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2020 Vol. 17, No. 33
Published: 2020-11-25
 
 
4 Effect of ERH gene on human bladder cancer cell cycle
ZHOU Rongsheng1,2 HAN Conghui1,2,3 CHEN Bo1 HAO Lin1,3 SHI Zhenduo1 JIANG Bo1 ZHANG Zhiguo1,3 PANG Kun1,2,3▲
Objective To investigate the molecular biological mechanism of enhancer of rudimentary homolog (ERH) gene affecting proliferation and apoptosis of human bladder urothelial carcinoma (BUC) cell line T24. Methods BUC T24 cells were divided into ERH knockdown group and ERH normal cell group. The expression of genes affected by ERH knockdown in the whole gene spectrum was detected by human transcriptome expression profile microarray. The possible molecular biological mechanism of ERH gene affecting the proliferation and apoptosis of human BUC T24 cells was determined by bioinformatics analysis technology, biological functional enrichment and protein interaction analysis techniques, and was verified by functional experiments. Results The results of human transcriptome expression profile microarray technology showed that ERH gene expression was significantly decreased in ERH knockdown group, and the FC value was -4.50, P ＜ 0.0001. The expression of 344 genes in the ERH knockout group was up-regulated and 254 genes were down-regulated (cutoff value |FC|>2) compared with the ERH normal group. The results of biological function enrichment analysis indicated that ERH gene was closely related to cytokines, tumor necrosis factor, P53 down-regulation and apoptosis. The results of protein interaction analysis showed that ERH gene might affect the proliferation and apoptosis of BUC T24 cells through cyclin. Functional experiments suggested that the ERH gene produces these effects through the cell cycle, which mainly affects the S phase of the cell cycle. Conclusion ERH gene affects the proliferation and apoptosis of human bladder cancer T24 cells by regulating cell cycle.
2020 Vol. 17 (33): 4-8,45 [Abstract] ( 183 ) HTML (1 KB)  PDF (1488 KB)  ( 114 )
9 Relationship between the levels of miRNA-193a and miRNA-4286 in tissues of squamous cell lung carcinoma and prognosis
BI Rui WANG Mingsong HU Rui JIANG Lianyong YANG Xuhui ZHONG Yuan
Objective To explore the relationship between the expression levels of microRNA (miRNA)-193a and miRNA-4286 in the tumor tissues of squamous cell lung carcinoma patients and prognosis, so as to provide a new direction for the prognosis evaluation of lung cancer. Methods A total of 126 patients with squamous cell lung carcinoma diagnosed from May 2016 to April 2019 with complete clinical data in Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were selected as research objects. The expression levels of miRNA-193a and miRNA-4286 in squamous cell lung carcinoma tissues and adjacent tissues were detected by real-time fluorescent quantitative reverse transcription PCR (qRT-PCR), and the relationship among miRNA-193a and miRNA-4286 in squamous cell lung carcinoma tissues and clinical data and prognosis were analyzed. Results The relative expression level of miRNA-193a in squamous cell lung carcinoma tissues was lower than that in adjacent tissues, and the relative expression level of miRNA-4286 was higher than that in adjacent tissues, with statistically significant differences (all P ＜ 0.05). The levels of miRNA-193a and miRNA-4286 in squamous cell lung carcinoma tissues were not correlated with age, sex, smoking history or family history, and the differences were not statistically significant (P ＞ 0.05). They were correlated with tumor size, TNM stage, lymph node metastasis and recurrence, and the differences were statistically significant (all P ＜ 0.05). miRNA-193a in squamous cell lung carcinoma tissues was not associated with the degree of differentiation (P ＞ 0.05), while miRNA-4286 was associated with the degree of differentiation (P ＜ 0.05). The median survival time of patients with low miRNA-193a expression in squamous cell lung carcinoma tissues was 36 months (95%CI: 0.371-1.198), while that of patients with high expression was 54 months (95%CI: 0.834-2.696), the difference was statistically significant (P ＜ 0.05). The median survival time of patients with low miRNA-4286 expression in squamous cell lung carcinoma tissues was 51 months (95%CI: 0.962-2.660), while that of patients with high expression was 39 months (95%CI: 0.376-1.039), the difference was statistically significant (P ＜ 0.05). Conclusion The expression levels of miRNA-193a and miRNA-4286 in squamous cell lung carcinoma are correlated with tumor size, TNM stage, lymph node metastasis and recurrence, and are related to the prognosis of patients. miRNA-193a and miRNA-4286 may be used as prognostic indicators for patients with squamous cell lung carcinoma.
2020 Vol. 17 (33): 9-12,60 [Abstract] ( 143 ) HTML (1 KB)  PDF (1169 KB)  ( 35 )
13 Clinical effect of treating refractory calcaneodynia with medial approach arthroscopic triple operation
LU Lin1 ZHANG Hanqing1 WANG Zhi1 CHEN Wei2 LI Shuanglei2
To investigate the clinical effect of treating refractory calcaneodynia with medial approach arthroscopic triple operation. Methods From December 2017 to February 2019 in Wuhan Hospital of Traditional Chinese Medicine, Hubei Province, 20 patients (21 feet) with heel pain who failed to respond to systematic conservative treatment for more than six months were selected. Under the direct vision of the medial approach arthroscopy, the treatment was performed with a triple operation (plasma knife ablation and vaporization of metatarsal fascia, calcaneal osteophyte grinding, calcaneal drilling and decompression). The American Orthopaedic of foot and ankle society ankle hindfoot scale (AOFAS-AH) and visual analogue scale (VAS) were used to evaluate the clinical efficacy of the patients before and 6 to 10 months after surgery. Results All the incisions of the patients were healed at the first grade without nerve, vascular injury or other complications. The patients could carry out daily activities in the early stage after the operation. The median follow-up time was 8.7 (6.0-10.0) months, and the median operative time was 40.7 (30.0-60.0) min utes. Postoperative AOFAS-HA scores of patients were significantly increased (P ＜ 0.01), and postoperative VAS score were significantly decreased (P ＜ 0.01). Conclusion Triple-combinative arthroscopic operation with the medial approach is a treatment modality of intractable calcaneodynia. It has features of little trauma, quick recovery, safe and accurate operation. It can treat the cause of pain comprehensively, improve the function of foot movement well, and has reliable curative effect, which is worthy of clinical reference and further research and promotion of treatment.
2020 Vol. 17 (33): 13-17 [Abstract] ( 158 ) HTML (1 KB)  PDF (983 KB)  ( 91 )
18 Screen and analysis of differential LncRNAs in vascular smooth muscle cell frothing process
HUANG Yan FENG Xi▲ HUANG Fangzhou HU Liang
Objective To analyze obtain the vascular smooth muscle cell (VSMCs) transcription profile by high-throughput sequencing, screen the main differentially expressed long nocoding RNA (LncRNA) transcription profile in VSMCs frothing process, and perform functional prediction and analysis of the screened differentially expressed LncRNAs. Methods Rabbit smooth muscle cells were treated with oxidized low density lipoprotein (ox-LDL) (concentration: 80 mg/mL 24 h) were the experimental group, while those in the control group were not treated. The cells of the experimental group and control group were cdlected, extracting RNAS, and quality inspection and RNA-seq sequencing were performed on the extracted RNA; LncRNA transcription profiles with significant differential expression levels were collected, potential target genes of differentially expressed LncRNAs were predicted by bioinformatics tools, and the relationship between screened LncRNAs and atherosclerosis(AS) was explored by predicting the functional genes of target genes through online database. Results The concentration and quality of RNA were in line with the requirements of LncRNA sequencing. By sequencing quality assessment, the error rate of LncRNA sequencing in single base position in cells was determined to be lower than 0.1%, the sequencing results were qualified and reliable. After screening, 28 LncRNAs with significant differences were obtained, those seven significantly transcription profiles were upregulated: TCONS_01701109, TCONS_02288701, TCONS_02636927, TCONS_00846803, TCONS_02499900, TCONS_02236116, TCONS_02225105; and five transcription profiles were significantly down-regulated: TCONS_01803508, TCONS_ 02523114, TCONS_00489746, TCONS_ 02443383, TCONS_01645487. Conclusion Ox-LDL has a significant effect on the expression level of LncRNA in VSMCs. The differentially expressed LncRNA transcripts obtained in this paper may be involved in the formation and development of atherosclerotic diseases, these differentially expressed LncRNA transcription profile may provide important target genes for subsequent studies.
