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2020 Vol. 17, No. 5
Published: 2020-02-15
 
 
4 Effect of the exosomes extracted from adipose-derived mesenchymal stem cells on hypoxia/reoxygenation-induced cardiomyocyte apoptosis
LIANG Zheng ZHONG Jianfeng WU Yancong WEN Wen CHEN Can LI Bo
Objective To investigate the effect of mouse adipose-derived mesenchymal stem cells (mASCs) derived exosomes (Exo) on hypoxia/reoxygenation (H/R) induced apopotosis of cardiomyocytes neonatal mouse cardiomyocytes. Methods The mascs-derived Exo (mascs-exo) was isolated and extracted by ultra-high speed centrifugation. The Exo was observed and identified by transmission electron microscopy (TEM), nanoparticle tracer analysis (NTA) and Western blot (WB). C57BL/6 suckled rat cardiomyocytes were extracted by differential adherent method. Expression of CTnI and conexin43 was detected by immunofluorescence. Pkh-26 was labeled Exo to indicate the uptake capacity of cardiomyocytes. The experiment was divided into three groups: normal control group (control group), hypoxia/reoxygenation group (H/R group) and hypoxia/reoxygenation + mascs-exo group (H/R+ mascs-exo group). Apoptosis of was detected by TUNEL staining. The expression level of apoptosis-related protein was detected by WB. Results compared with the control group, the apoptosis rate of cardiomyocytes in the H/R group was increased (P ＜ 0.01), and the apoptosis rate of cardiomyocytes in the H/R+ mascs-exo group was decreased (P ＜ 0.05). Compared with the control group, p-PI3K /PI3K, p-Akt /Akt, and Bcl-2 /Bax were decreased in the H/R group (P ＜ 0.01), while the cleaved caspase-9/caspase-9 ratio was increased (P ＜ 0.01). Compared with H/R group, the ratio of p-PI3K/PI3K, p-Akt /Akt and Bcl-2 /Bax in H/R+ mascs-exo group was increased (P ＜ 0.05 or P ＜ 0.01), and the ratio of cleaved caspase-9/caspase-9 was decreased (P ＜ 0.01). Conclusion mASCs-Exo can inhibit H/R induction of cardiomyocytes apoptosis, which may be mediated by activation of the PI3K/Akt signaling pathway.
2020 Vol. 17 (5): 4-7,22 [Abstract] ( 249 ) HTML (1 KB)  PDF (868 KB)  ( 130 )
8 Experimental study on the improvement of insulin resistance in rats with type 2 diabetes mellitus with Cortex Lycii Radicis based on AMPK/GLUT4/GSK3β/ PPARα signaling pathway
YAO Huanhuan1 CHEN Ji1 CHEN Sisi1 ZHOU Diyi2
Objective To study on the improvement of insulin resistance (IR) in rats with type 2 diabetes mellitus (T2DM) was conducted based on AMPK/GLUT4/GSK3β/PPARα signaling pathway. Methods Sixty Wistar rats were divided into control group and high-fat experimental group (n = 50), and 40 rats which were successfully modeled and met the requirements of the model in the high-fat experimental group were divided into, model group, positive control group [Rosiglitazone 2 mg/(kg·d)], Cortex Lycii Radicis low dose group [5 mg/(kg·d)] and high dose group [10 mg/(kg·d)] by the random number table method, with 10 rats in each group. Each groups were given continuous administration for 6 weeks. Fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), aminotransferase (AST) and alanine aminotransferase (ALT) levels of rats in each group were compared and liver morphology was observed. Protein mass concentration in liver was determined by BCA method. Results FBG levels in model group were higher than those in control group, while FBG levels in Cortex Lycii Radicis low dose group and Cortex Lycii Radicis high dose group were significantly lower than those in model group, with statistically significant differences (all P < 0.05). The levels of TC, TG and LDL-C in model group were higher than those in control group, while the levels of HDL-C were lower than those in control group, with statistically significant differences (all P < 0.05). After 6 weeks of intervention, the levels of TC, TG and LDL-C in Cortex Lycii Radicis low dose group and Cortex Lycii Radicis high dose group were lower than those in model group, while the levels of HDL-C were higher than those in model group, with statistically