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2018 Vol. 15, No. 7
Published: 2018-03-05
 
 
4 Effect of electroacupuncture at “Zusanli” points on perinatal nicotine exposure-induced lung dysplasia in newborn rats
LIU Yitian1 JI Bo1 SU Hang1 GE Yunpeng1 WANG Dan1 ZHAO Guozhen2 Reiko Sakurai3 Virender Kumar Rehan3
Objective To observe the effects of electroacupuncture at “Zusanli” points on lung function, lung index and lung morphology of neonatal rats exposed to nicotine during perinatal period. Methods Twenty adult female SD rats were divided into normal saline group (S group), normal saline plus electroacupuncture at “Zusanli” group (S + ST36 group), nicotine group (N group) and nicotine plus electroacupuncture at “Zusanli” group (N + ST36 group) by random number table. The model was established by subcutaneous injection of nicotine [1 mg/(kg·d), 100 μL] from gestational day 6 to postnatal day 21. The lung function of neonatal rats was detected by animal lung function analysis system. The lung index was calculated according to the weight and weight of lung tissue, and the morphological changes of lung tissue in newborn rats were observed by HE staining. Results Compared with group S, the PEF and Cydn in group N were significantly decreased (P < 0.05), RL was significantly increased (P < 0.05) and lung index was significantly decreased (P < 0.05). The numbers of alveoli in group N decreased obviously, and the volume of alveoli increased and part of alveolar wall ruptured and fused with each other. Compared with group N, PEF and Cydn in group N + ST36 were significantly increased (P < 0.05), RL was significantly decreased (P < 0.05) and lung index was significantly increased (P < 0.05). The number of alveoli in group N + ST36 increased, and the volume of alveoli decreased and the rupture and fusion of alveolar wall were improved. Conclusion Electroacupuncture at “Zusanli” points can protect lung development by improving lung function, lung morphology and lung index of newborn rats exposed to nicotine during perinatal period.
2018 Vol. 15 (7): 4-8 [Abstract] ( 203 ) HTML (1 KB)  PDF (1171 KB)  ( 86 )
9 Effect of Zhuanggu Zhitong prescription on CGRP and β2-AR in ovariectomized osteoporosis rats
GAN Guoxing1 LIU Yu1 LI Jinping2 ZHANG Guomin3 YI Zhongyuan1
Objective To explore the effect of Zhuanggu Zhitong prescription on the CGRP and β2-AR in ovariectomized osteoporosis rats and investigate its mechanism in anti-osteoporosis. Method 72 rats were randomly divided into sham operation group (12 cases) and model group (60 cases), the model group rats were ovariectomized osteoporosis and the sham operation group rats were excised equal weight fat. After the modeling, the rats were randomly divided into model group, Zhuanggu Zhitong prescription high-dose group (13.2 g/kg), middle-dose group (6.6 g/kg), low-dose group (3.3 g/kg) and estradiol valerate group (2.1×10-5 g/kg), with 12 rats in each group. The model group and sham operation group rats were given equal volume water. All intervened for 13 weeks. The content of CGRP in serum was detected by ELISA and protein expression of β2-AR in bone tissue were detected by immunohistochemistry. Results Compared with sham operation group, the content of CGRP in serum and protein expression of β2-AR in bone tissue of model group were significantly declined, with high statistically significant differences (all P ＜ 0.01). Compared with the model group, the content of CGRP in serum and protein expression of β2-AR in bone tissue of different doses Zhuanggu Zhitong prescription group and estradiol valerate group were increased significantly, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01). There were no significant differences in different doses of Zhuanggu Zhitong prescription groups (P ＞ 0.05). Conclusion Zhuanggu Zhitong prescription can promote the secretion of CGRP and protein expression of β2-AR, which may be one mechanism of ZhuangguZhitong prescription to anti-osteoporosis.
2018 Vol. 15 (7): 9-11,15 [Abstract] ( 285 ) HTML (1 KB)  PDF (594 KB)  ( 108 )
12 Construction and identification of a recombinant lentivirus with overexpression Slug gene
ZHOU Yuanhong1 LUO Youzhen1 ZHOU Xiaolin2 LIU Qiang2
Objective To construct recombinant lentivirus with Slug gene for further exploring the effect of Slug in metastatic recurrence. Methods The Slug gene was acquired from the breast cancer cell MDA-MB-231 by PCR assay, which was then connected into linearized GV367 vector digested by Age Ⅰ/Nhe I enzyme. The positive clones were identified by PCR and sequencing analysis. The constructed lentiviral vectors with Slug gene were then transfered into 293T cell lines. The lentivirus titer was detected by the fluorescence method. Results The lentiviral vector with Slug gene was successfully constructed and obtained, the virus titer of which was 5×108 TU/mL. Conclusion The lentiviral with Slug gene are successfully constructed, which will provide the experimental foundation for further exploring the effect of Slug in metastatic recurrence.
2018 Vol. 15 (7): 12-15 [Abstract] ( 263 ) HTML (1 KB)  PDF (763 KB)  ( 125 )
16 Effect of mTOR signaling on cardiac hypertrophy 
CHEN Xing1 CHENG Chuanfang2 FANG Yanling1 GONG Ya′nan1 XU Miqing1
Objective To detect protein the expression of mammalian target of rapamycin (mTOR) signaling in pressure-overloaded cardiac hypertrophy and H9c2 cardiomyocyte hypertrophy, and investigate effect of mTOR signaling on cardiac hypertrophy. Methods Sixteen SD rats were randomly grouped as the abdominal aorta coarctation (AAC) group and the sham group, with 8 rats for each group. Two weeks after AAC, echocardiography and histological analysis were performed. Norepinephrine (NE) was used to induce H9c2 cardiomyocyte hypertrophy in vitro. Relative protein expressions were detected for mTOR signaling by western blot. Results Compared with the sham group, rats in the ACC group showed a significant increase in left ventricular posterior wall end-diastolic thickness (LVPWd), interventricular septal end-diastolic thickness (IVSd) and heart weight index (HWI) (all P ＜ 0.05). Western blot showed that there was a significant increased ratio of P-mTOR and mTOR protein expression in the AAC group compared with the sham group (P ＜ 0.05). NE treatment significantly increased the ratio of P-mTOR and mTOR protein expression in vitro, with a significant difference compared with the control group (P ＜ 0.05). Conclusion Protein expressions in mTOR signaling can be significantly increased in pressure-overloaded cardiac hypertrophy and H9c2 cardiomyocyte hypertrophy. mTOR signaling may play a key role in the pathogenesis of cardiac hypertrophy.
2018 Vol. 15 (7): 16-19 [Abstract] ( 266 ) HTML (1 KB)  PDF (579 KB)  ( 169 )
20 Involvement of the Amygdala in the cerebral infarction complicated with arrhythmias
JIA Shuwei WANG Ling JIAO Runsheng
Objective To investigate the association between ischemic stroke-induced arrhythmia and the activity of amygdala and the possible mechanism. Methods Forty-eight rats were randomly and equally divided into the following groups: sham-operated group, 30 min, 1 h, 2 h, 4 h, and 8 h after ischemic stroke groups, and the changes of the activity of amygdala neurons in ischemic stroke rats were observed. Forty rats were randomly and equally divided into the following groups: blank control group, saline group, L-glutamate group, MK-801 before L-glutamate and MK-801 preceding making model group, and the effects of glutamate on arrhythmia induced by ischemic stroke were observed. The experimental cerebral ischemic animal model was established by occluding the right middle cerebral artery (MCAO). The electrocardiography was recorded by a biological signal collecting and processing system. Fos protein was used as an objective indicator to illustrate the functional state of neurons. Results The incidence of arrhythmia in model group was 0, and the sham-operated group was 78.75%, the incidence of arrhythmia in the sham-operated group was significantly higher than that in model group (P < 0.01), and the expression of Fos protein in the amygdala was also increased significantly during the arrhythmia (P < 0.01). The incidence of arrhythmia in blank control group and saline group was 0, L-glutamate group was 87.5%, which was significantly higher than blank control group (P < 0.01), and the expression of Fos protein in the amygdala of the L-glutamate group was also increased significantly (P < 0.05). The incidence of arrhythmia in both MK-801 preceding making model group and MK-801 preceding L-glutamate group was 0, and the expression of Fos protein had no obvious change (P > 0.05). Conclusion It is concluded that activation of the amygdala in ischemic stroke rats is likely mediated by glutamate via activation of N-methyl-D-aspartic acid receptors, which causes arrhythmias.
