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2018 Vol. 15, No. 4
Published: 2018-02-05
 
 
4 Effects of Fenofibrate on adipose triglyceride lipase in insulin resistant rats
ZHU Chaoyu XIAO Yuanyuan YE Yang LIU Mengdan ZENG Yuanyuan WEI Li▲
Objective To detect the effects of Fenofibrate on the expression of adipose triglyceride lipase (ATGL) in tissues of insulin resistant rats. Methods Eight-week old male SD rats were randomly divided into normal diet group (NC group, n = 8) and high fat diet group (HFD group, n = 16). After 8 weeks, the rats in the HFD group were divided into untreated (HFD-UT) group and Fenofibrate treatment (HFD-FT) group. The biochemical indices of all groups were detected, and the insulin sensitivity was detected by oral glucose tolerance (OGTT) and insulin tolerance (ITT). Western blot was used to assay ATGL protein in epididymal adipose, liver and muscle. Results High fat diet led to insulin resistance, ATGL in adipose tissue, liver and muscle in HFD-UT group were decreased compared with those of NC group, the differences were highly statistically significant (P ＜ 0.01). After Fenofibrate treatment, the insulin sensitivity was improved, and the ATGL levels in adipose tissue, liver and muscle were increased compared with those of HFD-UT group, the differences were statistically significant (P ＜ 0.01 or P ＜ 0.05). Conclusion Fenofibrate can enhance the ATGL levels in adipose tissue, liver and muscle of insulin resistant rats.
2018 Vol. 15 (4): 4-7,17 [Abstract] ( 254 ) HTML (1 KB)  PDF (824 KB)  ( 202 )
8 Effects of Pholidota chinensis Lindl Polysaccharides on the levels of chemokines of bronchoalveolar lavage fluid in a murine model of Mycoplasma pneumoniae pneumonia
DU Huichao1 HUANG Meiqing2 ZHAO Shiyuan3
Objective To investigate the Pholidota chinensis Lindl Polysaccharides (PCLP) on mice model of Mycoplasma pneumoniae pneumonia in bronchoalveolar lavage fluid (BALF) effect of chemokine. Methods Ninety BABL/C nude mice were randomized into model group, clarithromycin group and polysaccharide group, 30 rats in each group. Medium of Mycoplasma pneumoniae with PPLO broth, the successful isolation of Mycoplasma pneumoniae drops into the nasal cavity in 1×107 CCU/mL 50 μL, 8 d, on the second day after inoculation to 1 last polysaccharide with Pholidota intervention. After intervention of 1, 3 d and 6 d, respectively, bronchoalveolar lavage fluid (BALF) were collected, Mycoplasma pneumoniae of BALF was cutured by SP4 agar plate quantitative recovery of lung tissue, by formalin fixation and HE staining, the lesions of mouse lung of Mycoplasma pneumoniae infection in BALF mice were observed, Macrophage inflammatory protein-1α (MIP-1α), MIG, KC, Macrophage inflammatory protein-1 (MCP-1) and interferon-γ-inducible protein 10 (IP-10) chemotaxis cytokine levels were measured by ELISA. Results BAL Mycoplasma pneumoniae pneumonia concentrations in mice treated with PCLP tended to be reduced compared with mice treated with placebo (MpPl), however there was no statistically significant difference (P > 0.05); the lung HPS was significantly lower, as well as the parenchymal-pneumonia subscore. 3 d after Polysaccharide intervention in Mycoplasma pneumoniae pneumonia mice, the expression of chemokines MIP-1α, MIG and IP-10 in BALF mice were significantly reduced, the differences were statistically significant (P < 0.05). Conclusion Polysaccharide significantly reduce the Mycoplasma pneumoniae lung inflammation in mice, the mechanism may be related to the inhibition of MIP-1α, MIG and IP-10 chemokines in vivo in mice model of Mycoplasma pneumoniae.
2018 Vol. 15 (4): 8-12,22 [Abstract] ( 200 ) HTML (1 KB)  PDF (1023 KB)  ( 96 )
13 Study of the mechanism of miR-96-5p in anti-apoptosis induced by storage in platelet  
XU Hengshi1 YANG Ying1 CUI Hengxiang2
 Objective To study the anti-apoptosis mechanism of miR-96-5p in platelet during the storage, and explore the factor affecting the platelet storage. Methods The expression changes of apoptosis related 24 miRNAs in apheresis platelets on the starting and 5 days of the storage was detected by quantitative real time PCR, and the results were statistically analyzed. The effect of miRNAs on survival and apoptosis of platelet. Results Compared with the starting of the storage, the expression of miR-96-5p, miR-16-5p, miR-155-5p, miR-148a-5p and miR-296-5p on 5 days of the platelet storage was significantly increased (P < 0.01), while the expression of miR-7-5p, miR-145-5p, miR-15a-5p, miR-25-3p and miR-24-3p was significantly decreased (P < 0.01). 72 h after transfected the miR-96-5p inhibitors into the platelet, the activity of caspase-3 was increased and the expression of Bcl-2 and Bcl-xl proteins was decreased, the process of Bax accumulation and active of caspase-3 was promoted. Conclusion miR-96-5p may play a role in the anti-apoptosis of platele storage.
2018 Vol. 15 (4): 13-17 [Abstract] ( 270 ) HTML (1 KB)  PDF (735 KB)  ( 172 )
18 The role of DEPTOR-mTOR signaling pathway-mediated autophagy on osteoclasts differentiation and maturation in multiple myeloma
ZHANG Haoran1 QIAO Xuxu1 BI Minghong1 ZHAI Yunzhi1 QIAN Liyu2 PAN Chengwu2 ZHAO Lun1
Objective To study the role of DEPTOR knockdown in RPMI-8226 cells on the protein expression of RANKL and differentiation of THP-1 into osteoclast-like cells in a contactless co-culture system and its possible mechanism. Methods Constructed DEPTOR shRNA expression vector GV115-shRNA was transferred into RPMI-8226 cell to produce packaged lentivirus. Western blot was applied to measure the protein levels of DEPTOR and RANKL. The expression of autophagy-associated proteins LC-3 and Atg5 were confirmed by Western blot analysis. Three groups were divided：THP-1 group, THP-1 + RPMI-8226 group and THP-1 + DEPTOR shRNA group. Osteoclast-like cells were identified by TRAP. The mRNA levels of calcitonin receptor (CTR) and Cathepsin-K were examined using RT-PCR. Results The results showed that protein expression levels of DEPTOR and RANKL were significantly lower in RPMI-8226 cells transfected with GV115 DEPTOR shRNA compared with that in untransfected cells (P < 0.05). The expression levels of autophagy-associated proteins LC-3 and Atg5 in the DEPTOR shRNA group were significantly lower than those in the control shRNA group and the parental group (P < 0.05). In the co-culture system, THP-1 cell could differentiate into TRAP positive multinuclear cells. RPMI-8226 promoted mRNA expression of CTR and Cathepsin-K (P < 0.05). DEPTOR shRNA suppressed osteoclast-like cells formation and decreased CTR and Cathepsin-K mRNA expression in co-cultures, the differences were statistically significant (P < 0.05). Conclusion In the coculture system, DEPTOR shRNA inhibits the differentiation of THP-1 cells into TRAP positive multinuclear cells, which may be due to its inhibition on RANKL expression in RPMI-8226 cells, and the inhibition of autophagy will restrain osteoclast maturation.
