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2019 Vol. 16, No. 18 Published: 2019-06-25

	4	Effect and mechanism of twist promoting stem cell ability obtaining and chemotherapy resistance of colorectal cancer SW480 cells by EMT
		DENG Junjian1 ZHANG Fan2 BAO Wenting1 XIONG Lin1 LIU Yuanshi1 FAN Li1 XU Ximing1
		Objective To study the effect of Twist on epithelial-mesenchymal transition (EMT), cancer stem cell phenotype and chemotherapy resistance of SW480 cells. Methods From January to December 2012, 30 colorectal cancer samples were collected in Renmin Hospital, Wuhan University. And the expression of Twist in colon cancer tissues and adjacent tissues were analyzed; the effect of Twist on SW480 cells EMT phenotype switching was detected through the over expression assay. The role of Twist in SW480 cells mammospheres number, cancer stem cell markers expression and chemotherapy resistance were investigated. Results The expression of Twist in colon cancer tissues was significantly higher than that in adjacent tissues (P < 0.05). Twist could promote EMT phenotype switching, evidenced by the changes in cell morphology, the up-regulation of interstitial-associated N-cadherin expression, and the significant inhibition of epithelial-associated E-cadherin expression (P < 0.05). Twist increased mammospheres number and the expression of cancer stem cell markers SW480 cells, such as Bmi-1, Nanog, CD44 in (P < 0.05). Twist could promote SW480 cells to obtain chemotherapy resistance ability through ABCB1/P-gp pathway. Conclusion Twist could promote SW480 cells EMT phenotype switching, stem cell characteristics and chemotherapy resistance ability obtaining, indicating that Twist could serve as a potential target for chemotherapy resistance of colorectal cancer.
		2019 Vol. 16 (18): 4-8,24 [Abstract] ( 221 ) HTML (1 KB) PDF (956 KB) ( 91 )

	9	Expression of long non-coding RNA DEANR1 and others in lung cancer
		ZHANG Lei1 HE Yuefeng2 ZHANG Li1 ZHANG Tengfei1 YANG Kaiyun1 HUANG Yunchao1 TAN Hui1
		Objective To investigate the expression of long non-coding RNA (lncRNA) DEANR1, INXS, ANCR, FENDRR in lung cancer. Methods The study included 54 patients with lung cancer admitted to the Third Affiliated Hospital of Kunming Medical University from January to June 2018, including squamous cell carcinoma, adenocarcinoma, and small cell lung cancer in 28, 22, 4 cases, respectively. The cancer tissue, the lymph node metastasis and the tissue adjacent to carcinoma of 54 cases of patients with lung cancer was used to detect the expression of these genes by the real-time fluorescence quantitative PCR. Results The expression levels of INXS and ANCR in cancer tissues were higher than those in adjacent normal tissues (P ＜ 0.05). The expression levels of ANCR and INXS in lymph node tissues were positively correlated with ki-67 (r = 0.757, P = 0.049; r = 0.802, P = 0.030). Conclusion The increased expression of DEANR1, INXS and ANCR in cancer tissues may be a positive factor in the development of lung cancer. The expression of ANCR and INXS in lymph nodes is positively correlated with ki-67, which may be related to lymph node metastasis and poor prognosis of lung cancer.
		2019 Vol. 16 (18): 9-11 [Abstract] ( 184 ) HTML (1 KB) PDF (564 KB) ( 74 )

	12	Effects of aerobic swimming on the expression of acid-sensing ion channel of hippocampus in aging rats
		LUO Jie1 WANG Jingqiong1 XIE Li′na2 ZHOU Shouhong3
		Objective To observe the effects of aerobic swimming exercise on the expression of acid-sensing ion channel (ASIC) in aging rats. Methods Thirty-six male specific pathogen free (SPF) Sprague-Dawley (S-D) rats were divided into control group (C group), aging model group (AM group) and aging swimming training group (AST group) by random number table method, with 12 rats in each group. The rats in AM group were administrated with D-galactose [150 mg/(kg·d)] by intraperitoneal injection for 12 weeks. After treatment with D-galactose [150 mg/(kg·d)] by intraperitoneal injection, the rats in AST group were taken 60 minutes of aerobic swimming exercise every day for 12 weeks. The rats in C group were administrated the same amount of saline by intraperitoneal injection. The spatial learning and memory ability of rats were tested by Morris water maze test. Expression of ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3 and ASIC4 in hippocampus of rats were measured by Western blot. Results Compared with C group, the time of escape latency and the distance of reaching the platform were significantly increased, the number and time to across platform were significantly decreased, expression of ASIC1a and ASIC1b in hippocampus was significantly up-regulated and expression of ASIC4 was significantly down-regulated in AM group, the differences were statistically significant (P ＜ 0.05). Compared with the AM group, the time of escape latency and the distance to reach the platform were significantly decreased, the number and time to across platform were significantly increased, expression of ASIC1a and ASIC1b in hippocampus was significantly down-regulated and expression of ASIC4 was significantly up-regulated in AST group, the differences were statistically significant (P ＜ 0.05). Conclusion The aerobic swimming exercise improves the learning and memory in aging rats, of which, the mechanism may be related with decrease of expression of ASIC1a and ASIC1b and increase of expression of ASIC4 in hippocampus.
		2019 Vol. 16 (18): 12-16 [Abstract] ( 181 ) HTML (1 KB) PDF (720 KB) ( 105 )

	17	Effect of enhancing the activity of central cholinergic nervous system on postoperative cognitive dysfunction in mice
		WANG Tianhai1 ZHU Hongge2 HOU Yanshen1 DUAN Wenming1 YU Chanjuan1
		Objective To evaluate the effect and mechanism of enhancing the activity of central cholinergic nervous system on postoperative cognitive dysfunction (POCD) in mice. Methods Forty-five C57BL/6 mice were selected and divided into three groups by random number table method, blank group, operation +NS group, operation +Galan group, with 15 mice in each group. The latter two groups underwent internal fixation of unilateral tibial fracture to establish the model of postoperative cognitive dysfunction. In the operation +NS group, 0.9% NaCl was injected into the abdominal cavity every day. Postoperative intraperitoneal injection of central cholinergic neuroactivity enhancer Galan intervention. No surgical or medical intervention was performed in the blank group. The behavioral changes of learning and memory in three groups were assessed by the situational fear test on the third and seventh day after the operation. The activation degree and number of microglia cells in the hippocampus were detected on the third day after the operation. The expression of pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus were detected. Results In the behavioral test 3 days after the operation, compared with the blank group, the freezing time in the operation +NS group and the operation +Galan group was significantly reduced (P ＜ 0.01). Compared with the operation +Galan group, the freezing time of the operation +NS group was reduced (P ＜ 0.05). Seven days after the operation, the freezing time of the operation +NS group was significantly reduced compared with the blank group (P ＜ 0.01), and the freezing time of the operation +NS group was shorter than that of the operation +Galan group (P ＜ 0.05), while the difference between the operation +Galan group and the blank group was not statistically significant (P ＞ 0.05). 3 days after the operation, the number of microglia cells in the hippocampus in the operation +NS group was significantly increased compared with the blank group and the operation +Galan group (P ＜ 0.01), but the difference between the blank group and the operation +Galan group was not statistically significant (P ＞ 0.05). Compared with the blank group, IL-1β, IL-6 and TNF-α of the operation +NS group were significantly increased (P ＜ 0.01), and their IL-1β, IL-6 and TNF-α were significantly higher than those of the operation +Galan group (P ＜ 0.01 or P ＜ 0.05). There was no significant difference in IL-1β, IL-6 and TNF-α between the blank group and the operation +Galan group (P ＞ 0.05). There was no significant difference in IL-4 and IL-10 among the three groups (P ＞ 0.05). Conclusion Enhancing the activity of the central cholinergic nervous system can reduce the inflammatory response in the hippocampus by inhibiting the activation of microglia cells in the hippocampus, thus improving the postoperative cognitive ability of mice. Enhancing central cholinergic activity may be a therapeutic strategy for early POCD.
		2019 Vol. 16 (18): 17-20,41 [Abstract] ( 199 ) HTML (1 KB) PDF (1168 KB) ( 36 )

