a whole. Any disorder of “brain-heart-kidney-essence chamber” axis can lead to the occurrence of this disease, mainly including three types: loss of nourishment of heart and brain, confusion of the mind, kidney deficiency and instability, disturbance in functioning of qi, stagnation of lower jiao and dysfunction of seminal chamber. Guiyi Tonglong Formula is formulated under the guidance of the “brain-heart-kidney-essence chamber” axis theory. This prescription revolves around tonifying the kidney and warming yang, promoting blood circulation and resolving blood stasis, and has both dredging and tonifying functions. It can provide reference for the clinical treatment of benign prostatic hyperplasia.
		2023 Vol. 20 (36): 127-130 [Abstract] ( 24 ) HTML (1 KB) PDF (750 KB) ( 166 )

	131	Discussion of research status and hotspot of Zuogui Pills based on CiteSpace visualization software
		ZHANG Mingzhao1 LI Xiao2 JU Baojun1 MA Miaomiao1 ZHANG Yongtao1 LI Luyu1 YAO Junchao1 LIU Feng1
		DOI: 10.20047/j.issn1673-7210.2023.36.28
		Objective To understand the development status and research hotspots of Zuogui Pills by CiteSpace visualization software. Methods The literatures about Zuogui Pills from January 1993 to December 2022 were searched in CNKI, VIP, Wanfang Data, Wanfang Med Oline, and China Biology Medicine Literature Service System. CiteSpace 6.2.R2 software was used to visualize the authors, institutions, keywords, and other information. Results A total of 1 050 relevant literatures were included in the study. In 2017, the number of literatures published on Zuogui Pills was the highest, with 90 articles. There were 76 authors who had published more than five literatures. The institution with the highest number of publications was Liaoning University of Traditional Chinese Medicine. There were ten keywords with frequency ≥19 in the literatures about Zuogui Pills, forming 12 natural clusters, and 25 emergent keywords. Conclusion The clinical application of Zuogui Pills involves a variety of chronic diseases, and the mechanism of action is mostly focused on molecular expression.
		2023 Vol. 20 (36): 131-135,141 [Abstract] ( 22 ) HTML (1 KB) PDF (2043 KB) ( 56 )

	136	Visual analysis of major adverse cardiovascular events after percutaneous coronary intervention intervention by Chinese medicine based on CiteSpace
		YANG Zhifei1 WANG Wujiao1 GUO Lingli1 WU Yuze1 LIN Qian2 WAN Jie1
		DOI: 10.20047/j.issn1673-7210.2023.36.29
		Objective To analyze the current research status, hotspots, and development trend of Chinese medicine intervention for major adverse cardiovascular events major adverse cardiovascular events after percutaneous coronary intervention. Methods Literatures from CNKI, VIP, and Wanfang Data were searched from construction to April 2023, and CiteSpace software was used to visualize and analyze the authors, institutions, and keywords of the literature. Results A total of 1 504 articles were included, with a general upward trend in the number of publications; among the 13 core authors, Zhang Minzhou’s team published the most papers, among 390 institutions, the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine published the most papers, and the content of the studies involved three aspects: elements of traditional Chinese medicine syndrome and traditional Chinese medicine syndrome type, research on the clinical efficacy of traditional Chinese medicine, and research on the basic mechanism of traditional Chinese medicine intervention. Conclusion At present, this field is constantly developing, and the visualization analysis intuitively shows the research direction and the evolution pattern, providing reference for future research.
		2023 Vol. 20 (36): 136-141 [Abstract] ( 21 ) HTML (1 KB) PDF (1729 KB) ( 65 )