2018 Vol. 15 (4): 18-22 [Abstract] ( 279 ) HTML (1 KB)  PDF (852 KB)  ( 215 )
23 Experimental study of TLR4/NF-κB signal pathway in the mechanism of incisional pain
LIU Dehua1 WANG Jian2 GAO Zhiqiang1 ZOU Liansheng1 XU Ying3
Objective To investigate the mechanism of Toll like receptor 4 (TLR4)/ nuclear factor κB (NF-κB) signal pathway in rats with incisional pain. Methods One hundred healthy adult male Sprague-Dawley (SD) SPF rats of 20 weeks old were selected to establish incision pain models. Before operation and after operation for 0.5 h, 1 h, 2 h, 8 h, 12 h, 1 d, 2 d, 3 d, 5 d, 7 d, the mechanism withdraw threshold (MWT) in non-operative side and operative side of rats were detected by electronic von Frey pressure pain threshold detector. Before operation and after operation for 2 h, 8 h, 1 d, 2 d, 3 d, 5 d and 7 d, the expression of TLR4, NF-κB, interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) in the spinal cord were detected by real-time fluorescence quantitative PCR (real-time PCR). Results After operation, the MWT in the operative side of rats was lower than that before operation, which was the lowest after operation for 2 h, then increased gradually, and they were significantly lower than those of non-operative side (P ＜ 0.05). After operation, the expression levels of TLR4, NF-κB, IL-1β and TNF-α in spinal cord of rats were increased compared with those before operation, which of postoperative 2 h, 8 h, 1 d, 2 d and 3 d had statistically significant differences compared with those before operation (P ＜ 0.05), which of postoperative 5 d and 7 d had no statistically significant differences compared with those before operation (P ＞ 0.05). The expression levels of TLR4 and NF-κB in the spinal cord reached the highest after operation for 1 d, and the expression levels of IL-1β and TNF-α reached the highest after operation for 8 h. Pearson correlation analysis showed that there was a negative correlation of MWT in operative side with the expression of TLR4 and NF-κB (r = -0.473, P ＜ 0.05, r = -0.398； P ＜ 0.05), the TLR4 levels in spinal cord of rats were positively correlated with the expression levels of IL-1β and TNF-α (r = 0.302, P ＜ 0.05; r = 0.538, P ＜ 0.05), and the NF-κB levels in spinal cord of rats were positively correlated with the expression levels of IL-1β and TNF-α (r = 0.283, P ＜ 0.05; r = 0.467, P ＜ 0.05). Conclusion The signal pathway of TLR4/NF-κB in spinal cord of rats with incisional pain is activated, the expression levels of TLR4 and NF-κB are increased, and the expression levels of downstream inflammatory cytokines IL-1β and TNF-α are up-regulated, which is involved in the regulation process of incisional pain.
2018 Vol. 15 (4): 23-26 [Abstract] ( 256 ) HTML (1 KB)  PDF (605 KB)  ( 161 )
27 The content difference of gastrodin between Gastrodia Rhizoma prepared by ginger from Jianchang Faction and other processed products in Jiangxi Province
LU Ping1 JIN Lei1 JIA Caihong1 LI Xuran2 NIAN Fenghong2 GONG Qianfeng2 YE Xide2
Objective To establish a method for detecting the contents of gastrodin in processed products of Gastrodia Rhizoma, and to compare the content difference of gastrodin between Gastrodia Rhizoma prepared by ginger and other processed products. Methods High performance liquid chromatography method was conducted for the analysis. The chromatographic column was Ultimate3000 C18 (4.6 mm×250 mm, 5 μm), the flowing phase was acetonitrile-water (3∶97), the detection wavelength was 220 nm, the flow rate was 1 mL/min, and the column temperature was 25℃. Results The sample amount and peak area of gastrodin showed good linear relationship, the average recovery rate was 99.76%, RSD was 1.42%, the contents of gastrodin in Gastrodia Rhizoma prepared by ginger, raw Gastrodia Rhizoma and Gastrodia Rhizoma prepared by sulfur fumigation were 1.001%, 0.458%, 0.406% respectively. Conclusion The contents of gastrodin in Gastrodia Rhizoma prepared by ginger shows significant differences with other processed products. This method is sensitive, fast and easy, which can provide reference for further research of Gastrodia Rhizoma.
2018 Vol. 15 (4): 27-30 [Abstract] ( 269 ) HTML (1 KB)  PDF (446 KB)  ( 219 )
31 Pulmonary opportunistic infection in AIDS
ZENG Jing LIU Xuemei HUA Wei GUO Caiping JIN Ronghua▲ ZHANG Yulin▲
Pulmonary is a common target organ of opportunistic infection (OI) in acquired immune deficiency syndrome (AIDS), with a high incidence and mortality. The pathogenic spectrum of the pulmonary OI in AIDS is widespread, including bacteria, mycobacteria, fungi, viruses and parasites, and bacterial fungi, but the most common bacteria are bacterial, mycobacteria and fungi. There are certain characteristics in the clinical manifestation and the diagnosis and treatment. In this paper, the related characteristics of pulmonary OI in AIDS a reviewed, and hope is beneficial to the reader.
2018 Vol. 15 (4): 31-34 [Abstract] ( 246 ) HTML (1 KB)  PDF (519 KB)  ( 173 )
35 The progress of bariatric surgery treated obesity with obstructive sleep apnea hypopnea syndrome
ZHANG Ruoxi LIU Diangang
 Obesity has become one of the greatest public health concerns and obstructive sleep apnea hypopnea syndrome (OSAHS) is prevalent among obese patients. Bariatric surgery has been proved to be a effect strategy for obese patients with OSAHS. However, no related bariatric surgical guideline for OSAHS was found up to now. This article aims at summarizing the progress of the effect of bariatric surgery on obesity with OSAHS.
2018 Vol. 15 (4): 35-38 [Abstract] ( 247 ) HTML (1 KB)  PDF (518 KB)  ( 200 )
39 Research progress of echocardiography in assessment of right ventricular function in patients with coronary heart disease
ZHUANG Xiaochen MU Yuming
 Coronary heart disease (CHD) has been a serious threat to human health, right ventricular (RV) function indicates the unique value to the diagnosis, treatment and prognosis of CHD. However, the evaluation of RV function is hampered because of the complex anatomy of RV. With the rapid development of ultrasound technology, the accuracy has been improved in the assessment of RV function in recent years. This article reviews the current status and research progress of RV function evaluation in CHD patients by echocardiography.
2018 Vol. 15 (4): 39-42 [Abstract] ( 256 ) HTML (1 KB)  PDF (520 KB)  ( 126 )
43 Research progress on the interventions of second-generation antipsychotics Olanzapine-induced metabolism imbalance
DONG Wenfeng1 YAO Shuyong1 CAO Minjuan1 YANG Yong2 DU Xiangdong2
 As one of the second-generation antipsychotics, Olanzapine has been widely used in clinic with remarkable curative effect. However, as the application time progressed, it has been found that the incidence of metabolism imbalance is relatively higher in patients taking olanzapine, such as weight gain and abnormal levels of glucose and lipid. Drug-induced metabolism imbalance is a risk factor for cardiovascular disease and could affect the quality of life and patients′ medication compliance resulting in prolonging the course of disease. Olanzapine-induced metabolism imbalance has attracted much attention, and this article reviews the domestic and research progress on interventions of this issue with the hope to provide reference for clinical and mechanism research.
2018 Vol. 15 (4): 43-46 [Abstract] ( 233 ) HTML (1 KB)  PDF (538 KB)  ( 157 )
47 Association of alexithymia, resilience and suicidal ideation among depressive patients
BIAN Jun1 QI Wenfeng2 GUO Xin3 ZHAO Wenzhe4 LU Yueying3 JIA Na′na3 YUAN Jie5▲
Objective To investigate the characteristics and relationship between alexithymia, resilience and suicidal ideation in patients with depression, aiming at providing the basis for suicide prevention and intervention. Methods From October to December in 2014, the Self-rating Idea of Suicide Scale, Toronto Alexithymia Scale and Connor-Davdson Resilience Scale were investigated in 115 young (18-40 years old) and the elderly (>40~65 years old) patients with depression from two specialized psychiatric hospitals of the Fifth Hospital of Tangshan and Kailuan Mental Health Center in Hebei Province, the differences of different gender and age of patients with depression in alexithymia, resilience and self-rating idea of suicide; the relationship between alexithymia, resilience and self-rating idea of suicide; the prediction of self-rating idea of suicide by alexithymia and resilience were studied. Results ①There was no difference between different gender in alexithymia, resilience and suicidal ideation (P > 0.05). There was no difference between different ages in resilience and suicidal ideation(P > 0.05), while the score of alexithymia in the elderly group was higher than that in the young group (P < 0.05). ②There was a significant negetive correlation between the total score of alexithymia and resilience (P < 0.01), positive correlation between alex ithymia, suicidal ideation scores and the factors (P < 0.01), negative correlation between the total score of resilience and the total score and factor score of suicidal ideation (P < 0.01). ③The mediator effect test shows that the direct effect of alexithymia on suicidal ideation was significant (β=0.533, P < 0.01), the prediction of resilience on suicide ideation was also significant (β=-0.186, P < 0.01), and the rate of mediation effect was 13.34%. Conclusion Resilience can help the patients with depression express emotion and feelings effectively, it is essential to prevent suicidal ideation and behavior.