	21	Effects of Azithromycin on airway inflammation and cytokine expression in bronchial asthma mice
		YANG Junxia GUO Yingmeng
		Objective To observe the expression of inflammatory cytokines in bronchial asthma mice, and to explore the effect of Azithromycin on the expression of pulmonary inflammation and inflammatory cytokines. Methods According to random number table, 32 female BALB/c mice aged 6-8 weeks were randomly divided into four groups: group A, normal saline control group; group B, asthma group; group C, Azithromycin intervention group; group D, Dexamethasone intervention group, with 8 mice in each group. Mice in group B, C and D were intraperitoneally injected with ovalbumin (OVA) 25 μg (OH)3 1 mg at 0, 7, 14 days, respectively. After sensitization for 1 week, 2% OVA solution was nebulized and inhaled. Group A was sensitized and stimulated with normal saline instead of OVA for 6 days. In group C, Azithromycin (0.4 mg/mL) was injected subcutaneously 1 hour after atomization inhalation at day 14 consecutively for 7 days. In group D, 2 mg/kg of Dexamethasone Sodium phosphate was injected subcutaneously 1 hour after atomization inhalation at day 14 consecutively for 7 days. The pathological manifestations of lung tissues in each group were observed 24 hours after stimulation, and the left bronchoalveolar lavage fluid (BALF) was collected, and the percentage of interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), eosinophilic granulocytes (EOS) and white blood cell count were detected by enzyme linked immunosorbent assay (ELISA). Results Mice in group B, C and D were successfully modeled and presented asthma attack symptoms and pathological manifestations of airway inflammation. Compared with group A, the total number of white blood cells, percentage of EOS, IL-8 and TNF-α contents in BALF of mice in group B were significantly increased, with statistically significant differences (P ＜ 0.01). Compared with group B, the total number of white blood cells, percentage of EOS, IL-8 and TNF-α contents in BALF of group C and group D were significantly reduced, with statistically significant differences (P ＜ 0.01). There were no statistically significant differences in the indicators between group C and D (P ＞ 0.05). Conclusion Azithromycin can inhibit the expression of IL-8 and TNF-α, inhibit the production of Th2 cytokines, and relieve airway inflammation.
		2019 Vol. 16 (18): 21-24 [Abstract] ( 199 ) HTML (1 KB) PDF (608 KB) ( 114 )

	25	Research progress of new target GDF15/GFRAL signaling pathways for the treatment of obesity and metabolic related diseases
		XU Chuanyang1 WANG Zhaowei1 HE Lei1 PANG Zhijun1 ZHU Yichao2 LI Weina1 LI Zhengmin3▲
		Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor β superfamily and is involved in various biological processes such as energy homeostasis, body weight regulation, and cachexia driven caused by cancer and chronic diseases. GDF15 is able to control food intake and energy metabolism, which makes it important in the treatment of disorders such as obesity and anorexia. Further research into the biological function of this molecule has been limited due to the lack of its defined receptors, signaling mechanisms and target tissues. The GDNF family α-like receptor (GFRAL) has recently been identified as a receptor for the GDF15 molecule and is responsible for mediating the biological effects of controlling energy intake and energy metabolism regulation. The discovery of the GDF15/GFRAL signaling pathway provides new insights into the treatment of obesity and metabolic related diseases. In this paper, the biological function of energy stabilization of GDF15 and the influence of the discovery of GFRAL receptor on this field are briefly summarized.
		2019 Vol. 16 (18): 25-29 [Abstract] ( 429 ) HTML (1 KB) PDF (719 KB) ( 169 )

	30	Advance in pharmacological studies of Polygonati Rhizoma and its extract based on neurovascular unit
		CHAO Bin HUANG Shijing
		As the basic unit of structure and function of nervous system, neurovascular unit is an important aspect in the research of modern pharmacology of nervous system. In order to further understand the pharmacological effects of Polygonati Rhizoma and its extract on neurovascular unit, articles about the pharmacological effects of Polygonati Rhizoma on neurovascular unit are analyzed comprehensively. It is found that Polygonati Rhizoma and its extract affect the structure and function of the nervous system by regulating the apoptosis of nerve cells, anti-oxidation, improving the microstructure of each part of neurovascular unit and inducing the secretion of growth factors. So Polygonati Rhizoma may have the capacity for maintaining the stalibity of microenvironment of brain. Therefore, the application of Polygonati Rhizoma and its extracts may play a potential role in the treatment of nervous system diseases.
		2019 Vol. 16 (18): 30-33 [Abstract] ( 216 ) HTML (1 KB) PDF (635 KB) ( 149 )

	34	Advances in the application of nanocarbon staining in colorectal cancer surgery
		HUANG Longchang ZHANG Ye WANG Tong▲
		Colorectal cancer is an important cause of cancer morbidity and mortality worldwide. Surgical treatment is the main treatment. The use of carbon nanoparticles to stain and locate the tumors and lymph nodes before operation can reduce the time of searching for tumors during operation, increase the number of lymph nodes detected, and play a positive role in improving the effect of surgery and providing better prognosis for patients. This paper reviews the application of nanocarbon in colorectal cancer surgery, and describes the advantages, disadvantages and challenges of nanocarbon in colorectal cancer surgery.
		2019 Vol. 16 (18): 34-37 [Abstract] ( 196 ) HTML (1 KB) PDF (626 KB) ( 152 )

	38	Research progress of toxicity of Niuhuang Jiedu Tablets containing realgar
		XU Wenfeng JIN Pengfei XU Shuo ZHANG Shanshan KUANG Yongmei JIANG Wenqing
		Niuhuang Jiedu Tablets (NJT) is an effective and widely used traditional Chinese medicine (TCM) in clearing heat and detoxicating, and it is fficially listed in the Chinese Pharmacopeia (2015). As a TCM that contains realgar, its toxicity and safety has always been concerned. This article reviewed the research progress of safety study, toxicity, soluble arsenic and arsenic form of realgar influenced by compatibility of NJT, so as to provide a reference for its further researches and rational clinical uses.
		2019 Vol. 16 (18): 38-41 [Abstract] ( 207 ) HTML (1 KB) PDF (626 KB) ( 154 )

	42	Advances in research on disease model of ApoE knockout mice
		SONG Ke1 HOU Yanhong2 YANG Hui3 BAI Yunqi1 LI Hui3 NIE Bo1
		Apolipoprotein E (ApoE) is a kind of gene polymorphism and multifunctional protein, which is closely related to the metabolism of lipoprotein. Its deletions and mutations can cause metabolic disorders and dysfunction in the body, and even cause a series of diseases and complications. In recent years, ApoE-/- mice have been mainly used in atherosclerosis, diabetes, neurodegenerative diseases and kidney diseases. In order to better study the application mechanism of ApoE in various disease models and provide a more powerful basis for clinical treatment of diseases, this paper summarizes the pathogenesis of several diseases related to ApoE protein in human ApoE genotype, and summarizes the animal models for in vitro study of disease development process.
		2019 Vol. 16 (18): 42-45,48 [Abstract] ( 376 ) HTML (1 KB) PDF (646 KB) ( 288 )

	45	Application and prospect of PDX model in ovarian cancer researches
		LI Wei YANG Shuli TIAN Ming MIAO Jinwei▲
		Ovarian cancer is a common gynecology oncologic tumor. Its clinical presentations are untypical, mainly including abdominal distension and pelvic mass, et al. The pathologic types of ovarian cancer are varied, so its heterogenicity is obvious. Tumor cell line modals and transgenic animal modals are commonly used ovarian cancer models, and they gain great progress in ovarian cancer researches. But their defects are also inevitable. Ovarian cancer patient derived tumer xenograft (PDX) model is a brand new cancer research model, we summarize the application base and prospect of it PDX model ovarian cancer researches.
		2019 Vol. 16 (18): 45-48 [Abstract] ( 217 ) HTML (1 KB) PDF (622 KB) ( 221 )

	49	Determination of effective components in Banlangen Granules and research progress of pharmacological effects
		WANG Jianmin LI Wei
		Banlangen Granules are composed of two kinds of Chinese medicinal materials, which are Radix Isatidis and Folium Isatidis. They mainly contain alkaloids, organic acids, glycosides, amino acids, glucosinolates and their metabolites, metals and other ingredients. It has the effects of anti-pathogenic microorganisms, anti-endotoxin, improving immune function, anti-tumor, anti-aging, protection and prevention of metal poisoning, and so on. By measuring the effective components in Banlangen Granules, the quality of Radix Isatidis is improved to ensure the safety of this drug in clinical use. This paper reviews the effective components, determination methods, pharmacological effects and practical clinical application of Banlangen Granules, and provides some reference for the future research of Banlangen Granules.
		2019 Vol. 16 (18): 49-52 [Abstract] ( 233 ) HTML (1 KB) PDF (654 KB) ( 286 )

