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2023 Vol. 20, No. 26
Published: 2023-09-15
 
 
4 Study on vaginal microbiota in patients with missed abortion
SHI Suya BAI Huihui DU Mengyao CHENG Dongmei FAN Linyuan CHEN Suwen LIU Zhaohui
DOI: 10.20047/j.issn1673-7210.2023.26.01
Objective To analyze the vaginal microbiota of patients with missed abortion. Methods Patients attending Beijing Obstetrics and Gynecology Hospital, Capital Medical University from September 2020 to June 2021 were selected, 30 patients with missed abortion were included in the experimental group, and 30 normal early pregnancy who planned in the control group. Furthermore, the patients with missed abortion were further divided into 16 patients with normal chromosome group, six patients with abnormal chromosome group, and eight patients with unknown chromosome group according to the results of fetal villus chromosome examination. The questionnaire was filled in and the microecology detection of vaginal secretions was performed. The baseline data and vaginal microecology indexes of the four groups were compared by single factor. Meanwhile, 16S rRNA high-throughput sequencing technology was used to analyze the differences of vaginal microflora between the four groups. Results The comparison of baseline data and microecological indicators of the four groups showed that there were statistically significant differences in whether the four groups had a history of pelvic inflammatory disease, bacterial diversity, and dominant bacteria (P＜0.05), among which the proportion of patients with a history of pelvic inflammatory disease and the age of first sexual life in the chromosome abnormality group were higher than those in the control group (P＜0.05). The proportion of patients with previous abortion history was lower than that of control group (P＜0.05). The results of OTU cluster analysis showed that, compared with the missed abortion group, the number of OTUs in the control group was more, and the bacteria community was more abundant. The results of species classification analysis showed that, compared with the control group, normal chromosome group had imbalance of different lactobacillus strains (increased Lactobacillus inners, decreased Lactobacillus unclassified), and the relative abundance of other bacteria except Lactobacillus (Gardnerella, Prevotella, Escherichia-Shigella, etc.) increased. There was no significant difference in the abundance and proportion of Lactobacillus strains in the abnormal chromosome group. The results of Alpha diversity analysis showed that there were significant differences in the flora abundance among the four groups (P＜0.05). The flora abundance of the normal chromosome group was lower than that of the control group (P＜0.05), there was no difference in the flora abundance between the abnormal chromosome group and the control group (P＞0.05). The results of β-diversity analysis and line discriminant analysis effect size analysis showed that there was not significant difference in vaginal flora among the four groups (P＞0.05). Conclusion The imbalance of vaginal microflora in patients with missed abortion may be related to the decreased relative abundance of Lactobacillus and / or the imbalance in the proportion of different Lactobacillus strains and the increased relative abundance of other bacteria except Lactobacillus (Gardnerella, Prevotella, Escherichia-Shigella, etc.) in the vaginal microflora, but its direct etiology and mechanism need further study.
2023 Vol. 20 (26): 4-10 [Abstract] ( 26 ) HTML (1 KB)  PDF (1446 KB)  ( 210 )
11 Study on the medication rule of Chinese materia medica compound prescription in the treatment of spermatorrhea based on national patent
WEI Yongqiang1 GAO Zhan2 GAO Qinghe3 CHEN Haote4 LI Ming1 CHENG Pengyu1
DOI: 10.20047/j.issn1673-7210.2023.26.02
Objective To analyze the Chinese materia medica compound prescription for the treatment of spermatogenesis in the national patent database and explore the rules of drug concerted application. Methods The Chinese materia medica compound prescription patents for the treatment of spermatorrhea from January 2001 to January 2021 were retrieved from the China Patent Announcement Website, and the data were screened and input into the cloud platform of ancient and modern medical records (V2.3.5). The frequency of use, efficacy, nature, flavour, and channel tropism of the drugs in the compound prescription were analyzed statistically, and the correlation analysis, cluster analysis, and complex network analysis were carried out. Results A total of 170 compound prescription patents were included in the treatment of spermatogenesis, involving 441 kinds of Chinese materia medica. The top five commonly used high-frequency drugs were Lycii Fructus, Rehmanniae Radix Praeparata, Cuscutae Semen, Corni Fructus, Angelicae Sinensis Radix. The compound prescription drugs were mainly deficiency tonifying drugs, and the drugs with the function of tonifying liver and kidney had the highest frequency of use. The most frequently used drugs in the compound prescription were warm drugs, sweet drugs, and drugs that belong to kidney channel. There were six groups with higher frequency of use. Five groups of core drug combinations were obtained by cluster analysis. A core prescription was obtained by complex network analysis. Conclusion The national patent of Chinese materia medica compound prescription is mainly used as tonifying drugs in the treatment of spermatorrhea, which is suitable for the treatment of spermatorrhea caused by deficiency of kidney essence, deficiency of yin and blood, overstrain injuring heart and spleen, deficiency of kidney yin and deficiency of kidney yang. It has certain reference significance for clinical treatment and drug discovery.
2023 Vol. 20 (26): 11-15 [Abstract] ( 26 ) HTML (1 KB)  PDF (1350 KB)  ( 68 )
16 Study on the relationship between microRNA-142-5p and E2F7 gene and mechanism of its influence on the proliferation, invasion, metastasis of pancreatic cancer
Amutijiang·Mahemuti ZHENG Jianjiang Dixiati·Alimu
DOI: 10.20047/j.issn1673-7210.2023.26.03
Objective To investigate the relationship between microRNA-142-5P (miRNA-142-5p) and E2F7 gene and the mechanism of its influence on the proliferation, invasion, metastasis of pancreatic cancer (PC). Methods The cancer and adjacent tissues of 35 patients with PC who received surgical treatment in the People’s Hospital of Xinjiang Uygur Autonomous Region from December 2016 to January 2019 were selected. Real-time quantitative PCR was used to detect and compare the expression of miR-142-5p in cancer and adjacent tissues of PC patients. The expression of miR-142-5p in human PC cell lines (CFPAC-1, SW1990, Capan-1, PANC-1) and normal pancreatic duct epithelial cell lines (HPDE) was compared. Real-time quantitative PCR was used to detect and compare the differences of E2F7 mRNA in cancer and adjacent tissues of PC patients, the differences of E2F7 mRNA in Capan-1 and PANC-1 cells were compared, and the differences of E2F7 protein in Capan-1 and PANC-1 cells were compared by Western blot. The binding sites of miR-142-5p and E2F7 gene were predicted by Starbase database, and the miR-142-5p mimics group transfected with miR-142-5p mimics and the NC group transfected with meaningless sequences were set up, and the two groups were co-transfect E2F7 gene wild type (wt) and mutant (mut), respectively. Dual luciferase assay was used to verify the targeting relationship between miR-142-5p and E2F7 gene. The Capan-1 cells were divided into NC group, si-E2F7 group, E2F7 group, and miR-142-5p mimics+E2F7 group. CCK-8, flow cytometry, scratch assay, and Transwell assay were used to observe cell viability, apoptosis, migration, and invasion in each group. Twenty male BALB/c nude mice (4-6 weeks old) were selected to establish xeno-transplantation model of nude mice, and were divided into NC nude mice group, si-E2F7 nude mice group, E2F7 nude mice group, and miR-142-5p mimics+E2F7 nude mice group by random number table method, with five mice in each group. A total of 5×106 treated PC cells were mixed with 100 μl matrigel and injected subcutaneously into the skin below the front leg of nude mice. The four groups were killed at the 30th day after injection. The tumor volume and weight of the four groups were compared, and the tumor metastasis ability was observed by hematoxylin-eosin staining. Results The expression of miR-142-5p in cancer tissues of PC patients was lower than that in adjacent tissues, the expression of E2F7 mRNA was higher than that in adjacent tissues, and the expression of miR-142-5p in CFPAC-1, SW1990, Capan-1, and PANC-1 cells were lower than those in HPDE cells (P＜0.05). The expressions of E2F7 mRNA and protein in Capan-1 and PANC-1 cells were higher than those in HPDE cells (P＜0.05). Starbase database analysis showed that miR-142-5p was complementary to the 3’untranslated region of E2F7 gene. The results of dual luciferase reporter gene showed that after co-transfection with E2F7-wt, the luciferase activity of miR-142-5p mimics group was lower than that of NC group (P＜0.05). After co-transfection with E2F7-mut, there was no significant difference in luciferase activity between miR-142-5p mimics group and NC group (P＞0.05). The expression of E2F7 mRNA and protein, cell viability, scratch healing area, and relative number of invasive cells in E2F7 group were higher than those in NC group, and the apoptosis rate was lower than that in NC group (P＜0.05). The expression of E2F7 mRNA and protein, cell viability, scratch healing area, and relative number of invasive cells in miR-142-5p mimics+E2F7 group were lower than those in E2F7 group, and the apoptosis rate was higher than that in E2F7 group (P＜0.05). The tumor volume and weight of E2F7 nude mice group were higher than those of NC nude mice group, and the tumor volume and weight of miR-142-5p mimics+E2F7 nude mice group were lower than those of E2F7 nude mice group (P＜0.05). Hematoxylin-eosin staining showed that the tumor metastasis of E2F7 nude mice group was strong, while that of miR-142-5p mimics+E2F7 nude mice group was poor. Conclusion MiR-142-5p may affect the proliferation, migration, invasion, and apoptosis of PC cells by targeting E2F7gene.
