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| Effect of different concentrations of Dexmedetomidine combined with Sufentanil on cancer postoperative analgesia of elderly patients with gastric cancer in laparoscopic radical resection |
| DONG Haiping ZHANG Lei WANG Zhenhong |
| Department of Anesthesiology, Renji South Hosptial Shanghai Jiaotong University School of Medcine, Shanghai 201112, China |
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Abstract Objective To explore the analgesic effect of Dexmedetomidine combined with Sufentanil on cancer postoperative analgesia of elderly patients with gastric cancer in laparoscopic radical resection. Methods Patients with gastric cancer selected period to receive laparoscopic radical resection surgery from January to December 2016 in Shanghai Jiaotong University School of Medicine Affiliated Renji Hospital South Hospital. After the inclusion and exclusion criteria, the total of 90 patients were selected and divided into three groups according to randomized blind method, with 30 cases in each group. Control group (group S)： Sufentanil (2 g/kg) + Metoclopramide (20 mg); Dexmedetomidine group with low concentration (group D1)： Dexmedetomidine (1 μg/kg) + Sufentanil (2 g/kg) + Metoclopramide 20 mg; Dexmedetomidine group with high concentration (group D2)： Dexmedetomidine (2 g/kg) + Shufentanyl (2 g/kg) + Metoclopramide 20 mg. The degrees of pain (VAS scores) and sedation (Ramsay scores) were observed after operation of 1 (T1), 2 (T2), 6 (T3), 12 (T4), 24 h (T5) and 48 h (T6), and adverse reaction rates among these three groups were compared. Results VAS scores of three groups gradually decreased significantly at postoperative T1, T2, T3, T4, T5 and T6. VAS scores of the D1, Group D2 were significantly lower than those in group S at postoperative T2 to T6, and differences were statistically significant (P < 0.05). There were statistically significant differences that VAS scores of group D2 were apparently lower than those in group D1 at postoperative T3 to T6 (P < 0.05). Ramsay scores of three groups increased gradually at postoperative T1, T2, T3, T4, T5 and T6 with a significant difference, and Ramsay scores of group D1 and D2 were significantly higher than those in group S at postoperative T5 and T6, with statistically significant differences (P < 0.05). There were no statistically significant differences at the incidence of nausea, vomiting, sinus bradycardia, somnolence and other adverse reactions among three groups (P > 0.05), and there were no obvious respiratory depression happened. Conclusion The synergistic effect of Dexmedetomidine and Sufentanil, can significantly reduce the patients′ pain scores, and doesn’t increase the risk of respiratory depression, nausea and vomiting as well as other complications, which could be considered as a safe and effective method forpostoperative analgesia of elderly patients with gastric cancer in laparoscopic radical resection.
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