2018 Vol. 15 (4): 47-49,72 [Abstract] ( 208 ) HTML (1 KB)  PDF (652 KB)  ( 362 )
50 Gamma interferon release test for adult active tuberculosis diagnosis value of Meta-analysis
WEN An1,2 QU Xinhui1,2 ZHANG Kunnan1,2 LENG Erling3 REN Yue2 WU Xiaomu1,2
Objective To evaluate the diagnostic value of IGRAs for active tuberculosis as a reference standard for tuberculin skin test (TST). Methods The PubMed, Medline, Web of Science, the Cochrane Library, EBSCO, Elsevier, Chinese Knowledge Network Database, Wanfang Data, the Chinese Biomedical Literature Database were searched, from the building up to May 2017. The quality of selected documents was evaluated by the QUADAS item scale. Stata 12.0 software was used for Meta analysis to test heterogeneity and to evaluate the publication bias of the selected literature. Results At the beginning of the examination, 871 related articles were collected. According to the inclusion and exclusion criteria of the literature, 10 urticles were selected (6 articles adopted the T - SPOT. TB method, and 7 articles adopted QFT - GIT method), including 746 patients with active tuberculosis, 806 patients with inactive tuberculosis. TST as reference standard, T - SPOT. TB test and QFT - GIT test summary of the value of active TB diagnosis sensitivity, summarizing specificity, summary positive likelihood ratio, and summarize the negative likelihood ratio, and summarize diagnostic odds ratio, aggregate area under the receiver-operating characteristic curve were respectively 81%, 67%, 2.42, 0.29, 8.57, 0.82 and 87%, 68%, 2.71, 0.20, 13.72, 0.20. Conclusion Present evidence indicates that IGRAs test is significantly better than TST for the diagnostic efficacy of active tuberculosis in adults and the differential ability of non-active TB, but the overall diagnostic strength is moderate, and the negative results of the IGRAs test can largely exclude the possibility of active tuberculosis.
2018 Vol. 15 (4): 50-55,81 [Abstract] ( 257 ) HTML (1 KB)  PDF (1365 KB)  ( 114 )
56 The application effects of enhanced recovery after surgery in perioperative period of open hepatectomy
QI Shuo* CHEN Guodong* CAO Peng HU Jiangping HE Gengsheng LUO Jiaxing HE Jun
Objective To investigate the effect of postoperative recovery of the enhanced recovery after surgery (ERAS) in perioperative period of open hepatectomy. Methods Clinical data of 120 patients with open hepatectomy in the Department of Hepatobiliary Surgery of the First Affiliated Hospital of University of South China were retrospectively analyzed, and they were divided into experimental group (EG, Implement ERAS) and control group (CG, Not implement ERAS), the patients were subdivided into subgroups including hepatic stone group (n=73, EG 38 cases and CG 35 cases), hepatic tumor group (n=47, EG 22 cases and CG 25 cases), hepatectomy at least two segments group (n=49, EG 26 cases and CG 23 cases) and at most two segments group (n=71, EG 34 cases and CG 37 cases). The postoperative white blood cell (WBC), the incidence of moderate to severe pain, exhaust time, feeding time, ambulation time, complications, hospital stays and costs of patients in each groups were compared. Results In the four subgroups, compared with CG, most EG had low peak of WBC postoperative 1, 3 d, less time of exhaust, feeding, and ambulation, lower incidence of severe pain, shorter hospital stay and less hospital cost, the difference was statistically significant (P < 0.05). Conclusion ERAS programs can safely and effectively accelerate recovery of patient undergoing open hepatectomy.
2018 Vol. 15 (4): 56-60 [Abstract] ( 232 ) HTML (1 KB)  PDF (791 KB)  ( 141 )
61 Correlation between plasma ox-LDL, AIP levels and carotid artery intima-media thickness in patients with acute cerebral infarction
HUANG Rui HUANG Yong LIU Xingzhao HE Ling
Objective To investigate the correlation between plasma oxidative low density lipoprotein (ox-LDL), atherogenic index of plasma (AIP) levels and carotid artery intima-media thickness (CIMT) in patients with acute cerebral infarction (ACI). Methods From March to August in 2016, 131 patients with ACI (case group) and 60 healthy people (control group) in Jiangjin Central Hospital were recruited. Venous blood of subjects were collected to detected total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), HDL-C, ox-LDL, and AIP was calculated, and CIMT was measured by color Doppler ultrasonic diagnostic apparatus. Results The ox-LDL, AIP and CIMT in case group were significantly higher than those in control group (P < 0.05). The ox-LDL and AIP were both in positive correlation with the CIMT (r=0.618, 0.609, P < 0.05). Conclusion The ox-LDL and AIP levels in patients with ACI are in positive correlation with the CIMT, it has important significance to predict the extent of arterial stenosis, can help to conduct resist oxidation and lipid-lowering treatment, and reduce the risk of ACI
2018 Vol. 15 (4): 61-64 [Abstract] ( 216 ) HTML (1 KB)  PDF (895 KB)  ( 94 )
65 The changes of serum CXCL-12 levels in patients with septic shock and its influence for prognosis
YU Shanling1 LIU fengsui1 XU Shufeng2 LIU Feifei2
Objective To study the changes of serum CXCL-12 levels in patients with septic shock and its influence for prognosis. Methods From August 2016 to May 2017, 97 cases of septic shock patients treated in Qinhuangdao First Hospital were selected, including 79 cases of survivors and 18 cases of death. According to whether or not there were multiple organ functional disorder, they were divided into 34 patients with multiple organ functional disorder group (DF group) and 63 patients without multiple organ functional disorder group (NDF group). Over the same period, 40 healthy volunteers were selected as the control group. Serum CXCL-12 levels were detected, serum CXCL-12 and APACHEⅡ scores in different prognosis of patients were compared, influence factors of death were analyzed. Results The levels of serum CXCL-12 in DF group and NDF group were significantly higher than that of control group, and the level of serum CXCL-12 and the score of APACHEⅡ in the DF group were significantly higher than those in the NDF group, with statistically significant differences (P ＜ 0.05). The level of serum CXCL-12 and the score of APACHEⅡ in the survival group were significantly lower than those of the death group (P ＜ 0.05). The Logistic regression analysis showed that the influence factors of death in patients after treatment were CXCL-12 and APACHEⅡ score (P ＜ 0.05). Conclusion The level of serum CXCL-12 in patients with septic shock is significantly higher and continues to rise with the deterioration of illness and prognosis. CXCL-12 and APACHEⅡ score are the independent risk factors of death of patients with septic shock. The change of CXCL-12 level in patients with septic shock should be strictly monitored, the APACHEⅡ score should evaluated timely. Thus, the prognosis of patients with septic shock can be evaluated more scientifically and accurately
2018 Vol. 15 (4): 65-68 [Abstract] ( 257 ) HTML (1 KB)  PDF (691 KB)  ( 126 )
69 Effects of low molecular weight heparin anticoagulation in cirrhotic patients with portal vein thrombosis
LI Qing WANG Lilin
Objective To explore the effects of low molecular weight heparin anticoagulation in cirrhotic patients with portal vein thrombosis and to assess the impact on patients′ medical costs. Methods From January 2015 to April 2016, 200 cases of cirrhosis patients with portal vein thrombosis in Hengshui Fourth Hospital were selected and divided into the observation group and the control group according to the random number table, with 100 cases in each group. The control group was given routine treatment and the observation group was given low molecular weight heparin sodium anticoagulant 0.4 mL, 1 time a day for six months. The coagulation status, portal vein thrombosis, adverse reactions, hospitalization time and the hospital costs were compared between the two groups. Results After 2 weeks, 1, 2, 4 month and 6 month, the average volume of portal vein thrombosis in the observation group were all lower than those of control group, with statistically significant differences (P ＜ 0.05)； there were no significant differences in prothrombin time and platelet count between the two groups （P ＞ 0.05）. The recanalization rate of portal vein in the observation group was higher than that of control group, with statistically significant difference (P ＜ 0.05). The incidence of complications, hospitalization time and hospitalization cost in the observation group were all lower than that of control group, with statistically significant differences (P ＜ 0.05). Conclusion The application of low molecular weight heparin sodium anticoagulation in the treatment of cirrhosis with portal vein thrombosis can significantly reduce the volume of portal vein thrombosis, improve the recanalization rate, reduce the long-term complications, shorten the hospitalization time and reduce the medical costs.
