肺鳞癌组织miRNA-193a及miRNA-4286水平与预后的关系

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Abstract Objective To explore the relationship between the expression levels of microRNA (miRNA)-193a and miRNA-4286 in the tumor tissues of squamous cell lung carcinoma patients and prognosis, so as to provide a new direction for the prognosis evaluation of lung cancer. Methods A total of 126 patients with squamous cell lung carcinoma diagnosed from May 2016 to April 2019 with complete clinical data in Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were selected as research objects. The expression levels of miRNA-193a and miRNA-4286 in squamous cell lung carcinoma tissues and adjacent tissues were detected by real-time fluorescent quantitative reverse transcription PCR (qRT-PCR), and the relationship among miRNA-193a and miRNA-4286 in squamous cell lung carcinoma tissues and clinical data and prognosis were analyzed. Results The relative expression level of miRNA-193a in squamous cell lung carcinoma tissues was lower than that in adjacent tissues, and the relative expression level of miRNA-4286 was higher than that in adjacent tissues, with statistically significant differences (all P ＜ 0.05). The levels of miRNA-193a and miRNA-4286 in squamous cell lung carcinoma tissues were not correlated with age, sex, smoking history or family history, and the differences were not statistically significant (P ＞ 0.05). They were correlated with tumor size, TNM stage, lymph node metastasis and recurrence, and the differences were statistically significant (all P ＜ 0.05). miRNA-193a in squamous cell lung carcinoma tissues was not associated with the degree of differentiation (P ＞ 0.05), while miRNA-4286 was associated with the degree of differentiation (P ＜ 0.05). The median survival time of patients with low miRNA-193a expression in squamous cell lung carcinoma tissues was 36 months (95%CI: 0.371-1.198), while that of patients with high expression was 54 months (95%CI: 0.834-2.696), the difference was statistically significant (P ＜ 0.05). The median survival time of patients with low miRNA-4286 expression in squamous cell lung carcinoma tissues was 51 months (95%CI: 0.962-2.660), while that of patients with high expression was 39 months (95%CI: 0.376-1.039), the difference was statistically significant (P ＜ 0.05). Conclusion The expression levels of miRNA-193a and miRNA-4286 in squamous cell lung carcinoma are correlated with tumor size, TNM stage, lymph node metastasis and recurrence, and are related to the prognosis of patients. miRNA-193a and miRNA-4286 may be used as prognostic indicators for patients with squamous cell lung carcinoma.

Key words： microRNA-193a microRNA-4286 Squamous cell lung carcinoma Prognosis

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	BI Rui WANG Mingsong HU Rui JIANG Lianyong YANG Xuhui ZHONG Yuan

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BI Rui WANG Mingsong HU Rui JIANG Lianyong YANG Xuhui ZHONG Yuan. Relationship between the levels of miRNA-193a and miRNA-4286 in tissues of squamous cell lung carcinoma and prognosis[J]. 中国医药导报, 2020, 17(33): 9-12,60.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I33/9

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