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| Research progress on molecular mechanism related pathway of Sishen Pills in the treatment of ulcerative colitis |
| XIA Guozhen1 LIU Li1 LIANG Yanni2 LI Yi3 ZHANG Congwei3 LI Yao1 |
1.The First Clinical Medical College, Shaanxi University of Traditional Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Cooperative Innovation Center of Traditional Chinese Medicine Resources Industrialization, Shaanxi University of Traditional Chinese Medicine, Shaanxi Province, Xianyang 712000, China;
3.Department of Gastroenterology, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi Province, Xianyang 712000, China |
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Abstract Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colon. Western medicine treatment of UC has disadvantages such as high price and many side effects, etc. As a traditional Chinese medicine, Sishen Pills can effectively treat UC. In terms of molecular mechanism, NF-κB signaling pathway, JAK/STAT signaling pathway, PI3K/Akt signaling pathway, mitogen-activated protein kinase signaling pathway, Wnt/β-catenin signaling, Th17/Treg signaling pathways, Th1/Th2 signaling pathways. This article mainly investigates the related signaling pathways of Sishen Pills when treating the UC, hoping to provide some experimental basis.
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[1] Calderón M，Minckas N，Nu?觡ez S，et al. Inflammatory Bowel Disease in Latin America：A Systematic Review [J]. Value Health Reg Issues，2018，17：126-134.
[2] Darr U，Khan N. Treat to Target in Inflammatory Bowel Disease：An Updated Review of Literature [J]. Curr Treat Options Gastroenterol，2017，15（1）：116-125.
[3] 李飞，邓中甲.中医药学高级丛书·方剂学[M].2版.北京：人民卫生出版社，2011：944-946.
[4] Brennan JJ，Messerschmidt JL，Williams LM，et al. Sea anemone model has a single Toll-like receptor that can function in pathogen detection，NF-κB signal transduction，and development [J]. Proc Natl Acad Sci U S A，2017， 114（47）：E10122-E10131.
[5] Shen J，Cheng J，Zhu S，et al. Regulating effect of baicalin on IKK/IKB/NF-κB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis [J]. Int Immunopharmacol，2019，73：193-200.
[6] 加秀凤，沈霖，范恒，等.NF-κB p65在溃疡性结肠炎与结直肠癌患者肠黏膜中的表达差异与意义[J].世界华人消化杂志，2014，22（2）：279-285.
[7] Dorofeyev AE，Dorofeyeva AA，Kiriyan EA，et al. Genetic polymorphism in patients with early and late onset of ulcerative colitis [J]. Wiad Lek，2020，73（1）：87-90.
[8] 王迪，朱向东，李兰珍，等.四神丸对溃疡性结肠炎模型大鼠Toll样受体2、白细胞介素-1β和白细胞介素-4的影响[J].中国中医药信息杂志，2015，22（12）：64-67.
[9] 焦艳芳.基于TLR4/MyD88/NF-κB通路研究N-甲基野靛碱对小鼠溃疡性结肠炎的作用[D].银川：宁夏医科大学，2018.
[10] 王爱华，何兰娟，朱向东.四神丸对脾肾阳虚型溃疡性结肠炎模型大鼠结肠组织Toll样受体4及其负性调控因子IRAK-M 表达的影响[J].中国实验方剂学杂志，2019，25（14）：75-76.
[11] 王燕，何兰娟，朱向东，等.四神丸对脾肾阳虚型溃疡性结肠炎大鼠血清TGFβ1、IL-6及结肠组织TLR-4 mRNA表达的影响[J].中医药学报，2015，43（5）：118-122.
[12] Salas A，Hernandez-Rocha C，Duijvestein M，et al. JAK-STAT pathway targeting for the treatment of inflammatory bowel disease [J]. Nat Rev Gastroenterol Hepatol，2020， 17（6）：323-337.
[13] 何兰娟.温肾健脾法对溃疡性结肠炎模型大鼠结肠组织中负性调控因子SOCS2/3基因和蛋白表达影响的研究[D].兰州：甘肃中医药大学，2016.
