|
|
|
| Analysis of cognitive function characteristics and related influencing factors in middle-aged patients with obstructive hypopnea sleep apnea syndrome |
| WANG Hongyu1 GAO Qian1 ZHU Qilin1 WANG Meilan2▲ |
1.Department of Pneumology, the Third People’s Hospital of Nantong City Nantong Third Hospital Affiliated to Nantong University, Jiangsu Province, Nantong 226006, China;
2.Department of Nursing, the Third People’s Hospital of Nantong City Nantong Third Hospital Affiliated to Nantong University, Jiangsu Province, Nantong 226006, China |
|
|
|
|
Abstract Objective To analyze the cognitive function characteristics and related influencing factors of middle-aged patients with obstructive hypopnea sleep apnea syndrome (OSAHS). Methods A total of 98 middle-aged patients with OSAHS admitted to the Third People’s Hospital of Nantong City from January to November 2022 were included in the observation group, and 98 middle-aged healthy subjects were included in the control group during the same period. Baseline data of the two groups were collected, and Montreal cognitive assessment and polysomnography monitoring were performed to analyze the cognitive function characteristics and related influencing factors of OSAHS patients. Results The frequency of apnea in the observation group was higher than that in the control group, the longest apnea time and the average apnea time were longer than that in the control group, and the minimum oxygen saturation in arterial blood (SaO2) and the average level of SaO2 were lower than that in the control group, and the differences were statistically significant (P＜0.05). The scores of attention, delayed memory, visual space, and executive dimension of the Montreal cognitive assessment scale in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Logistic analysis showed that SaO2 level was an independent risk factor for cognitive impairment in OSAHS patients (OR＞1, P＜0.05). Conclusion OSAHS can lead to cognitive impairment in patients, and the concentrated manifestations are attention, delayed memory, visuospatial and executive dysfunction. SaO2 level is an independent risk factor for cognitive impairment in patients with OSAHS. Targeted intervention measures can be taken to reduce the risk of cognitive impairment in patients.
|
|
|
|
|
|
[1] 金雪文，蔡婉，金洋一，等.浙江玉环海岛地区职业司机OSAHS发病率及与交通事件的关联性[J].临床肺科杂志，2022，27（4）：545-548.
[2] 金岚，陈哲，何新平，等.长沙市社区老年人OSAHS相关因素分析[J].中国医师杂志，2020，22（8）：1172-1175.
[3] 林溶，吴淑芳.OSAHS对儿童体智发育、认知功能及行为能力的影响及护理对策[J].国际护理学杂志，2022，41（7）：1330-1333.
[4] Jiang X，Wang Z，Hu N，et al. Cognition effectiveness of continuous positive airway pressure treatment in obstructive sleep apnea syndrome patients with cognitive impairment：a meta-analysis [J]. Exp Brain Res，2021，239（12）：3537-3552.
[5] 刘奕姝，谭慧文，曾尹，等.阻塞性睡眠呼吸暂停低通气综合征患者认知功能与情绪及睡眠结构的关系研究[J].中国全科医学，2022，25（11）：1340-1345，1350.
[6] 庞帅，朱毅，蔡晓婷，等.画钟试验在OSAHS患者认知功能障碍评估中的作用及影响因素[J].临床肺科杂志，2022， 27（10）：1495-1500.
[7] 阻塞性睡眠呼吸暂停低通气综合征诊治指南（2011年修订版）[C]//第四届东北地区呼吸疾病学术会议暨吉林省第十一届呼吸病学年会论文集，2012：67-70.
[8] 张立秀，刘雪琴.蒙特利尔认知评估量表中文版的信效度研究[J].护理研究，2007，21（31）：2906-2907.
[9] 罗婧，郭军红.阻塞性睡眠呼吸暂停低通气综合征患者血清HIF-1α、EPO水平与认知的相关性[J].实用医学杂志，2019，35（9）：1433-1437.