2023 Vol. 20 (26): 16-21,42 [Abstract] ( 27 ) HTML (1 KB)  PDF (1710 KB)  ( 18 )
22 Expression of serum miR-374b-5p and VEGF-C in patients with non-small cell lung cancer and the relationship with prognosis
LI Minjie1 LIU Shuhong2 CHEN Hongyun1 YU Haiqing1
DOI: 10.20047/j.issn1673-7210.2023.26.04
Objective To investigate the expression of serum microRNA-374b-5p (miR-374b-5p) and vascular endothelial growth factor-C (VEGF-C) in patients with non-small cell lung cancer (NSCLC) and the relationship with prognosis. Methods A total of 105 patients with NSCLC admitted to Linyi Cancer Hospital of Shandong Province (hereinafter referred to as “our hospital”) from February 2018 to September 2019 were selected as NSCLC group, and 54 healthy individuals with physical examination during the same period in our hospital were control group. Serum miR-374b-5p and VEGF-C expression between two groups were detected and compared; the relationship between miR-374b-5p and VEGF-C was predicted by TargetScan database; the correlation between serum miR-374b-5p and VEGF-C expression was analyzed by Pearson correlation coefficient; the survival curves of NSCLC patients with different expression of miR-374b-5p and VEGF-C were plotted by K-M method; the influencing factors of NSCLC death were analyzed by Cox regression. Results Serum miR-374b-5p expression in NSCLC group was lower than that in control group, and VEGF-C expression was higher than that in control group, with statistical significance (P＜0.05). MiR-374b-5p and VEGF-C had binding sites in the 3’-untranslated regions of 381-388 and 585-591. Serum miR-374b-5p was negatively correlated with VEGF-C expression in NSCLC patients (r=-0.735, P＜0.01). The expression of serum miR-374b-5p and VEGF-C of NSCLC patients with different differentiation degrees, TNM stages, and lymph node metastasis were statistically significant (P＜0.05). The survival curves of NSCLC patients with different expression of  miR-374b-5p and VEGF-C were significantly different (P＜0.05). TNM stage Ⅲ, lymph node metastasis, and increased VEGF-C were independent risk factors for NSCLC death (HR=3.195, 4.212, 1.102, P＜0.05), and miR-374b-5p was independent protective factor (HR=0.988, P＜0.05). Conclusion The expression of miR-374b-5p is low and expression of VEGF-C is high in serum of NSCLC patients, and it is related to differentiation degree, TNM stage, lymph node metastasis, and prognosis.
2023 Vol. 20 (26): 22-26 [Abstract] ( 27 ) HTML (1 KB)  PDF (869 KB)  ( 78 )
27 Construction and validation of the nomogram model for risk prediction of mild cognitive impairment in patients with chronic heart failure
WANG Juanjuan1 XU Xiaoming2 LIU Ning2 NING Bin1 DUAN Yongli1
DOI: 10.20047/j.issn1673-7210.2023.26.05
Objective To construct and validate a risk nomogram model for mild cognitive impairment (MCI) in patients with chronic heart failure (CHF). Methods A total of 309 CHF patients in the Department of Cardiovascular Fuyang People’s Hospital of Anhui Province (hereinafter referred to as “our hospital”) from January to September 2021 were selected as the modeling group. From October to December 2021, 52 patients with CHF in the Department of Cardiovascular of our hospital were selected as the external validation group. Single and multi-factor analysis was used to explore the influencing factors, a prediction model, was built and internal and external verification were carried out. Results Age, education level, Pittsburgh sleep quality index scores were the influencing factors of MCI in CHF patients (OR＞1, P＜0.05). Internal verification showed that AUC=0.840, Youden index =0.480, sensitivity was 0.730, specificity was 0.750, and the model fit and prediction ability were good. External verification showed that AUC=0.876, Youden index =0.684, sensitivity was 0.743, specificity was 0.941, and H-L test P=0.448. Conclusion The incidence of MCI in CHF patients is 64.8%. Age, education, Pittsburgh sleep quality index scores and Frail scores are risk factors. This model could provide reference for assessing the risk of MCI in CHF patients.
2023 Vol. 20 (26): 27-32 [Abstract] ( 27 ) HTML (1 KB)  PDF (1010 KB)  ( 50 )
33 Study on the therapeutic effect and mechanism of Pingxuan Formula on cervical spondylotic arteriopathy model SD rats
WANG Yixuan1 PENG Nan2 XIAO Jingjing1 LI Tenglong1▲ LI Lu1
DOI: 10.20047/j.issn1673-7210.2023.26.06
Objective To investigate the effects of Pingxuan Formula on hemorheology, plasma endothelin (ET), and serum nitric oxide (NO) expression levels, and the medial membrane thickness of the vertebral artery wall in the rat model of vertebral arterial cervical spondylosis. Methods According to random number table method, 60 SPF SD rats were divided into normal group, model group, Flunarizine group, Pingxuan Formula low, medium, and high dose groups, with ten rats in each group. In addition to the normal group, the rats with vertebral artery type cervical spondylosis were established by modified hardener molding method. After four weeks of modeling, the Pingxun Formula low, medium, and high dose groups were given oral administration of concentrated liquid of Pingxun Formula 7.8, 15.6 and 31.2 g/kg, respectively, and the Fluunarizine group was given oral administration of Fluunarizine Hydrochloride Capsules 0.9 mg/kg, respectively. The normal group and model group were not treated. After two weeks of drug treatment, the blood flow of the vertebral artery, hemorheology indexes (whole blood viscosity, plasma viscosity, whole blood low/high shear relative index, red blood cell aggregation index), plasma ET, and serum NO levels, and the medial membrane thickness of the vertebral artery wall were measured in each group. Results Compared with the normal group, the average blood flow velocity of the vertebral artery in the model group was decreased, the pulsation index and resistance index of vertebral were increased, and the indexes of hemorheology were increased, the plasma ET content was increased, the plasma NO content was decreased, and the middle membrane thickness of the vertebral artery wall was increased, with statistical significance (P＜0.05). Compared with model group, the average blood flow velocity, pulse index and resistance index of vertebral artery were increased, the indexes of hemorheology were decreased, the plasma ET content was decreased, the plasma NO content was increased, and the middle membrane thickness of vertebral artery wall was decreased, with statistical significances (P＜0.05). Conclusion Pingxuan Formula effectively improve the vertebral artery blood flow and blood viscosity, relieve vasospasm and inhibit the proliferation of vascular smooth muscle cells in the model rats with cervical spondylotic arteriopathy, which maybe one of the mechanisms of Pingxuan Formula in treating cervical spondylotic arteriopathy in rats.
2023 Vol. 20 (26): 33-37 [Abstract] ( 28 ) HTML (1 KB)  PDF (1679 KB)  ( 27 )
38 Research progress of SPRY2 gene in cell phenotype
MEI Qijie1　HU Qi2　XU Wenfei1　GUO Jinrong1　LI Chongming2　ZHANG Jiuyi2　YUAN Changshen1　DUAN Kan1▲
DOI: 10.20047/j.issn1673-7210.2023.26.07
As an important messenger RNA, SPRY2 is involved in the pathological process of many diseases, plays a key role in maintaining cell homeostasis, and is even considered as a potential therapeutic target for studying cancer pathogenesis. Although SPRY2 has been extensively and deeply studied in many diseases, there is no systematic report on its role in cell phenotype. The research status and dynamic analysis of SPRY2 showed that it is specific in cell proliferation, apoptosis, migration, invasion, autophagy, epithelial mesenchymal transformation, and angiogenesis. Especially on cell proliferation, it provides ideas for SPRY2 follow-up research.
2023 Vol. 20 (26): 38-42 [Abstract] ( 20 ) HTML (1 KB)  PDF (609 KB)  ( 83 )
43 Research progress on molecular mechanism of macrophage polarization in atherosclerosis
PENG Chaojie WU Linke WU Hong
DOI: 10.20047/j.issn1673-7210.2023.26.08
Macrophages are one of the important immune cells in the development of atherosclerosis, and their phenotype and function play an important role in the occurrence and development of atherosclerosis. M1-type macrophages, by destroying their mitochondrial function, promote glycolysis and the release of reactive oxygen species, interfere with the balance of lipid metabolism of macrophages, maintain and expand the inflammatory response, and reduce the ability of macrophages to eliminate phagocytic necrotic cells. Accelerate the formation of necrotic cores and the occurrence of unstable plaque rupture. M2 type macrophages can maintain the normal respiratory function of mitochondria, promote oxidative phosphorylation metabolism, enhance intracellular lipid outflow, reduce inflammatory reaction, repair damaged tissues, clean necrotic cells, maintain plaque stability, and inhibit the progression of atherosclerosis. At present, the drugs used to prevent and treat atherosclerosis also show the potential to regulate the polarization of macrophages. Therefore, to further explore and summarize the molecular mechanism and effective target of regulating macrophage polarization in the pathological process of atherosclerosis is the potential direction of in-depth research on effective measures to prevent and treat atherosclerosis.        
2023 Vol. 20 (26): 43-46,50 [Abstract] ( 52 ) HTML (1 KB)  PDF (551 KB)  ( 175 )
47 Research progress in the application of metabolic glutamate receptor 5 positron emission tomography in neuropsychiatric diseases
ZHANG Linyue1 HUANG Qi2 HUA Fengchun1▲
DOI: 10.20047/j.issn1673-7210.2023.26.09
Metabolic glutamate  receptors 5 (mGluR5) play an important role in neuropsychiatric diseases, positron emission tomography (PET) can noninvitatively assess mGluR5 changes in nervous system diseases at the in vivo molecular level. In order to further explore the changes and pathological mechanism of mGluR5 in neuropsychiatric diseases, this paper reviews the molecular mechanism of mGluR5 and the application of PET in Alzheimer’s disease, Parkinson disease, epilepsy, mental diseases, and sleep and arousal, etc., in order to provide guidance for the experimental research and clinical application of mGluR5 imaging.
2023 Vol. 20 (26): 47-50 [Abstract] ( 17 ) HTML (1 KB)  PDF (464 KB)  ( 61 )
51 Research progress on the antipruritic effect of qūchí and xuèhǎi acupoint pair
LI Jiquan1 WANG Wei1 DAI Jianyu1 MA Tieming1 LI Sijia2
DOI: 10.20047/j.issn1673-7210.2023.26.10
Acupuncture and moxibustion has a definite antipruritic effect, but due to many diseases involved, the selection of acupoints is diverse and the use of acupoints is complex. With the key symptom of “skin itching” as the main concern, this paper clarifies that “disharmony between nutrient qi and defensive qi” is the common pathogenesis of itching. Combined with the high-frequency use of acupuncture points to stop itching, it is believed that the prescription composed of qūchí and xuèhǎi acupoint pair is the basic formula for acupuncture to “harmonize yingfen and weifen” to play an antipruritic effect. From the perspective of clinical research, it fully demonstrates the universal applicability of qūchí and xuèhǎi acupoint pair to the antipruritic effect, further summarizes the research progress of qūchí and xuèhǎi acupoint pair on the antipruritic effect mechanism, and believes that the evidence-based medical evidence of acupuncture antipruritic effect should be improved in the future, while deepening the mechanism research of antipruritic effect.