	142	Analysis of Zhang Xichun’s academic thoughts on the treatment of vertigo
		SUN Xingjia WANG Yang WANG Hui LIU Kun
		DOI: 10.20047/j.issn1673-7210.2023.36.30
		Vertigo is one of the common clinical symptoms and can be seen in many diseases. Zhang Xichun, based on the viewpoint of doctors in the past dynasties, learned and summarized the experience of predecessors, and put forward new ideas for the understanding and treatment of vertigo. Based on Records of Chinese Medicine with Reference to Western Medicine, this paper discusses Zhang Xichun’s academic characteristics in the treatment of vertigo. It is found that the etiology of Zhang Xichun’s treatment of vertigo starts from excess and deficiency, and deficiency syndrome is divided into qi-deficiency, blood-deficiency, and yin deficiency leading to vertigo. The excess syndrome are mostly caused by exogenous wind-cold and phlegm-dampness, the disease location is closely related to the liver, the pathogenesis involves the up-rushing of qi and the non-return of fire. Treatment of drugs to study drug properties, make good use of cold, tonifying, convergence, sedimentation, and other drugs. There are many innovations in the prescription, the creation of Zhengan Xifeng Decoction, Jianling Decoction, Litan Decoction, and other treatment of vertigo, against the blind use of Buyang Huanwu Decoction. Zhang Xichun enriched the diagnosis and treatment methods of vertigo, formed a complete ideological system, promoted the contention and development of the academic thought of vertigo. His academic ideas have important guiding significance for the treatment of vertigo today.
		2023 Vol. 20 (36): 142-146,150 [Abstract] ( 20 ) HTML (1 KB) PDF (806 KB) ( 115 )

	147	Effect of Guanxinning Tablets on hemodialysis patients with blood stasis type chronic renal failure complicated with carotid atherosclerosis
		ZHANG Xiaoyan YU Maoqiang▲ LIU Xiaoju ZHANG Zhunjing
		DOI: 10.20047/j.issn1673-7210.2023.36.31
		Objective To investigate the effect of Guanxinning Tablets on hemodialysis patients with blood stasis type chronic renal failure complicated with carotid atherosclerosis. Methods A total of 97 hemodialysis patients with carotid atherosclerosis blood stasis type chronic renal failure complicated with carotid atherosclerosis who received hemodialysis in Lishui Traditional Chinese Medicine Hospital from March 2021 to March 2023 were selected, they were divided into study group (49 cases) and control group (48 cases) by random number table method. Both groups received symptomatic treatment such as antihypertensive and lipid-lowering therapy combined with hemodialysis treatment. On this basis, the observation group was treated with Guanxinning Tablets for a total of 12 weeks. The changes of blood lipid, renal function, and carotid atherosclerotic plaque before and after treatment were compared between the two groups. Results After treatment, the levels of low density lipoprotein cholesterol, total cholesterol, and triglyceride in both groups were lower than before treatment, and study group was lower than control group (P＜0.05). After treatment, the levels of serum creatinine and urea nitrogen in both groups were lower than before treatment, and study group was lower than control group (P＜0.05). The maximum area of carotid atherosclerotic plaque decreased in both groups compared with before treatment, and the study group was smaller than the control group (P＜0.05). Conclusion The application of Guanxinning Tablets can effectively improve the blood lipid level of hemodialysis patients with blood stasis type chronic renal failure complicated with carotid atherosclerosis, and can improve their renal function and reduce carotid atherosclerosis plaque.
		2023 Vol. 20 (36): 147-150 [Abstract] ( 26 ) HTML (1 KB) PDF (792 KB) ( 51 )

	151	Effect of ultrasound-guided acupotomy of popliteal oblique ligament combined with intra-articular injection of Sodium Hyaluronate in the treatment of knee osteoarthritis with flexion deformity
		YUAN Ding1 SHAN Fenfen2 LI Tao3 ZHANG Jian1 SHI Rongrong1 JIANG Ping1 WANG Chun4 WANG Weijun1 BI Yanzhen5
		DOI: 10.20047/j.issn1673-7210.2023.36.32
		Objective To investigate the clinical efficacy of ultrasound-guided acupotomy of popliteal oblique ligament combined with intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis with flexion deformity. Methods A total of 108 patients diagnosed of knee osteoarthritis with flexion deformity in Qingdao Municipal Hospital from January 2021 to December 2021 were selected, and they were divided into treatment group and control group according to the random number table method, with 54 cases in each group. The control group was treated with intra-articular injection of Sodium Hyaluronate, and the treatment group was treated with ultrasound-guided acupotomy of popliteal oblique ligament basis on the control group, once a week, five consecutive times. The Hospital for Special Surgery (HSS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS) scores before and after treatment were compared, the clinical efficacy and complications were compared between the two groups. Results After treatment, the HSS score of the treatment group was higher than that before treatment, and the HSS score of the treatment group was higher than that of the control group, the differences were statistically significant (P＜0.05). The pain, stiffness, functional scores and total scores of WOMAC in both groups were lower than before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P＜0.05). After treatment, VAS score of the treatment group was lower than that before treatment, and VAS score of the treatment group was lower than that of the control group, the differences were statistically significant (P＜0.05). The clinical effect of the treatment group was better than that of the control group, and the difference was statistically significant (P＜0.05). There were no complications such as infection, hematoma and allergic reaction in the two groups. Conclusion Ultrasound-guided needle knife release of the oblique popliteal ligament combined with intra-articular injection of sodium hyaluronate can significantly relieve knee pain and improve knee flexion deformity. The therapeutic effect is better than that of intra-articular injection of Sodium Hyaluronate alone, and have high safety.
		2023 Vol. 20 (36): 151-155,160 [Abstract] ( 17 ) HTML (1 KB) PDF (751 KB) ( 90 )