2018 Vol. 15 (7): 20-22,35 [Abstract] ( 236 ) HTML (1 KB)  PDF (1050 KB)  ( 157 )
23 Study on Tetracycline Hydrochloride gastric floating microspheres
ZHONG Lei1 BIAN Fang1 ZHAO Chaoyang2 ZHANG Hong1
Objective To prepare Tetracycline Hydrochloride gastric floating microspheres using ionic gelation method, and to improve drug release percentage and therapeutic effect of anti-Helicobacter pylori. Methods Chitosan and alginate were chosen as the carriers, and NaHCO3 was utilized as the foaming agent. The orthogonal experiment was adopted to investigate the weight ration of tetracycline/alginate and alginate/NaHCO3, as well as the concentration of CaCl2 and chitosan. Therefore, the optimum preparation was determined by evaluating floating performances, drug release, encapsulation efficiency and balling index. Results The optimal conditions were as followed: the concentration of chitosan was 8 mg/mL, the weight ration of alginate/tetracycline was 4∶1, the concentration of CaCl2 was 20 mg/mL, and the weight ration of alginate/NaHCO3 was 2∶1. The microcapsules could float in stomach for 24 h with a floating rate of 95%, and the encapsulation efficiency was 79.90%. The in vitro experiments suggested that these floating microspheres had good sustain-release properties. Conclusion According to the results above, tetracycline gastric floating microspheres meet the requirements of gastric retention, which can increase drug absorption and therapeutic effect of anti-Helicobacter pylori, reduce dosing frequency, and have more selection of dosage forms.
2018 Vol. 15 (7): 23-26 [Abstract] ( 181 ) HTML (1 KB)  PDF (557 KB)  ( 75 )
27 Optimization of extraction process of Paoduqinq Lotion by central composite design and response surface methodology
LUO Yudong1 ZHONG Jiang2 TAN Anqiang1 FANG Gang3
Objective To optimize the extraction process of Paoduqinq Lotion and to control its quality. Methods Through central composite design and response surface methodology, using gallic acid and scutellarin content as the indicators, the effects of the amount of water, extraction time, extraction frequency on water extraction process were investigated. The best water extraction process of Paoduqinq Lotion was obtained and varified by pilot scale test. Results The best water extraction process of Paoduqinq Lotion was performed by extracting the decoction with 10 times the amount of water twice, 125 min each time. Conclusion The optimized extraction process with good reproducibility and stable quality can be used as the extraction process of blister lotion.
2018 Vol. 15 (7): 27-30 [Abstract] ( 226 ) HTML (1 KB)  PDF (629 KB)  ( 93 )
31 Research progress of biomembrane-biomimetic nanoparticles in drug delivery system
TIAN Hao CHEN Shichun HAN Yutong CHEN Fuming MA Aiqing LU Chengyu
Biomembrane-coated nanotechnology is a new biomimetic strategy for nanosystems. In this strategy, various kinds of biological membranes with versatile characteristics are used as functional materials and engineered on the surface of drug-loaded nano cores, which avoids the cumbersome process of traditional chemical methods to modify nanoparticles. Benefit from the camouflage function of biological membranes, the mimetic nanoparticles obtain the natural properties of the original biomembrane with good biocompatibility and characteristics of long circulation and lesion targeting. In the past few years, such biomimetic nanosystems have been successfully applied in drug delivery, showing broad application prospects in the fields of accurate diagnosis and treatment of diseases. This paper reviews the research progress of biomimetic nanoparticles in drug delivery system and prospect the future research.
2018 Vol. 15 (7): 31-35 [Abstract] ( 890 ) HTML (1 KB)  PDF (635 KB)  ( 369 )
36 Modern pharmacology research progress on the mechanism of Duhuo Jisheng Decoction in the treatment of knee osteoarthritis
SU Xiaolin1 WANG Jiangwei1 ZHAO Wan1 YANG Bingyou1 KUANG Haixue1 WANG Qiuhong1,2
Duhuo Jisheng Decoction is a common formula for curingorthopedic diseases, which is particularly extensive in the treatment of knee osteoarthritis. The author summarizes literatures at home and abroad in the nearly ten years, classifies and sums up the treatment mechanism, and finds that the formulae not only can inhibit inflammatory cytokines and affects oxidative stress indicators, but also plays an important role in the inhibition of matrix metalloproteinase, inhibition of chondrocyte apoptosis, increasing cartilage collagen content and influencing the expression of microRNA. With the further research of the mechanism, it can not only broaden the use of the formula, but also guide clinicians to use precise formula more clearly.
2018 Vol. 15 (7): 36-39 [Abstract] ( 250 ) HTML (1 KB)  PDF (627 KB)  ( 68 )
40 Progress in the study of Bcl-2 and tumor metastasis
LIU Lei1 LI Yan2 WANG Shasha3
Metastasis is one of the most important biological characteristics of malignant tumor, and it is the main risk factor to the patient's life. Bcl-2 is considered as a key factor in anti-apoptosis, but recent studies show that Bcl-2 may play an important role in promoting tumor metastasis. In this paper, review the function of bcl-2 in regulating cell migration, invasion and tumor metastasis and discuss associated molecular mechanism in cellular, animal models and patients levels, and also make a prospect for the therapeutic strategy to target Bcl-2, in order to provide a basis for the inhibition of tumor metastasis.
2018 Vol. 15 (7): 40-43 [Abstract] ( 269 ) HTML (1 KB)  PDF (631 KB)  ( 181 )
44 Composite tissue flap to repair the research progress of venous dysfunction in patients with tissue defect
LUO Yuanguo QIN Wanan WU Jiachang LIN Zhoudan YANG Hua
Flap is often used to repair tissue, the key to the survival of the flap depends on whether the blood circulation in the flaps can be reestablished. For normal tissue defects, the survival rate of flap transplantation was relatively high, but for some patients with functional impairment of venous vascular function, it is difficult to transplant the flap. It is one of the difficult clinical problems in orthopedics to explore the surgical method to maximize the limb function and reduce the disability rate. In this paper, the progress of composite tissue flap for repairing tissue defects in patients with venous dysfunction was discussed, although for patients with venous dysfunction the flap was not able to establish the physiological blood flaps in the early stage, but through the study of arteriovenous flap, to reduce the tension of skin flap, making the part cannot backflow of tissue fluid and blood extravasation directly, thus can avoid excessive local flap transplantation area edema aggravated and micro thrombosis in blood vessel caused by the flap tension. If necessary, it can through a blood transfusion to keep the flap alive. For patients with venous dysfunction but must have skin flap repair, this is a viable surgical procedure.
2018 Vol. 15 (7): 44-46,59 [Abstract] ( 270 ) HTML (1 KB)  PDF (633 KB)  ( 120 )
47 Research progress of vitamin K on osteoporosis
GUO Bin1 HU Xuesong2 PENG Fangyi1
Vitamin K (VK) is a kind of essential natural nutrient of human body. It plays a role in promoting bone mineralization and inhibiting bone resorption in regulating bone metabolism. This article focuses on the mechanism of VK in the regulation of bone metabolism, animal experiments and clinical trials, as well as the important role of VK in the prevention and treatment of osteoporosis, to provide objective and feasible basis for clinical treatment of osteoporosis.
