三阴性乳腺癌新辅助化疗后肝功能异常的影响因素分析

doi:10.20047/j.issn1673-7210.2023.26.27

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Abstract Objective To analyze the influencing factors of abnormal liver function after neoadjuvant chemotherapy in triple negative breast cancer (TNBC). Methods A total of 194 TNBC patients received neoadjuvant chemotherapy in Taihe Hospital, Shiyan, Hubei Province from June 2019 to June 2022 were selected and divided into study group (86 cases) and control group (108 cases) according to whether they had abnormal liver function after neoadjuvant chemotherapy. The clinical relevant indicators of the two groups were compared. Logistic regression model was used to analyze the influencing factors of abnormal liver function in TNBC patients after neoadjuvant chemotherapy. Results The incidence of abnormal liver function in 194 patients was 44.3% (86/194). The age, body mass index (BMI), proportion of menopausal patients, proportion of fatty liver patients, proportion of diabetes mellitus patients, proportion of TAC patients, and proportion of hepatitis B surface antigen positive patients in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The results of multivariate analysis showed that BMI (OR=1.494, 95%CI: 1.043-2.246), diabetes mellitus(OR=2.983, 95%CI: 1.619-5.547), fatty liver (OR=1.468, 95%CI: 1.011-2.129), TAC chemotherapy regimen (OR=5.574, 95%CI: 2.817-9.997), and hepatitis B surface antigen positive (OR=2.724, 95%CI: 1.134-5.581) were the influencing factors of abnormal liver function after neoadjuvant chemotherapy in TNBC patients (P＜0.05). Conclusion Various factors can lead to abnormal liver function in TNBC patients after neoadjuvant chemotherapy. Physical intervention should be taken to reduce the incidence of abnormal liver function and ensure the smooth progress of treatment.

Key words： Triple negative breast cancer Neoadjuvant chemotherapy Hepatic dysfunction Influencing factors

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	AI Yongbiao HUANG Jun ZHANG Shuming LI Wenfang

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AI Yongbiao HUANG Jun ZHANG Shuming LI Wenfang. Analysis of influencing factors of abnormal liver function after neoadjuvant chemotherapy for triple negative breast cancer[J]. 中国医药导报, 2023, 20(26): 126-129.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.26.27 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I26/126

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