	53	Investigation on quality of life and related factors of empty nesters with hypertension in Western Guangxi
		HUANG Fengxing1 LU Liuxue2 LUO Linxue2 WEI Liuqing3 HUANG Liwei1 LU Zhitan4 HUANG Lanjing3 HUANG Quyun5
		Objective To investigate the quality of life of empty nesters with hypertension in Western Guangxi, and to analyze the influencing factors, in order to improve the quality of life of empty nesters with hypertension in this area. Methods A total of 300 empty nester patients with hypertension in Western Guangxi who were hospitalized in the Affiliated Hospital of Youjiang Medical University for Nationalities from January 2016 to June 2017 were collected. Their quality of life was assessed by SF-36, and the related factors affecting their quality of life were analyzed by Logistic regression model. Results The total score of quality of life of 300 empty nesters with hypertension was (46.88±3.97) points. Among them, age, education level, marital status, underlying diseases, economic status and blood pressure control were single factors affecting the quality of life of empty nesters with hypertension (t = 10.616, F = 95.609， F = 29.639, t = 13.903, t = 13.505, F = 212.591, all P = 0.000); and age, underlying disease were risk factors for quality of life in empty nesters with hypertension (OR = 25.185, P = 0.000; OR = 0.213, P = 0.028); educational level, marital status, economic status and blood pressure control were protective factors for quality of life in empty nesters with hypertension (OR = 0.090, P = 0.000; OR = 0.116, P = 0.015; OR = 0.015, P = 0.000; OR = 0.124, P = 0.001). Conclusion The quality of life of empty nesters with hypertension in Western Guangxi is generally poor, and there are many factors affecting their quality of life, including age, education, marriage, economic status, etc. Active control measures should be taken to improve the quality of life.
		2019 Vol. 16 (18): 53-56 [Abstract] ( 669 ) HTML (1 KB) PDF (425 KB) ( 147 )

	57	Analysis the status and influencing factors of the primary tooth caries in 600 preschool children in Nanjing City
		CHEN Song JI Yan XIANG Jie ZHENG Lichun XIE Li WANG Yu GONG Ling
		Objective To investigate the status and influencing factors of the primary tooth caries in 600 preschool children in Nanjing City. Methods A total of 650 preschool children in Nanjing were selected for study in December 2017 by stratified cluster sampling method. Oral examination and questionnaire survey was conducted on all preschool children. The incidence of primary tooth caries of preschool children with different genders, ages and places of residence was analyzed, and the relationship between primary tooth caries of preschool children and eating before bed, regular oral examination, parents′ educational level, age at which they began to brush their teeth, number of teeth brushing times per day, annual household income and the use of fluoride toothpaste were analyzed, and the influencing factors of primary tooth caries in preschool children were analyzed. Results A total of 650 questionnaires were collected and 600 valid questionnaires were retrieved. Preschool children′s primary tooth caries rate of the city was lower than the preschoolers of villages and towns, and primary tooth caries rate of 3-＜4 years old preschool children was lower than 4-＜5 years old, 5-＜6 years old preschool children, and preschool children′s primary tooth caries rate of 4-＜5 years old was lower than 5-＜6 years old preschool children (all P < 0.05). The number of primary tooth caries in 600 preschool children was 1246, and most of them occurred in the second deciduous molar on the left side of the mandible. Parents′educational level, frequency of brushing teeth every day and family income were all the influencing factors of the primary tooth caries rate in preschool children (all P < 0.05). Multivariate Logistic regression analysis found that age, place of residence for townships, parental education below high school, daily brushing times <2 times, family annual income < 5000 yuan were independent risk factors for primary tooth caries of preschool children (all P < 0.05). Conclusion The incidences of primary tooth caries in 600 preschool children in Nanjing is high, and the age, the place of residence, the education level of the parents, the number of brushing teeth <2 times a day and the annual family income < 5000 yuan all increase the risk of primary tooth caries, which is worthy of clinical attention.
		2019 Vol. 16 (18): 57-60,64 [Abstract] ( 687 ) HTML (1 KB) PDF (673 KB) ( 158 )

	61	Effect of 131I second treatment on serum related indexes and hypothyroidism rates in the treatment of Graves disease
		CHEN Zhengping1 YI Jixiu2 LING Bing2 ZHAO Li2 PU Yinyan2
		Objective To investigate the effect of 131I second treatment on serum related indexes and hypothyroidism rates in the treatment of Graves disease. Methods From April 2015 to May 2017, 90 patients with Graves disease treated in Chongqing Qianjiang Central Hospital were selected, according to the random number table method, they were divided into control group (n=45) and study group (n=45). The patients in the control group were treated with Methamazole, while the patients in the research group were treated with 131I. The patients of two groups were treated for 12 months. The serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating an body (TSAb), thyroid stimulation-blocking antibody (TSBAb) and thyrotrophin receptor antibody (TRAb) of the two groups before and after treatment was compared. The hypothyroidism rates of the two groups after treatment was compared. Results There was no significant difference of the serum levels of TSH, FT3, FT4, TSAb, TSBAb and TRAb in the two groups before treatment (P > 0.05). After treatment, the serum TSH of the two groups was significantly higher than before treatment, the serum levels of FT3, FT4, TSAb, TSBAb and TRAb of the two groups were significantly lower than before treatment (P < 0.05); and the levels of serum TSH was higher than the control group after treatment, the levels of serum FT3, FT4, TSAb, TSBAb and TRAb in the study group were lower than the control group after treatment (P < 0.05). There was no significant difference in the incidence of hypothyroidism between the two groups after treatment (P > 0.05). Conclusion 131I in the second treatment of Graves disease can improve the serum levels of TSH, FT3, FT4, TSAb, TSBAb and TRAb, and the hypothyroidism rate between the 131I and Methamazole has no difference.
		2019 Vol. 16 (18): 61-64 [Abstract] ( 163 ) HTML (1 KB) PDF (371 KB) ( 83 )

	65	Analysis of influencing factors of flexible ureteroscopy in the treatment of renal stones
		ZHAO Guobin1 LIU Xin1 TANG Yuhong2 LING Haibin1 SU Hongwei1 TANG Lidong3 FENG Chao1 LI Xiangdong1
		Objective To investigate the clinical factors affecting the time of flexible ureteroscopy for the treatment of renal stones. Methods From December 2013 to December 2017, 202 patients from the First Affiliated Hospital of Hebei North University with flexible ureteroscope lithotripsy (FURL) were selected, all of them were treated with laser lithotripsy of medical doctors, 151 of them without residual stones reviewed by plain scan CT after 3 months of the operation, the patients were divided into two groups by the operation time, >90 min group (44 cases) and ≤90 min group (107 cases). The operation time was divided into three periods: total time, pre-crushing, post-crushing. The multivariate Logistic regression model analysis was used for the factors that may affect the operation time. Results The average operation time was (79.0±31.0) min. The main factors affecting operation time included stone volume, maximum and mean CT values, diameter of the soft sheath, and experiences of the doctor. Multivariate evaluation of total operation time and post-crushing time, showed that there relationships with stones volume (P < 0.01), experiences of doctor (P < 0.01), maximum CT value (P < 0.05), preoperative stenting (P < 0.05) and total operation time and post-crushing time. However, the time before the start of lithotripsy was not correlated with any clinical factors (P > 0.05). Conclusion The volume of stone, CT value, experience of the doctor, placeing a D-J tube before the operation are the main factors influce the total operation time and post-crushing time, and the time before the crushing stone is difficult to predict.
		2019 Vol. 16 (18): 65-68,84 [Abstract] ( 239 ) HTML (1 KB) PDF (726 KB) ( 112 )

	69	Analysis of common complications and influencing factors of "eight-shaped" double incision steel plate internal fixation in the treatment of calcaneal fracture
		AISINGIORO Qicheng1 LI Chang1 FAN Yonghong1 GUO Jing2 WANG Binghai1
		Objective To study common complications and influencing factors of "eight-shaped" double incision steel plate internal fixation in the treatment of calcaneal fracture. Methods Clinical data of 129 cases of calcaneal fracture treated with "eight-shaped" double incision steel plate internal fixation in the Second Affiliated Hospital of Inner Mongolia Medical University from February 2014 to February 2016 was retrospectively analyzed. All patients were followed up for 2 years, and the incidence of complications was analyzed. All patients were divided into complications group (47 cases) and non complications group (82 cases) according to whether there were complications. The basic data of the two groups was compared and the multivariate Logistic regression analysis of the postoperative complications was made. Results Complications group had a higher proportion of patient′s age≥65 years, smoking, diabetes mellitus, the time from injury to surgery ＜ 5 d, the operative time≥1.5 h, non-use of Kirschner wire contactless stretch technique to protect soft tissue and non-placement of drainage tube than non-complications group (all P < 0.05). Multivariate Logistic regression analysis showed that age≥65 years, smoking, diabetes mellitus, the time from injury to surgery＜5 d, the operative time≥1.5 h, non-use of Kirschner wire contactless stretch technique to protect soft tissue and non-placement of drainage tube were all independent risk factors for complications after "eight-shaped" double incision steel plate internal fixation (all P < 0.05). Conclusion The common complications of "eight-shaped" double incision steel plate internal fixation in the treatment of calcaneal fracture include incision exudation, incision infection and deep venous thrombosis, and many factors may increase the risk of postoperative complications, scientific measures should be taken clinically.
		2019 Vol. 16 (18): 69-72 [Abstract] ( 216 ) HTML (1 KB) PDF (478 KB) ( 49 )