	156	Clinical effect of akupotomye technique for the treatment of residual pain after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fracture
		JIE Zhou1　WANG Hongliang2　ZHOU Tao2　LI Kaiping3　LI Jian2　WANG Gang1
		DOI: 10.20047/j.issn1673-7210.2023.36.33
		Objective To discuss the clinical effect of akupotomye technique for the treatment of residual pain after percutaneous vertebroplasty (PVP) in patients with osteoporotic vertebral compression fracture (OVCF). Methods Forty patients with OVCF admitted to the Department of Spinal Orthopaedics, Maanshan People’s Hospital from June 2021 to September 2022 who underwent transsphenoidal PVP and had residual pain after surgery were selected, and they were divided into drug group and akupotomye technique group according to the random number table method, with 20 cases in each group. Both groups were treated with Calcium Vitamin D Chewable Tablets and Alfacalcidol Soft Capsules. The drug group was given Celecoxib Capsules on basis of this treatment. The akupotomye technique group was given akupotomye technique on basis of this treatment. The visual analogue score (VAS), the Oswestry dysfunction index (ODI) scores and the Hamilton anxiety scale (HAMA) were compared between the two groups before treatment, one day after treatment, one month after treatment, and three months after treatment. Results There were statistically significant differences in VAS score, ODI index, and HAMA score among groups, time point comparison and interaction (P＜0.05). Intra-group comparison: there were statistically significant differences in VAS score, ODI index, and HAMA score of the two groups at different time point (P＜0.05). Comparison between groups: VAS scores, ODI index and HAMA scores in the akupotomye group were lower than those in the drug group at one day, one month, and three months after treatment, and the differences were statistically significant (P＜0.05). Conclusion The clinical efficacy of the akupotomye technique in the treatment of residual pain after PVP is clear, and it can rapidly reduce the pain in the patient’s low back and improve the function of the patient’s low back earlier, which is worthy of clinical promotion.
		2023 Vol. 20 (36): 156-160 [Abstract] ( 17 ) HTML (1 KB) PDF (522 KB) ( 18 )

	161	Effect of chewing gum on rapid recovery of gastrointestinal function in children with acute appendicitis after operation
		ZHANG Ran1 LI Li1 ZHANG Boning1 MA Yihan1 ZHANG Yachen1 ZHANG Weiping2 LI Xianling1▲
		DOI: 10.20047/j.issn1673-7210.2023.36.34
		Objective To explore the effect of chewing gum on rapid recovery of gastrointestinal function in children with acute appendicitis after operation. Methods A total of 60 children with appendicitis and 60 their families admitted to the Department of Emergency Surgery, Beijing Children’s Hospital, Capital Medical University from February to August 2023 were selected as the study objects. They were divided into control group and observation group by random number table method, with 30 cases in each group. The control group received routine nursing, and the observation group was supplemented with chewing gum nursing intervention. The first postoperative exhaust time, hospital stay, pain degree, and nursing satisfaction were compared between the two groups. Results The first postoperative exhaust time of the observation group was shorter than that of the control group, and the difference was statistically significant (P＜0.05). Overall analysis found that there were statistically significant differences in pain scoring time, inter-group, and interaction between the two groups (P＜0.05). Further pairwise comparison and intra-group comparison: comparison of pain scores at different time points in the observation group showed statistically significant differences (P＜0.05). The pain score of the control group at 6 h after surgery was lower than that before surgery and 2 h after surgery, and the difference was statistically significant (P＜0.05). Comparison between the two groups: the pain scores of the observation group were lower than those of the control group 2,6 h after surgery(P＜0.05). The hospitalization time in observation group was shorter than that in control group, and the difference was statistically significant (P＜0.05). There was no significant difference in nursing satisfaction between the two groups (P＞0.05). Conclusion Strengthening the nursing intervention of chewing gum in the nursing care of children after laparoscopic appendectomy can effectively shorten the first postoperative exhaust time and hospital stay of children, and improve the quality of life and nursing satisfaction of patients.
		2023 Vol. 20 (36): 161-164 [Abstract] ( 21 ) HTML (1 KB) PDF (664 KB) ( 150 )