2020 Vol. 17 (33): 18-23,64 [Abstract] ( 147 ) HTML (1 KB)  PDF (1284 KB)  ( 85 )
24 CT diagnosis of acute methanol poisoning and literature review
QIU Tao1 DAI Xiaoyan2▲ CHEN Yong3 CHEN Ping3 LIU Jia3 CHEN Yue3 XU Xiaoya1 XIAO Hua1
A case of acute methanol poisoning was reported. The patient was a young man, who presented with rapid consciousness disorder and metabolic acidosis with increased anion gap of unknown cause. Brain CT showed that bilateral putamen necrosis with right hemorrhage. According to CT diagnosis of acute methanol poisoning, the patient died of ineffective treatment. The paper reviewed the literature, discussed the process of methanol metabolism, the way of methanol poisoning, the incubation period, the amount of methanol, the main symptoms, the imaging manifestations and the treatment prognosis, so as to improve the understanding of the disease.
2020 Vol. 17 (33): 24-28 [Abstract] ( 90 ) HTML (1 KB)  PDF (1590 KB)  ( 71 )
29 Simultaneous determination of six active ingredients in Shixingganmao Recipe 1 Mixture by HPLC
QIU Panzi XIAO Zuoqi HUANG Tao HUANG Yi PAN Tao OUYANG Bo
Objective To establish and optimize a method for determination of six active ingredients in Shixingganmao Recipe 1 Mixture, and to provide a method basis for the quality control of this traditional Chinese medicine compound preparation. Methods An Agilent C18 column (250 mm×4.6 mm, 5 μm) was used. The mobile phase was acetonitrile-0.1% phosphoric acid aqueous solution as gradient elution withflowing rate of 1.0 mL/min. The column temperature was 35℃ and the detection wavelength was 203 nm. Results Good linear relationships were found in the mass concentrations of puerarin, paeoniflorin, prim-O-glucosylcimifugin, 5-O-methylvisammioside, cinnamaldehyde, and 6-gingerol were 19.19-191.94 μg/mL, 9.80-98.04 μg/mL, 1.10-22.08 μg/mL, 1.07-21.40 μg/mL, 1.14-22.87 μg/mL and 1.09-21.74 μg/mL, respectively(all r ≥ 0.9997). The average recoveries of six components were in accordance with the requirements for determination. Conclusion This method is simple, quick, sensitive and accurate, and suitable for the quality control of Shixingganmao Recipe 1 Mixture.
2020 Vol. 17 (33): 29-32 [Abstract] ( 180 ) HTML (1 KB)  PDF (894 KB)  ( 121 )
33 Application of transperineal rectal mucosal resection of myometrial folding for rectal prolapse
LI Yingqian CHEN Qin TIAN Rui LI Huashan
Rectal prolapse is a benign disease with complex etiology and difficult clinical treatment. Although the disease is not dangerous, its related complications often have a significant impact on the quality of life of patients. Transperineal rectal mucosal resection of myometrial folding (Delorme’s surgery) is one of the most commonly used surgical methods for the treatment of rectal prolapse through the vaginal approach. After several generations of experts and scholars research and development, it has become a mature technique for the treatment of rectal prolapse. This article will discuss the recurrence rate, recurrence factors, complications, postoperative bowel function, adaptation to the population, etc. of Delorme surgery, in order to provide help for clinicians to use the surgery rationally.
2020 Vol. 17 (33): 33-37 [Abstract] ( 106 ) HTML (1 KB)  PDF (665 KB)  ( 18 )
38 Research progress of Rituximab in the treatment of refractory primary immunologic thrombocytopenic purpura
HUANG Ziming LI Ruibai HOU Li ZHANG Yayue
Primary immunologic thrombocytopenic purpura (ITP) is a hemorrhagic disease caused by immune-mediated acquired thrombocytopenia, and it is called refractory ITP if ITP is still confirmed as ITP after diagnosis and reassessment, ineffective ITP with splenectomy or postoperative recurrence. Due to the complicated pathogenesis, there is currently no unified treatment plan for clinically refractory ITP. Rituximab has a good therapeutic effect on ITP by killing abnormal B lymphocytes and alleviating platelet destruction. This article reviews the mechanism of action, clinical program, and efficacy of Rituximab in the treatment of refractory ITP, with a view to promoting further research of Rituximab in the treatment of refractory ITP.
2020 Vol. 17 (33): 38-41 [Abstract] ( 126 ) HTML (1 KB)  PDF (647 KB)  ( 188 )
42 Research progress of pain management and nursing intervention in malignant tumor patients
WANG Di WANG Qinglan▲ WU Long PAN Cen DENG Yangqing
Cancer pain is one of the most common and painful symptoms in patients with malignant tumors, which seriously affects the treatment effect of cancer patients. Effective management and scientific nursing of cancer pain can help patients relieve pain. This paper reviews the causes and management methods of cancer pain, and updates the management methods and comprehensive nursing intervention measures of cancer pain in clinical practice. In addition, this paper puts forward the positive influence of nursing intervention of cancer pain with close cooperation of medical staff, so as to provide theoretical basis and reference for the control of cancer pain in clinical practice.
2020 Vol. 17 (33): 42-45 [Abstract] ( 110 ) HTML (1 KB)  PDF (655 KB)  ( 12 )
46 Research progress on molecular mechanism related pathway of Sishen Pills in the treatment of ulcerative colitis
XIA Guozhen1 LIU Li1 LIANG Yanni2 LI Yi3 ZHANG Congwei3 LI Yao1
Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colon. Western medicine treatment of UC has disadvantages such as high price and many side effects, etc. As a traditional Chinese medicine, Sishen Pills can effectively treat UC. In terms of molecular mechanism, NF-κB signaling pathway, JAK/STAT signaling pathway, PI3K/Akt signaling pathway, mitogen-activated protein kinase signaling pathway, Wnt/β-catenin signaling, Th17/Treg signaling pathways, Th1/Th2 signaling pathways. This article mainly investigates the related signaling pathways of Sishen Pills when treating the UC, hoping to provide some experimental basis.
2020 Vol. 17 (33): 46-48 [Abstract] ( 136 ) HTML (1 KB)  PDF (680 KB)  ( 78 )
49 Progress in the treatment of cancer-related fatigue by Chinese and Western medicine and psychological intervention in patients with gastric cancer
LI Ye1 YANG Ruyi2
Gastric cancer is the fifth largest malignant tumor in the world, with high incidence, high mortality and many complications, especially the fatigue associated with gastric cancer, which seriously affects the rehabilitation treatment, quality of life and work of patient with the disease. In recent years, the research on cancer-related fatigue (CRF) has been increasing. In clinical practice, Western medicine has hormones, antipsychotic drugs, hematopoietic factors, etc., but there are few separate reports on the treatment of gastric cancer with CRF. Traditional Chinese medicine has its unique advantages in the treatment of CRF, such as moxibustion, Chinese medicine, etc., have certain effects in clinical treatment. Psychological factors are not negligible in the occurrence and development of the disease, and the psychological factors of gastric cancer patients are closely related to CRF. In this paper, the research progress of traditional Chinese and Western medicine and psychological intervention for CRF in patients with gastric cancer is reviewed.
2020 Vol. 17 (33): 49-52 [Abstract] ( 95 ) HTML (1 KB)  PDF (684 KB)  ( 122 )
53 Research progress of renal injury molecule-1 and renal diseases
ZHAO Ning ZHU Guozhen
In recent years, the prevalence of renal diseases has increased year by year. Early detection and early intervention of renal injury is the key to avoid further deterioration of renal function. Therefore, it is particularly important to find a biomarker that can early reflect renal injury. Kidney injury molecule-1 (KIM-1) is a type Ⅰ membrane protein, and expression increases rapidly during kidney injury, and its level increases with the degree of kidney injury. KIM-1 may play a role in the process of renal repair and injury through different molecular sites. KIM-1 in urine and blood are associated with various causes of acute renal injury, chronic renal disease, IgA nephropathy, henoch-schonlein purpura kidney and renal tumor. KIM-1 is not only an early biomarker of renal injury, but also has a potential role in predicting renal prognosis. This article reviews the research progress of KIM-1  and renal diseases.
2020 Vol. 17 (33): 53-56 [Abstract] ( 95 ) HTML (1 KB)  PDF (658 KB)  ( 27 )
57 Research progress of Oseltamivir combined with common traditional Chinese medicine in the treatment of influenza
LI Linlin XIE Dongmin YU Xinxiang PENG Ningning WANG Weilin WANG Decai LI Binglong
Influenza (“influenza” for short) is a respiratory disease caused by the invasion of influenza virus into human body, which is highly infectious and spreads rapidly. There are many kinds of traditional Chinese medicine for treating influenza, which can be divided into antiviral, antiphlogistic and antipyretic, respiratory treatment and so on according to their respective functions. In Western medicine, Oseltamivir is currently recognized as the first-line medicine for treating influenza, and its active metabolite, Oseltamivir carboxylic acid, is a neuraminidase inhibitor, which can inhibit the activity of influenza virus and prevent the virus from separating from the cell, thereby inhibiting the spread of influenza A and B viruses. However, Oseltamivir is easy to produce drug resistance and side effects when used alone. In order to treat the concurrent symptoms in influenza more effectively, Oseltamivir is often used in combination with the above several kinds of traditional Chinese medicine for treatment, which not only reduces the side effects, but also improves the efficacy. This article reviews the research progress of Oseltamivir combined with the above-mentioned traditional Chinese medicine in the treatment of influenza.