2023 Vol. 20 (26): 51-54 [Abstract] ( 21 ) HTML (1 KB)  PDF (582 KB)  ( 113 )
55 Analysis of influencing factors of subjective cognitive decline in community elderly population
GU Huaicong WANG Weiqiang DONG Yaqin
DOI: 10.20047/j.issn1673-7210.2023.26.11
Objective To explore the influencing factors of subjective cognitive decline (SCD) in community elderly population. Methods A total of 603 people in the Yongqiao neighborhood Dongguan Street Community in Suzhou City, Anhui Province were selected as the research object by convenient sampling method in December 2020. They were divided into the normal control group with the score ＜five scores and the SCD group with the score ≥five scores. The general information of the people in the Yongqiao district was collected, such as name, sex, age, height, weight, body mass index, education level, annual household income, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL) values, TG/HDL ratio, TC/HDL ratio, LDL/HDL ratio, and non-high-density lipoproteins were also converted. Univariate and multivariate logistic regression models were used to analyze the relevant influencing factors in patients with SCD. Results Among the 603 people tested in the community, 395 cases (65.51%) had subjective cognitive decline. Univariate analysis showed that there were statistically significant differences in age, sex, smoking status, drinking status, education level, family annual income, HDL, TC/HDL, and LDL/HDL between the two groups (P＜0.05). Logistic regression analysis showed that gender, age, smoking, drinking, and TC/HDL ratio were risk factors for subjective cognitive decline (OR＞1, P＜0.05), and LDL/HDL ratio was protective factor for subjective cognitive decline (OR＜1, P＜0.05). Conclusion In the elderly population in the community, the prevalence of SCD is high, and there is a correlation between gender, age, smoking, drinking, education, family income, HDL, TC/HDL ratio, LDL/HDL ratio, and SCD. Reasonable intervention should be carried out as soon as possible in the population with risk factors of SCD to delay the development of dementia.
2023 Vol. 20 (26): 55-59,99 [Abstract] ( 22 ) HTML (1 KB)  PDF (766 KB)  ( 169 )
60 Investigation on the relationship between quality of life and nutritional status and dietary structure in maintenance peritoneal dialysis patients
ZONG Jing XIA Li YUE Ping▲
DOI: 10.20047/j.issn1673-7210.2023.26.12
Objective To investigate the dietary outcomes of patients with maintenance peritoneal dialysis (PD) and to analyze the relationship between quality of life and nutritional status. Methods Convenience sampling method was used to select 85 PD patients who met the inclusion and exclusion criteria in the Department of Nephrology, Huaian First Hospital Affiliated to Nanjing Medical University (hereinafter referred to as “our hospital”) from January 2021 to January 2022 as the objects of this investigation. Patients’ quality of life and nutritional status were investigated by kidney disease quality of life short form 1.3 (KDQOL-SFTM1.3) and patient-generated subjective global assessment (PG-SGA), respectively. Meanwhile, patients’ dietary structure, demographic data and nutrition-related biochemical indicators were investigated by self-made questionnaires, and the correlation between quality of life and nutritional status of PD patients was analyzed. Results The diets of 80 PD patients were mainly soups, grains and beans, eggs and milk, marinated and fried, and fast food, but the frequency of consumption was low. PG-SGA≥4 points in 51 cases (63.75%); KDQOL-SFTM1.3 renal and dialysis-related quality of life and general health-related quality of life, the average scores of the two scales were (62.34±6.46) points, which was in the medium and low level. There were significant differences in dialysis duration, blood urea nitrogen (BUN), parathyroid hormone (PTH), calcium, phosphorus, kidney disease-targeted areas (KDTA) scores, and 36-item fhort form health survey (SF-36) scores among the three groups (P ＜ 0.05). KDTA score, SF-36 score, ALB, TC, Scr were negatively correlated with mild to moderate malnutrition group (P＜0.05). KDTA score, SF-36 score, ALB, TC, Scr, and dialysis time were negatively correlated with severe malnutrition group (P＜0.01). Conclusion The nutritional status and quality of life of PD patients are both at a low level, and the two are negatively correlated. Therefore, nursing staff should formulate a rational diet plan based on the dietary structure and nutritional status of patients, so as to improve the clinical outcome of PD patients.
2023 Vol. 20 (26): 60-63 [Abstract] ( 26 ) HTML (1 KB)  PDF (634 KB)  ( 144 )
64 Investigation of Legionella contamination in artificial water environment of public places and identification of disease prototypes in Yantai City
ZHU Dongnan1 DONG Zhaojing1 WANG Songsong1 HOU Chunmei2 WANG Yanqing1
DOI: 10.20047/j.issn1673-7210.2023.26.13
Objective To analyze the Legionella contamination in artificial water environment of public places in Yantai City Shandong Province, and identification of its pathogenic type. Methods A total of 150 samples of artificial water environment in public places in Yantai City, Shandong Province from January to December 2019 were selected as the research objects, and the detection rate of Legionella was statistically analyzed, and the types of Legionella detected were statistically compared. Meanwhile, the detection situation of Legionella in different water samples, places, total number of colonies, seasons and locations were analyzed and compared. Results Among 150 samples from artificial water environment in public places, 43 were detected with a detection rate of 28.67%, 40 were detected with single type, and 3 were detected with mixed type. The detection rate of Legionella haemophilus was significantly higher than that of non-haemophilus Legionella, and the proportion of Lp1 type was higher than that of other types, and the proportion of single type was higher than that of mixed condition, and the differences were statistically significant (P＜0.05). There was no statistical significance in the detection rate of Legionella in samples of different total colonies (P＞0.05), while the detection rate of Legionella in samples of air conditioning cooling water, medical units, summer, and suburban water were higher than those of other water samples, places and seasons, and the differences were statistically significant (P＜0.05). Conclusion In the artificial water environment of public places in Yantai City, Legionella contamination was prominent, with a high proportion of single types, and the detection rate of Legionella is relatively higher in air conditioning cooling water, medical units, summer, and suburban water samples, and there are great differences in the detection situation of different water samples, number of places and seasons, which can be used as a reference for formulating intervention and prevention and control measures.
2023 Vol. 20 (26): 64-67 [Abstract] ( 23 ) HTML (1 KB)  PDF (533 KB)  ( 159 )
68 Relationship between climatic and environmental factors and the incidence of acute myocardial infarction in Yancheng area
WANG Qingli CAO Jingyan▲
DOI: 10.20047/j.issn1673-7210.2023.26.14
Objective To analyze the relationship between the incidence of acute myocardial infarction (AMI) and climatic factors in Yancheng area. Methods The case data of 998 AMI patients admitted to Jiangsu Province Yancheng area (four tertiary hospitals: Yancheng First People’s Hospital, Yancheng Third People’s Hospital, Dongtai People’s Hospital, Jianhu County People’s Hospital and three secondary hospitals: Funing County People’s Hospital, Sheyang People’s Hospital，Xiangshui County People’s Hospital) from March 2018 to January 2022 were collected. Meteorological data came from Yancheng City, Jiangsu Province. Meteorological data were continuously collected on the day, the previous one day, and the previous two day during the study period when AMI occurred frequently. Logistic multivariate regression analysis was used to analyze the relationship between the incidence of AMI and meteorological factors. Results During the study period, the frequent days of AMI were 148 days (10.13%), and the infrequent days were 1 313 days (89.87%). The proportion of inpatients with AMI in winter and spring was higher than those in summer and autumn (P＜0.05). The average daily temperature and average wind speed in the two days before the AMI frequent occurrence day were higher than those of the non-frequent AMI occurrence(P＜0.05), and the average relative humidity was lower than that of the non-frequent AMI occurrence day (P＜0.05). Logistic multivariate analysis results showed that the average daily temperature (OR=3.418, 95%CI: 1.206-8.759), the average wind speed (OR=2.857, 95%CI: 1.186-7.436), the average relative humidity (OR=3.159, 95%CI: 1.054-8.035) were all influence factors affecting the incidence of AMI (P＜0.05). Conclusion The incidence of AMI has a certain correlation with meteorological factors of average daily temperature, average wind speed and average relative humidity.
2023 Vol. 20 (26): 68-71,81 [Abstract] ( 30 ) HTML (1 KB)  PDF (549 KB)  ( 40 )
72 Effect of left bundle branch pacing and right ventricular septal pacing in the treatment of atrioventricular block
HU Qin LIANG Jie ZHOU Feng JI Cheng LIU Jinbo HAN Weiwei▲
DOI: 10.20047/j.issn1673-7210.2023.26.15
Objective To investigate the effect of left bundle branch pacing and right ventricular septal pacing in the treatment of atrioventricular block. Methods One hundred and twenty-one patients with atrioventricular block treated from June 2020 to June 2021 in Shijiazhuang People’s Hospital were selected, and a total of 88 cases were enrolled after screening. They were divided into control group and study group by random number table method, with 44 cases in each group. The control group was given right septal pacing and the study group was given left bundle branch regional pacing. The cardiac function indexes, including left atrial anterior posterior diameter, left ventricular short axis shortening rate, left ventricular ejection fraction, brain natriuretic peptide (BNP) index, and QRS wave group width, and the occurrence of adverse effects in the two groups were compared. Results Three months after surgery, left ventricular short axis shortening rate, left ventricular ejection fraction in the two groups were higher than those before surgery, and left atrial anterior and posterior atrial diameter was lower than those before surgery, and left ventricular short axis shortening rate, left ventricular ejection fraction in study group were higher than those of control group, and left atrial anterior and posterior atrial diameter were lower than those of control group (P＜0.05). Three months after operation, BNP levels in two groups were lower than those before operation, QRS wave widths were longer than those before operation, BNP in study group was higher than that of control group, QRS wave width was shorter than that of control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Compared with pacing in the right ventricular septum, the left bundle branch region pacing has less effect on cardiac function in patients with atrioventricular block, especially in patients with preoperative heart dysfunction, pacing in the left bundle branch region has more obvious improvement in cardiac function than pacing in the right ventricular septum region, and has significant clinical effect and effectively reduces the occurrence of adverse reactions, which is worthy of clinical promotion and application.