	73	Effect of decompression extent of cervical anterior approach on cervical spondylotic radiculopathy
		LIU Yadong1 KONG Chao2 CUI Libin1 WANG Yanhui1 CHEN Xueming1
		Objective To investigate the effect of decompression extent of cervical anterior approach on cervical spondylotic radiculopathy (CSR). Methods From January 2016 to January 2018, 84 CSR patients were performed with anterior cervical discectomy and fusion (ACDF) in Beijing Luhe Hospital, Capital Medical University. According to degree of remission at the postoperative follow-up, the patients were divided into two groups (complete remission group, 73 cases and incomplete remission group, 11 cases). Compressive areas in operative level, visual analogue scale (VAS) and neck disability index (NDI) of patients were recorded at pre-operation and postoperative follow-up. Intra-operative blood loss and duration of operation were recorded. The post-operation and on short and midium term complications were also concerned. Results All of the patients were performed with operation successfully, average of duration of operation was (131.45±9.45) min and average of intra-operative blood loss was (51.23±31.16) mL. Postoperative VAS and NDI scores in both groups were lower than those before operation, and the area of pressure substance in both groups was smaller than that before operation, there was significant difference between two groups (P ＜ 0.05). Postoperative VAS and NDI scores of complete remission group were lower than those of incomplete remission group, and the area of pressure substance of complete remission group was smaller than that of incomplete remission group, there was significant difference between two groups (P ＜ 0.05). There was no vertebral artery injury or hematoma formation during perioperative period in all patients. Conclusion ACDF is a valid method for the therapy of CSR, but residual symptom of partial patients may be related with incomplete decompression. Complete decompression would not markedly increase the complications.
		2019 Vol. 16 (18): 73-76 [Abstract] ( 186 ) HTML (1 KB) PDF (626 KB) ( 56 )

	77	Effect of microscopically assisted lumbar discectomy in the treatment of lumbar disc herniation
		ZHU Wengang ZHU Lizhen ZHANG Zhipeng CHEN Yu CHEN Ying DAI Xiangheng WU Qiang
		Objective To investigate the effect of microscopically assisted lumbar discectomy (MSLD) in the treatment of lumbar disc herniation (LDH). Methods One hundred and five cases of LDH admitted to Yuebei People′s Hospital from February 2016 to April 2018 were selected. The patients were divided into percutaneous intervertebral disc percutaneous endoscopic lumbar discectomy (IL-PELD) group (n = 52, given IL-PELD) and MSLD group (n = 53, given MSLD). The operation time, intraoperative bleeding volume, incision length, fluoroscopy times, hospitalization time and complication rate were recorded. The clinical efficacy of the two groups after treatment was observed. The visual analogue score (VAS) and Osweatry dysfunction index (ODI) were recorded before operation, 1 d, 1 month, 3 months and 6 months after operation. Results There was no significant difference in incision length and hospitalization time after operation between two groups (P ＞ 0.05). The operation time of MSLD group was longer than that of IL-PELD group; the amount of bleeding, the number of fluoroscopy in MSLD group were less than those in IL-PELD group; the incidence of complication in MSLD group was lower than that in IL-PELD group (P ＜ 0.05). The total effective rate of two groups was not statistically significant (P ＞ 0.05). There was no significant difference in VAS and ODI scores between two groups before operation, 1 d after operation, 1 month after operation, 3 months after operation and 6 months after operation at the same period (P ＞ 0.05). The VAS and ODI scores of two groups were lower than those 1 d, 1 month, 3 months and 6 months after the operation, and presented a trend of decrease with time (P ＜ 0.05). Conclusion Compared with the traditional operation, MSLD can effectively reduce the amount of bleeding, the number of fluoroscopy and the incidence of complications. It is worthy of further clinical application.
		2019 Vol. 16 (18): 77-80 [Abstract] ( 183 ) HTML (1 KB) PDF (469 KB) ( 86 )

	81	A randomized control study on preventing postpartum hemorrhage with three regimens in high risk pregnancy women during cesarean section
		Nurgul·Yusuyun1 Dildar·Yusan1 Guzainuer·Maimaitituerxun1 Mayila·Maimaiti1 Minavar·Amaiti1 Riyangul·Tohuti1 Baharguli·Abulati1 CHEN Xing2▲
		Objective To study the preventive effect of three uterine contraction regimens in pregnancy women with postpartum hemorrhage risk factor during cesarean section. Methods From July 2017 to May 2018, 119 pregnancy women who with postpartum hemorrhage risk and undergoing cesarean section in Kashgar Prefecture Second People′s Hospital of Xinjiang Uygur Autonomous Region were selected, and they were divided into group A (Oxytocin), group B (Oxytocin combined with Kaprostatin Tromethamine), and group C (Oxytocin combined with Misoprostol) according to the different drug regimen, 39 cases in group A, 40 cases in group B, and 40 cases in group C. The amount of blood loss in 2 h and 2-24 h after operation and failure ratio were recorded independently. Results Blood loss of group B was significantly less than group A 2 h and 2-24 h after operation (P < 0.05). The blood loss of group C 2 h after operation has no significant difference with group A (P > 0.05), but was significantly less than group A 2-24 h after operation (P < 0.05). Compared with group C, group B had less blood loss 2 h after operation, but had no significant difference during 2-24 h after operation (P > 0.05). The failure ratio among three groups had no significant difference (P > 0.05). Conclusion The regimen of Oxytocin combined with Kaprostatin Tromethamine can effectively reduce blood loss in pregnancy women with postpartum hemorrhage risk after cesarean section. The regimen of Oxytocin combined with Misoprostol can reduce blood loss during 2-24 h after operation. All three regimens have definitely failed ratio.
		2019 Vol. 16 (18): 81-84 [Abstract] ( 159 ) HTML (1 KB) PDF (535 KB) ( 35 )

	85	Relationship between dioxins exposure and endometriosis
		LIU Juan CHEN Canming XU Yang ZHANG Wei ZHANG Lei
		Objective To investigate the relationship between dioxins exposure and endometriosis, and to provide theoretical basis for the prevention and treatment of disease. Methods From December 2016 to January 2019, 50 patients with pelvic pack block in Maternal and Child Health Hospital of Yangzhou were selected, and 25 patients with endometriosis confirmed by pathology after surgery were set as the case group, 25 patients without endometriosis were set as control group. The correlation between dioxins exposure and endometriosis was analyzed by means of homemade questionnaire survey, and blood specimens from patients were collected to detect dioxin levels of blood by Soxhlet extraction chromatography column purification-isotope dilution HRGC-HRMS, and those results were compared between the two groups. Results The proportion of people who cook regularly in case group were significantly higher than that in control group, the proportion of people who often eat duck and quail eggs in case group were lower than that in control group, the differences were statistically significant (P < 0.05). The contents and the toxic equivalence of dioxins such as Polychlorinated Dibenzofura, 2,3,7,8-Tetrachlorodibenzofuran (2,3,7,8-T4CDF), 1,2,3,7,8-Pentachlorodibenzofuran (1,2,3,7,8-P5CDF) and 2,3,4,7,8-Pentachlorodibenzofuran (2,3,4,7,8-P5CDF) in the blood of case group were significantly higher than those of control group, the differences were statistically significant (P < 0.05). Conclusion The association exits between dioxins exposure and endometriosis, and cooking regularly might be a risk factor for exposure dioxins for endometriosis.
		2019 Vol. 16 (18): 85-89 [Abstract] ( 238 ) HTML (1 KB) PDF (576 KB) ( 40 )

	90	Effect of maternal pelvic floor muscle training plan on perinatal outcomes and postpartum urinary incontinence
		HAN Manlin LIN Hexian▲ XING Shaoning
		Objective To explore the effect of pelvic floor muscle exercise program on perinatal outcomes and postpartum urinary incontinence during the second trimester of pregnancy. Methods Clinical data of 98 parturients delivered in Haikou Maternal and Child Health Hospital from January 2017 to January 2018 was retrospectively analyzed. According to the time of pelvic floor muscle exercises, they were divided into control group (49 cases) and observation group (49 cases), pelvic floor muscle exercises were performed at 7 days postpartum and 20 weeks postpartum respectively. The duration of labor, delivery outcome, postpartum uterine prolapse, stress urinary incontinence, vagina muscle strength [vaginal resting pressure(VRP) and vaginal systolic pressure(VSP)] and pelvic floor, PFDI-20 and PFIO-7 scores of the two groups were compared. Results The first, second and third stages of labor were shorter than those of the control group, and the number cesarean section rate in the observation group was lower than that in the control group (P < 0.05). At 42 d postpartum, the incidence of uterine prolapse and stress urinary incontinence, scores of PFDI-20 and PFIO-7 in the observation group were significantly lower than those in the control group (P < 0.05), and the number of pelvic floor muscle strength (greater than or equal to Ⅲ grade), VRP and VSP were significantly higher than those in the control group (P < 0.05). Conclusion Pelvic floor muscle exercise during the second trimester of pregnancy can effectively shorten the duration of labor, improve the birth rate, help to restore pelvic floor, vaginal muscle strength, and reduce the occurrence of uterine prolapse and stress urinary incontinence.
		2019 Vol. 16 (18): 90-93 [Abstract] ( 159 ) HTML (1 KB) PDF (565 KB) ( 49 )