2020 Vol. 17 (33): 57-60 [Abstract] ( 112 ) HTML (1 KB)  PDF (652 KB)  ( 78 )
61 Research progress on the influence of various factors of pre-pregnancy and during pregnancy on pregnancy outcome
LIU Shuaimei ZHOU Qing ZHANG Ruijin SHI Hui LIN Ning WU Yulin
The influence of various factors of pre-pregnancy and during pregnancy on pregnancy outcome of women of childbearing age is diversified, such as pre-pregnancy body mass index, vitamin, infection, etc.; hormones, cervical transparent layer, nutrition, etc. during the early pregnancy; reproductive tract infection, glucose and lipid metabolism, ultrasound, etc. during the second trimester; amniotic fluid, liver function, vaginal microecology and other factors in the third trimester of pregnancy are important factors that maintain maternal and infant health and affect pregnancy outcomes. This paper aims to elaborate the influence of the difference relevant factors on pregnancy outcomes of pregnant women pre-pregnancy, early, second and third trimesters of pregnancy, and to develop personalized health care guidance for clinical pregnant women, so as to accurately control clinical factors to improve adverse pregnancy outcomes and reduce the incidence of birth defects.
2020 Vol. 17 (33): 61-64 [Abstract] ( 162 ) HTML (1 KB)  PDF (646 KB)  ( 98 )
65 Investigation and analysis of the status quo of health management for the elderly and their intention to use the Internet + health management APP for the elderly
CHEN Juncong FAN Jinyan LIU Yuesheng ZHONG Xueping LIU Yi DAI Fengling
Objective To investigate the status quo of health management for the elderly and the demand for the use of the Internet+ health management APP for the elderly to provide a reference for the development and promotion of APP. Methods Using self-developed questionnaires, from December 2018 to February 2019, elderly people in five cities in Sichuan Province were selected to conduct a questionnaire survey to observe the status quo of health management for the elderly and their needs for health management APP service functions and service methods. Results A total of 250 questionnaires were issued, and 235 valid questionnaires were recovered, with an effective recovery rate of 94.00%. Most of the survey respondents were not aware of health management; the majority of respondents’ demand for health management APP functions was to assist in registration, shorten the queue time, provide health knowledge and health care methods; the demand for service methods was diverse, including fixed-point service, 24-hour online contact, regular door-to-door service, etc. Conclusion The application of the elderly health management APP in the context of Internet+ needs to enhance the concept of health management for the elderly, pay attention to the quality of health management services, and establish an effective industry management and supervision mechanism.
2020 Vol. 17 (33): 65-67,73 [Abstract] ( 221 ) HTML (1 KB)  PDF (684 KB)  ( 353 )
68 Construction of the content framework for evaluation and implementation project of inpatient cultural care
MA Lili1 PENG Youqing1 ZHANG Yajuan2 CAO Jin3 YU Laidi3 ZUO Ting3
Objective To construct the content framework for the evaluation and implementation of inpatient cultural care to provide a scientific basis for inpatient cultural care. Methods From October 2019 to February 2020, with the guidance of cross-cultural nursing theory, combined with literature research and qualitative research results, the first draft of the content framework for the evaluation and implementation of inpatient cultural care were constructed. Using the purpose sampling method, a total of 15 experts from six regions were selected to conduct two rounds of Delphi expert consultation to establish a framework for evaluation and implementation projects of inpatient cultural care. Results The total number of questionnaires issued and collected in the two rounds was 15 copies, the recovery rate was 100%, and the effective rate was 100%. The expert authority coefficient was 0.910, and the reliability of the expert coordination coefficient test was high (P ＜ 0.01). After two rounds of expert consultation, the framework for inpatient cultural care evaluation and implementation projects including eight first-level items, 21 second-level items and 51 third-level items was initially constructed. Conclusion Inpatient cultural care evaluation and implementation of the project content framework construction process is scientific, while the content combines the cultural evaluation needs of clinical nurses, which is practical.
2020 Vol. 17 (33): 68-73 [Abstract] ( 61 ) HTML (1 KB)  PDF (686 KB)  ( 35 )
74 Current status and influencing factors of self-management of autologous arteriovenous fistula complications in maintenance hemodialysis patients
XUE Guifang YANG Yujie YUAN Huaihong ZHANG Yingjun MA Dengyan
Objective To understand the current status of self-management of autologous arteriovenous fistula (AVF) complications in maintenance hemodialysis (MHD) patients, and to explore its influencing factors. Methods A self-designed general information questionnaire and AVF complications self-management scale were used to conduct a cross-sectional survey of 182 MHD patients undergoing dialysis treatment in Hemodialysis Center, West China Hospital Sichuan University from January to April 2020. Results In this study, a total of 182 questionnaires were distributed and 182 were recovered, with a recovery rate of 100%, while a total of 181 valid questionnaires with an effective rate of 99.5%. There were statistically significant differences between the AVF complication self-management scores of patients with MHD with different ages, medical payment methods, self-checking of internal fistulas frequency and blood pressure monitoring frequency(P ＜ 0.05). The total score for self-management of AVF complications in MHD patients was (63.13±6.64) points; the lowest score dimension was the prevention score of complications (11.14±1.90) points. Multiple linear regression analysis showed that self-checking of internal fistula frequency and blood pressure monitoring frequency were influencing factors for self-management of AVF complications in MHD patients (P ＜ 0.01). Conclusion The self-management of AVF complications in MHD patients is generally at an intermediate to low level. In clinical practice, attention should be paid to whether patients self-check for internal fistula abnormalities and whether to monitor blood pressure changes every day. Targeted interventions should be taken to improve the level and maintenance of self-management of AVF complications in MHD patients, and the vascular access function should be keep intact.
2020 Vol. 17 (33): 74-77,89 [Abstract] ( 117 ) HTML (1 KB)  PDF (703 KB)  ( 75 )
78 Survey on the knowledge and attitude of pressure injury among nurses within medical consortium
CHEN Changrong1 LIU Chunfeng2 CHEN Yachun3▲
Objective To understand the current status of nurses’ knowledge and attitudes towards pressure injury (PI) in a medical union in Chongqing, and to analyze their influencing factors to provide references for realizing homogenous care in the medical union. Methods Using convenient cluster sampling, a total of 1582 nurses from 54 hospitals in a medical treatment alliance in Chongqing were selected from December 12 to 25, 2019, and the PI attitude and knowledge scale were used for investigation. Results The score of nurses’ knowledge of PI was (49.53±12.74) points, which was lower than the middle level; the score of attitude was (3.10±0.30) points, which was higher than the middle level. There were statistically significant differences in the scores of nurses’ PI prevention knowledge and attitude among different hospital levels, titles, education backgrounds, years of service, position/role and nursing PI patients (P ＜ 0.05). The results of multiple stepwise regression analysis showed that whether PI patients have been nursed, professional title, and hospital grade were the influencing factors of PI nursing knowledge and attitude (P ＜ 0.05). Conclusion The knowledge of nurses on PI needs to be improved, especially in grassroots hospitals. Managers should integrate medical resources, help grassroots, and achieve homogeneous care.
