γ干扰素释放试验对成人活动性结核病诊断价值的荟萃分析

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Abstract Objective To evaluate the diagnostic value of IGRAs for active tuberculosis as a reference standard for tuberculin skin test (TST). Methods The PubMed, Medline, Web of Science, the Cochrane Library, EBSCO, Elsevier, Chinese Knowledge Network Database, Wanfang Data, the Chinese Biomedical Literature Database were searched, from the building up to May 2017. The quality of selected documents was evaluated by the QUADAS item scale. Stata 12.0 software was used for Meta analysis to test heterogeneity and to evaluate the publication bias of the selected literature. Results At the beginning of the examination, 871 related articles were collected. According to the inclusion and exclusion criteria of the literature, 10 urticles were selected (6 articles adopted the T - SPOT. TB method, and 7 articles adopted QFT - GIT method), including 746 patients with active tuberculosis, 806 patients with inactive tuberculosis. TST as reference standard, T - SPOT. TB test and QFT - GIT test summary of the value of active TB diagnosis sensitivity, summarizing specificity, summary positive likelihood ratio, and summarize the negative likelihood ratio, and summarize diagnostic odds ratio, aggregate area under the receiver-operating characteristic curve were respectively 81%, 67%, 2.42, 0.29, 8.57, 0.82 and 87%, 68%, 2.71, 0.20, 13.72, 0.20. Conclusion Present evidence indicates that IGRAs test is significantly better than TST for the diagnostic efficacy of active tuberculosis in adults and the differential ability of non-active TB, but the overall diagnostic strength is moderate, and the negative results of the IGRAs test can largely exclude the possibility of active tuberculosis.

Key words： Gamma interferon release test Tuberculosis Meta analysis

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	WEN An1
	2 QU Xinhui1
	2 ZHANG Kunnan1
	2 LENG Erling3 REN Yue2 WU Xiaomu1
	2

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WEN An1,2 QU Xinhui1,2 ZHANG Kunnan1, et al. Gamma interferon release test for adult active tuberculosis diagnosis value of Meta-analysis[J]. 中国医药导报, 2018, 15(4): 50-55,81.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I4/50

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