2018 Vol. 15 (4): 69-72 [Abstract] ( 230 ) HTML (1 KB)  PDF (681 KB)  ( 135 )
73 Levels and clinical value of serum homocysteine and cystatin C in patients with obstructive sleep apnea syndrome
WANG Shanquan1 LIU Chengzhou1 LIU Tongxiang2
Objective To explore the expression level of homocysteine and cystatin C in patients with obstructive sleep apnea syndrome and its clinical value. Methods From January 2015 to July 2017, 174 patients with OSAHS in People′s Hospital of Linqu County were selected as the OSAHS group. At the same time, 90 healthy people in the same hospital were selected as the control group. The levels of serum homocysteine and cystatin C in the two groups were compared. Pearson correlation analysis was used to analyze the correlation of homocysteine, cystatin C and apnea hypopnea index (AHI). Patients in OSAHS group were divided into mild, moderate and severe OSAHS group according to the severity of the disease and the homocysteine, Cystatin C in the three groups were compared. Results The homocysteine and cystatin C in the OSAHS group were higher than those of control group, with highly statistically significant differences (P ＜ 0.01). Pearson correlation analysis showed that serum homocysteine and cystatin C were positively correlated with AHI, with highly statistically significant differences (r = 0.79,0.74,P ＜ 0.01). There were statistically significant differences in homocysteine and cystatin C among the three OSAHS groups (P ＜ 0.05), the above indicators in moderate and severe OSAHS group were higher than those of mild OSAHS group and those in the severe OSAHS group were higher than those of moderate OSAHS group, with statistically significant differences (P ＜ 0.05). Conclusions The level of serum homocysteine and cystatin C in patients with OSAHS were significantly higher than those of normal population and are positively correlated with AHI, which can be used as a sensitive indicator for the diagnosis and evaluation of OSAHS.
2018 Vol. 15 (4): 73-76 [Abstract] ( 575 ) HTML (1 KB)  PDF (731 KB)  ( 162 )
77 Effect of early laparoscopic surgery combined with endoscopic nassl biliary (pancreatic) drainage in the treatment of severe acute pancreatitis patients
LIU Ning
Objective To investigate the effect of early laparoscopic surgery combined with endoscopic naso biliary (pancreatic) drainage in the treatment of severe acute pancreatitis and the postoperative follow-up results of mid term and long term. Methods Seventy-four patients with severe acute pancreatitis (SAP) from February 2011 to May 2014 in Xiaogan Hospital Affiliated to Wuhan University of Science and Technology were retrospectively analyzed and divided into experimental group and control group according to different surgical procedures, with 37 cases in each group. The control group received laparoscopic surgery, and the experimental group received laparoscopic surgery combined with endoscopic nasal biliary (pancreatic) drainage. The surgical results, postoperative complication rate, the changes of preoperative and postoperative 32 d of serum amylase and inflammatory factor [tumor necrosis factor (TNF) -α, interleukin (IL)-6, C reactive protein (CRP), IL-8] of the two groups were compared. Followed-up for three years, the mortality rates of both groups were counted. Results ①Serum amylase: there was no significant difference in serum amylase level between the two groups (P ＞ 0.05), the levels of serum amylase in the two groups were significantly lower than that before surgery, the experimental group was significantly lower than the control group, and the difference was highly statistically significant (P ＜ 0.01). ②Operation effect: the total effective rate in the experimental group (89.19%) was significantly higher than that in the control group (67.57%), the difference was statistically significant (P ＜ 0.05). ③Postoperative complications: the incidence of postoperative complication rate in the experimental group (10.81%) was significantly lower than that in the control group (29.73%), the difference was statistically significant (P ＜ 0.05). ④Serum inflammatory factors: the levels of serum inflammatory factors TNF-α, IL-6, CRP and IL-8 were significantly lower than those before operation (P ＜ 0.01). The levels of TNF-α, IL-6, CRP and IL-8 in the experimental group were significantly lower than those in the control group, the differences were highly statistically significant (P ＜ 0.01). ⑤Postoperative fatality rate: there was no statistically significant difference between the two groups in 1 year after surgery (P ＞ 0.05). The mortality rate of the experimental group (10.81%) was lower than that of the control group (29.73%), the difference was statistically significant (P ＜ 0.05). Conclusion Early laparoscopic surgery combined with endoscopic nasal biliary (pancreatic) drainage for the treatment of SAP can significantly reduce serum amylase, the levels of inflammatory factors TNF-α, IL-6, CRP and IL-8, and can effectively reduce the incidence of postoperative complication rate and fatality rate and further improve the operation effect.
2018 Vol. 15 (4): 77-81 [Abstract] ( 253 ) HTML (1 KB)  PDF (693 KB)  ( 98 )
82 Clinical study of dynamic monitoring of cerebral blood flow and cerebral oxygen saturation in prevention of ischemic brain injury after arthroscopic surgery of beach chair shoulder
CHEN Jingxia ZHAO Zhao
Objective To investigate the clinical effect of dynamic monitoring of cerebral blood flow and cerebral oxygen saturation on prevention of ischemic brain injury after arthroscopic surgery of beach chair shoulder. Methods From May 2014 to August 2016, 48 cases of undergoing arthroscopic shoulder surgery patients was selected in Shenzhen Second People′s Hospital. According to the simple random method they were divided into control group and observation group, with 24 cases in each group. The blood pressure and oxygen saturation were monitored during the operation in the control group and monitoring of cerebral blood pressure and cerebral oxygen saturation in the observation group was carried out. The operation situation, ULCA score 7 d after operation, blood pressure and blood oxygen saturation, and MMSE score were compared between two groups. Results There was no significant difference between the two groups in operation time, intraoperative blood loss, postoperative drainage volume and postoperative extubation time (P > 0.05). In the observation group, the excellent and good rate of ULCA score (87.50%) at 7 d after operation was not significantly different from that of the control group (91.67%) (P > 0.05). The postoperative blood pressure and blood oxygen saturation of patients in the two groups were decreased, the differences were statistically significant (P < 0.05). The postoperative blood pressure and blood oxygen saturation of patients in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). The postoperative MMSE scores of patients in the two groups were decreased, but the MMSE score of the observation group was significantly higher than that of the control group, the difference was statistically significant (P < 0.05). Conclusion The dynamic detection of cerebral blood flow and cerebral oxygen saturation can effectively reduce the risk of ischemic brain injury and improve the recovery of patients after undergoing arthroscopic surgery.
