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| Expression and correlation of claudin-4 and vascular E-cadherin in prostate cancer |
| KONG Huimei1 ZHANG Chunting2 ZHENG Zhibin3 |
1.Medical College, Jinhua Polytechnic, Zhejiang Province, Jinhua 321017, China;
2.Department of Urology, Jinhua People’s Hospital, Zhejiang Province, Jinhua 321000, China;
3.Department of Traditional Chinese Medicine, Jin Pan Development Zone Hospital, Zhejiang Province, Jinhua 321000, China
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Abstract Objective To investigate the expression and correlation of claudin-4 and vascular E-cadherin in prostate cancer. Methods The cancer and adjacent tissues of 82 patients with prostate cancer admitted to the Department of Urology, Jinhua People’s Hospital in Zhejiang Province from January 2015 to December 2017 were selected as the study objects, and the claudin-4 and vascular E-cadherin were detected by immunohistochemical staining. The positive rates of claudin-4 and vascular E-cadherin in cancer tissues of prostate cancer patients with different characteristics were compared, and correlation between claudin-4 and vascular E-cadherin expression was analyzed. Results The positive expression rates of claudin-4 and vascular E-cadherin in prostate cancer tissues were higher than those in adjacent tissues, and the differences were statistically significant (P＜0.05). The positive expression rate of claudin-4 in prostate cancer patients with different Gleason score, TNM stage, preoperative prostate-specific antigen (PSA), and seminal vesicle infiltrating were significantly different (P＜0.05). The positive expression rate of vascular E-cadherin in prostate cancer patients with different Gleason score, TNM stage, preoperative PSA, seminal vesicle infiltration, and resection margin were significantly different (P＜0.05). Correlation analysis showed that there was a positive correlation between claudin-4 and vascular E-cadherin in prostate cancer patients (r＞0, P＜0.05). Conclusion In prostate cancer patients, the expression of claudin-4 and vascular E-cadherin is increased, and their abnormal expression deserves clinical attention.
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