[10] 胡浩，葛继晖，张爱玲，等.合并阻塞性睡眠呼吸暂停低通气综合征的急性脑梗死病人认知功能障碍及偏头痛情况分析[J].中西医结合心脑血管病杂志，2022，20（11）：2073-2076.
[11] Elfil M，Bahbah EI，Attia MM，et al. Impact of Obstructive Sleep Apnea on Cognitive and Motor Functions in Parkinson’s Disease [J]. Mov Disord，2021，36（3）：570-580.
[12] 潘峰，唐蕾，孟雄.中重度阻塞性睡眠呼吸暂停低通气综合征患者血清神经肽Y和人生长激素释放多肽变化与认知功能的关系[J].临床与病理杂志，2019，39（2）：294-298.
[13] 张凯月，张媛媛.阻塞型睡眠呼吸暂停低通气综合征病人认知功能障碍的研究进展[J].中西医结合心脑血管病杂志，2021，19（9）：1518-1520.
[14] 刘颖，余蓉，辜德英.阻塞性睡眠呼吸暂停低通气综合征对双相情感障碍患者认知功能的影响分析[J].中国医学前沿杂志（电子版），2021，13（7）：114-118.
[15] 王玲，刘聪辉，李建，等.氧化应激指标对糖尿病伴阻塞性睡眠呼吸暂停低通气综合征认知功能的诊断效能[J].中华老年心脑血管病杂志，2020，22（3）：240-242.
[16] Bubu OM，Andrade AG，Umasabor-Bubu OQ，et al. Obstructive sleep apnea，cognition and Alzheimer’s disease： A systematic review integrating three decades of multidisciplinary research [J]. Sleep Med Rev，2020，50：101250.
[17] 王驰，宁博，刘星，等.OSAHS患者合并认知功能障碍的危险因素分析及防控建议[J].现代医学，2021，49（8）：950-959.
[18] 李双，吴师雄，黄铄，等.OSAHS患者血中NLR水平与认知功能的关系[J].国际精神病学杂志，2019，46（2）：316- 318，329.
[19] 张文文，赵莲萍，谢宇平，等.阻塞型睡眠呼吸暂停低通气综合征患者海马MRS参数与认知功能的相关性[J].中国医学影像技术，2019，35（8）：1175-1179.
[20] 邢昊昱，刘碧霞，戴西件.阻塞性睡眠呼吸暂停低通气综合征与认知功能障碍的研究进展[J].实用医学杂志，2019，35（1）：10-13.
[21] 吴欢，周建荣.住院中年阻塞性睡眠呼吸暂停低通气综合征患者认知功能特点及影响因素分析[J].护理学杂志，2019，34（8）：26-29.
[22] 马腾，韩彦青，李东芳，等.持续气道正压通气治疗对阻塞性睡眠呼吸暂停低通气综合征并轻度认知障碍患者的影响研究[J].实用心脑肺血管病杂志，2019，27（5）：93-98.
[23] 饶容丽，王守章，谷丽娟.阻塞性睡眠呼吸暂停低通气综合征对老年脑小血管病患者认知功能及血清同型半胱氨酸和胱抑素C水平的影响[J].中国老年学杂志，2020， 40（6）：1149-1151.
[24] 陆晓玲，钦光跃，黄勍栋，等.CPAP对OSAHS伴认知功能障碍患者的疗效和血同型半胱氨酸水平的影响[J].浙江医学，2019，41（9）：954-955，958.
[25] 刘晓夏，陈晓东.阻塞性睡眠呼吸暂停低通气综合征患者生活质量现状和影响因素分析[J].中国当代医药，2022， 29（26）：66-69.
[26] 李晨洋，许华俊，李馨仪，等.基于REDCap的CPAP干预对OSAHS患者认知功能影响随访系统的建立和应用[J].中国循证心血管医学杂志，2022，14（6）：650-653. |
|
|
|