2018 Vol. 15 (7): 47-50 [Abstract] ( 246 ) HTML (1 KB)  PDF (620 KB)  ( 333 )
51 Recent research progress on the pharmacological mechanisms of anti-aging and anti-oxidation by salidroside
LI Hui SUN Ledong
Rhodiola is a rare wild medicinal material.Salidroside is the main effective component of Rhodiola and has significant anti-aging and anti-oxidant pharmacological effects. After reviewing and summarizing the recent 3-year relative research at home and abroad, we found that studies mainly involved nervous system, cardiovascular system, skin and other aspects. The specific pharmacological mechanisms involved PI3K/Akt/GSK-3β,PI3K/Akt/Nrf2/HO-1, SIRT1/NF-κB, cAMP/PKA/CREB, NOX2/ROS/MAPKs, autophagy and so on. In conclusion, this review is of great significance for researchers who try to further research pharmacological mechanisms of salidroside and take use of targeted pathways to develop new drugs.
2018 Vol. 15 (7): 51-54,81 [Abstract] ( 570 ) HTML (1 KB)  PDF (1051 KB)  ( 340 )
55 Research progress of Fuke Qianjin capsults （tablets） in gynecological diseases
ZHI Yingchuan1 ZENG Xiaoqin2 ZHAO Yang3 SONG Yong4 ZHENG Tingping5 WANG Yanfang6 SUN Aijun6
With the development of traditional Chinese medicine, Chinese medicine is widely used in the treatment of various diseases, not only its curative effect is distinct, but also can overcome the shortages of western medicine which side effect is large and could not be long-term use. Fuke Qianjin capsults (tablets), a pure traditional Chinese medicine, is a safe and effective medicine with low cost and can be used in the treatment of a variety of gynecological diseases such as pelvic inflammatory disease, cervical inflammatory disease, senile vaginitis and so on. This paper reviewed and summarized the recent researches about Fuke Qianjin capsults (tablets) in the treatment of gynecological diseases, in order to provide guidance for clinical research and application and to promote the rational application of Fuke Qianjin capsults (tablets).
2018 Vol. 15 (7): 55-59 [Abstract] ( 373 ) HTML (1 KB)  PDF (634 KB)  ( 142 )
60 Proteomics analysis of differential expression proteins in thyroid well-differentiated tumour of uncertain malignant potential
TANG Ming1 YANG Hui1 LIU Pengjie2 XU Minjie1 ZHANG Yinghong1 CHEN Tianxing1
Objective To identify the differential expression proteins in thyroid well-differentiated tumour of uncertain malignant potential (WT-UMP) and to look for new protein biomarkers. Methods A total of 20 thyroid WT-UMP resection samples and 20 normal thyroid tissues adjacent to thyroid WT-UMP were obtained from January 2015 to December 2016 in the First People's Hospital of Yunnan Province (hereinafter referred to as "our hospital"). In addition, 30 blocks papillary thyroid carcinoma (PTC) were obtained from the pathology department of our hospital from January to December 2016. The total proteins which were extracted from frozen thyroid samples in each group were profiled with two-dimensional electrophoresis (2-DE). The differential protein spots were identified by PDQuest 7.3 software and identified by matrix-assisted laser desorption ionization time-of-fight mass spectrometry (MALDI-TOF-MS) and SWISS-PROT database. The different proteins were classified by PANTHER analysis and five differentially expressed proteins of these spots were further validated through immunohistochemistry (IHC). Results 27 proteins were identified with MS. There were 25 high expression and 2 low level expression proteins in thyroid WT-UMP. IHC revealed the following five proteins located in the cytoplasm: cytosolic non-specific dipeptidase (CNDP2), cytokeratin 18 (CK18), cathepsin B (CTSB), calreticulin (CRT) and annexin A5 (ANXA5). Four kinds of proteins include CK18, CTSB, CRT and ANXA5 were over-expressed in thyroid WT-UMP compared with normal tissues, the difference was statistically significant (P ＜ 0.05); Meanwhile, the four proteins were over-expressed in PTC compared with thyroid WT-UMP (P ＜ 0.05). Conclusion The differentially expressed protein molecules were successfully screened and identified in thyroid WT-UMP. The changes of these proteins expression may be involved in the genesis and development of thyroid WT-UMP. The newly identified protein biomarkers can positively contribute to early thyroid WT-UMP diagnosis by using IHC.
2018 Vol. 15 (7): 60-65 [Abstract] ( 329 ) HTML (1 KB)  PDF (954 KB)  ( 306 )
66 The value of ATG16L1 and Galectin-9 in judging the activity of ulcerative colitis
WU Na LI Duo YU Yongqiang
Objective To explore the value of ATG16L1 and galectin-9 (Gal-9) in judging the activity of ulcerative colitis (UC). Methods From March 2015 to March 2016, 80 patients with UC in the First Affiliated Hospital of Hebei North University (“our hospital” for short) were selected as the observation group, and 20 patients with no intestinal disease over the same period as the control group. The UC activity was evaluated using the modified Mayo scoring system evaluation. Spearman correlation was used to analyze the correlation between the expression level of ATG16L1 gal-9 in the observation group and the Mayo score. Results The relative expression of ATG16L1 and the protein positive expression rate in the observation group were significantly lower than those in the control group (P < 0.05), and the relative expression of Gal-9 and the positive expression rate in the observation group were significantly higher than those in the control group (P < 0.05). The relative expression level and positive rate of ATG16L1 showed a significant negative correlation with Mayo score (rs=-0.78，P < 0.05；rs=-0.80，P < 0.05). The relative expression level of Gal-9 and the protein positive rate showed a significant positive correlation with Mayo score (all rs=0.81，P < 0.05). Conclusion The expression of ATG16L1 and Gal-9 is closely related to the activity of UC, which can be used as an index to judge the activity of UC.
2018 Vol. 15 (7): 66-69 [Abstract] ( 222 ) HTML (1 KB)  PDF (670 KB)  ( 166 )
70 The clinical effect of nerve intervention therapy in the treatment of short-term and long-term ischemic cerebrovascular diseases
Zuhereayi·Yahefu1 DANG Hui1 WANG Chengfeng1 CHEN Wei2▲
Objective To explore the clinical effect of nerve intervention therapy in the treatment of short-term and long-term ischemic cerebrovascular diseases. Methods One hundred and thirty-four patients with ischemic cerebr?鄄ovascular disease from March 2015 to June 2016 in People′s Hospital of Xinjiang Uygur Autonomous Region were selected and divided into control group and study group by random number table, with 67 cases in each group. The control group received routine treatment and the study group received neural neurological therapy. One month after trea?鄄tment, the incidence of recanalization, the incidence of complications, the peak systolic velocity (Vs) and end-diastolic velocity (Vd) of the patients were evaluated. The neurological deficit, life ability and the relapse and mortality of ischemic cerebrovascular disease of patients before and after treatment were assessed. Results The recanalization rate of the study group was higher than that of the control group, the total complication rate of the study group was lower than that of the control group, the difference was statistically significant (P ＜ 0.05). The Vs and Vd of the study group were lower than those of the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the scores of NIHSS were lower than before in two groups, the study group after 1, 3, 6 and 12 months treatment were lower than those of the control group, the differences were statistically significant (P ＜ 0.05). The ADL scores of the study group after 6 and 12 months treatment were lower than those of control group, the difference was statistically significant (P ＜ 0.05). The total incidence of recurrence and death of the study group were lower than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Nerve intervention therapy for patients with ischemic cerebrovascular disease can significantly improve the vascular recanalization rate and neurological function, reduce the incidence of complications in a short-term. It can significantly improve the patient's neurological function and the life ability, reduce the recurrence rate and mortality in long-term.