2023 Vol. 20 (26): 72-75 [Abstract] ( 25 ) HTML (1 KB)  PDF (553 KB)  ( 48 )
76 Evaluation of efficacy and safety of left bundle branch pacing and traditional right ventricular pacing in patients with atrioventricular block
CHEN Liangchuan XU Lu ZHU Xianguan XIANG Xuejun ZHENG Yuanxi QIAO Rui▲
DOI: 10.20047/j.issn1673-7210.2023.26.16
Objective To compare the efficacy and safety of left bundle branch pacing and conventional pacing in patients with atrioventricular block. Methods A total of 174 patients with atrioventricular block who were admitted to the Department of Cardiology, Anqing Hospital, Anhui Medical University and underwent cardiac pacemaker implantation from January 2020 to June 2021 were selected as the research objects. The patients were divided into the traditional right ventricular pacing group (right ventricular apex pacing) and the left bundle branch pacing group (left bundle branch pacing) according to random number table method, with 87 cases in each group. Left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), serum brain natriuretic peptide (BNP), pacing parameter threshold, impedance, perception, and QRS duration were compared between the two groups during operation, 1 month, and 12 months after surgery. The left ventricle 12 segments  Ts standard deviation (Tsd-12-LV) and the difference between left ventricular lateral wall base segments and right ventricular free wall base systolic velocity peak time（Ts） (Ts-LV-RV), left ventricular filling time(LVFT) and RR interval ratio (LVFT/RR), as well as operation time, radiation exposure time, radiation dose, and patient complications. Results LVEDD and BNP levels in traditional right ventricular pacing group 12 months after surgery were higher than those before surgery and one month after surgery, and the differences were statistically significant (P＜0.05); BNP level in left bundle branch pacing group 12 months after operation was lower than that in traditional right ventricular pacing group, and the difference was statistically significant (P＜0.05). There were statistically significant differences in threshold comparison between two groups at different points, and the perceptual ability 12 months after surgery was higher than that during surgery and one month after surgery, the differences were statistically significant (P＜0.05); the duration of QRS wave in left bundle branch pacing group during operation, 1 month and 12 months after operation were lower than that in traditional right ventricular pacing group during the same period, and the differences were statistically significant (P＜0.05). The Tsd-12-LV, Ts-LV-RV, and LVFT/RR values of the two groups 12 months after surgery were lower than those before surgery, and the differences were statistically significant (P＜0.05); the LVFT/RR in the traditional right ventricular pacing group at 12 months after surgery was lower than that at one month after surgery, and the difference was statistically significant (P＜0.05). The Ts-LV-RV value and LVFT/RR value in the left bundle branch pacing group at 12 months after surgery were lower than those at one month after surgery, and the differences were statistically significant (P＜0.05). Tsd-12-LV, Ts-LV-RV, and LVFT/RR in left bundle branch pacing group were lower than those in traditional right ventricular pacing group at 12 months after surgery, and the differences were statistically significant (P＜0.05). The Ts-LV-RV value in left bundle branch pacing group was lower than that in traditional right ventricular pacing group one month after operation, and the differences were statistically significant (P＜ 0.05). The operation time and radiation exposure time in the left bundle branch pacing group were longer than those in the traditional right ventricular pacing group, and the radiation dose was higher than that in the traditional right ventricular pacing group, the differences were statistically significant (P＜0.05). The incidence of complications in the left bundle branch pacing group was lower than that in the traditional right ventricular pacing group, and the difference was statistically significant (P＜0.05). Conclusion Left bundle branch pacing is better than traditional pacing in reducing the threshold level of atrioventricular block, and the QRS wave is stable. Left bundle branch pacing can avoid the deterioration of cardiac function, maintain normal left ventricular synchrony, and is safe.
2023 Vol. 20 (26): 76-81 [Abstract] ( 23 ) HTML (1 KB)  PDF (738 KB)  ( 37 )
82 Effect of psychological distress on sleep quality in patients with multiple myeloma during chemotherapy
JIA Lei1 WEN Xiaoyu2
DOI: 10.20047/j.issn1673-7210.2023.26.17
Objective To analyze the effect of psychological distress on sleep quality in patients with multiple myeloma (MM) during chemotherapy. Methods A total of 100 MM patients who received chemotherapy in West China Hospital of Sichuan University from July 2020 to December 2021 were retrospectively collected and analyzed. All patients were evaluated by the degree of psychological distress (Kessler psychological distress scale [K10]) and sleep quality (Pittsburgh sleep quality index scale [PSQI]) after three courses of chemotherapy. The sleep quality of patients with different data characteristics and psychological distress was compared, and the relationship between psychological distress and sleep quality was analyzed by Spearman bivariate correlation. The effect of psychological disturbance on sleep quality was analyzed by linear regression. Results After three courses of chemotherapy, the average PSQI score of 100 patients was (9.02±2.37) points. The average K10 score was (25.60±6.76) points, among which 14, 29, 38, and 19 cases had low, lower, high, and higher degree of psychological distress, respectively. The total PSQI scores of patients with different age, disease ISS stage, education level and psychological distress were statistically significant (P＜0.05). Spearman bivariate correlation analysis showed that the degree of psychological distress of MM patients during chemotherapy was positively correlated with the total score of PSQI (rs=0.515, P＜0.05). Multiple linear regression analysis showed that age and degree of psychological distress were related to sleep quality of MM patients during chemotherapy (B=1.089, 1.353, P＜0.05). Conclusion The more serious the psychological distress of MM patients during chemotherapy, the worse their sleep quality. In order to improve their sleep quality and life quality, targeted measures should be taken to alleviate the psychological distress of MM patients and improve their sleep quality.
2023 Vol. 20 (26): 82-85 [Abstract] ( 23 ) HTML (1 KB)  PDF (599 KB)  ( 203 )
86 Analysis of influencing factors of death in patients with autoimmune encephalitis
LI Yimeng WANG Yaoyao SUN Yidi LIAN Yajun CHENG Xuan
DOI: 10.20047/j.issn1673-7210.2023.26.18
Objective To investigate the influencing factors of death in patients with autoimmune encephalitis (AE). Methods Clinical data of 202 patients diagnosed with AE in the First Affiliated Hospital of Zhengzhou University from August 2015 to December 2021 were collected. The patients completed at least six months of follow-up, and were divided into death group (47 cases) and survival group (155 cases) according to their survival during follow-up. The modified Rankin scale (mRS) and clinical assessment scale for AE (CASE) were used to assess the severity of the disease at admission. The clinical data of the two groups were compared, and the influencing factors of death in AE patients were analyzed by logistic regression model. Results There were statistically significant differences in age, seizure, consciousness level, mechanical ventilation, intensive care unit (ICU) admission, deep vein thrombosis, complicated tumor, number of complications, antibody type, mRS score, CASE score, neutrophil/lymphocyte ratio, and monocyte/lymphocyte ratio between the two groups (P＜0.05). Univariate logistic regression analysis showed that age, seizure, consciousness level, mechanical ventilation, ICU admission, deep vein thrombosis, complicated tumor, number of complications, antibody type, mRS score, and CASE score were all influencing factors of death in AE patients (P＜0.05). Further multivariate logistic regression analysis showed that old age, complicated tumor, multiple complications, antibody type γ-aminobutyric acid B-receptor antibody, and CASE score ≥ 10 points on admission were all independent risk factors for death in AE patients (OR＞1, P＜0.05). Conclusion The prognosis of AE patients is affected by many factors such as age, comorbidities, antibody type, etc. Physicians should pay special attention to it in clinical work.
2023 Vol. 20 (26): 86-90 [Abstract] ( 25 ) HTML (1 KB)  PDF (591 KB)  ( 26 )
91 Relationship between the expression of miR-125a-3p and miR-224-3p in serum and carotid atherosclerotic plaque in patients with cerebral infar-ction
LI Xing LIU Jingfeng LI Bo
DOI: 10.20047/j.issn1673-7210.2023.26.19
Objective To investigate the relationship between the expression of miR-125a-3p and miR-224-3p in serum and carotid atherosclerotic (CAS) plaque in cerebral infarction. Methods A total of 120 patients with cerebral infarction admitted to Beijing Hepingli Hospital from March 2019 to December 2021 were selected and divided into unstable group (75 cases) and stable group (45 cases) according to their CAS plaque stability. Clinical data of the two groups were collected and compared, and the expression of miR-125a-3p and miR-224-3p in serum of the two groups was detected by real-time fluorescent quantitative PCR. The influencing factors of CAS instability in patients with cerebral infarction were analyzed by logistic regression model, and the predictive value of CAS plaque plaque stability in patients with cerebral infarction was further analyzed by receiver operation characteristic (ROC) curve. Results The proportion of smokers, the proportion of diabetic mellitus patients, the level of low-density lipoprotein cholesterol (LDL-C), and the expression of miR-125a-3p in unstable group were higher than those in stable group, and the expression of miR-224-3p was lower than that in stable group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that smoking, diabetes mellitus, LDL-C, miR-125a-3p, and miR-224-3p were all influencing factors of CAS plaque instability in patients with cerebral infarction (P＜0.05). The area under the ROC curve of the five items combined to predict CAS plaque instability in patients with cerebral infarction was 0.915, and the sensitivity and specificity were 84.00% and 91.11%, respectively. Conclusion Serum miR-125a-3p and miR-224-3p levels in patients with cerebral infarction are associated with CAS plaque instability, which can be predicted by combining smoking, diabetes mellitus, and LDL-C.
2023 Vol. 20 (26): 91-95 [Abstract] ( 28 ) HTML (1 KB)  PDF (636 KB)  ( 164 )
95 Effects of low-frequency repetitive transcranial magnetic stimulation on cognitive function and P300 potential in patients with traumatic brain injury
ZHAI Jiajia XU Qian HAN Zhenzhen HU Zhenni WANG Liang GUO Guanlan LU Hongjian▲
DOI: 10.20047/j.issn1673-7210.2023.26.20
Objective To investigate the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on cognitive function and P300 potential in patients with traumatic brain injury (TBI). Methods A total of 50 TBI patients hospitalized in the Department of Neurosurgery and Rehabilitation Medicine, Nantong First People’s Hospital of Jiangsu Province from December 2019 to June 2021 were selected, and they were divided into experimental group and control group, with 25 cases in each group according to the random number table method. Both groups received clinical basic treatment and conventional cognitive function training, and the experimental group was supplemented with low-frequency rTMS treatment, while control group was given sham stimulation treatment, continuous treatment for six weeks. The mini-mental state examination (MMSE) score, Loewenstein occupational therapy cognitive assessment (LOTCA) score, and P300 amplitude and latency were compared before and after treatment, the occurrence of adverse reactions during treatment was observed. Results After treatment, the scores of orientation, memory, recall, attention and computation, language ability, and MMSE total score of two groups were higher than those before treatment, and the scores of orientation, attention and computation, and MMSE total score of experimental group were higher than those of control group, and the differences were statistically significant (P＜0.05). After treatment, the scores of orientation, visual perception, spatial perception, motor use, visual motor organization, thinking operation, attention and concentration, and LOTCA total score in two groups were higher than those before treatment, and those of experimental group were higher than those of control group, and the differences were statistically significant (P＜0.05). After treatment, P300 amplitude was larger than that before treatment, and latency was shorter than that before treatment, and P300 amplitude in experimental group was higher than that in control group, and latency was shorter than that in control group, and the differences were statistically significant (P＜0.05). There were no adverse reactions such as epilepsy during treatment in both groups. Conclusion Low-frequency rTMS can significantly improve the cognitive function in patients with TBI, which is worthy of clinical application and promotion. P300 can objectively reflect the effect of rTMS on cognition function.