	165	Effect of intraoperative thermal insulation combined with comfortable postural nursing on core body temperature and coagulation function in patients with breast cancer
		LI Xiao YAN Lijie ZHANG Qian▲
		DOI: 10.20047/j.issn1673-7210.2023.36.35
		Objective To explore the effect of intraoperative thermal insulation combined with comfortable postural nursing on core body temperature and coagulation function in patients with breast cancer. Methods A total of 89 breast cancer patients from the First Affiliated Hospital of Nanjing Medical University from January 2020 to January 2022 were selected as the study objects, they were divided into control group (n=44) and observation group (n=45) according to random number table method. The control group was treated with intraoperative thermal insulation + conventional postural intervention, and the observation group was treated with intraoperative thermal insulation combine with comfortable postural nursing, the changes of body temperature and coagulation function indexes were compared between the two groups at different time points. Results Overall analysis showed that there were statistically significant differences in body temperature between groups, time point, and interaction comparison (P＜0.05). Further pairwise comparison and intra-group comparison: in the observation group, the body temperature before intubation was lower than before operation, 60 min after extubation and after surgery was higher than that before intubation, and the differences were statistically significant (P＜0.05). In the control group, the body temperature before intubation and 60 min after extubation was lower than that before operation, and the body temperature 60 min after extubation and after surgery was higher than that before intubation. The body temperature at the completion of the operation was higher than 60 min after extubation, and the differences were statistically significant (P＜0.05). Comparison between groups: the body temperature of the observation group before intubation and 60 min after extubation was higher than that of the control group, and the difference was statistically significant (P＜0.05). Twenty-four hours after operation, thrombin time, activated partial thrombin time, prothrombin time and fibrinogen in two groups were higher than before operation, but observation group was lower than control group; the platelet count of the two groups was lower than before surgery, but the observation group was higher than the control group, the difference was statistically significant (P＜0.05). Conclusion Intraoperative thermal insulation combine with comfortable position nursing for patients with breast cancer can effectively avoid the phenomenon of hypothermia during the operation, improve the index of blood coagulation function, and benefit the good prognosis of patients, which is worthy of reference and application by various departments.
		2023 Vol. 20 (36): 165-168,193 [Abstract] ( 20 ) HTML (1 KB) PDF (993 KB) ( 75 )

	169	Effects of chronic disease trajectory framework model intervention on disease cognition and self-management ability of elderly patients with diabetes mellitus complicated with pancreatitis
		XU Xuemei1 YANG Xueli2 LIU Jun1 WANG Minyu1 HAN Lamei1
		DOI: 10.20047/j.issn1673-7210.2023.36.36
		Objective To explore the effects of chronic disease trajectory framework model intervention on disease cognition and self-management ability of elderly patients with diabetes mellitus complicated with pancreatitis. Methods Taking the intervention regimen based on chronic disease trajectory framework model implemented in Ganzi Tibetan Autonomous Prefecture People’s Hospital as the dividing line, 61 elderly patients with diabetes mellitus and pancreatitis who underwent routine intervention from July 2020 to June 2021 were included in control group, complicated with another 61 elderly patients who received chronic disease trajectory framework model intervention from July 2021 to June 2022 were enrolled as observation group. Disease cognition, self-management ability, quality of life were compared before and after three months of intervention. Results After three months of intervention, the scores of disease cognition (disease perception, emotional state, and disease understanding degree) in the two groups were decreased compared with those before intervention, and the various scores in observation group were significantly lower than those in control group (P＜0.05). The scores of self-care ability (self-concept, self-responsibility, health knowledge level, and self-care skills) and quality of life (physical health, mental health, social function, and material life) were enhanced compared to before intervention, and the above scores in observation group were higher than those in control group (P＜0.05). Conclusion Chronic disease trajectory framework model intervention can improve the disease cognition, enhance the self-management ability, and increase the quality of life of elderly patients with diabetes mellitus complicated with pancreatitis.
		2023 Vol. 20 (36): 169-172 [Abstract] ( 19 ) HTML (1 KB) PDF (640 KB) ( 60 )