2018 Vol. 15 (7): 70-73 [Abstract] ( 250 ) HTML (1 KB)  PDF (663 KB)  ( 65 )
74 Relationship between respiratory symptoms level and lower extremity functional performance for patients with stable chronic obstructive pulmonary disease
WU Zhenyun NIU Mei′e HAN Yanxia QIAN Hongying ZHANG Xiuqin WANG Ling
Objective To explore the relationship between respiratory symptoms level and lower extremity functional performance for patients with stable chronic obstructive pulmonary disease（COPD）. Methods 109 patients of stable COPD outpatients in the First Affiliated Hospital of Soochow University from September 2016 to January 2017 were investigated by homemade general information questionnaire，chronic obstructive pulmonary disease assessment test (CAT), modified medical research council dyspnea scale (MMRC) and six-minute walking test(6MWT). The MMRC, CAT and six-minute walking distance (6MWD), and the correlations of variables were analyzed. Results 6MWD of patients with stable COPD was (440.97±91.55）m, and univariate analysis showed that the lower extremity functional performance was affected by age, acute attack times, course of disease and severity of disease (P < 0.01). The lower extremity functional performance was negatively correlated with the MMRC, the total scores of CAT, feeling of climbing or climbing up a layer of stairs, household activities and confidence level away from home (r < 0, P < 0.01). Hierarchical regression analysis showed that the respiratory symptoms level could influence the lower extremity functional performance of the total variation 10%. Conclusion Strengthen the management of respiratory symptoms in patients with stable COPD and reduce attack times of patients, which can help to improve lower extremity functional performance.
2018 Vol. 15 (7): 74-77,89 [Abstract] ( 236 ) HTML (1 KB)  PDF (688 KB)  ( 94 )
78 Application value of intracranial pressure monitoring in patients with acute severe craniocerebral injury
DING Jian1 SHENG Luoping2
Objective To explore the application value of intracranial pressure monitoring(IPM) in patients with acute severe craniocerebral injury (ASCI). Methods From June 2015 to October 2016, 96 patients with ASCI admitted to Department of Neurosurgery of Qingpu Branch Hospital of Zhongshan Hospital Affiliated to Fudan University were selected, and divided into study group and control group by random number table, with 48cases in each group. The control group was given routine clinical treatment, the study group was given IPM on the basis of routine treatment in the control group, and targeted treatment according to the patient's monitoring results. Follow-up was conducted for 6 months, the conditions of prognosis, use time of mannitol, dosage of mannitol and hospital stay, postoperative complications between two groups were compared. Results The conditions of prognosis in the study group was better than control group, the difference was statistically significant (P < 0.05). The use time of mannitol and hospital stay in the study group were shorter than those of control group (P < 0.05), the dosage of mannitol was lower than control group (P < 0.05). The upper digestive tract hemorrhage, electrolyte disorders and renal damage rate in the study group were lower than those of control group, the difference were statistically significant (P < 0.05). Conclusion IPM should be effective in the treatment of patients with ASCI, which can effectively reduce the use time and dosage of mannitol, shorten the length of hospital stay and reduce the incidence of postoperative complications. The safety is better, and it is worthy of clinical application.
2018 Vol. 15 (7): 78-81 [Abstract] ( 230 ) HTML (1 KB)  PDF (626 KB)  ( 129 )
82 The effect of hemoperfusion combined with hemodiafiltration treatment on expression of serum Visfatin and Ghrelin in patients with severe acute pancreatitis
JIN Yulan1 WU Xiaoliang2
Objective To investagate the effect of hemoperfusion (HP) combined with hemodiafiltration (HDF) treatment on expression of serum Visfatin and Ghrelin in patients with severe acute pancreatitis (SAP). Methods From June 2015 to June 2017, 88 patients with SAP in Dongyang Hospital of Traditional Chinese Medicine were selected, and divided into control group and observation group by random number table,with 44 cases in each group. The control group was treated with HDF method on the basis of conventional treatment, and the observation group was treated with HP combined with HDF method on the basis of conventional treatment. The serum was collected at admission, the first, seventh and fourteenth days of hospitalization. The biochemical parameters, Ghrelin, Visfatin levels between two groups were compared, and the gastrointestinal function recovery time, abdominal pain relief time and evacuation of ventilator time of two groups were compared. Results At admission, the first, seventh and fourteenth days of hospitalization, the tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), Visfatin and Ghrelin levels in both groups were all decreased gradually, the difference were highly statistically significant (P < 0.01). The TNF-α, CRP, IL-6, Visfatin and Ghrelin levels of patients in both groups on the seventh and fourteenth days of hospitalization were compared with that at admission and the first days of hospitalization, the difference were statistically significant (P < 0.05). The TNF-α, CRP, IL-6, Visfatin and Ghrelin levels in observation group on the seventh and fourteenth days of hospitalization were lower than those control group, the difference were statistically significant (P < 0.05). The gastrointestinal function recovery time, abdominal pain relief time and evacuation of ventilator time in observation group were lower than those control group, the difference were  highly statistically significant (P < 0.01). Conclusion HP combined with HDF can effectively relieve the inflammatory response in patients and reduce the expression level of visfatin Ghrelin, and the clinical effect is good.
2018 Vol. 15 (7): 82-85,102 [Abstract] ( 242 ) HTML (1 KB)  PDF (919 KB)  ( 123 )
86 The analysis of clinical and pathological multiple basal cell carcinoma of the skin
WANG Zhiwei1,2 ZHENG Deyi2 LI Weiren 3▲ LIU Li1 Han Qingling1 YAN Xiaoling1
Objective To investigate the clinical and pathological features of multiple basal cell carcinoma in Chinese population. Methods "Multiple" and "basal cell carcinoma" were used as key words, and the retrieval time was limited from November 1985 to January 2017. Relevant literatures are retrieved in the China Journal Full-text Database (CNKI), Wanfang database, Wiper database. Cases that in different journals or repeated in different forms were removed. The sex, age, course of disease, location, pathological results and prognosis of the patients with multiple basal cell carcinoma were analyzed. Results A total of 38 literatures were retrieved, and 52 cases of multiple basal cell carcinoma were found. From 1985, 3 cases, 5 cases, 19 cases and 25 cases were reported at each stage according to the division of each 8 years. The proportion of men and women was 1.26∶1, and the range of the age was from 4 to 82 years old, of which 31 cases were over 50 years old (59.6%). The median of the course of the disease was 7 years. 7 cases were engaged in outdoor work for a long time in the 16 reported occupations. 48 cases (92.3%) were located at the site of light exposure. Among the reported lesions of 51 cases, there were 25 cases with a total number of less than 5 of lesions cases. 21 cases (40.4%) of lesion accompanied by ulceration and 33 cases of nodular ulcers (63.5%) in clinical classification. 25 cases (59.5%) were entity type of the 42 cases about the pathological classification. The coincidence rate of clinical and pathological diagnosis was 69.2%. Lymph node metastasis was found in 2 cases (3.8%). 22 cases reported for treatment, 17 cases (77.3%) were excised. There were 2 cases relapsed (13.3%) , respectively in 1 and 2 years after operation in 15 cases of follow-up and prognosis patients. Conclusion Multiple basal cell carcinoma occurs at the head, neck and upper limb in the elderly. The treatment time is late, and the rate of clinical misdiagnosis, ulcer incidence, metastasis, and recurrence are high. Surgical excision is still the main treatment. Moreover, there has an increasing number of the reported cases in the near future, it should pay more attention .