2018 Vol. 15 (4): 82-85 [Abstract] ( 279 ) HTML (1 KB)  PDF (450 KB)  ( 175 )
86 Comparison on the effects of Propofol and Sevoflurane on patients with obstructive jaundice during general anesthesia
ZHANG Xiaohua1 LI Xirong2 LI Yuchan1 ZHANG Jinxiong1 XIONG Xiang3
Objective To compare the anesthesia of Propofol target controlled infusion and Sevoflurane inhalation anesthesia recovery time and recovery of patients with obstructive jaundice of the bispectral index （BIS）, the influence of adverse reactions and postoperative extubation time. Methods From January 2016 to May 2017, 72 patients of general anesthesia on downward abdominal surgery in Maoming Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, all were ASA I or Ⅱ, according to the serum level of total bilirubin they were divided into jaundice group and non jaundice group, with 36 cases in each group, then the jaundice group and non jaundice group were randomly divided into Propofol group A, B and Sevoflurane group A, B, with 18 cases in each group. The awakening time, BIS, extubation time and postoperative adverse reaction of each groups were recorded. Results The recovery time, BIS, and extubation time of patients in the Sevoflurane group A were the longest, the recovery time, BIS at recovery time and extubation time of patients in the Propofol group A were significantly shorter than those in Sevoflurane group A, the differences were statistically significant （P < 0.05）. BIS, recovery time and extubation time of patients in the Propofol group B were longer than those of the Sevoflurane group B, the differences were statistically significant （P < 0.05）. The incidence of PONV, dizziness and drowsiness 24 h after surgery of patients in the Propofol group B was significantly lower than that in the Sevoflurane group B, and the incidence of PONV, dizziness and drowsiness 24 h after surgery in the Propofol group A was lower than that in the Sevoflurane group A, the differences were statistically significant （P < 0.05）. Conclusion Propofol target controlled infusion anesthesia has a lower rate of PONV and more rapid recovery compared with Sevoflurane patients with obstructive jaundice, and the anesthetic effect of Propofol is better than that of Sevoflurane.
2018 Vol. 15 (4): 86-89 [Abstract] ( 242 ) HTML (1 KB)  PDF (444 KB)  ( 104 )
90 Imperative supply-side reform of TCM
YANG Hongguang SHI Jian rong SONG Xinyang LI Haiying WANG Shuo
Supply-side reform has become a normal hand in all walks of life, as well as in the TCM industry. It is imperative to reform the supply side of traditional Chinese medicine in the face of Chinese medicine trade downward pressure, lack of innovation, research and development of Chinese medicine industry form “small, scattered” characteristics, Chinese financial attributes and other practical problems. The unique advantage of culture and resource of TCM, as well as achievements in recent years provide a good foundation for the supply-side reform of TCM. Participation in grading therapy, mutual penetration of services and products, the leading role of TCM centers overseas, creative transboundary cooperation, and the consummation of standard construction and market guidance will provide feasible measures for the reform of supply side of TCM. Implementation of supply-side reform of TCM is inseparable from the principle of innovation, culture, cooperation and confidence.
2018 Vol. 15 (4): 90-93,107 [Abstract] ( 276 ) HTML (1 KB)  PDF (705 KB)  ( 112 )
94 Visualization analysis of Chinese medicine guidance based on Citespace
SHI Jingjing1 BO Rongqiang2 HU Yuanhui1▲ QIU Zhiling1 WANG Huan1 SONG Qingqiao1 WANG Jiuzhong1
Objective To analysis the present situation, hot spot and trend of traditional Chinese medicine guidance field by visualization knowledge analysis software, which can provide reference for future research. Methods A total of 659 Chinese medicine-guided literatures were collected from 1953 to 2017 in CNKI. CiteSpace software was used to analyze the visualization of the authors, institutions and keywords. The status quo and hotspots of traditional Chinese medicine guided study was explored. Results Chinese medicine guided study showed a trend of growth, the high amount of published were LIU Tianjun, DAI Jingang, ZHANG Xuemin, ZHAO Haihong, CAO Xiao, SUN Aiping, ZHAO Wenru and other scholars, Chinese medicine guidance on the more closely related institutions were Beijing University of Traditional Chinese Medicine, Shanghai Qigong Research Institute, Capital Medical University Affiliated Beijing Tongren Hospital Nerve Training Rehabilitation Center, Shanghai University of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, and Chinese Academy of Traditional Chinese Medicine Medical Center. Healthy, the Inner Canon of Huangdi, Tuina, Kung fu method, Various pathogenic designate theory, Baduanjin, Qigong, Tai Chi, preventive treatment of disease were main research directions. Conclusion In recent years, the amount of literature on the Chinese medicine guide is gradually increased, with the spread of disease thinking, related research will be payed more attention, guided surgery as a non-pharmacological therapy in clinical disease research should also be increased.
2018 Vol. 15 (4): 94-98 [Abstract] ( 289 ) HTML (1 KB)  PDF (1213 KB)  ( 146 )
99 Effects of Kaixin Jieyu Decoction in the treatment of vascular depression and its impact on serum 5-hydroxytryptamine and brain-derived neurotrophic factor
ZHANG Xiaonan1,2 HUANG Shijing1▲ WU Wei3 ZHANG Ying1 YANG Ge3
Objective To observe the clinical effects of Kaixin Jieyu Decoction in the treatment of vascular depression and to explore its mechanism preliminarily. Methods Sixty patients with vascular depression in Outpatient Department of Guang′anmen Hospital, China Academy of Chinese Medical Sciences finished the observation from March 2012 to February 2014, they were divided into the treatment group (35 cases) and the control group (25 cases) by practical randomized control and proportion of 3∶2. The treatment group was treated with Kaixin Jieyu Decoction, and the control group was treated with Citalopram Hydrobromide Tablets. The scores of Hamilton depression scale (HAMD) and TCM symptom scores in the two groups were recorded before treatment and after treatment for 2, 4, 8 weeks. The concentrations of serum 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF) and routine blood and urine test, hepatic and renal function were tested before and after treatment. Results After treatment for 2, 4, 8 weeks, the scores of HAMD scale in the two groups were all significantly lower than those before treatment (all P ＜ 0.01), while there were no significant differences between the two groups after treatment (P ＞ 0.05). The results of depression efficacy showed that the total effective rate of the treatment group was 88.57%, which of control group was 88.00%, there was no significant difference between the two groups (P ＞ 0.05). After treatment for 2, 4, 8 weeks, the scores of TCM symptoms in the two groups were all significantly lower than those before treatment (all P ＜ 0.01), there were no significant differences between the two groups after treatment for 2, 4 weeks (P ＞ 0.05), but the score of TCM symptoms in the treatment group after treatment for 8 weeks was significantly lower than that of control group (P ＜ 0.01). The comprehensive curative effect of TCM symptoms showed that the total effective rate in the treatment group was 85.71%, which of the control group was 64.00%, there was no significant difference between the two groups (P ＞ 0.05). The treatment group had more advantages in improving poor appetite, preference for sighing, lacking in strength, insomnia than control group (P ＜ 0.05). After treatment, the concentration of 5-HT and BDNF in the two groups were significantly higher than those before treatment (P ＜ 0.01), while there were no significant differences between the two groups after treatment (P ＞ 0.05). Conclusion Kaixin Jieyu Decoction has good anti-depression effects, which is comparable to Citalopram Hydrobromide, while it has more advantages in improving TCM symptoms, whilch may be related to promoting the synthesis or release of 5-HT, BDNF.
2018 Vol. 15 (4): 99-102,112 [Abstract] ( 730 ) HTML (1 KB)  PDF (721 KB)  ( 192 )
103 Meta analysis of auricular point sticking in the treatment of post-stroke depression
WANG Qiang GUO Yang LIU Yao WANG Yuan▲
Objective To systematically assess the clinical efficacy of auricular point sticking in the treatment of post-stroke depression. Methods The database of PubMed, EMBase, The Cochrane Library, Wed of Science, CBM, CNKI, VIP and Wanfang Data were searched by computer to collect randomized controlled trials (RCTs) about auricular point sticking combined with other therapy (experimental group) comparing with other routine therapy (control group) in the treatment of post-stroke depression, the retrieval time limit was from data building to November 2017. Two researchers made literature screening, data extraction, quality assessment independently, then RevMan5.3 software was used to make meta analysis. Results Total 10 RCTs involving 744 patients were enrolled into this research. The meta analysis showed that: the total effective rate of experimental group was significantly higher than that of control group (OR = 3.21, 95%CI: 1.65 - 6.24，P = 0.0006); after treatment, the score of Hamilton depression scale in the experimental group was significantly lower than that of control group (MD = -3.26, 95%CI: -4.56 - -1.96, P ＜ 0.000 01); there were no statistically significant differences of the scores of Barthel index and neurologic impairment between the two groups after treatment (MD = 4.5, 95%CI: -0.99 - 10.00，P = 0.11; MD = 0.76, 95%CI: -0.20 - 1.72, P = 0.12). Conclusion Auricular point sticking in the treatment of post-stroke depression is effective, but the enrolled randomized controlled trials still need high quality, large sample, multi-center randomized studies to further verify.