[14] Chen Q，Duan X，Fan H，et al. Oxymatrine protects against DSS-induced colitis via inhibiting the PI3K/AKT signaling pathway [J]. Int Immunopharmacol，2017，53：149-157.
[15] Jiang W，Han YP，Hu M，et al. A study on regulatory mechanism of miR-223 in ulcerative colitis through PI3K/Akt-mTOR signaling pathway [J]. Eur Rev Med Pharmacol Sci，2019，23（11）：4865-4872.
[16] Liu DY，Xu R，Huang MF，et al. Si Shen Wan Regulates hospholipase Cγ-1 and PI3K/Akt Signal in Colonic Mucosa from Rats with Colitis [J]. Evid Based Complement Alternat Med，2015，2015：392405.
[17] Yue J，López JM. Understanding MAPK Signaling Pathways in Apoptosis [J]. Int J Mol Sci，2020，21（7）：2346.
[18] Bai XS，Bai G，Tang LD，et al. MiR-195 alleviates ulcerative colitis in rats via MAPK signaling pathway [J]. Eur Rev Med Pharmacol Sci，2020，24（5）：2640-2646.
[19] Zhao HM，Huang XY，Zhou F，et al. Si Shen Wan Inhibits mRNA Expression of Apoptosis-Related Molecules in p38 MAPK Signal Pathway in Mice with Colitis [J]. Evid Based Complement Alternat Med，2013，2013：432097.
[20] Dong LN，Wang M，Guo J，et al. Influences of probiotics combined with sulfasalazine on rats with ulcerative colitis via the Wnt/β-catenin signaling pathway [J]. Eur Rev Med Pharmacol Sci，2019，23（14）：6371-6378.
[21] Zhao HM，Liu Y，Huang XY，et al. Pharmacological mechanism of Sishen Wan?誖 attenuated experimental chronic colitis by inhibiting wnt/β-catenin pathway [J]. J Ethnopharmacol，2019，240：111936.
[22] Sheng Y，Wu T，Dai Y，et al. The effect of 6-gingerol on inflammatory response and Th17/Treg balance in DSS-induced ulcerative colitis mice [J]. Ann Transl Med，2020，8（7）：442.
[23] Ivanov II，McKenzie BS，Zhou L，et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells [J]. Cell，2006，126（6）：1121-1133.
[24] Fontenot JD，Gavin MA，Rudensky AY. Pillars Article：Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells [J]. Nat J Immunol，2017，198（3）：986-992.
[25] Ohno M，Nishida A，Sugitani Y，et al. Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells [J]. PLoS One，2017，12（10）：e0185999.
[26] Xu X，Wang Y，Wei Z，et al. Madecassic acid，the contributor to the anti-colitis effect of madecassoside，enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway [J]. Cell Death Dis，2017， 8（3）：e2723.
[27] 刘端勇，徐荣，黄敏芳，等.四神丸调节结肠炎大鼠PP结T细胞亚群及Treg/Th17间平衡的作用机制[J].中国实验方剂学杂志，2016，22（3）：107-111.
[28] 王迪.温肾健脾法对溃疡性结肠炎大鼠结肠组织TLR/IL-1信号通路调控因子基因表达影响的研究[D].兰州：甘肃中医药大学，2016.
[29] 李能莲，高建平，李兰珍，等.四神丸对脾肾阳虚型溃疡性结肠炎模型大鼠Th1/Th2免疫平衡的影响[J].河南中医，2018，38（10）：1501-1505.
[30] 刘佳星，彦礼，李彧，等.四神丸对腹泻型肠易激综合征大鼠肠道菌群影响的实验研究[J].药学学报，2019，54（4）：676.
[31] 黄小英，赵海梅，管咏梅，等.四神丸对溃疡性结肠炎小鼠外周血CD40，CD40L的调节作用[J].时珍国医国药，2011，2（11）：2625-2627.
[32] 毛颖.四神丸对溃疡性结肠炎大鼠TNF-α、NO、OFR水平影响的实验研究[D].哈尔滨：黑龙江中医药大学，2013. |
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