2018 Vol. 15 (7): 86-89 [Abstract] ( 378 ) HTML (1 KB)  PDF (669 KB)  ( 343 )
90 Clinical application study of vacuum sealing drainage after the operation of severe acute pancreatitis
DENG Xinsheng WANG Shuai▲
Objective To investigate the application effect of vacuum sealing drainage after the operation of severe acute pancreatitis. Methods The clinical data of 71 patients with severe acute pancreatitis in Zhuozhou City Hospital  of Hebei Province from October 2014 to November 2016 were analyzed retrospectively, and they were randomly divided into experimental group and control group according to the different treatment method. In the experimental group, 36 cases were treated with vacuum sealing drainage, 35 cases in the control group were treated by routine surgical drainage. The clinical effects of the two groups were compared. Results The average length of hospital stay, feeding time and white blood cell count in experimental group were significantly lower than those in control group, the degree of wound healing was significantly better than that in control group, the difference was statistically significant (P ＜ 0.05). At the same time, the total satisfaction of patients in experimental group was 97.22%, and the control group was 80.00%, the total satisfaction of the experimental group was significantly higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The vacuum sealing drainage of patients with severe acute pancreatitis can effectively promote the recovery of patients, accelerate the healing of wounds and shorten the length of hospital stay. The prognosis of patients with acute pancreatitis is generally good, and the patient satisfaction is high, which is worthy of clinical application.
2018 Vol. 15 (7): 90-93 [Abstract] ( 209 ) HTML (1 KB)  PDF (624 KB)  ( 84 )
94 The Effects of Dexmedetomidine on hemodynamics, emergence agitation and postoperative pain in children
YUAN Zhenwu1,2 YANG Mingchang2 WANG Long1▲
Objective To observe the effects of Dexmedetomidine on hemodynamics, emergence agitation and postoperative pain in children under anesthesia. Methods A total of 60 children with tonsillectomy and adenoidectomy in Renmin Hospital of Wuhan Universiy from March 2016 to March 2017 were selected and randomly divided into Dexmedetomidine group and control group, with 30 cases in each group. Children in the Dexmedetomidine group were given the Dexmedetomidine combined with Sevoflurane for maintenance of anesthesia, and children in the control group were given the Sevoflurane only for anesthesia maintenance. The operation time, anesthesia time, extubation time and recovery time, Heart rate (HR) and mean arterial pressure (MAP) were compared between the two groups in the times that before anesthesia (T0), tracheal intubation (T1), beginning of surgery (T2), end of surgery (T3). The incidence of emergence agitation, the PAED score and FPS score were investigated in the two groups. Results There were no statistically significant difference in operation time, anesthesia time, extubation time and recovery time between the two groups (P > 0.05). HR and MAP were higher at the time T1, T2 and T3 than those at T0 in both groups and there was no statistically significant difference in HR and MAP at T0 between the two groups (P > 0.05). Compared with the control group, HR and MAP at T1 and HR at T3 in the Dexmedetomidine group were lower than those in the control group, the differences were statistically significant (P < 0.05). The incidence of emergence agitation in the Dexmedetomidine group was lower than the control group, the PAED score and FPS score were lower in the Dexmedetomidine group than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Dexmedetomidine can improve the hemodynamics, reduce emergence agitation and relieve postoperative pain in children, which increases the safety and comfort of anesthesia.
2018 Vol. 15 (7): 94-97,106 [Abstract] ( 273 ) HTML (1 KB)  PDF (852 KB)  ( 217 )
98 Effect of different concentrations of Dexmedetomidine combined with Sufentanil on cancer postoperative analgesia of elderly patients with gastric cancer in laparoscopic radical resection
DONG Haiping ZHANG Lei WANG Zhenhong
Objective To explore the analgesic effect of Dexmedetomidine combined with Sufentanil on cancer postoperative analgesia of elderly patients with gastric cancer in laparoscopic radical resection. Methods Patients with gastric cancer selected period to receive laparoscopic radical resection surgery from January to December 2016 in Shanghai Jiaotong University School of Medicine Affiliated Renji Hospital South Hospital. After the inclusion and exclusion criteria, the total of 90 patients were selected and divided into three groups according to randomized blind method, with 30 cases in each group. Control group (group S)： Sufentanil (2 g/kg) + Metoclopramide (20 mg); Dexmedetomidine group with low concentration (group D1)： Dexmedetomidine (1 μg/kg) + Sufentanil (2 g/kg) + Metoclopramide 20 mg; Dexmedetomidine group with high concentration (group D2)： Dexmedetomidine (2 g/kg) + Shufentanyl (2 g/kg) + Metoclopramide 20 mg. The degrees of pain (VAS scores) and sedation (Ramsay scores) were observed after operation of 1 (T1), 2 (T2), 6 (T3), 12 (T4), 24 h (T5) and 48 h (T6), and adverse reaction rates among these three groups were compared. Results VAS scores of three groups gradually decreased significantly at postoperative T1, T2, T3, T4, T5 and T6. VAS scores of the D1, Group D2 were significantly lower than those in group S at postoperative T2 to T6, and differences were statistically significant (P < 0.05). There were statistically significant differences that VAS scores of group D2 were apparently lower than those in group D1 at postoperative T3 to T6 (P < 0.05). Ramsay scores of three groups increased gradually at postoperative T1, T2, T3, T4, T5 and T6 with a significant difference, and Ramsay scores of group D1 and D2 were significantly higher than those in group S at postoperative T5 and T6, with statistically significant differences (P < 0.05). There were no statistically significant differences at the incidence of nausea, vomiting, sinus bradycardia, somnolence and other adverse reactions among three groups (P > 0.05), and there were no obvious respiratory depression happened. Conclusion The synergistic effect of Dexmedetomidine and Sufentanil, can significantly reduce the patients′ pain scores, and doesn’t increase the risk of respiratory depression, nausea and vomiting as well as other complications, which could be considered as a safe and effective method forpostoperative analgesia of elderly patients with gastric cancer in laparoscopic radical resection.
2018 Vol. 15 (7): 98-102 [Abstract] ( 274 ) HTML (1 KB)  PDF (535 KB)  ( 159 )
103 Application of mind mapping in prescriptions of Chinese materia medica
FU Shufei NIAN Li LIN Sheng
Mind mapping is a visual visualization tool originated in Europe. This study mainly discusses its application in the teaching and learning process of prescriptions of Chinese materia medica. By drawing the idea of individualized medication with the composition, function and indications, as well as integrating of multiple prescriptions with the syndrome differentiation system, this paper explores the importance of mind mapping in the cultivation of TCM philosophical thinking mode.
2018 Vol. 15 (7): 103-106 [Abstract] ( 328 ) HTML (1 KB)  PDF (693 KB)  ( 234 )
107 Composition principles of prescriptions for bronchial asthma in the randomized controlled clinical trials based on data mining technology
WANG Shengnan1 CHEN Yuanbin2,3 CHEN Ruifeng1 YANG Jianya1 XU Yinji3
Objective To analyze the prescription and herb rules of traditional Chinese medicines (TCMs) in the treatment of bronchial asthma in CNKI, Wanfang and CBM databases based on the Traditional Chinese Medicine inheritance support platform system. Methods The randomized controlled clinical trials of Chinese medicine prescriptions in the treatment of bronchial asthma in related databases were search and screened from inception of the databases through May, 2017, and the medication rules of TCMs for bronchial asthma were analyzed by using data mining technology. Results A total of 15 832 literatures were retrieved, and 1244 articles for the treatment of asthma with Chinese Medicine were included. A total of 510 prescriptions were about treating asthma, involving 309 kinds of herbs. Heat-asthma, cold-asthma, dual vacuity of the lung and kidney were most common syndromes, the clinical frequently used prescriptions were Xiaoqinglong Tang, Shegan-Mahuang Decoction and Dingchuan Decoction, getting 7 new prescriptions. Conclusion Composition principles of prescriptions and syndromes differentiation for bronchial asthma in the randomized controlled clinical trials is basically consistent with Internal Medicine of Traditional Chinese Medicine, the used frequently of prescriptions containing ephedra is higher in acute attack stage, Yuping-feng Powder is most used in stable phase, the new prescriptions suggest complex pathogenesis of asthma, and provide reference for treatment with asthma.