2020 Vol. 17 (33): 78-81 [Abstract] ( 147 ) HTML (1 KB)  PDF (682 KB)  ( 85 )
82 Investigation on satisfaction of medical treatment of patients with five types of chronic diseases in Chifeng, Inner Mongolia Autonomous Region
QU Jianwei1 ZHOU Zhiqiang2▲ QU Jianjiao3 QU Jianhui4 XIAN Bensong5
Objective To investigate and analyze the current situation of medical satisfaction of patients with five types of chronic diseases in Chifeng,  Inner Mongolia Autonomous Region and to provide relevant suggestions and countermeasures for improving medical quality, optimizing medical services, and enhancing people’s sense of medical treatment. Methods Patients with renal dialysis, stroke sequelae, diabetes, chronic obstructive pulmonary disease, and rheumatoid arthritis in Chifeng, Inner Mongolia Autonomous Region were selected as the research objects. Taking a third-class hospital as the sample unit, through the questionnaire survey method, from March to October 2019, the satisfaction of patients with long-term chronic diseases was investigated. Results In this study, a total of 280 patients with five types of chronic diseases were investigated, and a total of 235 valid questionnaires were returned. The effective recovery rate was 83.93%. The per capita total score of medical satisfaction was 118.27, total scores accounted for 173 cases (73.9%) of patients ≥75%, and 11 cases (4.7%) of patients accounted for ≥95%. The analysis of the total scores of each dimension accounted for ≥75% and the number of patients showed that 51.5% were satisfied with medical expenses; 57.54% were satisfied with medical insurance services; 64.7% were satisfied with medical services. There was a statistically significant difference in the total scores of medical treatment services, medical insurance services, doctor-patient communication, medical information, medical expenses, and satisfaction of various diseases (P ＜ 0.05). The overall satisfaction of patients with sequelae of stroke was lower than that of patients with dialysis and chronic obstructive pulmonary disease, the overall satisfaction of patients with rheumatoid arthritis was higher than that of patients with sequelae of stroke, while the overall satisfaction of patients with diabetes was higher than that of patients with chronic obstructive pulmonary disease and sequelae of stroke, and the differences were statistically significant (P ＜ 0.05). Conclusion The satisfaction of patients with long-term chronic diseases needs to be further improved. Relevant management departments and medical institutions should continuously improve and perfect the weak links of services from the perspective of medical services, medical insurance services and medical expenses, so as to effectively improve patients’ sense of medical treatment.
2020 Vol. 17 (33): 82-85 [Abstract] ( 81 ) HTML (1 KB)  PDF (627 KB)  ( 75 )
86 Status and related factors analysis of high-risk human papillomavirus infection in 1587 female fieldworkers
LIU Xuewei1 NIE Ying1 ZHAO Xueying2 YAN Lihong1 CHEN Xiaohong2
Objective To investigate the status of high-risk human papillomavirus (HPV) infection in female fieldworkers and to analyze risk factors. Methods From January 2018 to December 2019, a total of 1587 female fieldworkers who participated physical examinations in Department of Gynecology, Huabei Petroleum Administration Bureau General Hospital were selected for high-risk HPV type detection, and the risk factors of HPV infection were analyzed by questionnaire survey. Results A total of 1587 questionnaires were issued, and 1552 valid questionnaires were collected, with the effective recovery rate was 97.8%. A total of 264 high-risk HPV positive cases were detected, with a positive detection rate of 17.01%. The main types of infection were single type infections, and the dominant types were 52, 16, 58, 33, and 18. Age ≤ 30 years old, number of sexual partners ≥ 2, having had reproductive system inflammation within half a year were the main risk factors for high-risk HPV infection (OR = 2.651, 3.127, 3.825, P ＜ 0.05), do not use condoms for sex, share toilet facilities were the secondary risk factors for high-risk HPV infection (P ＜ 0.05). Conclusion The high-risk HPV infection rate of female workers in the field is relatively high. Improving the sanitary conditions in the work area and raising the awareness of personal hygiene have a positive effect on reducing the infection rate of high-risk HPV female workers.
2020 Vol. 17 (33): 86-89 [Abstract] ( 140 ) HTML (1 KB)  PDF (681 KB)  ( 44 )
94 Correlation between lipoprotein-associated phospholipase A2 level and major cardiovascular events in senile patients with diabetes mellitus
YAO Yao1 YANG Rongli2▲ XU Tongda3 CHEN Junhong3 XUAN Haochen3 WANG Chaofan3
Objective To investigate the correlation between lipoprotein-associated phospholipase A2 (Lp-PLA2) and major cardiovascular events (MACE) in senile patients with diabetes mellitus. Methods A total of 240 senile patients with type 2 diabetes mellitus from January 2016 to March 2017 in the Affiliated Hospital of Xuzhou Medical University were selected as study subjects. According to Lp-PLA2 level, the group was divided into Lp-PLA2 increased group (124 cases) and Lp-PLA2 decreased group (116 cases). According to the occurrence of MACE, the patients were divided into MACE group (50 cases) and non-MACE group (190 cases). The risk factors of MACE and the correlation between LP-PLA2 and MACE were analyzed. Results The level of Lp-PLA2 in MACE group was higher than that of non-MACE group (P < 0.05). Age, diabetes mellitus course, systolic blood pressure, glycosylated hemoglobin (HbA1c), Lp-PLA2 were correlated with MACE accumulation (P < 0.05). Diabetes mellitus course, Lp-PLA2 and HbA1c were independent factors influencing the accumulation of MACE (P < 0.05). The incidence of MACE in Lp-PLA2 increased group was higher than that in Lp-PLA2 decreased group (P < 0.05). The accumulation time of MACE in Lp-PLA2 increased group was shorter than that in Lp-PLA2 decreased group (P < 0.05). Conclusion Lp-PLA2 is closely related to MACE in senile patients with diabetes mellitus, and the risk of MACE is increased in patients with elevated Lp-PLA2.
2020 Vol. 17 (33): 94-97 [Abstract] ( 140 ) HTML (1 KB)  PDF (409 KB)  ( 32 )
98 Analysis of risk factors for urinary sepsis after soft ureteroscopic lithotripsy
DONG Zhen1 XU Weidong2 ZHOU Wanli2 Ma Limin3
Objective To analyze the risk factors of urinary sepsis after soft uretroscope lithotripsy. Methods The clinical data of 150 patients who underwent soft ureteroscopic lithotripsy in Affiliated Hospital of Nantong University from January 2017 to February 2020 were retrospectively analyzed. According to the presence or absence of urinary sepsis, they were divided into the occurrence group (14 cases) and the non-occurrence group (136 cases). The risk factors of urinary sepsis after soft ureteroscope were explored. Results Univariate analysis revealed statistically significant differences in age, preoperative urine culture, infectious stones, stone size, operation time, pyelourinary bacterial culture during operation, postoperative procalcitonin (PCT), postoperative interleukin-6, and postoperative white blood cell count (WBC) （all P ＜ 0.05）. Multivariate analysis revealed that age, infectious stones, pyelourinary bacterial culture during operation, postoperative PCT, and postoperative WBC were independent risk factors for urinary sepsis after soft ureteroscopy lithotripsy. Conclusion Age, infectious stones, pyelourinary bacterial culture during operation, postoperative PCT, and postoperative WBC are independent risk factors for uremia sepsis after soft ureterotomy lithotripsy, which deserve the attention of clinicians.
2020 Vol. 17 (33): 98-101 [Abstract] ( 71 ) HTML (1 KB)  PDF (335 KB)  ( 15 )
102 Effect of self-massage on JOA and VAS scores in patients with lumbar disc herniation after recovery
GAN Wei1 TANG Hongliang1 LIANG Yingye1 LU Dongming1 WANG Xiongjiang2 NONG Zhangsong1 PANG Jun3
Objective To analyze the effect of self-massage on the changes of the Japanese orthopaedic association evaluates treatment scores (JOA) and visual analogue scale (VAS) scores in patients with lumbar disc herniation after a period of time. Methods A total of 160 patients, who were determined to meet the criteria of recovery from lumbar disc herniation after receiving treatment in the outpatient clinic and ward of the Department of Massage of Dongge Hospital, the First Affiliated Hospital of Guangxi University of Chinese Medicine from April 2016 to September 2017, were enrolled. They were divided into the treatment group and the control group according to the random number table method, with 80 patients in each group. The treatment group adopted self-massage treatment, while the control group adopted “Feiyan-style” dorsal extensor muscle exercise, which was treated twice a day, with 20 days as one course of treatment, and both groups had three courses of treatment. Results JOA score comparison: the differences in intergroup comparison, time point comparison and interaction were highly significant (P ＜ 0.01). Intra-group comparison: compared with 20 days after treatment, JOA score of both groups decreased after 40 and 60 days of treatment, and JOA score of 60 days after treatment was lower than that of 40 days after treatment, the differences were highly statistically significant (P ＜ 0.01). Comparison between groups: after 20 and 40 days of treatment, there was no statistically significant difference in JOA scores between the two groups (P ＞ 0.05). After 60 days of treatment, JOA score in the treatment group was higher than that in the control group, and the difference was highly significant (P ＜ 0.01). Comparison of VAS scores: the differences in intergroup comparison, time point comparison and interaction were highly significant (P ＜ 0.01). Intra-group comparison: VAS score in the treatment group increased after 60 days of treatment compared with that after 20 days of treatment, and the difference was statistically significant (P < 0.05). VAS scores in the control group increased after 60 days of treatment compared with 40 days after treatment, and the difference was highly statistically significant (P ＜ 0.01). Comparison between groups: after 20, 40 and 60 days of treatment, VAS scores of the two groups were compared, and the differences were highly statistically significant (P ＜ 0.01). Conclusion Clinically cured patients with lumbar disc herniation can use self-massage to improve JOA score and reduce VAS score, which is worthy of clinical promotion.