2018 Vol. 15 (4): 103-107 [Abstract] ( 302 ) HTML (1 KB)  PDF (1280 KB)  ( 202 )
108 Chinese medicine service under the "Belt and Road" initiative
CUI Yuanyue HU Lingjuan MENG Haoting
In 2013, China proposed the construction of the silk road economic belt and the "Silk Road on the sea" for the first time in twenty-first century. This is a win-win road to common development and common prosperity. With the increasing emphasis on the development of service industries, service trade has become a new driving force for world economic growth. The service trade of Chinese medicine, as a national health industry with completely independent intellectual property rights and original innovation potential, plays an important strategic role in the development of Chinese medicine service trade. In the background of the "Belt and Road" initiative, the service trade of Chinese medicine in China ushered in the opportunity of rapid development period. But we can not ignore the TCM service trade in development also faces many challenges, including the TCM service trade development is not balanced, the supporting policies are not perfect, foreign legal restriction, the overseas development of Chinese medicine "desinicization", compound talents insufficient storage. In view of these problems, the author puts forward some suggestions on the development of the service trade of Chinese medicine, improving the relevant policies of Chinese medicine trade in services, improving the service level of TCM and paying attention to the training of qualified personnel.
2018 Vol. 15 (4): 108-112 [Abstract] ( 280 ) HTML (1 KB)  PDF (694 KB)  ( 91 )
113 Clinical study of acupuncture combined with Huoxue Tongluo Decoction in the treatment of post-stroke cognitive impairment
JIA Yunzhe1 LYU Xiaoyu2
Objective To investigate the effects of acupuncture combined with Huoxue Tongluo Decoction in the treatment of post-stroke cognitive impairment. Methods A total of 79 patients with post-stroke cognitive impairment in Wuhan Eleventh Hospital from January 2015 to December 2016 were enrolled in this study. The subjects were randomly divided into the control group (39 cases) and the treatment group (40 cases). The control group was treated with Huoxue Tongluo Decoction, the treatment group was treated with acupuncture combined with Huoxue Tongluo Decoction. The two groups were treated for 30 days. The clinical effects of the two groups after treatment were compared. The cognitive function by mini-mental state examination (MMSE) was evaluated, the levels of serum cortisol (Cor) and heat shock protein 70 (heat shock protein 70, HSP70) were detected before and after treatment, the adverse reactions of the two groups during treatment were observed. Results The total effective rate of the treatment group was significantly higher than that of control group (P ＜ 0.05). After treatment, the MMSE score of the two groups was significantly higher than that before treatment, the MMSE score of the treatment group was significantly higher than that of control group (P ＜ 0.05). After treatment, the levels of serum Cor in the two groups were significantly lower than those before treatment, the levels of serum HSP70 in the two groups were significantly higher than those before treatment, and the changes of serum Cor and HSP70 levels after treatment in the treatment group were significantly better than those in the control group, the differences were statistically significant (P ＜ 0.05). There were no significant adverse reactions in the two groups during the treatment. Conclusion Acupuncture combined with Huoxue Tongluo Decoction for patients with post-stroke cognitive impairment has a good efficacy, which can improve the cognitive function and neurologic prognosis, with good safety, and it is worthy of clinical promotion and application.
2018 Vol. 15 (4): 113-116 [Abstract] ( 663 ) HTML (1 KB)  PDF (651 KB)  ( 98 )
117 Correlation between musculoskeletal system imaging features and clinical features in patients with rheumatoid arthritis and hip involvement
SONG Yanqi ZHAO Wen SONG Min GAO Keyong
Objective To investigate the correlation between musculoskeletal system imaging features and clinical features in patients with rheumatoid arthritis and hip involvement. Methods Retrospective study was used in this study, from August 2013 to January 2017, 65 patients with rheumatism in the Second People's Hospital of Dalian (“our hospital” for short) for diagnosis and treatment were selected as the observation group, and 65 cases of healthy volunteers examined in our hospital were selected as the control group at the same period, the Harris score was used to evaluated the hip joint function, and the MR musculoskeletal imaging features was recorded and the correlation results was analyzed. Results The excellent and good rate of Harris score in the observation group and the control group were 53.8% and 100.0%, respectively, and the observation group was significantly lower than that of the control group (P < 0.05). There were 46 cases of synovitis in the observation group of the MR imaging features, 32 cases were bone marrow edema, 28 cases of bone erosion; so that were 2, 2 cases and 1 case in the control group, there were statistically significant difference between the two groups (P < 0.05). The hip joint T2 values of the observation group and the control group were (32.39±1.87) and (23.11±1.66), respectively, and the observation group was significantly higher than that of the control group (t = 8.298, P < 0.05). Spearman′s rank correlation test showed that, there were significant positive correlation between the Harris and T2 values of the synovitis, bone marrow edema, bone erosion and hip joint (rs = 0.452, 0.399, 0.499, 0.633, all P ＜ 0.01). Conclusion MR musculoskeletal system used in rheumatoid arthritis patients can effectively reflect the hip involvement, and its imaging features, it is closely related with the function of hip join, it has clinical guidance values for evaluation hip joint involvement in patients with rheumatic diseases.
2018 Vol. 15 (4): 117-119,125 [Abstract] ( 245 ) HTML (1 KB)  PDF (616 KB)  ( 153 )
120 Effectiveness of Shengxuening tablet in the treatment of renal anemia: a Meta-analysis
LIU Qiaoyan CHEN Fan CAO Shiyi▲
Objective To systematically review the effectiveness of Shengxuening tablet for renal anemia. Methods We electronically searched databases including Pubmed, Web of Science, VIP, WanFang Data and CNKI for published articles of randomized controlled trials (RCTs) of Shengxuening tablets versus other drugs and conventional drugs for renal anemia from inception to August 2017. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data and assessed the risk of bias in included studies. Then, Meta-analyses was performed with Stata 12.0 software. Results A total of 17 RCTs involving 1193 patients with renal anemia were included. The results of Meta-analyses showed that the improvement of laboratory indications, such as Hemoglobin [WMD = 1.52, 95%CI (1.18, 1.86), P ＜ 0.001], Hematocrit [WMD = 1.90, 95%CI (1.19, 2.60), P ＜ 0.001], Serum Ferritin [WMD = 2.01, 95%CI (1.38, 2.65), P ＜ 0.001] and Transferrin Saturation [WMD = 1.90, 95%CI (1.30, 2.50), P ＜ 0.001]. Conclusion The current evidence shows that Shengxuening tablet may significantly improve the effectiveness. Due to the limited quality and quantity of the included studies, the above conclusions need more high quality studies to verify.
2018 Vol. 15 (4): 120-125 [Abstract] ( 592 ) HTML (1 KB)  PDF (961 KB)  ( 221 )
126 Research and discussion on the present situation of postgraduate education about clinical pharmacy in our university
LI Yaling1,2 YE Yun1 HUANG Yilan1,2 LI Jun3
In recent years, the development of clinical pharmacy graduate education in Southwest Medical University ("our school" for short) has been rapid, and has achieved some results, but there are still deficiencies compared with the domestic and foreign first-class clinical pharmacy postgraduate education. This paper aims to understand the clinical pharmacy graduate status and the domestic and foreign education with the professional graduate education present situation, and analyze the shortcomings of the current clinical pharmacy graduate education, study the new trends of the specialty in our school, according to the existing conditions and advantages from the realitya put forward feasible suggestions to cultivate high-quality innovative and practical service clinical pharmacy personnel in accordance with its own educational philosophy and characteristics, so as to provide reference strategies for the reform and development of postgraduate education in clinical pharmacy.