	94	Application of prolonged protocol in aged women undergoing IVF/ICSI treatment
		LU Xiaosheng1 WU Yanhong1 XI Haitao1 SU Weijue2 ZHAO Junzhao1
		Objective To assess the feasibility of prolonged protocol performed in aged patients undergoing in vitro fertilization/intracytoplasmic sperm injection（IVF/ICSI） treatment. Methods A Retrospective analysis was conducted on the data of 333 aged women who were given IVF/ICSI treatment with fresh embryo transplantation in the Reproductive Center of the Second Affiliated Hospital of Wenzhou Medical University from July 2016 to July 2018，of which 143 cases were given mild stimulation，and 190 cases were given prolonged protocol. The laboratory and clinical outcomes of two schemes were compared. Then patients in prolonged group were further divided into two groups according to their age. one included 107 cases aged >35-38 years old and the other contained 83 cases aged >38-42 years old，and laboratory and clinical outcomes were compared between the groups. Results Patients with the prolonged protocol used more doses of gonadotropin and longer treatment duration than those with mild stimulation, but patients with prolonged protocol achieved higher clinical pregnancy rates and embryo implantation rates. In patients with mild stimulation，the clinical pregnancy rate of patients aged >38-42 years old group was similar to that of the >35-38 year-old group（P > 0.05），while the embryo implantation rate was lower than the >35-38 year-old group （P < 0.05）. Conclusion The prolonged protocol is expected to be one of preferred option for elderly patients with tolerable ovarian reverse（≤ 42 years old, AFC≥5 and basic FSH≤12 U/L）.
		2019 Vol. 16 (18): 94-98 [Abstract] ( 229 ) HTML (1 KB) PDF (582 KB) ( 127 )

	99	Study on the difference of Keratron corneal ultrasound thickness gauge and Pentacam in the measurement of central corneal thickness in patients with refractive error in Inner Mongolia Region
		WANG Zhaoge ZHAO Haixia GUAN Wenying GE Ruichun WANG Ruifang
		Objective To compare the difference in central corneal thickness measurement of patients with refractive error in Inner Mongolia Region performed with Keratron corneal ultrasound thickness gauge and Pentacam, and provide reference for the analysis of corneal biomechanical parameters and basis for the safety of excimer laser surgery. Methods From March 2015 to November 2016, 140 patients with refractive error were randomly selected from the Myopia Laser Treatment Center of the Affiliated Hospital of Inner Mongolia Medical University, including 70 Mongolian (137 eyes) and 70 Han (140 eyes) patients. Pentacam and Keratron corneal ultrasound thickness gauge were used to measure the central corneal thickness of Mongolian and Han patients with refractive error in Inner Mongolia Region, and the data of the measurement results were analyzed. Results The central corneal thickness of Mongolians patients was (549.02±33.55) μm, that of Han patients was (575.92±37.19) μm measured with Keratron, the central corneal thickness of Mongolians patients was (538.34±32.61) μm, that of Han patients was (557.75±31.99) μm measured with Pentacam, there were high statistically significant differences in central corneal thickness for the different nationalities measured with same equipment and for the same nationality measured with different equipment (P < 0.01). Conclusion The thickness of the central cornea measured by Pentacam was thinner than that of Keratron corneal ultrasound thickness gauge, and the thickness of the central cornea of the Mongolian patients in the study objects is thinner than that of the Han patients.
		2019 Vol. 16 (18): 99-101 [Abstract] ( 159 ) HTML (1 KB) PDF (462 KB) ( 105 )

	102	Efficacy comparison of Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops and Hydroxycarboside Eye Drops in the treatment of dry eye after age-related cataract operation
		FANG Cheng CHEN Ling YIN Jin
		Objective To compare the efficacy of Recombinant Bovine Basic Fibroblast Growth Factor (rb-bFGF) Eye Drops and Hydroxycarboside Eye Drops in the treatment of dry eye after age-related cataract (ARC) operation. Methods Eighty-nine patients with ARC who underwent phacoemulsification in Tongling People′s Hospital from January 2015 to June 2018 were observed. Patients were divided into observation group (45 cases) and control group (44 cases) by random number table method. On the basis of routine medication, the control group was treated with Hydroxycarboside Eye Drops after operation, while the observation group was treated with rb-bFGF Eye Drops after operation. After 3 months, the efficacy, inflammatory factor, clinical indicators and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group (P ＜ 0.05). After treatment, the levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the two groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant (P ＜ 0.05). The Schirmer I test (SIt), fluorescein corneal staining (FL) and dry eye symptom score of the two groups were significantly lower than those before treatment, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The tear break-up time (BUT) of the two groups after treatment was longer than that before treatment, and the observation group was longer than the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion rb-bFGF Eye Drops has better efficacy and safety in the treatment of dry eye after ARC operation, and can effectively improve inflammation, tear film injury and corneal condition. It is worthy of promotion in clinic.
		2019 Vol. 16 (18): 102-105 [Abstract] ( 302 ) HTML (1 KB) PDF (513 KB) ( 96 )

	106	Relationship between peripheral blood T cell subsets and onset of sudden deafness
		LI Wei1 SHE Wensheng1 WU Xinyu1 HU Xian2
		Objective To investigate the relationship between peripheral blood T cell subsets and onset and prognosis of sudden deafness. Methods Seventy-six patients with sudden deafness admitted to Ezhou Central Hospital from August 2016 to August 2018 were selected as the study group. Another 60 healthy people who underwent health examination during the same period were selected as the control group. The patients in the study group received routine treatment for 10 d. The level of peripheral blood T cell subsets of the two groups was detected and compared. According to the curative effect, the study group were divided into effective group (54 cases) and ineffective group (22 cases), the level of peripheral blood T cell subsets of the two groups was compared. According to the imbalance of peripheral blood T cell subsets of the study group, the patients were divided into normal group (27 cases) and imbalance group (49 cases), the effective rate of the two groups was compared. Results Compared with the control group, CD3+, CD4+ and CD4+/CD8+ in peripheral blood of the study group before treatment were significantly lower, while CD8+ was significantly higher, the differences were statistically significant (P ＜ 0.05). The peripheral blood CD4+ and CD4+/CD8+ in the study group were significantly increased and CD8+ was significantly decreased after treatment compared with those before treatment, the differences were statistically significant (P ＜ 0.05). Compared with the control group, there was no significant difference in CD3+ and CD4+ in peripheral blood after treatment in the study group (P ＞ 0.05), but CD4+/CD8+ was significantly lower and CD8+ was significantly higher in the study group (P ＜ 0.05). Compared with the effective group, CD3+, CD4+ and CD4+/CD8+ in the ineffective group were significantly lower, while CD8+ was significantly higher, the differences were statistically significant (P ＜ 0.05). The effective rate of treatment in the normal group (88.89%) was significantly higher than that in the imbalance group (61.22%) (P ＜ 0.05). Conclusion The onset of sudden deafness is related to the imbalance of peripheral blood T cell subsets. Immune dysfunction may affect the hearing recovery of sudden deafness patients.
		2019 Vol. 16 (18): 106-108,116 [Abstract] ( 196 ) HTML (1 KB) PDF (804 KB) ( 89 )

	109	Correlation between drug use intensity of carbopenems and drug resistance of common gram negative bacilli
		SHEN Xiaohong1 LYU Meiyan1 WANG Lizhi1 XU Xiangwei2
		Objective To analyze the changes of defined daily doses of carbapenems antibacterial agents and the changes of main gram negative bacilli of carbapenems resistant drugs, and the relationship between them. Methods The use conditions of carbapenems antibacterial agents in Yongkang First People′s Hospital of Zhejiang Province (“our hospital” for short) from January 2014 to January 2017 were collected by hospital information system, and the resistant rate of gram negative bacilli for carbapenems was calculated by WHONET 5.4 software, and the correlation analysis was performed. Results The amount of carbapenems antibacterial agents in our hospital was increasing year by year, among which, the used number, consumption sum and defined daily doses of Meropenem increased rapidly. The total bacteria inspection results of our hospital were increased year by year, among the several major gram negative bacilli, the growth rate of Acinetobacter baumannii detection among 4 years had highly statistically significant difference (P ＜ 0.01), as well as, Acinetobacter baumannii had a significant growth resistance to Meropenem and Imipenem/Cilastatin Sodium (P ＜ 0.05), Klebsiella pneumonia had a significant growth resistance to Meropenem (P ＜ 0.01). Furthermore, the resistance rate of Acinetobacter baumannii and Klebsiella pneumoniae for Meropenem was positively correlated with the defined daily doses of Meropenem (P ＜ 0.05). Conclusion Along with the application of carbapenems antibacterial agents and the increased test number of main gram negative bacilli year by year, there is some correlation between defined daily doses of carbapenems and the increase of some drug-resistance bacteria. It is necessary to strengthen the management of carbapenems, and control the production of drug-resistant bacteria.
		2019 Vol. 16 (18): 109-112 [Abstract] ( 165 ) HTML (1 KB) PDF (449 KB) ( 142 )