2018 Vol. 15 (7): 107-110 [Abstract] ( 293 ) HTML (1 KB)  PDF (694 KB)  ( 65 )
111 Effect of Tangbi Washout Formula in the treatment of peripheral vascular disease in patients with type 2 diabetes mellitus
LU Qiyun1 CHEN Benjian2 LIN Yuping2
Objective To observe the effect of Tangbi Washout Formula in the treatment of peripheral vascular disease in patients with type 2 diabetes mellitus. Methods Sixty patients with diabetic peripheral vascular disease treated in the Diabetes Specialist Outpatient and Ward of Guangdong Hospital of Traditional Chinese Medicine from June 2016 to June 2017 were selected as the research objects. According to a randomized, double-blind and controlled study protocol and the random number table method, they were divided into two groups. 30 cases in the treatment group were treated with basic treatment plus Tangbi Washout Formula for footbath, and 30 cases in the control group were treated with routine treatment plus placebo Chinese medicine for footbath. Among which, the basic treatment included regular hypoglycemic, antihypertensive, lipid-lowering and diet exercise therapy. All patients were followed up for 12 weeks. The TCM symptom score, quality of life scale and the levels of interleukin-6 (IL-6) and serum high-sensitivity C-reactive protein (hs-CRP) in the two groups were observed and compared before and after treatment. The experimental data was analyzed by SPSS 19.0. Results After treatment, the scores of TCM syndrome in two groups were lower than those before treatment (P ＜ 0.05), and the scores of quality of life were higher than those before treatment (P ＜ 0.05). After treatment, the score of TCM syndrome in the treatment group was lower than that of the control group (P ＜ 0.05), and the score of quality of life of the treatment group was higher than that of the control group (P ＜ 0.05). The total effective rate of the treatment group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the levels of hs-CRP and IL-6 in the treatment group were lower than those before treatment, which were also lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion Tangbi Washout Formula can effectively improve the clinical symptoms of numbness, pain, paresthesia, intermittent claudication and the quality of life in patients with diabetic peripheral vascular disease, and decrease the levels of inflammatory factors IL-6 and hs-CRP.
2018 Vol. 15 (7): 111-114 [Abstract] ( 248 ) HTML (1 KB)  PDF (643 KB)  ( 109 )
115 Treatment effect of traditional Chinese medicine combined with acupuncture on oculomotor nerve paralysis
LI Shouqing1 ZHANG Haitao2 HUANG Xudong1 WANG Jibing1▲
Objective To analyze the therapeutic effect and safety of traditional Chinese medicine combined with acupuncture on patients with oculomotor nerve palsy. Methods From January 2012 to June 2016, 80 patients with oculomotor nerve palsy treated in Weifang Eye hospital were divided into two groups by random number table, with 40 cases in each group. The control group was treated by administered acupuncture treatment, and the observation group was treated by traditional Chinese medicine combined with acupuncture treatment. With 10 days as a course of treatment, both groups were treated with 3 courses of treatment. The total effective rate, the incidence of adverse reactions as well as scores of TCM syndrome integral and quality of life were compared. Results After treatment, the total effective rate and quality of life score in the observation group were higher than those in the control group, while the TCM syndrome integral in the observation group was lower than that in the control group, with statistically significant difference (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two group (P > 0.05). Conclusion Acupuncture combined with Chinese medicine can effectively improve the clinical symptoms and quality of life of patients with oculomotor paralysis, so it is worthy of promotion.
2018 Vol. 15 (7): 115-118,122 [Abstract] ( 253 ) HTML (1 KB)  PDF (653 KB)  ( 166 )
119 Research and thinking on the construction of ancient literature database of traditional Chinese Medicine
YANG Qilin1 TIAN Sisheng1 MA Meiqing2
The construction of ancient literature database of traditional Chinese medicine is a long-term and systematic project, its principle mainly lies in standardization and standardization. This paper expounds the construction standard and application scope of ancient Chinese medicine literature database, through summarized and researched the development status of ancient Chinese literature database of traditional Chinese medicine in recent years combination with field investigation. It is found that the database construction of ancient Chinese medicine literature is generally divided into those parts: metadata processing, graph and text association, digital processing, construction of service platform, copyright maintenance and so on. To improve the database of traditional Chinese medicine literature which can make better use of database construction to develop the culture of traditional Chinese medicine, and better serve the majority of Chinese medicine scholars.
2018 Vol. 15 (7): 119-122 [Abstract] ( 273 ) HTML (1 KB)  PDF (600 KB)  ( 258 )
123 Comparative analysis of radiofrequency ablation and microwave ablation in treating benign thyroid nodules
ZHANG Xiufang LIU Jingping HU Jian MA Jinqiu
Objective To discuss the comparative values of radiofrequency ablation and microwave ablation in the treatment of benign thyroid nodules. Methods From August 2013 to January 2017, 92 patients with benign thyroid nodules in Tangshan People's Hospital were selected and divided into observation group and control group by random number table, with 46 cases in each group. The control group was treated by ultrasound guided radiofrequency ablation therapy, and the observation group was treated by ultrasound guided microwave ablation treatment. The prognosis in the two groups were recorde. Results All patients were completed the ablation successfully. After treatment, the total effective rates of the observation group and the control group were 87% and 82.6% respectively, and there was no significant difference compared between the two groups (P > 0.05). Three days after treatment, incidence rates of hepatic dysfunction in observation group and control group were 4.3% and 17.4% respectively, and the incidence of the observation group was lower than that of the control group (P < 0.05). Fourteen days after treatment, the serum TT3 and TT4 values of the observation group and the control group were significantly higher than before treatment (P < 0.05), and the values of the observation group were higher than those of the control group (P < 0.05). Three months after treatment, the total complication incidence rate in the observation group was 6.5%, 26.1% in the control group, so the observation group was significantly lower than the control group (P < 0.05). Conclusion Compares with ultrasound guided radiofrequency ablation, microwave ablation of benign thyroid nodules has good ablation effect. It can promote thyroid hormone secretion, reduce liver damage, reduce the incidence of complications, and it has very good application values.
2018 Vol. 15 (7): 123-126 [Abstract] ( 259 ) HTML (1 KB)  PDF (408 KB)  ( 176 )
127 Diagnostic value of prenatal ultrasonographic scoring system in placenta previa with placenta accreta
FU Min HAN Jiangtao▲
Objective To explore the diagnostic clinical significance of prenatal ultrasonographic scoring system in placenta previa with placenta accreta. Methods From May 2013 to April 2017, 186 pregnant women were selected in Department of Obstetrics, the First People′s Hospital of Yibin. According to the clinical and pathological results, they were divided into placenta accreta group (64 cases, placenta previa with placenta increta), non-placenta accreta group (82 cases, placenta previa without placenta accreta) and control group (40 cases, neither placenta previa nor placenta increta). Among 64 cases of placenta previa with placenta implantation, 24 cases were adhesion type, 22 cases were implanted type and 18 cases were penetrating type. The prenatal ultrasonographic scores in the groups were compared. The diagnostic value of prenatal ultrasonographic score in placenta previa with placenta increta was assessed by receiver operating characteristic curves (ROC). Results The score of prenatal ultrasonography in the placenta accreta group was higher than those in the non-placenta accreta group and the control group (P < 0.05). There was no significant difference of prenatal ultrasonography score in adhesive patients, implanted patients and the penetrating patients (P > 0.05). There were 64 cases with placenta accrete by clinical and pathological findings, and there were 60 cases with placenta accrete by prenatal ultrasonographic signs score. The diagnostic sensitivity of prenatal ultrasonographic score was 93.75% and specificity was 96.34%. The diagnostic value of prenatal ultrasonographic signs score in placenta accrete and the  ROC was 0.959. Conclusion Prenatal ultrasound imaging score has a high sensitivity and specificity for the diagnosis of placenta previa with placenta accreta, which can provide basis for clinical diagnosis and treatment.