2020 Vol. 17 (33): 102-105,109 [Abstract] ( 205 ) HTML (1 KB)  PDF (770 KB)  ( 85 )
106 High risk factors and preventive interventions of early postoperative fever in children with developmental dislocation hip
HUANG Zhijiao1 HA Yingpeng2▲ LI Guoqing3
Objective To explore the risk factors of early postoperative fever in children with developmental dislocation hip (DDH) and preventive intervention measures. Methods Clinical data of 100 children with DDH in the First Affiliated Hospital of Xinjiang Medical University from March 2019 to March 2020 were retrospectively analyzed. According to the occurrence of early fever, they were divided into early fever group (n = 65) and non fever group (n = 35). Clinical indexes of two groups were analyzed and the corresponding preventive measures were put forward. Results There were significant differences in age, body weight and hemoglobin level within one day after operation between two groups (P < 0.05). There were no significant differences in gender, operation time, anesthesia method, chest X-ray results within one day after operation, white blood cell count within one day after operation, C-reactive protein within one day after operation and procalcitonin level within one day after operation between two groups (P > 0.05). The independent risk factor of postoperative fever in children with DDH was hemoglobin ≤ 80 g/L within one day after surgery (P < 0.05). Conclusion The independent risk factor of postoperative early fever in children with DDH is postoperative hemoglobin ≤ 80 g/L. In view of the causes of early fever in children with DDH, nursing intervention measures should be strengthened, which has a positive role in reducing the incidence of early postoperative fever in children.
2020 Vol. 17 (33): 106-109 [Abstract] ( 81 ) HTML (1 KB)  PDF (562 KB)  ( 24 )
110 Correlation between total bile acid level and fetal distress in patients with intrahepatic cholestasis of pregnancy
ZHOU Liqin1 CHEN Jie2 WU Hui1 WANG Zhihui1▲
Objective To explore the correlation between the serum total bile acid (TBA) level and fetal distress in intrahepatic cholestasis of pregnancy (ICP). Methods Eighty-seven cases of ICP pregnant women admitted to Department of Obstetrics and Gynecology of Xiangcheng People’s Hospital of Suzhou from July 2014 to June 2019 were selected as research objects. According to the serum TBA level, they were divided into mild ICP group (57 cases, serum TBA 10.00-<40.00 μmol/L) and severe ICP group (30 cases, TBA ≥ 40.00 μmol/L). Another 38 healthy pregnant women were selected as control group. The levels of serum TBA, gamma-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and cholyglycine (CG) and the occurrence of fetal distress were compared among three groups. The correlation between serum TBA level and liver function indexes of ICP pregnant women was observed, and the correlation between TBA and fetal distress in ICP pregnant women was analyzed. Results The levels of TBA, AST, ALT, GGT and CG in mild ICP group and severe ICP group were higher than those in normal control group (P < 0.05), and the above indexes in mild ICP group were lower than those in severe ICP group (P < 0.05). There was no correlation between serum TBA and AST, ALT, GGT, GC (P > 0.05). There was significant difference in the incidence of fetal distress among three groups (P < 0.05). The critical value of serum TBA in predicting fetal distress was 38.600 μmol/L, the area under ROC curve was 0.792, and the progressive P value was 0.002. The difference of serum TBA in predicting fetal distress was statistically significant (P < 0.05). Conclusion Serum TBA can damage the liver function of pregnant women. The level of TBA is closely related to the risk of fetal distress in ICP pregnant women, which provides reference for clinical treatment and disease judgment.
2020 Vol. 17 (33): 110-113,125 [Abstract] ( 139 ) HTML (1 KB)  PDF (830 KB)  ( 94 )
114 Clinical study on atomization inhalation of N-acetylcysteine combined with pulmonary surfactant in the treatment of neonatal severe meconium aspiration syndrome
CHEN Qiaoling SU Caiyun CHEN Shuxia
Objective To investigate clinical effect of atomization inhalation of N-acetylcysteine (NAC) combined with pulmonary surfactant (PS) in the treatment of neonatal severe meconium aspiration syndrome (MAS). Methods Seventy-eight children with severe MAS admitted to Huaibei Miner General Hospital in Anhui Province from February 2014 to January 2020 were selected and divided into control group (n = 39) and study group (n = 39) according to random number table method. Control group was given conventional treatment and PS, and study group was treated with NAC on the basis of control group. Clinical indexes, blood gas analysis indexes, inflammatory factors and complications were compared between two groups. Results The time of hospitalization, ventilation and oxygen exposure in study group were shorter than those in control group (P < 0.05). The partial pressure of arterial blood carbon dioxide and oxygenation index of two groups decreased gradually after 12 hours and 24 hours of treatment, and study group was lower than the control group (P < 0.05), arterial oxygen partial pressure increased gradually, and study group was higher than that control group (P < 0.05). The level of interleukin-8 decreased gradually in two groups after 12 hours and 24 hours of treatment, and study group was lower than that control group (P < 0.05). The level of interleukin-10 increased gradually, study group was higher than the control group (P < 0.05). There was no significant difference in the incidence rate of complication between two groups （P > 0.05）. Conclusion Atomization inhalation of NAC combined with PS in the treatment of neonatal severe MAS can effectively improve the symptoms, blood gas analysis index and inflammatory factor index, and without increasing the incidence of adverse reactions, it has high clinical application value.
2020 Vol. 17 (33): 114-117 [Abstract] ( 158 ) HTML (1 KB)  PDF (535 KB)  ( 74 )
118 Effect and mechanism of Insulin Aspart Injection in the treatment of gestational diabetes mellitus patients
XU Dong ZHENG Haoyu ZHANG Muling▲
Objective To investigate the effect of Insulin Aspart Injection in the treatment of patients with gestational diabetes mellitus (GDM). Methods A total of 120 GDM patients admitted to Obstetrics and Gynecology Department of Huai’an First Hospital Affiliated to Nanjing Medical University from February 2016 to October 2018 were selected as research objects, and they were divided into combined group and control group of 60 cases by using a random number table. Both groups were given Metformin for glucose control, and combined group was given Insulin Aspart. After three months of continuous treatment, fasting blood glucose (FPG), two-hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), cystatin C (Cys-C), homocysteine (Hcy), N-acetyl-β-D-glucosidase (NAG), urinary microalbumin (mALB), pregnancy complications and delivery were compared between two groups before and after intervention. Results After intervention, the levels of FPG, 2hPG and HbA1c in two groups were lower than those before intervention, and those in combined group were lower than those in control group (P < 0.05). After intervention, Cys-C, Hcy, NAG and mALB levels in two groups were lower than those before intervention, and those in combined group were lower than those in control group (P < 0.05). There were no significant differences in the incidence rates of polyhydramnios, hypoglycemia and cesarean section between two groups (P > 0.05). The incidence rate of macrosomia in combined group was lower than that in control group (P < 0.05). There were no significant differences in the incidence rates of neonatal jaundice, respiratory distress and neonatal hypoglycemia between two groups (P > 0.05). Conclusion Metformin combined with Insulin Aspart in the treatment of GDM has a better sugar control effect, and at the same time has a certain protective effect on renal function, which can effectively reduce the incidence of huge children.
2020 Vol. 17 (33): 118-121 [Abstract] ( 96 ) HTML (1 KB)  PDF (566 KB)  ( 64 )
122 Analysis of clinical practice teaching cost between higher medical colleges and “affiliated hospitals”
WANG Mingli1 ZHANG Ruichun2
The progress and innovation of education bring medical education into a new era, the focus of educational work has also changed to the applicable mode of combining theoretical teaching and practical teaching, it has become an important means to train professional talents with advantages and competitiveness. By reviewing the historical background and development status of clinical practice teaching, the essential change course of the practical teaching cost pattern of school and college from free obligation to paid acceptance to market choice, this paper analyzes the causes and influencing factors of practice teaching cost in the economic form of paid service exchange in market regulation activities, this paper analyzes the current situation and causes of practical teaching costs from the perspective of supply and demand and management mechanism. This paper analyzes and discusses the formation of important proposition mechanisms, such as the refinement of the setting of practical teaching cost subjects, the achievement of goals and tasks, and the scientific construction of implementation path, pay attention to the dynamic performance and functional direction of practice teaching costs, the aim is to provide experience reference for the establishment of the scale, development direction and standard of practical teaching cost in the “affiliated hospital” of higher medical colleges and teaching practice bases.