	113	Clinical study of hyperthermia combined with Aescinate Sodium for Injection in treating pneumonia-like pleural effusion
		WANG Ziting1 ZHAO Fang2 JIANG Guorong3 WANG Jian1 CHEN Jing2 TAI Yanmiao1 SUN Yancheng1
		Objective To investigate the clinical efficacy and safety of hyperthermia combined with Aescinate Sodium for Injection in the treatment of pneumonia-like pleural effusion. Methods A total of 120 patients with pneumonic pleural effusion admitted to Baoding Second Central Hospital of Hebei Province from July 2016 to July 2018 were selected. The patients were divided into control group (60 cases) and research group (60 cases) by random number table method. The control group was treated with Sodium Aescinate for Injection, and the research group was combined with deep hyperthermia on the basis of the treatment in the control group. Both groups were given 2 courses of treatment, and 5 days was one course of treatment. The clinical effects, absorption time of pleural effusion, antipyretic time and hospitalization time in two groups were evaluated and compared. Pulmonary function indexes, including forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were compared between the two groups before and after treatment. The adverse reactions during treatment were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group, and the difference between the two groups was statistically significant (P ＜ 0.05). The absorption time of pleural effusion, antipyretic time and hospitalization time in the research group were significantly shorter than those in the control group, and the differences were statistically significant (all P ＜ 0.05). After treatment, FVC and FEV1 were significantly increased in the two groups compared with those before treatment, and the increase degree in the study group was greater than that in the control group (P ＜ 0.05). During the treatment, there was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Hyperthermia combined with Aescinate Sodium for Injection has obvious therapeutic effect on pneumonia-like pleural effusion, and can shorten the treatment time, with good safety.
		2019 Vol. 16 (18): 113-116 [Abstract] ( 194 ) HTML (1 KB) PDF (448 KB) ( 81 )

	117	Effect of integrated traditional Chinese and Western medicine on 5-year survival of children with malignant solid tumors
		ZHANG Ji1 SHI Xue2▲ LI Haitian3 ZHU Xiudan4 TIAN Li5 LIU Zhengmao6
		Objective To explore the effect on 5-year survival of integrated traditional Chinese and Western medicine to children with malignant solid tumors. Methods The subjects were 167 children with malignant solid tumors admitted to Beijing Children′s Hospital, Capital Medical University from January 2005 to December 2009, continuous return visit for 5 years, up to January 2015. The children who met the inclusion criteria were divided into treatment group (83 cases) and control group (84 cases) by random number table method. Among them, there were 67 cases in treatment group (16 cases of exfoliation) and 64 cases in control group (20 cases of exfoliation). The treatment group received routine chemotherapy, surgery and traditional Chinese medicine, while the control group received routine chemotherapy and surgery. The survival time, survival and recurrence conditions of two groups were compared. Results The 5-year survival rate was 69.0% in treatment group and 46.7% in control group, there was significant difference in the average survival time between two groups (P ＜ 0.01). There was no significant difference in recurrence rate between two groups (P ＞ 0.05). There was significant difference in disease-free survival between two groups (P ＜ 0.05). Conclusion Fuzheng Jianpi traditional Chinese medicine combined with Western medicine in the treatment of children with solid tumors can successfully complete chemotherapy, prolong the survival time, improve the survival rate and improve the quality of life by reducing adverse reactions of chemotherapy.
		2019 Vol. 16 (18): 117-120 [Abstract] ( 203 ) HTML (1 KB) PDF (418 KB) ( 81 )

	121	Clinical effect of acupuncture combined with chiropractic therapy in treating acute lumbar sprain
		LI Xi1 GAO Yang1 DU Shuangqing1▲ LIU Haiyong2 YANG Shuling2 GAO Jianhong2 SHI Lianhong2 ZHANG Jin2
		Objective To observe the clinical efficacy of acupuncture acupuncture at Li?觃ngqiū and Y?觃nglíngqu?觃n two points combined with chiropractic therapy in the treatment of acute lumbar sprain. Methods From April 2017 to December 2018, 200 patients with acute lumbar sprain treated in Outpatient Department of the Affiliated Hospital of Hebei University of Chinese Medicine and Sanhe Hospital in Hebei Province were selected as the study subjects. They were divided into treatment group and control group according to random number table method, with 100 cases in each group. The treatment group was treated with acupuncture at Li?觃ngqiū and Y?觃nglíngqu?觃n acupoints combined with chiropractic therapy, once a day, 5 days as a course of treatment; the control group was treated with Tongluo Qutong Cream for external use combined with chiropractic therapy, once a day, 5 days as a course of treatment. The efficacy of the two groups was evaluated after 1 course of treatment. The degrees of low back pain before and after treatment were evaluated by visual analogue scale (VAS) and the scores of clinical symptoms and signs (lumbar pain, lumbar function examination, forced posture, lumbar muscle tension, forward bending, lateral bending, turning over, standing, walking, pick-up test, straight leg elevation test). Results There was no significant difference in VAS scores between the two groups before treatment (P > 0.05). The VAS scores of the two groups were lower than those before treatment (P < 0.01), and the treatment group was lower than the control group (P < 0.05). There were no significant differences between the two groups in the symptoms and signs scores before treatment (P > 0.05). After treatment, the symptoms and signs scores of the two groups were lower than before treatment (P < 0.01), and the treatment group was lower than the control group (P < 0.05 or P < 0.01); the total effective rate of the treatment group was significantly higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Acupuncture at Li?觃ngqiū and Y?觃nglíngqu?觃n points combined with chiropractic therapy is effective in treating acute lumbar sprain, which is worthy of promotion.
		2019 Vol. 16 (18): 121-124 [Abstract] ( 237 ) HTML (1 KB) PDF (695 KB) ( 209 )

	125	Professor Wang Qingguo′s experience in the treatment of allergic rhinitis
		ZHANG Cuixin1 WANG Qingguo2▲
		In China, allergic rhinitis is a common and frequently-occurring disease of rhinolaryngology. The incidence of allergic rhinitis has increased dramatically in recent 20 years, and it has become a global health problem. The course of allergic rhinitis is repeated and protracted, which seriously affects the quality of life of patients. Western medicine treatment can only temporarily relieve some symptoms, such as nasal obstruction and runny nose. People pay more and more attention to the treatment of allergic rhinitis by traditional Chinese medicine because of its exact effect and small side effects. Professor Wang Qingguo has been engaged in teaching and clinical practice for more than 40 years. He has accumulated rich clinical experience in the treatment of allergic rhinitis with traditional Chinese medicine and has achieved remarkable results. It is believed that the disease is closely related to the five zang organs, paying attention to warming and tonifying the kidney yang, strengthening the surface and regulating the liver and gallbladder. According to the differentiation of symptoms and signs, the prescriptions of Guizhi Decoction, Mahuang Fuzi Xixin Decoction, Yupingfeng Power, Xiao Chaihu Decoction, Chuanxiong Chatiao Power and Chaihu Guizhi Decoction are added or subtracted unilaterally, the curative effect is remarkable. This article summarizes Professor Wang Qingguo's clinical experience in the treatment of allergic rhinitis in order to help readers.
		2019 Vol. 16 (18): 125-129,132 [Abstract] ( 281 ) HTML (1 KB) PDF (678 KB) ( 231 )

	129	Clinical effect of Tongluo Huoxue Mushou Prescription in the treatment of poor maturity of arteriovenous fistula in hemodialysis patients
		CAI Cun LUN Longwei LI Yin LIU Xusheng
		Objective To explore the clinical efficacy of Tongluo Huoxue Mushou Prescription in the treatment of poor maturity of arteriovenous fistula in hemodialysis patients. Methods From October 2016 to October 2018, 60 patients with poor maturity of internal fistula after arteriovenous fistula operation admitted to Guangdong Hospital of Traditional Chinese Medicine were selected as research objects. The patients were divided into control group (30 cases) and study group (30 cases) by random number table method. The control group was treated with warm water and the research group was treated with Tongluo Huoxue Mushu Prescription. The internal fistula index at different time points, pump controlled blood flow in hemodialysis and maturity time of arteriovenous fistula were compared between the two groups, and the adverse reactions of the two groups during treatment were observed. Results After 4 weeks of treatment, the blood flow per minute, the diameter of vein and the thickness of vessel wall in the study group were higher than those in the control group (P ＜ 0.05). Pump-controlled blood flow in the study group was more than that in the control group, and the maturation time of arteriovenous fistula in the study group was shorter than that in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Tongluo Huoxue Mushou Prescription can effectively promote the maturation of arteriovenous fistula in hemodialysis patients, shorten the maturation time of arteriovenous fistula without increasing the incidence of adverse reactions, and has certain clinical application value.
		2019 Vol. 16 (18): 129-132 [Abstract] ( 200 ) HTML (1 KB) PDF (653 KB) ( 90 )