2018 Vol. 15 (4): 126-129 [Abstract] ( 246 ) HTML (1 KB)  PDF (553 KB)  ( 150 )
130 The application and significance of mind mapping in the teaching process of nursing students in the digestive department
HOU Yongjia CHEN Qian
Objective To explore the application and significance of mind mapping in the process of clinical teaching  in nursing students of the digestive department. Methods A total of 82 nursing students in the digestive department of Nantong Second People's Hospital from September to October 2016 were collected, and divided into the control group and experiment group by random number table, with 41 students in each group. The control group was taught by oral instruction + multimedia presentation(PPT), and the experiment group was taught by oral instruction + PPT + mind mapping. After the end of the teaching, the examination and questionnaire were used to evaluate the teaching effect. Results After teaching, the assessment grades of theory and operation in the experiment group were higher than those of control group (P < 0.05). The total score and six dimensions (except cognitive maturity) scores of critical thinking ability in the experiment group were higher than those of control group (P < 0.05). The satisfaction of nursing students on the quality of teaching in the experimental group was significantly higher than control group (P < 0.05). Conclusion Mind mapping can effectively increase the achievement of theory and operation of nursing students in the digestive department, and improve their critical thinking ability and the satisfaction of the quality of teaching.
2018 Vol. 15 (4): 130-133,168 [Abstract] ( 314 ) HTML (1 KB)  PDF (1228 KB)  ( 172 )
134 The necessity for biotechnology major of medical college for set up pharmacogenomics
LI Meng1 DUAN Ran2 JIANGXinju2 GUO Yanhai1 LU Zifan1 YUAN Yuan3
Pharmacogenomics is a new discipline which intend to go deep and extend of genomics in the field of pharmacy. Pharmacogenomics can not only helps people better understand the causes of different individuals differences in drug reactions, but also directs the development and clinical use of new drugs. With the introduction of the concept of "precision medicine" and the arrival of the era of "personalized medicine", pharmacogenomics is becoming more and more concerned and is gradually enter clinical application. On the other hand, biotechnology has been widely used in diagnosis, pharmaceutical and other fields in recent years, medical and pharmaceutical colleges and universities have set up biotechnology major, with a view to training pharmaceutical professionals for laboratory, pharmacy and new drug development. However, most biotechnology majors currently have very few pharmacogenomics, which is very bad for cultivating talents in the era of "individualized medicine". Based on the research content and practical application of pharmacogenomics, this paper analyzes the necessity of pharmacogenomics in the specialty of biotechnology in medical and pharmaceutical colleges, which provide information for improving the curriculum system of biotechnology.
2018 Vol. 15 (4): 134-137 [Abstract] ( 310 ) HTML (1 KB)  PDF (554 KB)  ( 177 )
138 The Application Effect of PBL Combined with Micro-Video Method in Teaching of Pelvic Organ Prolapse
HU Ming HONG Li
Objective To investigate the application value of PBL combined with Micro-Video method in the teaching of pelvic organ prolapse. Methods In September 2016, 80 students started learning course of Gynaecology and Obstetrics in the first clinical college of wuhan university were selected as the research object, and divided into group A (PBL combined with micro video teaching group) and group B (PBL teaching group) by random number table, with 40 students in each group. The subjective feelings (quantification of questionnaire results), teaching effect and quality (test achievement quantification) between two groups were compared. Results The subjective feelings (quantification of questionnaire results) in the A group was higher than B group, the difference was statistically significant (P < 0.05). The teaching effect and quality (test achievement quantification) in the A group was higher than B group, the difference was statistically significant (P < 0.05). Conclusion PBL combined with Micro-Video method had good effect in the teaching of pelvic organ prolapsed, and it was worthy of popularization and application in gynecology and obstetrics teaching.
2018 Vol. 15 (4): 138-141 [Abstract] ( 287 ) HTML (1 KB)  PDF (590 KB)  ( 137 )
142 Innovative teaching mode and practice of all-English curriculum of Introduction to Natural Products for pharmaceutical postgraduates
CHEN Haixia CHEN Zhongqin
In order to carry out the reform and practice of the teaching mode of the all-English curriculum of Introduction to Natural Products, an innovation teaching mode including "interactive discussion" and "case-based practice" is put forward, which could change the conventional teaching pattern and prompt the reform of all-English teaching model. During the teaching process, the traditional teaching mode is changed, "Interactive discussion" and "case-based practice" teaching mode could stimulate students’ interest in learning, arouse the learning enthusiasm and autonomy of students, and finally cultivate students’ practical abilities such as problems analyzing and solving abilities. Ultimately, it is expected to improve the teaching quality of education and realize the goal of cultivating high quality international and professional talents for the Chinese medicine modernization and internationalization in our country.
2018 Vol. 15 (4): 142-145 [Abstract] ( 206 ) HTML (1 KB)  PDF (607 KB)  ( 111 )
146 Exploration of people-oriented service of resident physician in outpatient and emergency department
LIAO Shengwu1 CAI Wang2 LIU Jie2
The service of hospital window unit the outpatient and emergency department is a way to measure the medical social service level in hospital. Currently there are some problems exist in outpatient and emergency department such as the medical process lack of humanistic concern, poor treatment environment, the lack of medical guidance and the long queuing time. Humanity medical service in the outpatient and emergency department could convenient for patients, and bring more considerate service for patients, improve medical quality, meet the patients physiological and psychological requirements and improve people's well-being. This paper will discuss the problems existing in the service of the outpatient and emergency department of the hospital window, and emergency department and how to improve and enhance the humane medical services.
2018 Vol. 15 (4): 146-150 [Abstract] ( 195 ) HTML (1 KB)  PDF (500 KB)  ( 133 )
151 The exploration for development of medical alliance in psychiatric hospitals in Shanghai
XIE Fei XIE Bin▲
According to medical reform policy requirements, medical alliances in China were established one after another in health institutions and achieved the initial success. But there are still many problems to be solved, a number of "test water breaking" medical couplet presents a state of "incompatibility", which led to the alliances could not play the functions completely, even affected the formation of the domestic hierarchical medical system. There are many problems between insufficient government investment, self-governance among specialist hospitals, poor coordination and unreasonable distribution of mental health resources in Shanghai city mental health management and service, to carry out establish psychiatric medical alliances is one of the effective ways to solve these problems, and it has realistic significance. It is suggested that in the establish psychiatric medical alliances, government should play a leading and coordinating role in the construction of the psychiatric medical alliances, it is responsible for the top-level design and coordination of the organization, clarifying the four basic principles of fairness, accessibility, hierarchical medical care and the leading role of public hospitals. Give different supporting measures and policy support according to different needs, and increase the investment on the construction of medical alliance. So that the psychiatric medical alliances can return to the initial purpose of the establishment of the hierarchical medical system and reach the goal of the new medical reform, which aims to effectively alleviate "difficulties and expensive medical treatment".
2018 Vol. 15 (4): 151-155 [Abstract] ( 283 ) HTML (1 KB)  PDF (540 KB)  ( 108 )
156 The effect of quality nursing on cognitive dysfunction and life ability of alzheimer′s patients
MA Yan1 LIN Wei1▲ ZHANG Minghui2 WANG Pengjun2
Objective To explore the application value of quality nursing in patients with Alzheimer′s disease and the improvement in cognitive dysfunction and living ability. Methods From January 2015 to December 2016, 200 patients with Alzheimer′s disease in the Outpatient Department, the Fourth Affiliated Hospital of Harbin Medical University were selected and divided into the observation group and the control group by random number table, with 100 cases in each group. The control group was given routine nursing mode and the observation group was given high quality nursing intervention. The mini-mental state examination (MMSE), Montreal cognitive assessment scale (MoCA), Alzheimer′s disease assessment scale (ADAS-cog), Alzheimer′s disease cooperative study ADL (ADCS-ADL) were applied to evaluate the cognitive function and the living ability in the two groups. Results Before nursing, there were no statistically significant differences in the scores of MMSE, MoCA, ADAS-cog and ADCS-ADL (P ＞ 0.05). After nursing of 3 month and 6 month, the scores of MMSE, MoCA and ADCS-ADL in the observation group were all significantly higher than those of control group, the scores of ADAS-cog  was lower than that of control group, with statistically significant differences (all P ＜ 0.05). Conclusion Quality nursing can improve the cognitive function and daily living ability of Alzheimer′s patients. It can improve the independent living ability and reduce the burden of family. It is worthy of promotion and application.