2018 Vol. 15 (7): 127-130 [Abstract] ( 262 ) HTML (1 KB)  PDF (451 KB)  ( 176 )
131 Study on HPV subtype distribution in Dali region of yunnan province
ZHAO Lixian BI Lei YANG Xitong WANG Guangming HE Ju
Objective To understand the characteristics of human papillomavirus (HPV) infection in Dali region of yunnan province by analysis of the infection of HPV in the population of physical examination. Methods From January 2013 to November 2015, 2912 female patients received in Medical Examination Center of the First Affiliated Hospital of Dali University were selected, and divided into 13 type group (1587 cases) and 21 type group (1325 cases) according to the random number table. 13 type group was used to 13 types of high risk HPV detection by real-time PCR, 21 type group was used to type 21 HPV subtype detection by molecular hybridization, and the results of two kinds of detection techniques are compared and analyzed. Results In the 13 type group, a total of 206 cases of positive patients with 13 high-risk subtypes including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 were detected,with a positive rate of 12.98%(206/1587). In the 21 type group, 246 cases were infected with HPV, with the positive rate of 18.57% (246/1325). A total of 20 subtypes except low-risk HPV43 were detected. The most common HPV genotypes were HPV16 with the positive rate of 29.67%(73/246). Second, HPV52 subtype 21.14% (52/246) in 20 types of HPV subtypes. Conclusion The infection of HPV in Dali region, Yunnan Province, has heterogeneity. The detection rate of the two detection methods was not different, and the selection of the detection method should be selected according to the clinical needs.
2018 Vol. 15 (7): 131-134 [Abstract] ( 277 ) HTML (1 KB)  PDF (341 KB)  ( 153 )
135 Clinical teaching experience of refresher physicians majoring in cerebrovasular disease in the neurology department
XUE Sufang FAN Chunqiu SONG Haiqing▲
This paper expounds receiving access system, pre-service training, various forms of teaching way and so on, combined with the special experience of clinical education for refresher physicians majoring in cerebrovascular disease (CVD) in the neurology department of Xuanwu Hospital, Capital Medical University, in order to explore the methods and effects of clinical teaching in neurology department. It focuses on the application of the teaching model based on the combination of the cases in the three-level teaching rounds. At the same time, it emphasizes the combination of professional training lectures, difficult case discussion, self-learning ability training and continuing education learning class. Through the clinical teaching of the above comprehensive method, the refresher physicians majoring in CVD had made great progress in the standardized diagnosis and treatment of cerebrovascular disease system, and the clinical teaching effect is relatively ideal.
2018 Vol. 15 (7): 135-137,142 [Abstract] ( 237 ) HTML (1 KB)  PDF (515 KB)  ( 130 )
143 Exploration and practice of scientific research ability training for medical undergraduates
WANG Honghai1 LU Ying2 MAO Jun3
With the deepening of medical education reform, new requirements have been raised for the reform of college students' quality education and the training of innovative ability. Cultivation of scientific research ability is an important way to cultivate innovative talents. Dalian Medical University attaches great importance to scientific research ability of medical undergraduates, through the establishment of adjusting curriculum system, improving the tutorial system and open research platform, setting up extra credit and a series of reform to explore the scientific teaching mode of undergraduate medical conditions in our country, which has achieved good results. The scientific research teaching model of medical undergraduates can improve students' independent learning ability and train their innovative thinking and scientific research ability. It is an effective way to train innovative medical talents.
2018 Vol. 15 (7): 143-145,149 [Abstract] ( 280 ) HTML (1 KB)  PDF (771 KB)  ( 182 )
146 Discussion on the construction of occupational safety and health management system in medical institutions
HU Qiao PENG Minjin LIAO Hanlin ZENG Jing FU Xiangyun Chen Xinhe XIE Duoshuang LAI Ruiping
To ensure the occupational safety and health of the medical staff in China and to solve this problem systematically, the paper summarizes the occupational injury related factors at present based on literature review. The results show that the occupational injury is related with hospital environment, occupational characteristics and factors of the medical staff. So we come up with the framework and details of occupational safety and the disposalof health management system, mainly including coordination, routine guarantee, occupational exposure assessment and the disposal of follow-up. This rudiment can give medical institutions advice on establishment of occupational safety and health management system.
2018 Vol. 15 (7): 146-149 [Abstract] ( 250 ) HTML (1 KB)  PDF (492 KB)  ( 122 )
150 Reform and practice of performance distribution system of hospital medical staff in KPI examination mode
GAO Qi GUO Xin
Taking a public tertiary hospital in China as an example, this paper selects nearly 20 key indicators such as the efficiency, quality, service, medical consumable expenditures, satisfaction and so on of the development of the medical departments of the related hospitals. From the aspects of daily department management, routine biochemical projects Testing, POCT project management, clinical quality and safety, clinical satisfaction, complaint management and dispute resolution rate, medical consumables and other costs and other aspects of the establishment of a more scientific and complete three-dimensional performance appraisal system, combined with clinicians, nursing staff, medical and technical personnel workload, intensity of work, the degree of risk, the number of hours of care and other aspects of reference comparison, in order to draw the assessment of different medical personnel methods. It has certain reference and guiding significance to deepen the current public hospital performance management reform, improve the assessment examination and allocation system and improve the overall level of hospital diagnosis and treatment.
2018 Vol. 15 (7): 150-153 [Abstract] ( 290 ) HTML (1 KB)  PDF (452 KB)  ( 63 )
154 Effects of predictive nursing intervention on negative emotions and life quality in perioperative patients of hepatolithiasis complicated with cholan?鄄giocarcinoma
YANG Chunyu SUN Dan▲ YIN Dalong
Objective To explore and analyze the effects of predictive nursing intervention on negative emotions and life quality in perioperative patients of hepatolithiasis complicated with cholangiocarcinoma. Methods From April 2015 to April 2017, 90 patients with hepatolithiasis complicated with cholangiocarcinoma treated in the First Affiliated Hospital of Harbin Medical University were selected as the research subjects and divided into the observation group and the control group by random number table, with 45 cases in each group. The control group was given routine nursing and the observation group was given predictive nursing intervention. Self-rating depression scale (SDS) and the self-rating anxiety scale (SAS) were applied to assess the negative emotions of the patients. The postoperative life quality and nursing satisfaction were compared between the two groups. Results After nursing, the scores of SDS and SAS in the two groups were all lower than those of before nursing, the scores above in the observation group decreased much more remarkably, with statistically significant differences (P ＜ 0.05). After nursing, the scores of the physical function, role function, cognitive function, emotional function and social function in the two groups were all higher than those of before nursing, the scores above in the observation group increased much more remarkably, with statistically significant differences (P ＜ 0.05). The nursing satisfaction in the observation group was higher than that of control group, with statistically significant difference (P ＜ 0.05). Conclusion Predictive nursing intervention can significantly reduce the negative emotions of perioperative patients of hepatolithiasis complicated with cholangiocarcinoma. It can promote the nursing satisfaction and the life quality. It is worthy of clinical promotion and application.
2018 Vol. 15 (7): 154-157 [Abstract] ( 206 ) HTML (1 KB)  PDF (618 KB)  ( 135 )
158 Application of digital management model based on HIS system in intravenous infusion
YUAN Sanyin HAN Aihua GUO Xiaohua LIU Bo PENG Fangxing
Objective To analyze the application effect of digital management model based on HIS system in intravenous infusion. Methods From July 2015 to July 2016, 217 patients received inpatient treatment in Sichuan Mianyang 404 Hospital were selected as the control group, while 224 patients from August 2016 to August 2017 received infusion therapy in the same hospital were selected as the observation group. The control group used the conventional management mode while the observation group used the intravenous infusion management mode of digital management system based on HIS. The work efficiency of the nurses, occurrence of adverse events caused by the intravenous infusion, patients′ complaints and the nursing satisfaction were compared between the two groups. Results There were no significant differences in the nursing record time and inspection time between the two groups (P ＞ 0.05). The incidence of adverse events in the observation group was lower than that of control group, with highly statistically significant difference (P ＜ 0.01). The number of patients who complained about the infusion environment and waiting time in the observation group were significantly lower than those of control group, with highly statistically significant differences (P ＜ 0.01). There was no significant difference in the total incidence of complaints between the two groups (P ＞ 0.05). The nursing satisfaction in the observation group was higher than that of control group, with highly statistically significant difference (P ＜ 0.01). Conclusion The digital management of intravenous infusion based on HIS system is good for improving the nursing satisfaction, decline the incidence of venous transfusion adverse events and has good clinical application prospect.