	173	Effect of Roy adaptation model intervention mode on mental toughness and knee function in patients with knee replacement
		HAN Li1 LIU Jia2 CHEN Yafen3
		DOI: 10.20047/j.issn1673-7210.2023.36.37
		Objective To explore the application effect of Roy adaptation model (RAM) in knee replacement patients. Methods A total of 100 patients with knee replacement in Jishuitan Hospital from January 2021 to February 2022 were included and grouped by random number table method. Control group (50 cases) received routine nursing, RAM group (50 cases) received RAM intervention based on routine nursing. The mental toughness, functional exercise compliance, and knee joint function of the two groups were observed. Results After intervention, the scores of fortitude, strength and optimism in two groups were higher than before intervention, and those of RAM group were higher than those of control group, and the differences were statistically significant (P＜0.05). After intervention, the scores of psychological compliance, active learning compliance and physical compliance in the two groups were higher than before intervention, and those of the RAM group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the score of American Knee Society score in both groups was higher than before intervention, and those of the RAM group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion RAM intervention mode can help improve mental toughness and compliance of functional exercise, and promote functional recovery of knee joint after knee replacement.
		2023 Vol. 20 (36): 173-176 [Abstract] ( 20 ) HTML (1 KB) PDF (637 KB) ( 25 )

	177	Application effect of feedback health education combined with peer interaction support intervention in diabetic nephropathy patients
		SUN Siming1 WANG Hua1 TAO Dan1 QU Miao1 GAO Yanling2 HOU Fang1▲
		DOI: 10.20047/j.issn1673-7210.2023.36.38
		Objective To explore the effect of feedback health education combined with peer interaction support intervention on diabetic nephropathy (ND) patients. Methods A total of 120 patients with ND were selected from the Second Affiliated Hospital of Air Force Military Medical University from March 2020 to April 2022, according to the random number table method, they were divided into reference group and study group, with 60 cases in each group. The reference group received routine care; in the study group, feedback health education combined with peer interaction support intervention were performed on the basis of routine nursing. The changes of self-management ability and hope level before and after intervention were observed. Results After intervention, the scores of self-monitoring, disease knowledge mastery and core management ability in the self-management scale of the two groups were lower than those before intervention, and the study group was lower than the reference group, and the differences were statistically significant (P＜0.05); after intervention, the scores of Herth hope scale and global happiness scale in the two groups were higher than before intervention, and the study group was higher than the reference group, and the differences were statistically significant (P＜0.05). Conclusion Feedback health education combined with peer interaction support intervention for ND patients plays an obvious role in improving self-management ability and hope level.
		2023 Vol. 20 (36): 177-180 [Abstract] ( 18 ) HTML (1 KB) PDF (657 KB) ( 77 )

	181	A meta-analysis of the effects of dual task training on cognitive function in patients with mild cognitive impairment
		LI Feifei1 ZHENG Yao2 HU Rongrong1 ZHENG Huiling1 CHEN Chunying3 LIU Caixia4
		DOI: 10.20047/j.issn1673-7210.2023.36.39
		Objective To systematically evaluate the effects of dual task training (DTT) on cognitive function in patients with mild cognitive impairment (MCI). Methods Databases in CNKI, Wanfang knowledge service platform, VIP network, Chinese biomedical literature database, PubMed, Web of Science, Cochrane Library, nursing database and EMbase database Randomized controlled trials on the effect of DTT intervention on cognitive function in patients with MCI from database establishment to November 2022 were searched. Meta-analysis was performed using RevMan 5.4 software. Results A total of 14 articles were included, with a total of 953 patients. The results of meta-analysis showed that DTT could improve the scores of MCI patients on summary mini-mental state examination (SMD=0.71, 95%CI: 0.23 to 1.20, P=0.004) and Montreal cognitive assessment (SMD=1.45, 95%CI: 0.73 to 2.17, P＜0.001), cognitive scores on the Alzheimer’s disease assessment scale-cog were reduced (MD=-1.28, 95%CI: -2.06 to -0.49, P=0.002). The Montreal cognitive assessment score funnel plot showed no publication bias. Conclusion DTT can effectively improve the cognitive function of MCI patients, but it needs to be further verified by large samples and high-quality studies.
		2023 Vol. 20 (36): 181-185 [Abstract] ( 24 ) HTML (1 KB) PDF (1591 KB) ( 160 )