2020 Vol. 17 (33): 122-125 [Abstract] ( 93 ) HTML (1 KB)  PDF (413 KB)  ( 42 )
126 Application effect observation of Roxadustat in the treatment of renal anemia in maintenance hemodialysis
KONG Xiangdong XU Jinhua YU Yangjie CHEN Linyan
Objective To observe the efficacy and safety of Roxadustat in the treatment of renal anemia in maintenance hemodialysis (MHD). Methods From August to October 2019, 15 MHD patients with renal anemia treated by the Blood Purification Center of the First People’s Hospital of Fuyang District, Hangzhou City, Zhejiang Province were selected as the study subjects, all of them received exogenous erythropoietin (EPO) treatment. The patient stopped EPO, and the iron agent was stopped at the same time when the iron agent was applied. After one week, the oral Roxadustat treatment was started, with the dose of 100-120 mg/time, three times per week, and the course of treatment was 12 weeks. The changes of hemoglobin, blood lipid (triacylglycerol [TG], total cholesterol [TC], low-density lipoprotein (LDL), high-density lipoprotein [HDL]) and ferritin were detected before and after treatment. Adverse drug reactions during treatment were recorded. Results After treatment, the hemoglobin level and ferritin level were significantly increased and decreased compared with those before treatment, with statistically significant differences (all P ＜ 0.05). After treatment, the TC and LDL levels of the patients were significantly decreased compared with those before treatment, and the differences were statistically significant (all P ＜ 0.05); however, TG and HDL of the patients did not change significantly before and after treatment, and the differences were not statistically significant (P ＞ 0.05). Conclusion Roxadustat can effectively treat renal anemia in MHD patients, which may provide a new treatment method for clinical practice.
2020 Vol. 17 (33): 126-128 [Abstract] ( 113 ) HTML (1 KB)  PDF (348 KB)  ( 124 )
129 Meta analysis of the effectiveness of traditional Chinese medicine fumigation in the nursing of patients after anterior cruciate ligament reconstruction
LI Pin1 HAN Yanhong2 YANG Weiyi2 CHEN Hongyun2 HUANG Xiujun1 CHEN Liyi1▲
Objective To systematically assess the clinical effect of traditional Chinese medicine fumigation in the nursing of patients after anterior cruciate ligament reconstruction. Methods From the establishment of the database to June 2020, the databases of PubMed, Wanfang Data, CNKI, VIP and CBM were searched by computer. All the randomized controlled trials conducted after surgery were collected that experimental group using traditional Chinese medicine fumigation and none using traditional Chinese medicine fumigation as control group. Cochrane Handbook was used to analyze the quality of included literature. RevMan 5.3 software was used to evaluate total effective rate, visual analogue scale (VAS) and Lysholm score. Results Seven articles that contained 544 patients were included. Meta analysis results suggested that compared with control group, total effective rate of experimental group increased (OR = 10.43, 95%CI[4.98, 21.83], P ＜ 0.000 01), VAS of experimental group decreased (MD = -0.47, 95%CI[-0.62, -0.31], P ＜ 0.000 01), Lysholm score of experimental group increased (MD = 8.24, 95%CI [5.41, 11.07], P ＜ 0.000 01). Conclusion The application of traditional Chinese medicine fumigation in the nursing of patients after anterior cruciate ligament reconstruction has good clinical efficacy. However, due to the low quality of the included literature and limitations of the included researches, more rigorously designed and high quality clinical studies are required for confirmation in the future.
2020 Vol. 17 (33): 129-132,144 [Abstract] ( 192 ) HTML (1 KB)  PDF (1326 KB)  ( 15 )
133 Study on the tongue characteristics of patients with anal fistula among different syndromes
YANG Qiqi1 YANG Wei1 WANG Yiqin2 PEI Yanni1 PENG Yunhua1▲
Objective To compare the tongue characteristic of anal fistula among different syndromes. Methods Two hundred and six patients with anal leakage hospitalized in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from June 2019 to March 2020 were selected. According to the main symptoms, they were divided into damp-heat diffusing downward (110 cases), healthy qi deficiency and lingering pathogen (49 cases) and yin fluid depletion (47 cases). The tongue body and coating color features were recorded, and the tongue characteristics were collected, including tongue body and coating color index, tongue body and coating quality index. Results The R value of tongue chroma of damp-heat diffusing downward was higher than that of other two types, the V value of tongue chroma of damp-heat diffusing downward was lower than that of other two types (P ＜ 0.05 or P ＜ 0.01). G value and B value of tongue chroma of yin fluid depletion were lower than those of damp-heat diffusing downward (P < 0.05 or P ＜ 0.01). In terms of color S value of tongue, yin fluid depletion was higher than damp-heat diffusing downward, healthy qi deficiency and lingering pathogen (P < 0.01). R value, G value and S value of tongue coating color of damp-heat diffusing downward were higher than the other two syndrome types, but V value of damp-heat diffusing downward was lower than the other two syndrome types (P < 0.01). The color G value of tongue coating in yin fluid depletion was higher than that in healthy qi deficiency and lingering pathogen (P < 0.05). The chroma H value of tongue coating of damp-heat diffusing downward was higher than that of yin fluid depletion (P < 0.05). The crack index of damp-heat diffusing downward was lower than that of yin fluid depletion (P < 0.05). The obesity index of healthy qi deficiency and lingering pathogen was lower than that of damp-heat diffusing downward (P < 0.05). The rotting and greasy index of damp-heat diffusing downward was higher than that of healthy qi deficiency and lingering pathogen (P < 0.05). The thickness index of damp-heat diffusing downward was higher than that of the other two syndrome types (P < 0.01). Conclusion The tongue texture of anal fistula patients with damp-heat diffusing downward is closer to red, the color of tongue texture and tongue coating is darker, and the fur is thicker and greasy. The type of healthy qi deficiency and lingering pathogen has thinner and whiter fur and thinner tongue. The tongue color of yin fluid depletion is darker, the fur color is lighter, and the cracks are more.
2020 Vol. 17 (33): 133-136 [Abstract] ( 125 ) HTML (1 KB)  PDF (743 KB)  ( 37 )
137 Clinical effect of Bupiwei Xieyinhuo Shengyang Decoction in the treatment of insomnia with syndrome of spleen deficiency and stomach heat
XIAO Rong1 ZHAO Chunyi1 ZHENG Liming2 YANG Lingling2 LI Yan2
Objective To observe clinical effect of Bupiwei Xieyinhuo Shengyang Decoction in the treatment of insomnia characterized by spleen deficiency and stomach heat and its influence on sleep quality and inflammatory factors. Methods From December 2017 to March 2019, 60 cases of insomnia patients with syndrome of spleen deficiency and stomach heat were recruited in Guangdong Provincial Hospital of Traditional Chinese Medicine, and they were divided into control group and experimental group according to random number table method, with 30 cases in each group. Thirteen cases fell off in control group, three cases fell off in experimental group, with 17 cases in control group and 27 cases in experimental group finally. Control group was given the simulation agent, and experimental group was given Bupiwei Xieyinhuo Shengyang Decoction, the total course of treatment was four weeks. Pittsburgh sleep quality index (PSQI), insomnia severity index (ISI), serum cortisol (CORT) and cytokines [interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), tumor necrosis factor-β (TNF-β), interleukin-10 (IL-10), interferon-α (IFN-α)] levels of two groups were observed before and after treatment. Results Total scores of PSQI and ISI in two groups after treatment were lower than those before treatment (P < 0.05). The levels of serum IL-1β and TNF-α in experimental group were higher than those before treatment (P < 0.05). The level of serum IL-10 in experimental group was higher than that before treatment (P < 0.05). The level of serum IFN-α in control group was lower than that before treatment (P < 0.05). After treatment, the serum IFN-α level in experimental group was higher than that in control group (P < 0.05). There were no serious adverse events in this study. There were two mild adverse events. Conclusion Bupiwei Xieyinhuo Shengyang Decoction can significantly improve the subjective sleep quality of insomnia with syndrome of spleen deficiency and stomach heat, improve immunity and regulate the inflammatory status.