	133	Introduction on the experience of Professor Qiu Xiangzhong in treating ankylosing spondylitis
		XUE Fan1 DENG Hao1 DENG Milang1 QIU Xiangzhong2
		Ankylosing spondylitis is clinical common chronic inflammatory autoimmune disease, which is called “Da Lou” in traditional Chinese medicine and is popular in adolescence. Professor Qiu Xiangzhong has engaged in clinical work of traditional Chinese medicine for more than 35 years, who has rich experience for the treatment of this disease. Professor Qiu Xiangzhong believes that this disease is deficient in origin and excessive in superficiality. The origin is kidney and Du-meridian deficiency, while the superficiality is static blood blocking collaterals. Professor Qiu Xiangzhong lays emphasis on cold and heat as the main link to carry out treatment by stages in clinic, he is specialized in mild tonification, initiates that kidney, liver, spleen should be tonified at the same time, he is good at using parasitic drugs and medicinal guide drugs, which has received good clinical effects. It is worthy of promotion.
		2019 Vol. 16 (18): 133-135,140 [Abstract] ( 195 ) HTML (1 KB) PDF (667 KB) ( 111 )

	136	Research on the image of traditional Chinese medicine science and technology based on co-word analysis
		LIANG Tiantian ZHAO Yuyang QIAN Siyan DU Yirong WANG Ranyu LIU Qian TAN Wei
		Objective To analyze the core journal papers in the field of traditional Chinese medicine by using co-ward analysis and cluster analysis, so as to construct the secondary dimension of the image of traditional Chinese medicine science and technology. Methods The high frequency keywords of 15 333 papers related to traditional Chinese medicine were analyzed by co-ward analysis and cluster analysis. Results Fifty-nine high-frequency keywords could be divided into basic research of traditional Chinese medicine, clinical research of traditional Chinese medicine, inheritance and application of traditional Chinese medicine, development and application of traditional Chinese medicine. The first two categories belong to the exploration and cognition of traditional Chinese medicine, the latter two belong to the achievement and application of modernization of traditional Chinese medicine. Conclusion The secondary dimension of the image of Chinese medicine science and technology are constructed by analyzing the results, which is the image of scientific research, the image of transformation of achievements and the image of contribution of science and technology
		2019 Vol. 16 (18): 136-140 [Abstract] ( 200 ) HTML (1 KB) PDF (1134 KB) ( 85 )

	141	Clinical effect of acupuncture combined with ginger moxibustion on Yìntáng to treat allergic rhinitis with syndrome of deficient cold of lung qi
		WU Weibin1 ZHAO Ran1 LI Jing2 FAN Qun1▲
		Objective To observe the clinical effect of acupuncture combined with ginger moxibustion on Yìnt?觃ng to treat allergic rhinitis with syndrome of deficient cold of lung qi, and to explore its feasibility and effectiveness. Methods From January 2017 to January 2018, 72 patients with allergic rhinitis admitted to the acupuncture department of Integrative Medicine Hospital of Minhang District in Shanghai from January 2017 to January 2018 were randomly divided into the treatment group (n = 36) and the control group (n = 36) by the method of allocation concealment. The treatment group used acupuncture combined with ginger moxibustion on Yìnt?觃ng, 20 min / time, 3 times / week, and the control group was treated with conventional Western medicine. Changes in nasal symptom scores (TNSS) were observed after 3 weeks of treatment in both groups. Results Before treatment, there was no significant difference in TNSS score between the two groups (P > 0.05). After 1 and 2 weeks of treatment, the TNSS scores of the two groups were lower than those before treatment, and the differences were statistically significant (P < 0.05), but the difference between the two groups was not statistically significant (P > 0.05). After 3 weeks of treatment, the TNSS scores of the two groups were lower than before treatment, the differences were statistically significant (P < 0.05), and the treatment group was lower than the control group, the difference was statistically significant (P < 0.05). After 3 weeks of treatment, the total effective rate was 88.92% in the treatment group and 77.83% in the control group. There was no significant difference in the total effective rate between the two groups (P > 0.05). Conclusion Acupuncture combined with ginger on Yìnt?觃ng is effective in treating allergic rhinitis with syndrome of deficient cold of lung qi, and it is superior to Western medicine treatment. It has no side effects and is worthy of clinical promotion.
		2019 Vol. 16 (18): 141-143,158 [Abstract] ( 196 ) HTML (1 KB) PDF (1153 KB) ( 113 )

	144	A case of granulomatosis with polyangiitis misdiagnosed as invasive pulmonary asperillosis
		FU Xiaotong JIANG Chunyang LI Ling
		Granulomatosis with polyangiitis (GPA) is an autoimmune disease with a variety of clinical manifestations that are easily confused with invasive pulmonary asperillosis (IPA). This article reports a case of a 44-year-old man with GPA misdiagnosed as IPA. Through the discussion of the differential diagnosis of the two diseases, the ability of clinician′s diagnosis and differential diagnosis in GPA was improved.
		2019 Vol. 16 (18): 144-146,166 [Abstract] ( 222 ) HTML (1 KB) PDF (937 KB) ( 41 )

	147	Status quo and developments of medical English-Chinese parallel corpus from perspective of ESP
		GUO Zikai1 XUE Yingli1 ZHANG Xiao2 TAN Tian3
		Against the background of the "Double First-Class" university project in China and the rapid development of corpus technologies, the construction of subject-specific corpuses has been an unstoppable trend, and the construction and study of medical English-Chinese parallel corpuses also need enhancing. This paper analyses the status quo of medical English-Chinese parallel corpuses, and mainly discusses the developments in their application to medical translation and writing as well as the improvement of their construction. As medical English-Chinese parallel corpuses can effectively help medical translation and writing in terms of both medical knowledge and language quality, it is necessary to enhance their construction, and build the corpuses annotated with disciplinary subdivision and medical knowledge.
		2019 Vol. 16 (18): 147-149 [Abstract] ( 292 ) HTML (1 KB) PDF (708 KB) ( 138 )

	150	Application effect of multidisciplinary collaborative team in early rehabilitation of patients with Alzheimer′s disease
		FENG Xiaobin1 CHEN Zheli2
		Objective To explore the application of multidisciplinary collaborative teams in the early rehabilitation of patients with Alzheimer′s disease (AD). Methods Sixty patients with AD in Huzhou Third People′s Hospital of Zhejiang Province were selected as the study subjects. Thirty patients who took routine intervention from May 2016 to May 2017 were selected as the control group, and 30 patients who were implemented with multidisciplinary team on the basis of routine intervention from June 2017 to June 2018 were selected as experimental group, both groups were intervened for 6 months. After 6 months of intervention, treatment compliance, intervention satisfaction, and function score (MMSE), dementia severity score (GDS), mental behavior symptom score (NPI), daily life Ability score (ADL), quality of life score (QOL-AD) before and after 6 months of intervention were compared. Results After 6 months of intervention, the treatment compliance of the experimental group was higher than that of the control group (P < 0.05), the MMSE score of the experimental group was higher than that before the intervention and the control group, the GDS and NPI scores were lower than those before the intervention and the control group (P < 0.05), the scores of ADL and QOL-AD in the experimental group were higher than those before the intervention, and higher than the control group (P < 0.05). After 6 months of intervention, the satisfaction of group intervention was higher than that of the control group (P < 0.05). Conclusion AD patients with multidisciplinary collaborative team intervention can significantly improve treatment compliance, improve cognitive function, daily living ability and quality of life, alleviate mental behavior symptoms, reduce the severity of dementia, and improve satisfaction.
		2019 Vol. 16 (18): 150-153,170 [Abstract] ( 201 ) HTML (1 KB) PDF (794 KB) ( 73 )