2023 Vol. 20 (26): 95-98 [Abstract] ( 30 ) HTML (1 KB)  PDF (689 KB)  ( 32 )
100 Therapeutic effect of Jieyu Qingxin Decoction combined with ultra-low frequency transcranial magnetic stimulation on Parkinson disease with depression of liver stasis and blood deficiency type
XIANG Shang ZHOU Tao WANG Yequn HONG Liang FANG Wujie
DOI: 10.20047/j.issn1673-7210.2023.26.21
Objective To explore the therapeutic effect of Jieyu Qingxin Decoction combined with ultra-low frequency transcranial magnetic stimulation on Parkinson disease with depression of liver stasis and blood deficiency type. Methods A total of 135 patients with Parkinson disease with depression of liver stasis and blood deficiency type admitted to Lu’an Traditional Chinese Hospital of Lu’an in Anhui Province from June 2020 to April 2022 were selected as subjects, and they were divided into control group 1, control group 2, and observation group by random number table method, with 45 cases in each group. The control group 1 was treated with conventional treatment+ultra-low frequency transcranial magnetic stimulation, the control group 2 was treated with conventional treatment+Jieyu Qingxin Decoction treatment, and the observation group was treated with conventional treatment+Jieyu Qingxin Decoction+ultra-low frequency transcranial magnetic stimulation treatment, four weeks for one course, treatment of three courses. The clinical efficacy was compared; and the scores of the unified Parkinson disease rating scale (UPDRS), Montgomery-Asberg depression rating scale (MADRS), the traditional Chinese medical syndrome score before and after treatment were compared; the occurrence of adverse reactions during the treatment were observed. Results The clinical efficacy of observation group was better than that of control group 1 and control group 2 (P＜0.05). After treatment, the scores of UPDRS, MADRS, and traditional Chinese medical syndrome score of three groups were lower than those before treatment, and observation group was lower than that of control group 1 and control group 2 (P＜0.05). No serious adverse reactions occurred in three groups. Conclusion Jieyu Qingxin Decoction combined with ultra-low frequency transcranial magnetic stimulation can effectively improve the symptoms of patients with Parkinson disease with depression of liver stasis and blood deficiency type, and has good safety.
2023 Vol. 20 (26): 100-103,109 [Abstract] ( 28 ) HTML (1 KB)  PDF (701 KB)  ( 60 )
104 Visual analysis of anti-Müllerian hormone in polycystic ovary syndrome based on CiteSpace and VOSviewer
ZHANG Ming1 KUANG Hongying2 ZHAO Shanshan1
DOI: 10.20047/j.issn1673-7210.2023.26.22
Objective To analysis of anti-Müllerian hormone (AMH) in polycystic ovary syndrome (PCOS) based on CiteSpace and VOSviewer. Methods Related literature on AMH in the field of PCOS from CNKI, VIP, Wanfang, and China Biomedical Literature Database were searched, the search time was from January 2003 to October 2022. VOSviewer 1.6.18 and CiteSpace 6.1.R3 were used to map the annual publication volume of AMH in the field of PCOS, author cooperation, institutional cooperation, and visual knowledge map of keyword co-occurrence, clustering, time line, and emergence analysis. Results A total of 780 literatures were retrieved, and the number of published papers showed an overall increasing trend. A total of 116 core authors and 40 core institutions were selected, and the density of institutional cooperation map was 0.000 3. A total of 242 keywords were included in the atlas, and 12 clustering, and 27 high-frequency keywords were obtained. Conclusion The research on AMH in the field of PCOS has received continuous attention, which is closely related to the clinical manifestations, patient demands, diagnostic criteria, and treatment methods of PCOS.
2023 Vol. 20 (26): 104-109 [Abstract] ( 24 ) HTML (1 KB)  PDF (1992 KB)  ( 25 )
110 Clinical effect of ginger umbilical moxibustion combined with Kegel training in the treatment of perimenopausal women with stress urinary incontinence
LI Yanxia1 SHEN Li2 YAO Hongyi1 WANG Lin1 CAO Jing1 LI Cai1
DOI: 10.20047/j.issn1673-7210.2023.26.23
Objective To observe the clinical effect of ginger umbilical moxibustion combined with Kegel training in the treatment of perimenopausal women with stress urinary incontinence (SUI). Methods A total of 64 perimenopausal women with SUI treated in Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology from August 2018 to February 2020 were selected. They were divided into control group and treatment group according to random number table method, with 32 patients in each group. The control group was treated with Kegel training, and the experimental group was treated with ginger umbilical moxibustion on the basis of control group, treatment lasted 12 weeks. The clinical efficacy of two groups was compared; urine leakage, International Consultation on Incontinence questionnaire short form (ICI-Q-SF) score, and pelvic floor muscle strength before and after treatment were compared between two groups. Results The clinical effect of treatment group was better than that of the control group (P＜0.05). After treatment, urine leakage in both groups was lower than those before treatment, and treatment group was lower than control group (P＜0.05). After treatment, the ICI-Q-SF score of two groups was lower than that before treatment, and treatment group was lower than control group (P＜0.05). After treatment, the pelvic floor muscle strength of two groups were better than those before treatment, and treatment group was better than control group (P＜0.05). Conclusion The clinical effect of ginger umbilical moxibustion combined with Kegel training in the treatment perimenopausal women with SUI is better, and it is worthy of clinical promotion and use.
2023 Vol. 20 (26): 110-113,189 [Abstract] ( 26 ) HTML (1 KB)  PDF (751 KB)  ( 36 )
114 Application value of fractional exhaled nitric oxide in etiological diagnosis of chronic cough in children
ZHANG Yu SHEN Yongwang TIAN Junping
DOI: 10.20047/j.issn1673-7210.2023.26.24
Objective To explore the application value of fractional exhaled nitric oxide (FeNO) in etiological diagnosis of chronic cough in children. Methods A total of 200 children with chronic cough treated in Dingzhou People’s Hospital of Hebei Province from July 2020 to July 2021 were selected as the study objects. The etiological of chronic cough was analyzed; FeNO, lung function, and eosinophilic granulocyte count in induced sputum were compared; the diagnostic value of FeNO in children with chronic cough of different etiology was analyzed. Results Among 200 children with chronic cough, 198 cases were identified and 2 cases were unknown. There were 172 cases of single cause and 21 cases of double cause, 5 cases of other reasons. The top five etiologies of chronic cough in children were upper airway cough syndrome (UACS), cough variant asthma (CVA), postinfectious cough (PIC), eosinophilic bronchitis (EB), and CVA+UACS. There were statistically significant differences in FeNO, the cumulative amount of provocative medication required to reduce forced expiratory volume in one second by 20%, and the percentage of eosinophils in induced sputum among children with different etiologies (P＜0.05); there were no significant differences in forced expiratory volume in one second and forced expiratory volume in one second/forced vital capacity of children with different etiologies (P＞0.05). The area under the curve (AUC) value of FeNO diagnosis PIC was 0.765 [95%CI (0.651-0.878)], the optimal cut-off value was 19.0 ppb, the sensitivity was 80.0%, the specificity was 63.8%, and the Yoden index was 0.44. The AUC value for FeNO diagnosis of UACS was 0.835[95%CI(0.760-0.909)], the optimal cut-off value was 15.5 ppb, the sensitivity was 82.0%, the specificity was 73.2%, and the Yoden index was 0.55. The AUC value for FeNO diagnosis of CVA was 0.947[95%CI (0.898-0.996)], the optimal cut-off value was 24.5 ppb, the sensitivity was 86.0%, the specificity was 88.0%, and the Yoden index was 0.74. The AUC value of FeNO diagnosis of EB was 0.814[95%CI (0.693-0.935)], the optimal cut-off value was 19.5 ppb, the sensitivity was 81.0%, the specificity was 83.0%, and the Yoden index was 0.64. The AUC value for FeNO diagnosis of CVA+UACS was 0.916[95%CI (0.817-1.000)], the optimal cut-off value was 18.5 ppb, the sensitivity was 80.0%, the specificity was 73.3%, and the Yoden index was 0.53. Conclusion FeNO, as a marker of airway inflammation, can be used as a method to evaluate airway inflammation, and it can be used to identify eosinophile-associated airway inflammatory diseases from other causes of chronic cough. FeNO can be used as an important diagnostic basis for chronic cough in children.
2023 Vol. 20 (26): 114-117 [Abstract] ( 27 ) HTML (1 KB)  PDF (683 KB)  ( 114 )
118 Construction of recurrence risk prediction model for multiple uterine myomectomy in women of childbearing age
HE Shaowei HUANG Baohui▲
DOI: 10.20047/j.issn1673-7210.2023.26.25
Objective To explore the influencing factors of the recurrence of multiple uterine myomectomy in women of childbearing age, and to construct the risk prediction model of nomogram. Methods The medical records of 140 patients undergoing multiple uterine myomectomy treated in Chuzhou First People’s Hospital of Anhui Province from October 2020 to March 2022 were retrospectively analyzed. They were divided into recurrence group (42 cases) and non-recurrence group (98 cases) according to whether there was recurrence after surgery. The influencing factors of the recurrence of multiple uterine myomectomy in women of childbearing age were analyzed; nomogram model was established and receiver operating characteristic curve to confirm the prediction efficiency evaluation was drawn. Results There were significant differences in age, menarche age, uterine fibroids number, and postoperative pregnancy between two groups (P＜0.05). Age, menarche age, uterine fibroids number, and postoperative pregnancy were the influencing factors of the recurrence of multiple uterine myomectomy in women of childbearing age (P＜0.05). Internal verification of Bootstrap method showed that C-index was 0.749 (95%CI: 0.693-0.835). The area under the curve predicted by the nomogram model for recurrence of multiple uterine myomectomy in women of childbearing age was 0.827. Conclusion The recurrence of multiple uterus myomectomy in women of childbearing age may be related to age, menorrhagia age, hysteromyoma number, and postoperative pregnancy. Establishing a nomogram model is effective in predicting the recurrence of multiple uterus myomectomy.