2020 Vol. 17 (33): 137-140 [Abstract] ( 223 ) HTML (1 KB)  PDF (743 KB)  ( 73 )
141 Discussion on acupoint selection rule of Chinese medicine autohemotherapy in the treatment of urticaria based on data mining
QIU Xinrui1 YAN Xiaoning2 CHEN Lu2 LI Wenbin2
Objective To summarize and analyze rules and characteristics of acupoint selection of autohemotherapy in the treatment of urticaria. Methods Papers were retrieved from CNKI, CBM, VIP, Wanfang data and PubMed. Acupoint database was established with excel 2016 software. Cluster analysis and association rules were used to analyze the rules of acupoint selection. Results Total 103 articles and 103 prescriptions were included in the research. The acupoints with higher frequency of autohemotherapy in the treatment of urticaria were zúsānlǐ, qūchí, xuèhǎi, fèishù, géshù. The selected acupoints were mainly stomach meridian of foot yangming, large intestine meridian of hand yangming and spleen meridian of foot taiyin, and specific acupoints were often used. Association rule analysis showed that qūchí-zúsānlǐ, qūchí-géshù had the highest correlation, three clusters were obtained by cluster analysis. Conclusion This study analyzes the acupoint selection rules of autohemotherapy in the treatment of urticaria. Embodying the idea that “searching for root cause of disease” and “therapy with syndrome differentiation”, which provides the basis for the clinical treatment of this disease by autohemotherapy.
2020 Vol. 17 (33): 141-144 [Abstract] ( 90 ) HTML (1 KB)  PDF (750 KB)  ( 79 )
145 Experience exploration on master of national physician Professor Xiong Jibai in the differentiation and treatment of nephrotic edema
DENG Linrong SUN Guixiang▲ SUN Haoxian ZHANG Ting LI Jiajun XIAO Dan
This article summarizes the clinical experience of Professor Xiong Jibai in the treatment of nephrotic edema. Nephrotic edema is firstly seen in Huangdi Neijing. Kidney deficiency is affected by wind, and the governing water function is abnormal, which develops into edema. The diagnosis of nephrotic edema is mainly based on the Western medical laboratory examination. The clinical differentiation of syndromes should distinguish between yin edema and yang edema, deficiency and excess syndrome, cold syndrome and heat syndrome, and edema position. According to the main symptoms of the patients, it can be divided into four types: edema of qi deficiency, edema of yin deficiency, edema of yang deficiency, and edema of damp-heat. While determining the treatment method based on syndrome differentiation and choosing the main prescription, it is also necessary to flexibly match the secondary symptoms of the patients’ symptoms, including proteinuria, hematuria, high uric acid, high serum creatinine, hypertension, lumbago and heel pain.
2020 Vol. 17 (33): 145-148,164 [Abstract] ( 160 ) HTML (1 KB)  PDF (1142 KB)  ( 289 )
149 Effects of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of ulcerative colitis
NIE Zhenjing SHEN Wenjing YAO Rui WANG Xinlei
Objective To analyze the effects of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of ulcerative colitis (UC). Methods One hundred and twenty patients with UC admitted to Fengrun People’s Hospital of Tangshan City from January 2017 to May 2019 were divided into control group and treatment group according to the random number table method, with 60 cases in each group. The control group was treated with Mesalazine enema, while the treatment group was treated with oral Baitouweng Decoction on the basis of the control group, with 12 weeks of treatment course. The TCM symptom scores, peripheral immune function, humoral immunity level, serum inflammatory factor levels, inflammatory bowel disease questionnaire (IBDQ) before and after treatment were compared between the two groups, and the adverse reactions during treatment were recorded. Results After treatment, the TCM symptom scores, CD8+, IgM, IgA and IgG, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in the two groups were lower than those before treatment, which in the treatment group were significantly lower than those in the control group (all P ＜ 0.05); the CD4+, natural killer cells (NK cells), CD4+/CD8+, the scores of IBDQ in the two groups were higher than those before treatment, which in the treatment group were significantly higher than those in the control group (all P ＜ 0.05). No obvious adverse reactions occurred during the treatment of the two groups. Conclusion The efficacy of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of UC is better than single-agent Mesalamine enema, and the safety is good.
2020 Vol. 17 (33): 149-152,169 [Abstract] ( 111 ) HTML (1 KB)  PDF (1146 KB)  ( 149 )
153 Analysis on the rule of traditional Chinese medicine artificial menstrual cycle in the treatment of ovulatory dysfunctional infertility by Professor He Chengyao based on the association rule mining
LENG Anming1 YANG Jing2 ZHANG Xianghua3 ZHOU Zuotao1
Objective To explore the medication rules of Chinese distinguished veteran doctor of traditional Chinese medicine He Chengyao in the treatment of ovulatory dysfunctional infertility based on the traditional Chinese medicine inheritance support system. Methods According to the inclusion and exclusion criteria, 475 prescriptions of ovulatory dysfunctional infertility diagnosed and treated by Professor He Chengyao were collected, and the database of ovulatory dysplastic infertility was established. By searching “luteal phase”“follicular phase”“ovulation phase” and “menstrual phase” respectively and using software integrated statistical methods, the medication rules of Professor He in the treatment of this disease were analyzed. Results The analysis of 475 prescriptions showed that the common drugs used in all stages of the disease included common cnidium fruit, prepared rehmannia root, Chinese angelica, Chinese magnoliavine fruit, sargentgloryvine stem, dodder seed, Sichuan lovage rhizome, palmleaf raspberry fruit, debark peony root, barbary wolfberry fruit, etc. According to the analysis of medication in the artificial menstrual cycle, the drugs such as common curculigo rhizome, epimedium herb and degelatined deer-horn were often used in the luteal phase; the drugs such as dwarf lilyturf tuber, himalayan teasel root and tangshen were often used in the follicular phase; the drugs such as Chinese thorowax root, beautiful sweetgum fruit and hirsute shiny bugleweed herb were often used in the ovulation phase; the drugs such as English walnut seed, cattail pollen and flying squirrel’s droppings were often used in the menstrual phase. Conclusion Professor He Chengyao’s treatment for ovulatory dysfunctional infertility is based on tonifying kidney, nourishing blood and regulating menstruation throughout the whole menstrual cycle. And according to the menstrual cycle, it mainly focuses on warming yang, nourishing yin, promoting blood circulation and regulating qi-flowing.
2020 Vol. 17 (33): 153-156 [Abstract] ( 104 ) HTML (1 KB)  PDF (738 KB)  ( 79 )
157 Analysis on the experience of Professor Wei Junping in differentiating and treating diabetic nephropathy
LI Fei1,2 WEI Junping2▲
Diabetic nephropathy is one of the most common capillary vessel complications of diabetes. Professor Wei Junping believes that the pathogenesis of diabetic nephropathy in traditional Chinese medicine is always based on root deficiency and branch excess. The root is the deficiency of qi and yin. The excess of branch is mainly manifested in the accumulation of pathological products, such as phlegm, blood stasis, and dampness. The zang-fu organs mainly involve the liver, spleen and kidney. In the treatment, diabetic nephropathy is combined with disease and syndrome, and it is divided into four syndrome types: deficiency of both qi and yin, internal blockade of damp-turbidity, yin deficiency of liver and kidney, yang deficiency of spleen and kidney. Professor Wei believes that diabetic nephropathy lesions involve sanjiao, and diabetic nephropathy is treated by stages, which are divided into early, middle and late periods, in order to reverse early intervention, delay progress in the middle period, and improve symptoms in the late stage. In the clinical process, by combining modern pharmacological research and medication, Professor Wei always guides the lifestyle of patients with diabetic nephropathy. And the idea of “preventive treatment of disease” of traditional Chinese medicine is used throughout the treatment process, as far as possible to delay the development process of diabetic nephropathy.
2020 Vol. 17 (33): 157-160 [Abstract] ( 92 ) HTML (1 KB)  PDF (703 KB)  ( 30 )
161 Application effect of PBL on eight-year interns in clinical practice teaching of psychosomatic department
CAI Yanhui1 WANG Zhongheng1 LIU Wenming1 GUO Haiyun2 WANG Huaning1
Objective To analyze the effects of problem-based learning (PBL) on eight-year interns in practice teaching clinical medicine students of psychosomatic department. Methods A total of 100 eight-year interns from the psychosomatic department of the First Affiliated Hospital of Air Force Medical University from January 2016 to December 2019 were selected as the research objects. According to the different teaching methods, they were divided into LBL teaching group (lecture-based learning) and PBL teaching group, with 50 cases in each group. After study for one month, the teaching effect of PBL was compared through the evaluation of theoretical knowledge, practical skills and satisfaction degree of the two groups. Results The theoretical scores, practical skills and total scores of PBL teaching group were significantly higher than those of the LBL teaching group (P ＜ 0.01). The satisfaction of the learning interest, communication ability, thinking inspiration and learning atmosphere of PBL teaching group were significantly higher than those of the LBL teaching group (P ＜ 0.01). Conclusion In the eight-year clinical practice teaching of psychosomatic department, PBL teaching method is helpful to the teaching quality and worth popularizing.
