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| The changes of serum CXCL-12 levels in patients with septic shock and its influence for prognosis |
| YU Shanling1 LIU fengsui1 XU Shufeng2 LIU Feifei2 |
1.the Second Department of Critical Care Medicine, Qinhuangdao First Hospital, Hebei Province, Qinhuangdao 066000, China;
2.the First Department of Respiration, Qinhuangdao First Hospital, Hebei Province, Qinhuangdao 066000, China |
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Abstract Objective To study the changes of serum CXCL-12 levels in patients with septic shock and its influence for prognosis. Methods From August 2016 to May 2017, 97 cases of septic shock patients treated in Qinhuangdao First Hospital were selected, including 79 cases of survivors and 18 cases of death. According to whether or not there were multiple organ functional disorder, they were divided into 34 patients with multiple organ functional disorder group (DF group) and 63 patients without multiple organ functional disorder group (NDF group). Over the same period, 40 healthy volunteers were selected as the control group. Serum CXCL-12 levels were detected, serum CXCL-12 and APACHEⅡ scores in different prognosis of patients were compared, influence factors of death were analyzed. Results The levels of serum CXCL-12 in DF group and NDF group were significantly higher than that of control group, and the level of serum CXCL-12 and the score of APACHEⅡ in the DF group were significantly higher than those in the NDF group, with statistically significant differences (P ＜ 0.05). The level of serum CXCL-12 and the score of APACHEⅡ in the survival group were significantly lower than those of the death group (P ＜ 0.05). The Logistic regression analysis showed that the influence factors of death in patients after treatment were CXCL-12 and APACHEⅡ score (P ＜ 0.05). Conclusion The level of serum CXCL-12 in patients with septic shock is significantly higher and continues to rise with the deterioration of illness and prognosis. CXCL-12 and APACHEⅡ score are the independent risk factors of death of patients with septic shock. The change of CXCL-12 level in patients with septic shock should be strictly monitored, the APACHEⅡ score should evaluated timely. Thus, the prognosis of patients with septic shock can be evaluated more scientifically and accurately
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