2023 Vol. 20 (26): 118-121 [Abstract] ( 23 ) HTML (1 KB)  PDF (758 KB)  ( 25 )
122 Expression and correlation of claudin-4 and vascular E-cadherin in prostate cancer
KONG Huimei1 ZHANG Chunting2 ZHENG Zhibin3
DOI: 10.20047/j.issn1673-7210.2023.26.26
Objective To investigate the expression and correlation of claudin-4 and vascular E-cadherin in prostate cancer. Methods The cancer and adjacent tissues of 82 patients with prostate cancer admitted to the Department of Urology, Jinhua People’s Hospital in Zhejiang Province from January 2015 to December 2017 were selected as the study objects, and the claudin-4 and vascular E-cadherin were detected by immunohistochemical staining. The positive rates of claudin-4 and vascular E-cadherin in cancer tissues of prostate cancer patients with different characteristics were compared, and correlation between claudin-4 and vascular E-cadherin expression was analyzed. Results The positive expression rates of claudin-4 and vascular E-cadherin in prostate cancer tissues were higher than those in adjacent tissues, and the differences were statistically significant (P＜0.05). The positive expression rate of claudin-4 in prostate cancer patients with different Gleason score, TNM stage, preoperative prostate-specific antigen (PSA), and seminal vesicle infiltrating were significantly different (P＜0.05). The positive expression rate of vascular E-cadherin in prostate cancer patients with different Gleason score, TNM stage, preoperative PSA, seminal vesicle infiltration, and resection margin were significantly different (P＜0.05). Correlation analysis showed that there was a positive correlation between claudin-4 and vascular E-cadherin in prostate cancer patients (r＞0, P＜0.05). Conclusion In prostate cancer patients, the expression of claudin-4 and vascular E-cadherin is increased, and their abnormal expression deserves clinical attention.
2023 Vol. 20 (26): 122-125 [Abstract] ( 27 ) HTML (1 KB)  PDF (684 KB)  ( 110 )
126 Analysis of influencing factors of abnormal liver function after neoadjuvant chemotherapy for triple negative breast cancer
AI Yongbiao HUANG Jun ZHANG Shuming LI Wenfang
DOI: 10.20047/j.issn1673-7210.2023.26.27
Objective To analyze the influencing factors of abnormal liver function after neoadjuvant chemotherapy in triple negative breast cancer (TNBC). Methods A total of 194 TNBC patients received neoadjuvant chemotherapy in Taihe Hospital, Shiyan, Hubei Province from June 2019 to June 2022 were selected and divided into study group (86 cases) and control group (108 cases) according to whether they had abnormal liver function after neoadjuvant chemotherapy. The clinical relevant indicators of the two groups were compared. Logistic regression model was used to analyze the influencing factors of abnormal liver function in TNBC patients after neoadjuvant chemotherapy. Results The incidence of abnormal liver function in 194 patients was 44.3% (86/194). The age, body mass index (BMI), proportion of menopausal patients, proportion of fatty liver patients, proportion of diabetes mellitus patients, proportion of TAC patients, and proportion of hepatitis B surface antigen positive patients in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The results of multivariate analysis showed that BMI (OR=1.494, 95%CI: 1.043-2.246), diabetes mellitus(OR=2.983, 95%CI: 1.619-5.547), fatty liver (OR=1.468, 95%CI: 1.011-2.129), TAC chemotherapy regimen (OR=5.574, 95%CI: 2.817-9.997), and hepatitis B surface antigen positive (OR=2.724, 95%CI: 1.134-5.581) were the influencing factors of abnormal liver function after neoadjuvant chemotherapy in TNBC patients (P＜0.05). Conclusion Various factors can lead to abnormal liver function in TNBC patients after neoadjuvant chemotherapy. Physical intervention should be taken to reduce the incidence of abnormal liver function and ensure the smooth progress of treatment.
2023 Vol. 20 (26): 126-129 [Abstract] ( 25 ) HTML (1 KB)  PDF (533 KB)  ( 20 )
130 Risk analysis of low anterior resection syndrome after laparoscopic radical resection of rectal cancer
HUANG Junjie1 ZHENG Weiqing1 WANG Zhaohui2 REN Jian1▲
DOI: 10.20047/j.issn1673-7210.2023.26.28
Objective To analyze the risk of low anterior resection syndrome (LARS) after laparoscopic radical resection of rectal cancer. Methods A total of 80 patients with rectal cancer who underwent laparoscopic radical resection of rectal cancer in Huangshan People’s Hospital Anhui Province from June 2017 to January 2020 and were followed up for 24 months were selected as the study subjects. Patients were divided into LARS group and non-LARS group according to whether or not occurred LARS after surgery. Clinical data of patients were collected to analyze the related factors that may affect the occurrence of LARS in patients after laparoscopic radical resection of rectal cancer, and the risk factors were identified by logistic regression analysis. Results A total of 80 patients followed up for 24 months, 49 (61.25%) of the patients with LARS were the LARS group, and 31 (38.75%) of the patients without LARS were the non-LARS group. Univariate analysis showed that the anastomotic distance from stamo to anus in the LARS group was shorter than the non-LARS group (P＜0.05), and the proportion of body mass index (BMI)＞25 kg/cm2 in the LARS group was higher than that in the non-LARS group (P＜0.05). Logistic regression analysis showed that BMI＞25 kg/cm2 (OR=2.385, 95%CI: 1.875, 2.895), anastomotic distance from the anus (OR=0.321, 95%CI:-0.381, 1.023) were risk factors for LARS in rectal cancer patients undergoing laparoscopic radical resection for rectal cancer (P＜0.05). Conclusion  BMI and the anastomotic distance from stoma to anus are important influencing factors for LARS in patients with rectal cancer after operation, and the risk of LARS is high. Identifying risk factors is helpful for clinical selection of scientific surgical methods and reduction of LARS incidence.
2023 Vol. 20 (26): 130-133 [Abstract] ( 24 ) HTML (1 KB)  PDF (548 KB)  ( 20 )
134 Real-world study on the application effect of national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection in the treatment of community acquired pneumonia
LIU Yan1 YU Jing2 LIU Huan3 ZHANG Yanjing2 ZHAO Mingyi1
DOI: 10.20047/j.issn1673-7210.2023.26.29
Objective To compare the efficacy and safety of national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection and innovator drug in the treatment of community acquired pneumonia (CAP). Methods A total of 250 CAP patients admitted to the First Hospital of Hebei Medical University from October 2020 to October 2021 were retrospectively collected. Among them, 63 patients who used the national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection were included in the collection group, 187 patients who received innovator drug as the innovator drug group. The effectiveness and safety of the two groups were compared after using propensity score matching to adjust the differences between the two groups. Results After matching, 61 patients were included in the collection group and 111 patients in the innovator drug group. There was no significant difference in treatment effect between the two groups at 72 h of treatment and discharge (P＞0.05). At discharge, the body temperature, C-reactive protein, and procalcitonin in the two groups were lower than those at admission, the differences were statistically significant (P＜0.05). There were no significant differences in temperature, C-reactive protein, and procalcitonin between the two groups at discharge (P＞0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The efficacy and safety of national centralized acquisition with quantity of Moxifloxacin Hydrochloride Sodium Chloride Injection are comparable to the innovator drug in the treatment of CAP, and can be widely used in clinical practice.
2023 Vol. 20 (26): 134-137 [Abstract] ( 26 ) HTML (1 KB)  PDF (684 KB)  ( 222 )
138 Research on medication rules of traditional Chinese medicine in treatment of hepatolenticular degeneration based on literature data mining
JIANG Zhenzhen1 WANG Meixia2 TAO Zhuang2 WANG Fei1 SUN Kuo1 HAN Hui1 CAI Shengxing3 YANG Wenming2
DOI: 10.20047/j.issn1673-7210.2023.26.30
Objective To analyze the medication rules of traditional Chinese medicine in the treatment of hepatolenticular degeneration based on data mining. Methods Clinical research literature on traditional Chinese medicine in the treatment of hepatolenticular degeneration collected from CNKI, Wanfang Data, VIP, PubMed, Cochrane Library, and EMBase database from establishment to July 2022 were searched, and a Chinese materia medica prescription database was established. The method of frequency analysis, association rules, cluster analysis, and complex network analysis was used for mining. Results A total of 78 effective prescriptions were included, involving 133 kinds of Chinese materia medica, and the single herb with the highest frequency was Rhei Radix Et Rhizoma. The drug nature was mainly cold and warm, the drug flavour was mainly bitter and sweet, and the channel tropism was mainly liver and spleen channels. The top three drugs in terms of efficacy frequency were promoting blood circulation for removing blood stasis drug, tonifying deficiency drug, and clearing heat drug. Rhei Radix Et Rhizoma and Coptidis Rhizoma were used most in the combination of drugs. Six new formulas were obtained by cluster analysis. The results of complex network analysis showed that the core nodes of the network were Rhei Radix Et Rhizoma, Curcumae Radix, Dioscoreae Spongiosae Rhizoma, Curcumae Rhizoma, Alismatis Rhizoma, Curcumae Longae Rhizoma, Lysimachiae Herba, Salviae Miltiorrhizae Radix Et Rhizoma, Coptidis Rhizoma, Spatholobi Caulis, and Citri Reticulatae Pericarpium. Conclusion The main pathogenesis of hepatolenticular degeneration is manifestation deficiency and root excess, intermingled deficiency and excess with traditional Chinese medicine, such as promoting blood circulation for removing blood stasis, clearing heat, promoting diuresis and diffusing dampness, purging and so on. The patients with intermingled deficiency and excess with traditional Chinese medicine can also supplement deficiency to provide diagnosis and treatment ideas for hepatolenticular degeneration.
2023 Vol. 20 (26): 138-142 [Abstract] ( 24 ) HTML (1 KB)  PDF (1188 KB)  ( 51 )
143 Study on the medication rules of spinal bi in Chinese Medical Code based on data mining
MA Yucao LYU Liu HUANG Zhenghui HU Jie ZHENG Xiaojia FANG Jinying WANG Hailong
DOI: 10.20047/j.issn1673-7210.2023.26.31
Objective To analyze the medication rules of internal prescriptions for the treatment of spinal bi included in Chinese Medical Code based on data mining technology. Methods All the prescriptions in the Chinese Medical Code were searched with the search terms “spinal bi, spinal pain, spinal vessel pain, lumbar spinal pain, median spinal pain, lumbar spinal qiang, lumbar spinal disease, spinal qiang, and back bone pain”, and Excel 2016 was used to establish a database. After the data were normalized, the frequency, nature, flavour, channel tropism, and the efficacy of medication of the treatment of spinal bi were analyzed. SPSS Modeler 18.0 and SPSS Statistics 20.0 were used for association rules and cluster analysis. Results A total of 171 spinal bi related prescriptions and 265 kinds of Chinese materia medica were included. The four nature of drugs were mainly warm, the five flavours of drugs were mainly sweet, pungent, and bitter, the channel tropism of drugs were mainly liver channel, and the efficacy of the drugs were mainly deficiency tonifying drug. Twenty-seven core drug combinations were obtained by association rule analysis. Five groups of clustering methods were obtained by cluster analysis. Conclusion The principle of tonifying deficiency and strengthening vital qi as main, as well as dispelling wind and dispelling cold and dispelling dampness, promoting blood circulation for removing blood stasis are the rules of the Chinese Medical Code.