2018 Vol. 15 (7): 158-161 [Abstract] ( 237 ) HTML (1 KB)  PDF (587 KB)  ( 112 )
162 The application effect of empowerment health education in orthopaedic nursing management
CHEN Xue QIN Yanguo LI Junfeng MA Li LI Jinqiu ZHONG Lili▲
Objective To explore the application effect of empowerment health education in orthopaedic nursing management. Methods From January 2015 to May 2016, 98 patients with hip fractures in the Second Hospital of Jilin University were selected and divided into the experimental group and the control group by random number table, with 49 cases in each group. The control group was given routine nursing health education and the experimental group was given empowerment health education. The Barthel index scale and the general self-efficacy scale (GSES) were applied to evaluate the activities of daily living and the general self-efficacy before operation and 3 weeks after operation. The complications were compared between the two groups during hospitalization. Results Before operation, there were no statistically significant differences in the scores of Barthel index and the GSES between the two groups (P ＞ 0.05). After operation of 3 weeks, the scores above were all higher than those of before operation, those in the experimental group were significantly higher than those of control group, with statistically significant differences (P ＜ 0.05). The incidence of complications in the experimental group was lower than that of control group, with statistically significant difference (P ＜ 0.05). Conclusion Empowerment health education can improve the general self-efficacy and daily living activity of patients with hip fracture, reduce the incidence of complications, which is conducive to promote the patient's self-management of the disease.
2018 Vol. 15 (7): 162-165 [Abstract] ( 236 ) HTML (1 KB)  PDF (588 KB)  ( 101 )
166 The application effect of inpatient blood glucose quality nursing program in non-endocrinology departments′ nurses training
NI Ping YUAN Li YANG Xiaoling
Objective To evaluate the application effect of inpatient blood glucose quality nursing program in non-endocrinology departments′ nurses training. Methods From July to August in 2016, 542 non-endocrinology departments' nurses from 10 hospitals in Sichuan province were selected as the research subjects by convenient sampling method. A 12 d hospital blood glucose quality nursing training was conducted in the form of web-based teaching. The content of training contained 4 modules such as bedside testing of blood glucose, first aid of hyperglycemia or hypoglycemia, usage of hypoglycemic agent and perioperative management of blood glucose. The scores of knowledge management and the quality rate were compared before and after training. Results After training, the scores of bedside testing of blood glucose, first aid of hyperglycemia or hypoglycemia, usage of hypoglycemic agent, perioperative management of blood glucose and the quality rate were all higher than those of before training, with statistically significant differences (P ＜ 0.05). Conclusion Inpatient blood glucose quality nursing program in nurses of non-endocrinology departments can effectively improve the blood glucose management knowledge of nurses and plays an important role in the blood glucose management in the whole hospital. It is worthy of promotion and application.
2018 Vol. 15 (7): 166-168,180 [Abstract] ( 248 ) HTML (1 KB)  PDF (632 KB)  ( 134 )
169 Application of situational teaching in feeding of infants with cleft lip and palate after operation
GUO Yuan SHU Maoguo ZHANG Jun HAN Liang SU Xin XING Qian
Objective To investigate the effects of situational teaching in feeding of infants with cleft lip and palate after operation. Methods From January 2015 to January 2017, 160 cases of infants received repair of cleft lip and palate at Department of Burn and Plastic Surgery of the First Affiliated Hospital of Xi'an Jiao Tong University were selected, and they were divided into the control group and the observation group by random number table, with 80 cases in each group. The routine postoperative feeding nursing was applied to the control group, while the situational teaching method of feeding nursing was applied to the observation group. The incidences of complications and nursing satisfaction between the two groups were compared. Results The mastery degree of feeding knowledge including feeding precautions, feeding methods and feeding time in family members of the observation group was higher than that of the control group, with statistically significant difference (P < 0.05). The feeding compliance of the observation group was 96.25%, while that of the control group was 81.25%. The compliance of the observation group was significantly higher than that of the control group, with statistically significant difference (P < 0.05). The incidence of postoperative complications in the observation group was 2.50%, while that of the control group was 11.25%. The observation group was significantly lower than the control group, with statistically significant difference (P < 0.05). The total satisfaction rate of the families of the children in the observation group was 96.25%, while the total satisfaction rate of the family members in the control group was 86.25%. The total satisfaction rate of observation group was significantly higher than the control group, with statistically significant difference (P < 0.05). Conclusion The application of situational teaching method in postoperative children with cleft lip and palate can improve family members' mastery of feeding knowledge, improve children's feeding compliance, reduce complications, and further improve their family members' satisfaction with nursing services.
2018 Vol. 15 (7): 169-172 [Abstract] ( 214 ) HTML (1 KB)  PDF (591 KB)  ( 125 )
173 The application of the comfort care in patients underwent burn and plastic surgery
LAN Fen LUO Jing CHEN Min WANG Wenjun
Objective To explore the application effect of the comfort care in patients underwent burn and plastic surgery. Methods From January to November 2016, 100 patients underwent burn and plastic surgery in Burn and Plastic Surgery Branch, the First People's Hospital in Zaoyang were selected and divided into the experimental group and the control group by random number table, with 50 cases in each group. The control group was given routine nursing care and the experimental group was given comfort care on the basis of the control group. The curative effect and the nursing satisfaction of patients between the two groups were compared. Results The incidence of clinical curative effect in the experimental group and the nursing satisfaction were all higher than those of control group, with statistically significant differences (P ＜ 0.05) Conclusion The comfort care is a comprehensive model which shows a more humanized service concept. It can improve the effect of burn and plastic surgery and promote nursing satisfaction of the patients.
2018 Vol. 15 (7): 173-176 [Abstract] ( 237 ) HTML (1 KB)  PDF (616 KB)  ( 91 )
177 Effect of evidence-based nursing on medical compliance, self-efficacy and angina attack in patients of coronary heart disease combined with angina pectoris
HU Ming HAN Yonghong
Objective To explore the effect of evidence-based nursing on medical compliance, self-efficacy and angina attack in patients of coronary heart disease combined with angina pectoris. Methods From April 2015 to April 2017, the clinical data of 100 patients of coronary heart disease combined with angina pectoris diagnosed in the Oncology Department of the Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science ti Technology were analyzed retrospectively. According to the different clinical nursing approaches given, patients were assigned into the control group and the observation group, with 50 cases in each group. The control group was given routine nursing, while the observation group was given evidence-based nursing on the basis of the control grouop. The medical compliance, self-efficacy and angina attack were compared between the two groups. Results The compliance of regular medication, balanced diet and emotions in the observation group were all better than those of control group, the score of the self-efficacy in the observation group was higher than that of control group, the incidence of angina attack was lower than that of control group, with statistically significant differences (P ＜ 0.05) Conclusion For patients of coronary heart disease combined with angina pectoris, evidence-based nursing can improve the medical compliance and self-efficacy, reduce the incidence of angina attack. Therefore, it has significant value to be popularized in clinical application.
2018 Vol. 15 (7): 177-180 [Abstract] ( 249 ) HTML (1 KB)  PDF (589 KB)  ( 142 )
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