	154	Effect of Dexmedetomidine-assisted general anesthesia on serum T lymphocyte subsets in elderly patients with femoral neck fracture
		XU Yiguo WU Xiang▲ LI Hongbao ZHU Binbin ZHU Wei
		Objective To explore the effect of Dexmedetomidine-assisted general anesthesia on serum T lymphocyte subsets in elderly patients with femoral neck fracture. Methods From February 2017 to January 2019, 86 elderly patients with femoral neck fracture from the Affiliated Hospital of Medical School of Ningbo University were selected to undergo hip replacement under general anesthesia. They were divided into observation group and control group according to different anesthesia schemes, with 43 cases in each group. The observation group was given 0.5 μg/kg Dexmedetomidine before induction of anesthesia and injected by intravenous infusion pump. The control group was given normal saline of equal volume before induction of anesthesia and injected by intravenous infusion pump. Heart rate (HR) and mean arterial pressure (MAP) were monitored before administration (T0), 10 minutes after administration (T1), immediately after tracheal intubation (T2), skin incision (T3), 30 minutes after operation (T4), 5 minutes after tracheal intubation (T6), 30 minutes after tracheal intubation (T7). Flow cytometry was used to detect the levels of CD3+, CD4+, CD8+, CD4+/CD8+ in peripheral blood before and 1 d after surgery. Cognitive function was assessed before and after 1, 3, 7 days by mini-mental state examination (MMSE), and the amount of Propofol and Fentanyl during operation and the incidence of adverse reactions were counted. Results The HR and MAP of T2 and T6 in the observation group were lower than those in the control group (P < 0.05); Fentanyl and Propofol used in the observation group were less than those in the control group (P < 0.05); CD3+, CD4+, CD4+/CD8+ of peripheral blood in the observation group were higher than those in the control group at 1 and 3 days after operation, and CD8+ level was lower than that in the control group (P < 0.05). Cognitive function score in the observation group were higher than that in the control group at 1, 3 and 7 days after operation (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The application of Dexmedetomidine-assisted general anesthesia in elderly patients with femoral neck fracture is helpful to reduce the amount of anesthetics used during the operation and maintain the stability of perioperative hemodynamics. It has little effect on T lymphocyte subsets and cognitive function, with high safety.
		2019 Vol. 16 (18): 154-158 [Abstract] ( 209 ) HTML (1 KB) PDF (794 KB) ( 40 )

	159	Improvement method of medical institutions for establishment and examination work of clinical trial project
		CAI Junlong WU Jianyuan CHEN Bo ZHOU Jingjing LIN Jun HUANG Jianying
		Through analyzing the new policy situations of filling system of clinical trial facility, on-site data verification and other policies, this paper discusses the importance of establishment and examination work of clinical trial project for medical institutions to undertake high quality projects and avoid medical risks. Taking the establishment of project establishment and examination system as the entry point, thia paper briefly expounds the project establishment and examination procedure of medical institutions, namely project negotiation - project application - project preliminary screening and acceptance - project review. In addition, this paper takes multi-dimension and multi-level analsis for the content of project establishment and key problems needing to be paid attention to, discusses the review contents and methods for the important aspects, such as research basis and scientific significance of the project, experiment design, ethical compliance and research team, and emphasizes the key review of whether the project involves activities related to the collection, collection, export and exit of human genetic resources. This paper takes analysis and discussion focusing on the establishment and examination work of clinical trial project, to provide scientific, standard, rigorous and practical management mechanism and specific operation method for reference for medical institutions to establish normalized project establishment and examination procedure, aimed at strengthening the ability of project establishment and examination of medical institutions and ensuring the project quality.
		2019 Vol. 16 (18): 159-162 [Abstract] ( 187 ) HTML (1 KB) PDF (768 KB) ( 124 )

	163	Bibliometric analysis on the construction of Chinese medicine culture in colleges and universities in China
		WANG Liqin1 HE Wenxin2 CHEN Xi2 YANG Suzhen2 GAO Zhaohong2 YUAN Meiqi2 LI Yanqiu3
		Objective To understand the present situation and trend of Chinese medicine culture construction in colleges and universities in China, and to provide reference for related research. Methods From January 1995 to October 2018, the literature on the construction of Chinese medicine culture in colleges and universities was retrieved from CNKI, VIP and Wanfang database, the relevant literatures were extracted and the statistical analysis was carried out by using noteexpress literature management software and Excel. Results Included in 131 literatures, published in 73 periodicals respectively, and the volume was the most loaded with "modern distance education of Chinese medicine in China". The first author involves 47 colleges and universities, all over 20 provinces in China, including Jiangsu, He′nan, Guangdong, Hu′nan 4 provinces sent more letters. The research institutions with the largest number of communications are Nanjing University of Chinese Medicine. The research covers 9 aspects. Conclusion At present, the field of Chinese medicine culture construction in colleges and universities in China has been paid more attention, the research hotspots are more, and the development momentum of campus culture construction and humanistic quality education is good.
		2019 Vol. 16 (18): 163-166 [Abstract] ( 158 ) HTML (1 KB) PDF (717 KB) ( 50 )

	167	Thinking and practice of "studies on the theoretical and practical issues of party building" in public hospitals based on Marxism theory
		ZHOU Wei XIE Bin JIANG Yalian WU Shanqin
		Since the 18th National Congress of the Communist Party of China, the Party Central Committee has always focused on strengthening the Party′s ideological and political construction, constantly promoting the comprehensive and strict governance of the Party, and carrying out a series of learning and education activities such as "studies on the theoretical and practical issues of party building". As the national health care reform enters a critical period, how to improve the overall quality and core competitiveness of public hospitals has become an important issue to be solved in front of hospital administrators. In this paper, combined with the practice of " studies on the theoretical and practical issues of party building" in the Party committee of Shanghai Mental Health Center in recent years, it clarifies the leading and guiding role of Marxist philosophy practice in "studies on the theoretical and practical issues of party building" in public hospitals, and improves the Marxist theoretical accomplishment of medical workers. It is of great significance to better serve patients and promote the healthy and sustainable development of hospitals.
		2019 Vol. 16 (18): 167-170 [Abstract] ( 181 ) HTML (1 KB) PDF (714 KB) ( 73 )

	171	Analysis on international talents cultivation of master of nursing students in TCM colleges
		ZHANG Ping YIN Yongtian CHEN Lijun
		This paper summarizes the present situation of nursing education development at home and abroad, the current situation and existing issues of talents cultivation of master of nursing students in Chinese medicine colleges according to the current situation of nursing education development, and puts forward some countermeasures based on the advantages of traditional Chinese medicine (TCM) characteristics of our school. It provides a theoretical basis for colleges of TCM to explore the internationalized cultivation of master of nursing students with TCM characteristics under the new situation.
		2019 Vol. 16 (18): 171-173 [Abstract] ( 191 ) HTML (1 KB) PDF (707 KB) ( 168 )

	174	Dissemination of Chinese medicine culture under the circumstance of “New Opium War”
		ZHANG Li1 ZHANG Yan2
		Opium drugs abuse in today′s America brings big side effect on the economy, politics and the health of humans. Under the circumstance of “New Opium War”, overseas Chinese medicine practitioners should stand out and shoulder this holy duty to contribute to the healthcare of the mankind. Meanwhile, overseas Chinese medicine practitioners should try hard to improve their own levels of diagnosis and treatment by cooperate with other medical institutes and studying hard on Chinese medical classics continuously， to receive the word of mouth and disseminate Chinese medicine culture better and broaden the Chinese medicine service and trade.
		2019 Vol. 16 (18): 174-176 [Abstract] ( 165 ) HTML (1 KB) PDF (757 KB) ( 62 )

	177	Influence of targeted functional training on the neural function, cognitive function, body movement function and life quality of hematencephalon patients after operation
		XU Ping
		Objective To approach the influence of targeted functional training on the neural function, cognitive function, body movement function and life quality of hematencephalon patients after operation. Methods A total of 120 patients with hematencephalon in the First People′s Hospital in Yongkang City of Zhejiang Province from January 2016 to January 2018 was selected, and they were grouped by random paper method, patients in control group (60 cases) were given regular rehabilitation training, and patients in observation group (60 cases) were given targeted functional training. The NIHSS score, cognitive function score, Barthel index, Fugl-Meyer score, life quality, ADL score and therapeutic effect of two groups before and after training intervention were evaluated. Results Before intervention, there was no statistically significant difference in the NIHSS score, cognitive function score, Barthel index, Fugl-Meyer score, life quality and ADL score between the two groups (P > 0.05). After intervention, the NIHSS scores of the two groups were lower than before intervention, the cognitive function score, Barthel index, Fugl-Meyer score, life quality and ADL score were higher than before intervention, and the NIHSS score of observation group was lower than that of control group, the cognitive function score, Barthel index, Fugl-Meyer score, life quality and ADL score of observation group were higher than those of control group, the differences were statistically significant (P < 0.05). The total clinical efficiency of observation group was higher than that of control group, the difference was statistically significant (P < 0.05). Conclusion The implementation of targeted functional training in hematencephalon patients, could improve the neural function, cognitive function, body movement function and life quality, increase prognostic level, it is worthy of clinical application.
		2019 Vol. 16 (18): 177-180 [Abstract] ( 187 ) HTML (1 KB) PDF (780 KB) ( 52 )

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