2023 Vol. 20 (26): 143-147 [Abstract] ( 24 ) HTML (1 KB)  PDF (953 KB)  ( 17 )
148 Professor Li Hao’s experience in treating alopecia from “deficiency of blood and excess of retained fluid” with Danggui Shaoyao Powder
LI Zehui YANG Yang LIU Nanyang ZHANG Zhen PEI Hui LI Hao
DOI: 10.20047/j.issn1673-7210.2023.26.32
Alopecia is a common disease in clinics, which can be treated with syndrome differentiation in traditional Chinese medicine and achieve better results. Professor Li Hao considers that the main pathogenesis of alopecia in traditional Chinese medicine is “deficiency of blood and excess of retained fluid”. When yin blood is insufficient, hair is lost nourishment, because hair roots are empty and withered. In addition, water and dampness erode hair roots, accelerating their decay and shedding. The liver stores blood and regulates the operation of blood, and the spleen is the source of qi and blood. The stagnation of  wood is stronger than earth, which causes dysfunction of spleen in transportation, so water and dampness invade the top of the head. Blood deficiency will also cause blood flow poorly. Unsmooth blood circulation results in water retention. The pathogenesis is a combination of liver and spleen dysfunction with abnormalities in blood and water. Danggui Shaoyao Powder is composed of three “blood medicines” Angelicae Sinensis Radix, Paeonia lactiflora Pall., and Chuanxiong Rhizoma, and three “water medicines” Poria, Alismatis Rhizoma, and Atractylodis Macrocephalae Rhizoma. It has the effect of invigorating the spleen and dispersing the stagnated liver-energy, nourishing blood and invigorating blood circulation, eliminating dampness and diuresis. It harmonizes the liver and spleen and treats blood and water simultaneously. When using Danggui Shaoyao Powder to treat alopecia,  Professor Li Hao usually reduces the amount of Paeonia lactiflora Pall. increases the amount of Angelicae Sinensis Radix and Poria, and takes into account invigorating the liver and kidney as appropriate, or accompanied by eliminating heat and removing stasis.
2023 Vol. 20 (26): 148-151 [Abstract] ( 25 ) HTML (1 KB)  PDF (588 KB)  ( 105 )
152 Effect of traditional Chinese medicine anal dilation and hormone injection combined with oral administration of traditional Chinese medicine in the treatment of puborectal muscle syndrome
JIA Fei1 ZHI Jianwen1 YANG Yi1 CHEN Xinyu2 WANG Song2 HONG Zifu1
DOI: 10.20047/j.issn1673-7210.2023.26.33
Objective To investigate clinical effect of traditional Chinese medicine anal dilation and hormone injection combined with oral administration of traditional Chinese medicine in the treatment of puborectal muscle syndrome. Methods Sixty patients with puborectal muscle syndrome admitted to Department of Anorectal, Guanganmen Hospital, China Academy of Chinese Medical Sciences from March 2020 to June 2022 were selected and they were divided into observation group and control group according to the random number table method, with 30 patients in each group. Minimally invasive surgery was adopted in both groups. The observation group was treated with traditional Chinese medicine anal dilation and hormone injection, while control group was treated with partial resection of the puborectal muscle. Both groups were given Yangxue Runchang Granules orally for three months after surgery. Efficacy, intraoperative indicators, hospitalization day, Wexner constipation quantification score main symptom score, visual analogue scale score, defecography anorectal angulation degree, and postoperative complications of two groups were compared. Results There was no statistically significant difference in overall efficacy between two groups (P＞0.05). The intraoperative bleeding in observation group was less than that in control group, and the surgical duration and hospitalization day in observation group were shorter than those in control group, the differences were statistically significant (P＜0.05). Overall analysis found that there were statistically significant differences in the intergroup comparison, time point comparison, interaction differences of incomplete emptying sensation score and each defecation time score (P＜0.05). Further pairwise comparison, intra group comparison: the scores of incomplete emptying sensation and defecation time in both groups during postoperative and follow-up were lower than before surgery, the differences were statistically significant (P＜0.05). Comparison between groups: the scores of incomplete emptying sensation and defecation time in observation group during follow-up were lower than those in control group, the differences were statistically significant (P＜0.05). Overall analysis found that there were statistically significant differences in the intergroup comparison, time point comparison, interaction differences of visual analogue scale score (P＜0.05). Further pairwise comparison, intra group comparison: visual analogue scale scores of two groups on the third and seventh day after surgery were lower than those on the first day after surgery, visual analogue scale scores of two groups on the seventh day after surgery were lower than those on the third day after surgery, the differences were statistically significant (P＜0.05). Comparison between groups: visual analogue scale scores of observation group on the third and seventh day after surgery were lower than those of control group, the differences were statistically significant (P＜0.05). Before surgery, there were no statistically significant differences in anorectal angulation degree between two groups during rest and exertion (P＞0.05). During follow-up, there were no statistically significant differences in anorectal angulation degree between two groups during rest and exertion (P＞0.05). During follow-up, anorectal angulation degree in both groups during exertion was greater than before surgery, the difference was statistically significant (P＜0.05). There was no statistically significant difference in anorectal angulation degree between two groups at rest before surgery and during follow-up (P＞0.05). Both groups did not experience complications such as anal incontinence or anal stenosis. Conclusion Traditional Chinese medicine anal dilation and hormone injection combined with oral administration of traditional Chinese medicine can improve constipation symptoms caused by puborectal muscle syndrome, increase the anorectal angulation degree. Compared to partial resection of the puborectal muscle, it has less intraoperative bleeding, shorter surgical duration and hospitalization day, and less postoperative pain.
2023 Vol. 20 (26): 152-156 [Abstract] ( 22 ) HTML (1 KB)  PDF (741 KB)  ( 26 )
157 Clinical effect of Tongxie Decoction on ulcerative colitis of damp-heat type of spleen and stomach
YE Jia1 ZHU Meiping1 SUN Mingyu2 LIU Chang1
DOI: 10.20047/j.issn1673-7210.2023.26.34
Objective To explore the clinical effect of Tongxie Decoction on the treatment of ulcerative colitis of damp-heat type of spleen and stomach. Methods A total of 88 patients with ulcerative colitis of damp-heat type of spleen and stomach admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from June 2021 to August 2022 were selected and they were divided into observation group and control group by random number table method, with 44 cases in each group. The control group was treated with Enteric Coated Sulfamethoxazole Tablets, while the observation group was treated with Tongxie Decoction on the basic of control group. A total of 15 days as a course of treatment, after three courses of treatment, clinical efficacy, the traditional Chinese medicine syndrome scores, intestinal mucosal barrier function, and treatment safety of the two groups were compared. Results The clinical effect of observation group was better than control group, the difference was statistically significant (P＜0.05). After treatment, the scores of diarrhea and blood stool, posterior gravity, anal burning, and tongue red and moss yellow in two groups were lower than those before treatment, and the observation group were lower than those in control group, the differences were statistically significant (P＜0.05). After treatment, the levels of diamine oxidase, endotoxin, and D-lactic acid in two groups were lower than before treatment, and the observation group were lower than those in control group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Tongxie Decoction has a significant therapeutic effect on ulcerative colitis of deep-heat type of spleen and stomach, which can improve traditional Chinese medicine syndrome and enhance intestinal mucosal barrier function.
2023 Vol. 20 (26): 157-160 [Abstract] ( 26 ) HTML (1 KB)  PDF (603 KB)  ( 72 )
161 Effect of Fuzheng Qufeng Decoction on treating chronic urticaria of Qi deficiency type and its influence on C-reactive protein, serum amyloid A, and D-dimer levels#br#
MA Anzhe1 MO Wei2 CHEN Jingjing3
DOI: 10.20047/j.issn1673-7210.2023.26.35
Objective To explore the effect of Fuzheng Qufeng Decoction on the treatment of chronic urticaria (CU) with qi deficiency type and its influence on C-reactive protein (CRP), serum amyloid A (SAA), and D-dimer (D-D) levels. Methods A total of 98 CU patients with qi deficiency type admitted to Guilin Municipal Hospital of Traditional Chinese Medicine from January 2020 to January 2022 were selected and divided into two groups according to the random number table method, with 49 cases in each group. The control group received Loratadine Tablets and Vitamin C Tablets, and the observation group received Fuzheng Qufeng Decoction, all treated continuously for 14 d. The clinical efficacy, traditional Chinese medicine syndrome scores, 7-day Urticaria Activity Decoction (UAS7), chronic urticaria quality of life questionnaire (GU-Q2oL), and levels of CRP, SAA, and D-D were compared between two groups before and after treatment. Results The clinical efficacy of the observation group was better than that of the control group (P＜0.05). After treatment, the traditional Chinese medicine syndrome scores, UAS7, and GU-Q2oL scores of the two groups were lower than before treatment, and the observation group was lower than the control group, the differences were statistically significant (P＜0.05). After treatment, the plasma levels of CRP, SAA and D-D in both groups were lower than before treatment, and the observation group was lower than the control group the differences were statistically significant(P＜0.05). Conclusion Fuzheng Qufeng Decoction has a definite therapeutic effect on CU of qi deficiency type, and can effectively improve skin lesions and itching symptoms. Its mechanism may be related to regulating inflammation and coagulation factor levels.
2023 Vol. 20 (26): 161-164 [Abstract] ( 28 ) HTML (1 KB)  PDF (625 KB)  ( 58 )
165 Discussion on the three-dimensional dynamic diagnosis and treatment model based on the Qisexingtai hand diagnostic method combination of “symptom-differentiation-diagnosis”
LIU Qian1 WANG Shiheng2 LI Yu2 LIU Jianfeng2
DOI: 10.20047/j.issn1673-7210.2023.26.36
In the current clinical diagnosis and treatment process, the traditional medical diagnosis and treatment system and the modern medical diagnosis and treatment system have their own advantages and disadvantages. The understanding of diseases is mainly carried out through three aspects and three dimensions: symptoms, traditional medical syndrome differentiation, and modern medical diagnosis, and the information obtained from the three has its limitations. How to better combine the three is a question that Chinese medical practitioners have been thinking about and have put forward many ideas. For example, the combination of disease and syndrome, integrative medicine, etc. The combination of disease and syndrome is a two-dimensional system that combines modern medicine and traditional medicine. In his long-term clinical practice, Professor Liu Jianfeng published Observing the Hand to Know the Disease - Essential Manual Diagnosis of Complexion Shape in 1991, creatively proposed the theory and method of manual diagnosis of complexion shape. On this basis, he combined the patient’s symptoms, traditional medical syndrome differentiation and modern medical diagnosis to form a three-dimensional dynamic diagnosis and treatment model, which solved the theoretical problems of incompatible three cognitive systems. It has improved the efficiency and effect of clinical diagnosis and treatment, and enhanced the service capacity and level of medicine.