2018 Vol. 15 (4): 156-159 [Abstract] ( 782 ) HTML (1 KB)  PDF (559 KB)  ( 192 )
160 The effect of comprehensive emergency care on the lower limb function and life quality in patients with osteoporotic compression fracture
JIANG Senting1 CAO Yang2▲
Objective To explore the effect of comprehensive emergency care on the lower limb function and life quality in patients with osteoporotic compression fracture. Methods From May 2014 to May 2016, 90 patients with osteoporotic compression fracture treated in the First Affiliated Hospital of Harbin Medical University were selected and divided into the control group and the observation group by random number table, with 45 cases in each group. The control group was given the routine emergency care and the observation group was given comprehensive emergency care on the bases of control group. The postoperative activity time, hospitalization time, postoperative pain score, the nursing satisfaction, the lower limb motor function score and the life quality after 1 year follow-up were compared between the two groups. Results The postoperative activity time and the hospitalization time in the observation group were shorter than those of control group, the postoperative pain score was lower than that of control group, with statistically significant differences (P ＜ 0.05). The nursing satisfaction in the observation group (91.11%) was obviously higher than that of control group (71.11%), with statistically significant differences (P ＜ 0.05). After nursing, the scores of lower limb motor function and the life quality in the two groups were higher than those of before nursing, and those in the observation group improved much more remarkably, with statistically significant differences (P ＜ 0.05). Conclusion Comprehensive emergency nursing can effectively improve the postoperative rehabilitation in patients with osteoporotic compression fracture, promote the nursing satisfaction, improve the lower limb motor function and life quality. It is worthy of promotion and application.
2018 Vol. 15 (4): 160-163 [Abstract] ( 198 ) HTML (1 KB)  PDF (556 KB)  ( 79 )
164 Effects of humanized nursing intervention on anxiety and depression in patients underwent surgery
YANG Li1 CHU Chengmei2
Objective To explore the effects of humanized nursing intervention on anxiety and depression in patients underwent surgery. Methods From January 2016 to January 2017, 148 patients underwent surgical treatment in People′s Hospital of Hai′an County were selected as research objects and divided into the routine group and the observation group by random number table, with 74 cases in each group. The routine group was given basic care intervention and the observation group was given humanized nursing intervention on the bases of routine group. The changes of mental status were observed before and after operation， and the vital signs and nursing satisfaction were observed. The psychological status before and after operation was compared, the vital signs and the nursing satisfaction after the operation were compared between the two groups. Results After operation, the scores of self-rating anxiety scale and self-rating depression scale in the observation group were lower than those of routine group, with statistically significant differences (P ＜ 0.05). The respiration, heart rate, diastolic blood pressure and systolic blood pressure in the observation group were all lower than those of routine group, with statistically significant differences (P ＜ 0.05). The total nursing satisfaction rate was higher than that of routine group, with statistically significant difference (P ＜ 0.05). Conclusion Humanized nursing intervention can reduce the anxiety and depression in patients underwent surgery, reduce the stress responses, improve the surgical tolerance and promote the nursing satisfaction.
2018 Vol. 15 (4): 164-168 [Abstract] ( 219 ) HTML (1 KB)  PDF (593 KB)  ( 90 )
169 Effect of FOCUS-PDCA management mode on postoperative recovery and the occurrence of complications in patients with minimally invasive rotary varicotomy for breast mass
GAO Shijie1 GUAN Rui2 DONG Nanjun1 XU Dan2
Objective To analyze the influence of FOCUS-PDCA management mode on postoperative recovery and the occurrence of complications in patients with minimally invasive rotary varicotomy for breast mass. Methods One hundred cases of patients with minimally invasive rotary varicotomy for breast mass admitted to Fushun Central Hospital in Liaoning Province from January 2015 to June 2017 were randomly divided into observation group and control group, with 50 cases in each group. The control group received routine nursing management mode, the observation group received the FOCUS-PDCA management mode. The hospital stay, hospitalized expense, informed conditions of healthy knowledge, satisfaction degree, the qualified rate of implementation of grading nursing and the qualified rate of health education in the two groups were investigated. The swelling degree of patients was investigated before discharge, and the QLQ-C30 scale and symptom checklist were respectively used to evaluate the quality of life and psychological status after discharge for 3 months. Results The hospital stay, total hospitalized expense, and the incidence of complications in the observation group were significantly lower than those of control group, the differences were statistically significant (P ＜ 0.05), and the awareness rate of health knowledge, the qualified rate of implementation of grading nursing, satisfaction degree of patients, the qualified rate of health education, the breast swelling degree, the scores of quality of life and psychological status in the observation group were all significantly better than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion FOCUS-PDCA management mode can effectively improve the postoperative recovery treatment conditions of patients with minimally invasive rotary varicotomy for breast mass and reduce the incidence of postoperative complications.
2018 Vol. 15 (4): 169-172 [Abstract] ( 306 ) HTML (1 KB)  PDF (584 KB)  ( 142 )
173 Influence of individualized nursing on negative emotions and quality of life in skin ulceration patients with breast cancer
PENG Lijuan FAN Zhigang
Objective To explore the influence of individualized nursing on negative emotions and quality of life in skin ulceration patients with breast cancer. Methods From December 2015 to May 2017, 58 cases of skin ulceration patients with breast cancer treated in 3201 Affiliated Hospital of Xi′an Jiaotong University Medical College were selected as the research objects and divided into the control group and the study group according to the random number table, with 29 cases in each group. The control group was given routine nursing and the study group was given individualized nursing on the basis of control group. The two groups were all intervened for 4 weeks. The scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS) and functional assessment of cancer therapy-breast (FACT-B) were compared in the two groups. Results After nursing, the scores of SAS and SDS in the two groups were significantly lower than those before nursing, and those in the study group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05). After nursing, the physiological status, social and family status, emotional status, functional status, and additional concerns in each dimension of FACT-B and the total score in the two groups were significantly higher than those before nursing (P < 0.05), and those in the study group were significantly higher than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion Individualized nursing can effectively alleviate negative emotions of skin ulceration patients with breast cancer and improve quality of life. It is worthy of promotion and application.
2018 Vol. 15 (4): 173-176 [Abstract] ( 244 ) HTML (1 KB)  PDF (557 KB)  ( 120 )
177 Influences of family care on psychological state, self-management behavior and self-perceived burden in patients with maintenance hemodialysis
TONG Huaqing
Objective To study the influences of family care on psychological status, self-management behavior and self-perceived burden in patients with maintenance hemodialysis. Methods From June 2012 to February 2016, 82 patients treated with maintenance hemodialysis in Zigong Third People′s Hospital were selected as research subjects and divided into the good family function group (37 cases) and the poor family function group (45 cases) according to the family APGAR index. The self-rating depression scale (SDS) and the self-rating anxiety scale (SAS) were used to evaluate the psychological status of the patients. The self-management behavior was evaluated by hemodialysis patients′self-management scale. The self-perceived burden scale (SPBS) was used to assess the degree of the patients′ self-perceived burden. Results The average scores of SDS and SAS, the proportion of depression and anxiety in the good family function group were all lower than those of poor family function group, with statistically significant differences (P ＜ 0.05). The total score of self-management behavior and each dimension score in the good family function group were higher than those of poor family function group, with statistically significant differences (P ＜ 0.05). The total score of SPBS and each dimension score in the good family function group were all lower than those of poor family function group, with statistically significant differences (P ＜ 0.05). Conclusion The improvement of family care can directly optimize the psychological status and self-management behavior in patients with maintenance hemodialysis, and reduce the burden of self-perception.
2018 Vol. 15 (4): 177-180 [Abstract] ( 275 ) HTML (1 KB)  PDF (555 KB)  ( 230 )
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