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| The effect of hemoperfusion combined with hemodiafiltration treatment on expression of serum Visfatin and Ghrelin in patients with severe acute pancreatitis |
| JIN Yulan1 WU Xiaoliang2 |
1.Department of Intensive Medicine, Dongyang Hospital of Traditional Chinese Medicine, Zhejiang Province, Dongyang 322100, China;
2.Department of Intensive Medicine, The First Affiliated Hospital of Zhejiang University, Zhejiang Province, Hangzhou 310000, China |
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Abstract Objective To investagate the effect of hemoperfusion (HP) combined with hemodiafiltration (HDF) treatment on expression of serum Visfatin and Ghrelin in patients with severe acute pancreatitis (SAP). Methods From June 2015 to June 2017, 88 patients with SAP in Dongyang Hospital of Traditional Chinese Medicine were selected, and divided into control group and observation group by random number table,with 44 cases in each group. The control group was treated with HDF method on the basis of conventional treatment, and the observation group was treated with HP combined with HDF method on the basis of conventional treatment. The serum was collected at admission, the first, seventh and fourteenth days of hospitalization. The biochemical parameters, Ghrelin, Visfatin levels between two groups were compared, and the gastrointestinal function recovery time, abdominal pain relief time and evacuation of ventilator time of two groups were compared. Results At admission, the first, seventh and fourteenth days of hospitalization, the tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), Visfatin and Ghrelin levels in both groups were all decreased gradually, the difference were highly statistically significant (P < 0.01). The TNF-α, CRP, IL-6, Visfatin and Ghrelin levels of patients in both groups on the seventh and fourteenth days of hospitalization were compared with that at admission and the first days of hospitalization, the difference were statistically significant (P < 0.05). The TNF-α, CRP, IL-6, Visfatin and Ghrelin levels in observation group on the seventh and fourteenth days of hospitalization were lower than those control group, the difference were statistically significant (P < 0.05). The gastrointestinal function recovery time, abdominal pain relief time and evacuation of ventilator time in observation group were lower than those control group, the difference were highly statistically significant (P < 0.01). Conclusion HP combined with HDF can effectively relieve the inflammatory response in patients and reduce the expression level of visfatin Ghrelin, and the clinical effect is good.
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