2020 Vol. 17 (33): 161-164 [Abstract] ( 128 ) HTML (1 KB)  PDF (657 KB)  ( 45 )
165 Comparison of three commonly used evaluation criteria for potentially inappropriate medication in elderly
LI Yanhua LI Zhongkun XIA Hongying ZHAO Fangyun ZHANG Yue LIANG Yueqing▲
The elderly have a higher risk of potentially inappropriate medication (PIM), so reasonable medication evaluation standards are needed to guide the clinical medication of the elderly. This article compares the Beers standard, the screening tool of older persons’ prescription (STOPP) / screening tool to alert to right treatment (START) standard, and the “Criteria of potentially inappropriate medications for older adults in China rational drug use branch of Chinese”. Through comparative studies, it is found that the contents of these three standards have overlaps and different items. Different standards will lead to differences in the incidence of PIM. Only by adopting appropriate standards can we choose more reasonable clinical medications for the elderly.
2020 Vol. 17 (33): 165-169 [Abstract] ( 194 ) HTML (1 KB)  PDF (668 KB)  ( 76 )
170 Research on technological innovation mechanism of Chinese pharmaceutical enterprises based on Malerba innovation theory
XU Yang1 XU Lang2
This paper starts from the characteristics of innovation mechanism and innovation method, combines the current situation of China’s pharmaceutical industry, takes the Malerba industrial innovation system theory as the theoretical support, and constructs the technological innovation mechanism suitable for the current situation of China’s pharmaceutical industry, analyzes the innovation restriction mechanism structure of pharmaceutical enterprises from the aspects of the market structure and enterprise scale of the pharmaceutical industry, technological capital investment capacity, and innovative human capital investment capacity. From the strategic layout of pharmaceutical enterprises, the distribution of independent research and development forces, the operating mechanism that affects industry policies, the choice of pharmaceutical enterprises’ technological innovation mode, the patent system and the innovation and decision-making capabilities of pharmaceutical enterprises, the innovation operation mechanism structure of pharmaceutical enterprises are analyzed. Therefore, this article proposes measures to build a composite technological innovation entity, broaden the ideas for improving technological innovation capabilities, strengthen basic innovation research, highlight the ability of intellectual property to escort technological innovation, and accelerate the incubation of technological innovation achievements through multiple investment channels which are the key to the innovation mechanism of Chinese pharmaceutical enterprises.
2020 Vol. 17 (33): 170-173 [Abstract] ( 96 ) HTML (1 KB)  PDF (736 KB)  ( 79 )
174 Analysis of academic planning strategies for freshmen in marketing major of medicine and pharmacology colleges and universities based on major recognition
LI Ang HAN Yanhua WANG Qiuying
Aiming at the problems of lack of understanding of the marketing major of medicine and pharmacology colleges and universities and insufficient recognition of the major in the college entrance stage, the lack of academic planning at the college level and the confusion about the learning of professional knowledge will occur. The freshmen majoring in marketing among medicine and pharmacology colleges and universities in Heilongjiang province as the study subjects, we conducted research and learned that they did not have a strong sense of belonging to the marketing major in medical schools, freshmen lacked a systematic understanding of professional training goals, curriculum settings and development directions and felt at loss for professional courses but still had the willingness to study. Taking this as an entry point, we proposes to strengthen the professional cognitive education for freshmen to stimulate students’ interest in professional learning, combine their own characteristics to strengthen the planning of personal postgraduate entrance examinations and employment directions, strengthen professional adaptation education and broaden students’ professional horizons through various forms, which will help students to better learn professional knowledge and promote the formation of a good style of study.
2020 Vol. 17 (33): 174-176,180 [Abstract] ( 105 ) HTML (1 KB)  PDF (664 KB)  ( 84 )
177 Analysis on the application of delicacy management of hospital archives
HE Yangfang ZHANG Hong
Hospital archives management is a basic work in hospital management. The improvement of the quality of hospital archives management plays an important role in the long-term healthy development of the hospital. The application of delicacy management concept in archives management is to meet the development demand of archives work in the new era. This article tries from the current situation of hospital archives management to delicacy management ideas and methods in hospital archives management analysis, discusses the path of the concrete application, in order to improve the quality of hospital delicacy management and hospital archives utilization value, broaden the service mode of hospital records, for improving the quality of hospital management and medical service level is of great significance.
2020 Vol. 17 (33): 177-180 [Abstract] ( 143 ) HTML (1 KB)  PDF (652 KB)  ( 102 )
181 Thoughts and suggestions on scientific and technological innovation in medical field
SUN Wenyingge1,2 LI Yiying1,2
The innovation and development of different disciplines in the medical field are different. This article takes the scientific and technological innovation development path of Beijing Neurosurgery Institute as an example to explore its specific practices in the process of producing and promoting innovations. This article proposes that the innovation and development of the medical field need to grasp the current situation and follow up the breaking point in time. While ensuring the vitality and diversity of the disciplines, it is necessary to increase interdisciplinary research and strengthen investment in basic disciplines. At the same time, researchers need to be given full and free exploration space in the training of researchers, promote more foreign exchanges and promote the construction of core talent teams.
2020 Vol. 17 (33): 181-184 [Abstract] ( 168 ) HTML (1 KB)  PDF (696 KB)  ( 15 )
185 The present situation and optimization measures of the construction of “embedded” combination of medical and health care in Shandong Province
WEI Qinghao WU Xian▲ SUN Meng
Nowadays, with the increasing number of elderly population in China, the problem of population aging is becoming more and more serious. The combination of medical and health care is an effective solution to alleviate the pressure of providing for the aged and improve the quality of service for the aged, among which “embedded” combination of medical and health care is the current development trend of providing for the aged. Through the strategy of on-the-spot investigation and literature information collection, three embedded types of “embedded” combination of medical and health care in Shandong Province were introduced from the point of view of overall embedding, equipment embedding and agreement embedding. And the phenomenon and causes of the combination of medical and health care were also discussed. In view of this proposed, some optimization measures were put forward in this article, such as introducing the service mode of graded pension, promoting the transformation of talents, developing “intelligent medical treatment”, increasing income and reducing fees for the aged, so as to speed up the development of the construction of the combination of medical and health care in our country.
2020 Vol. 17 (33): 185-189,193 [Abstract] ( 106 ) HTML (1 KB)  PDF (555 KB)  ( 132 )
190 Research progress of traditional Chinese medicine health care for the aged
GE Xinying1,2 YUAN Yuanjian2 LYU Dan3▲
Traditional Chinese medicine is rich in resources, and its concepts and methods of health care and prevention of diseases have unique advantages in health care services for the elderly and have broad prospects for development. This article summarizes, analyzes and reviews the development of traditional Chinese medicine health care services from several aspects, including the connotation of traditional Chinese medicine health care services, the advantages of traditional Chinese medicine health care services, the development model of traditional Chinese medicine health care services, and case studies of traditional Chinese medicine health care services. It is found that the current definition of traditional Chinese medicine health care services is unclear and the industry positioning is unclear; traditional Chinese medicine health care services do not have uniform standards and specifications, and the service quality is not high and the order is chaotic; traditional Chinese medicine health care services policy support research is not strong enough, professional and technical personnel admittance, financing channels, business supervision and other links lack policy support, supply and demand imbalances, and development are limited. Therefore, the government and social forces should actively take action to clarify the concept and connotation of traditional Chinese medicine health care services, formulate relevant support policies, formulate industry standards and norms, so as to promote the healthy and rapid development of traditional Chinese medicine health care service industry.
2020 Vol. 17 (33): 190-193 [Abstract] ( 91 ) HTML (1 KB)  PDF (476 KB)  ( 168 )
194 Study on the optimization of health management model for the elderly in urban communities under the background of smart medical treatment
WU Xing1 WU Ying2 HUANG Xiaomei3 LIAO Shengwu1
By combining the latest national spirit of old-age service with the elderly’s demand for health management, and giving full play to urban smart medical technology, the health management model of the elderly in urban communities will be further optimized. Through literature analysis, data analysis, random interviews and other methods, the real needs of the elderly population for health management were identified, and the pain points and difficulties such as mismatch between supply and demand, poor medical service, and few service paths existed in the current health management model for the elderly in urban communities were solved. Take advantage of the latest of the health committee of the national health policy, take advantage of modern medical technology wisdom, from the top design, legitimate business, multiple patterns, the wisdom pension community elderly health management model optimization, makes the family, community, hospital many ways of urban community elderly health management wisdom medical new patterns.
2020 Vol. 17 (33): 194-封三 [Abstract] ( 192 ) HTML (1 KB)  PDF (762 KB)  ( 447 )
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