	186	A case report and literature review of perioperative management of laparoscopic cholecystectomy in patients with hemophilia
		ZHOU Zheyu1 WANG Kai2 LIU Qiaoyu3 YIN Yin3
		DOI: 10.20047/j.issn1673-7210.2023.36.40
		Hemophilia C (factor Ⅺ deficiency) is a rare coagulation dysfunction disorder. Spontaneous bleeding is rare in patients with hemophilia C, and significant bleeding usually occurs after trauma or surgical procedures. According to the literature review, there have been no reports of patients with hemophilia C undergoing laparoscopic cholecystectomy. The patient sought medical treatment due to “gallstone discovery for more than four years and intermittent dull pain in the abdomen for more than ten months”, and had a previous history of hemophilia C. Preoperative coagulation function examination showed that the activated partial thromboplastin time was significantly prolonged (67.4 s), and the factor Ⅺ activity was 2.4%. According to the consultation of hematology department, the patient was treated with fresh frozen plasma and tranexamic acid in perioperative period. In the end, the operation was successful, and there was no obvious bleeding during and after the operation. This case report suggests that it is safe for hemophilia C patients to receive laparoscopic cholecystectomy after symptomatic treatment, and can provide reference for clinical diagnosis and treatment of similar cases.
		2023 Vol. 20 (36): 186-188 [Abstract] ( 20 ) HTML (1 KB) PDF (313 KB) ( 177 )

	189	Interpretation of expert consensus of Asian Working Group for Sarcopenia and implications for prevention and treatment of sarcopenia in Chinese community elderly
		MA Yue1 CHEN Yuhua1 GU Haoran2
		DOI: 10.20047/j.issn1673-7210.2023.36.41
		Sarcopenia is closely associated with a variety of adverse outcomes and seriously affects the quality of life of the elderly. With the increase of the elderly population in the community, sarcopenia has become a growing problem. To further address muscle health issues in the elderly, the Asian Working Group for Sarcopenia 2022 released the Role of Nutrition in the muscle health of the elderly in the community: evidence-based Expert consensus of the Asian Sarcopenia Working Group, which provides specific evidence-based nutrition recommendations in terms of malnutrition screening, diet, and eating patterns, nutritional supplements, lifestyle, and outcome assessment. This article interprets the consensus guidelines in order to provide reference for the prevention and treatment of sarcopenia in Chinese community elderly.
		2023 Vol. 20 (36): 189-193 [Abstract] ( 13 ) HTML (1 KB) PDF (510 KB) ( 223 )

	194	SWOT analysis and strategy selection of professional construction of health service and management from the perspective of “Healthy China”
		LUO Guihua LIU Lingfeng LIU Juhua ZHANG Yuekun DENG Nianyao ZHANG Jing OUYANG Jing
		DOI: 10.20047/j.issn1673-7210.2023.36.42
		Health management is a powerful starting point to implement the construction of “Healthy China”, and its professional personnel guarantee is very important. Health service and management specialty to meet the needs of people’s health as the starting point and end point, to help the development of health industry. This paper applies SWOT method to analyze the strengths, weaknesses, opportunities, and threats of the internal and external environment of professional development as well as its own existence, and proposes that under the guidance of the concepts of new medicine and new liberal arts, the unified talent training goal should be established, the combination of horizontal and vertical course group modules should be constructed, the“1+X” certificate system should be implemented, and the long-term school-enterprise cooperative education mechanism should be established. We will thoroughly implement the concept of professional construction, promote the construction of “Healthy China” and help the action of “Healthy China”, and cultivate the development strategy of broad caliber generalists with self-confidence and autonomy. This is of great significance for the sustainable and long-term development of health service and management profession.
		2023 Vol. 20 (36): 194-封三 [Abstract] ( 19 ) HTML (1 KB) PDF (635 KB) ( 264 )

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