2023 Vol. 20 (26): 165-168 [Abstract] ( 24 ) HTML (1 KB)  PDF (730 KB)  ( 96 )
169 Application of intermittent oral tube feeding combined with oral ice stimulation in patients with dysphagia after stroke
BAO Yan HOU Xiaofang YU Canping▲ LIU Li
DOI: 10.20047/j.issn1673-7210.2023.26.37
Objective To explore the application effect of intermittent oral tube feeding combined with oral ice stimulation in patients with dysphagia after stroke. Methods A total of 100 stroke patients with dysphagia admitted to the Nanjing Medical University Affiliated Brain Hospital from January 2021 to December 2022 were selected, they were divided into control group and observation group by random number table method, with 50 cases in each group. The control group received conventional oral care and nasal feeding tube, and the observation group received conventional oral care and intermittent oral tube feeding combined with oral ice stimulation intervention. The swallowing function and quality of life of the two groups were observed before intervention and one month after intervention. Results After intervention, the modified Mann swallowing ability scale scores of both groups were higher than those before intervention, and the observation group was higher than those of the control group, the difference was statistically significant (P＜0.05); after intervention, the volume-viscosity swallowing test food volume viscosity grading in the observation group was better than that in the control group, and the damage rate of safety and effectiveness was lower than that in the control group, the difference was statistically significant (P＜0.05); after intervention, the quality of life scale scores of patients with swallowing disorder in both groups were lower than those before intervention, and the observation group was lower than those of the control group, the difference was statistically significant (P＜0.05). Conclusion The intermittent oral gavage combined with ice stimulation oral intervention can improve swallowing function and quality of life in stroke patients with swallowing disorders.
2023 Vol. 20 (26): 169-172 [Abstract] ( 25 ) HTML (1 KB)  PDF (553 KB)  ( 104 )
173 Effects of KTA-based cognitive intervention and nursing on self-management efficacy, quality of life, and functional status of patients with soft tissue sarcoma
ZHANG Pingping JIA Yan
DOI: 10.20047/j.issn1673-7210.2023.26.38
Objective To explore the effects of KTA-based cognitive intervention and nursing on self-management efficacy, quality of life, and functional status of patients with soft tissue sarcoma. Methods A total of 80 patients with soft tissue sarcoma admitted to Jiangsu Provincial Hospital from April 2021 to April 2022 were prospectively selected as the study objects. They were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was given the general care method, and the observation group was given KTA-based cognitive intervention and nursing measures. Nursing until both groups of patients were discharged, the self-management efficiency (the Chinese version of the cancer self-management efficacy scale [C-SUPPH]), quality of life (36-item short form health survey, short form 36 [SF-36]), and functional status (Karnofsky’s score) of the two groups before and after the nursing intervention were compared. Results After nursing, C-SUPPH scores in both groups were higher than those before nursing, and observation group were higher than those of control group (P＜0.05). After nursing, SF-36 scores in both groups were higher than those before nursing, and observation group was higher than those of control group (P＜0.05). After nursing, KAS scores in both groups were higher than those before nursing, and those in observation group were higher than those in control group (P＜0.05). Conclusion KTA based cognitive intervention and nursing applied to patients with soft tissue sarcoma can improve self-management efficacy, quality of life, and functional status, which is worthy of clinical promotion.
2023 Vol. 20 (26): 173-176 [Abstract] ( 25 ) HTML (1 KB)  PDF (551 KB)  ( 19 )
177 Application effect of continuous dynamic follow-up nursing under the concept of general practice in patients with hypertension and coronary heart disease
HU Jianying GUO Liangmin▲
DOI: 10.20047/j.issn1673-7210.2023.26.39
Objective To explore the application effect of continuous dynamic follow-up nursing under the concept of general practice in patients with hypertension and coronary heart disease (CHD). Methods A total of 300 patients with hypertension and CHD treated in the Third People’ s Hospital of Chengdu from January 2021 to January 2022 were selected as the study objects, and they were divided into routine group (routine nursing mode was used) and general practice group (continuous dynamic follow-up nursing under the concept of general practice was used) according to random number table method, with 150 cases in each group. The disease cognition degree, self-management ability, and healthy life-related behavior were compared between the two groups before and after intervention, and the occurrence of adverse cardiovascular events during intervention were recorded. Results After intervention, the scores of aspects of disease cognition degree in the two groups were higher those before intervention, and the scores in general practice group were higher than those in routine group (P＜0.05). After intervention, the self-management ability and healthy life-related behavior in both groups were higher than those before intervention, and the scores in general practice group were higher than those in routine group after intervention (P＜0.05). The total incidence rate of adverse events in general practice group was lower than that in routine group (P＜0.05). Conclusion Continuous dynamic follow-up nursing under the concept of general practice in the intervention of patients with hypertension and CHD can enhance the self-management ability, improve the healthy life-related behavior, and reduce the risk of adverse cardiovascular events.
2023 Vol. 20 (26): 177-180 [Abstract] ( 25 ) HTML (1 KB)  PDF (528 KB)  ( 17 )
181 A case report and literatures review of bilateral column of fornix infarction
LEI Xiaojing1 DONG Lihua2 WANG Yuanqing2 LING Yitong3 JIANG Xiuli2 ZHENG Jiaping2
DOI: 10.20047/j.issn1673-7210.2023.26.40
Column of Fornix infarction is a special type of cerebral infarction with acute cognitive impairment as the main clinical manifestation, which is rare in clinical practice. Because of its few positive signs of nervous system and special anatomical location, it is easy to misdiagnose and miss diagnosis. This paper reports a case of a young patient with bilateral fornix column infarction who was admitted to People’s Hospital of Rizhao in March 2022. The main reason was “memory declines for two days”. Clinical symptoms were acute anterograde amnesia and language repetition. Head magnetic resonance imaging showed bilateral fornix column infarction. The symptoms improved greatly after the treatment of cognitive improvement and routine treatment of cerebral infarction. This paper combined imaging examination and neuropsychological scale to sort out his medical records, in order to improve raise awareness of the disease.
2023 Vol. 20 (26): 181-184 [Abstract] ( 29 ) HTML (1 KB)  PDF (833 KB)  ( 129 )
185 Construction and practice of subject construction evaluation system under DRG point value payment
WANG Xia SHI Shuyuan YANG Yongxue▲
DOI: 10.20047/j.issn1673-7210.2023.26.41
Objective To establish a discipline construction evaluation system based on diagnosis-related groups (DRG) score payment background, and to promote the formation of a discipline construction management mechanism with efficient operation and strong supervision. Methods By using the methods of literature review, current situation investigation and DRG index measurement, the discipline construction evaluation index system suitable for large Class Ⅲ public hospital was constructed. Results The whole system has set up 6 first-level indicators, 18 second-level indicators and 63 third-level indicators, including 12 core indicators and 3 single rejection indicators. With the third-level indicators as the minimum unit, assessment scores were assigned, and quantitative indicators such as case portfolio index, number of DRG groups, and medium-low risk mortality were put into the evaluation system to clarify the scoring criteria and evaluation methods. Conclusion The selection of indicators is highly representative, mainly based on benefit and ratio indicators, which can objectively reflect the real level of discipline construction, guide the implementation of discipline construction to improve medical ability, solve clinical practical problems, and enhance the connotation of modern hospital management.
2023 Vol. 20 (26): 185-189 [Abstract] ( 25 ) HTML (1 KB)  PDF (861 KB)  ( 191 )
190 Construction and application of the whole process traceability system for surgical patients based on radio frequency identification technology
CHEN Jue1 ZHENG Yue1 DAI Jinjie1 YUAN Junyi2 HOU Xumin3
DOI: 10.20047/j.issn1673-7210.2023.26.42
Radio frequency identification technology is a communication technology based on the principles of wireless wave signal transmission and reception, gradually becoming popular in hospital management. Radio frequency identification technology is used to establish a visualization, dynamic, and interactive whole process traceability system for patients’ families, nursing staff, doctors/anesthesiologists, and medical management, which can automatically and real-time obtain the time and space information of surgical patients and help medical staff understand the dynamics of surgical patients so as to make preparations in advance. At the same time, through data analysis, it helps medical managers identify and correct blockages in the operation of operating rooms, thereby improving the efficiency of operating room operations and enhancing hospital management capabilities.
2023 Vol. 20 (26): 190-193 [Abstract] ( 26 ) HTML (1 KB)  PDF (1499 KB)  ( 75 )
194 Application and effect evaluation of detail management in the practice of Party organization general election in large public hospitals
CHEN Yuheng ZHOU Yan JIN Qi ZHANG Ping
DOI: 10.20047/j.issn1673-7210.2023.26.43
The Party organization general election in public hospitals is the most extensive and vivid political education and practice that hospital Party members participate in, and it is an important way to strengthen and standardize the political life of party members. In order to improve the effectiveness and efficiency of the Party organization’s implementation of the general election in large public hospitals, and to form a good accumulation of Party building work, this paper takes the specific practice of the general election of the Party organization in the Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College in October 2021 as an example, and uses the detail management tool to analyze the three dimensions of notification, election implementation, and conference management. Refine the experience and practice of detailed management of the eight contents of the notice, fully implement the requirements of the notice, quickly count the number of people, orderly distribution of ballots, set up voting lines, accurately count ballots, properly arrange meeting elements, and orderly group discussion, so as to ensure that the organizational intention is implemented in all aspects of the general election procedure. It is expected to achieve the effect of improving the quality of the transition work, improving the efficiency of the transition work, and stimulating the consciousness of democratic participation of Party members, so as to provide reference and reference for standardizing the transition election of Party organizations in large public hospitals.
2023 Vol. 20 (26): 194-封三 [Abstract] ( 20 ) HTML (1 KB)  PDF (999 KB)  ( 44 )
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