significant differences (all P < 0.05). The levels of ALT and AST in model group were higher than those in control group. After 6 weeks of intervention, the levels of ALT and AST in Cortex Lycii Radicis low dose group and Cortex Lycii Radicis high dose group were lower than those in model group, with statistically significant differences (all P < 0.05). HE staining showed clear hepatic lobule structure in the control group. In model group, the arrangement of hepatocytes was disordered and lipid vacuoles were obvious. The hepatic fat vacuoles of rats in Cortex Lycii Radicis high dose group were significantly reduced and the structural changes of hepatocytes and steatosis were significantly improved. Oil red O staining showed liver was significant accumulation of lipid droplets in the liver of rats in model group and was decreased lipid deposition in Cortex Lycii Radicis high dose group. The levels of p-AMPK, PPARα and GLUT4 of liver in model group were lower than those in control group, and the GSK3β levels were higher than those in control group, with statistically significant differences (all P < 0.05). The levels of p-AMPK, PPARα and GLUT4 of liver were significantly up-regulated and GSK3 levels were significantly down-regulated in Cortex Lycii Radicis high dose group (P < 0.05). Conclusion The FBG of T2DM rats can be significantly reduced by Cortex Lycii Radicis, improve dyslipidemia and liver pathological changes. It may up-regulate the expression of GLUT4 and PPARα protein and down-regulate the over-expression of GSK3β protein through AMPK signaling pathway to improve IR.
2020 Vol. 17 (5): 8-12 [Abstract] ( 319 ) HTML (1 KB)  PDF (987 KB)  ( 118 )
13 Effect of Edaravone combined with ischemic postconditioning on cerebral ischemia-reperfusion injury in rats
WANG Ying ZHOU Hongqun YIN Mei MIAO Wei ZHU Yuhong
Objective To investigate the effect of Edaravone (Eda) combined with ischemic postconditioning (IP) on cerebral ischemia-reperfusion injury (I/R), and to evaluate whether Eda combined with IP have superimpose protective effects on I/R compared with IP alone. Methods Thirty-six SD rats were selected and divided into the control group (I/R group), IP group and IP+Eda group according to the random number table method, with 12 rats in each group. The rat I/R model was established in the I/R group by suture method. The rat I/R model was established by suture method in the IP group with IP intervention. The rat I/R model was established by suture method in the IP+Eda group with Eda and IP intervention. At 48 h after the operation, the rats were evaluated for neurological deficits and the volume of cerebral infarction was measured. By fluorescence quantitative PCR, Western blot and immunohistochemical method the expression of tissue angiotensin Ⅱ with type 1 and type 2 receptor (AT1, AT2) in the rat brain tissue was detected. The inhibition rate of superoxide dismutase (SOD) of rats in each group was detected. Results Compared with I/R group, IP+Eda group and IP group showed a decrease in neurological deficit score, a decrease in cerebral infarction volume, a decrease in mRNA and protein expression of AT1 and AT2, a decrease in the number of AT1 and AT2 positive cells, and an increase in SOD inhibition rate, with statistically significant differences (P ＜ 0.01 or P ＜ 0.05). There was no significant difference in the above indicators between the IP+Eda group and the IP group (P ＞ 0.05). Conclusion The IP+Eda group can protect rat I/R, but the combination of the two groups does not produce a superimposed protective effect.
2020 Vol. 17 (5): 13-17 [Abstract] ( 205 ) HTML (1 KB)  PDF (965 KB)  ( 210 )
18 ERBB3 expression in thyroid cancer and its significance
WANG Yan* YANG Longyan* SUN Rongxin ZHANG Yuanyuan FU Ying ZHAO Dong▲
To investigate the effect and function of ERBB3 in the occurrence and development of thyroid cancer at clinical level. Methods The fine needle puncture tissues of 4 patients with thyroid cancer and 6 patients with thyroid nodule in Department of Endocrinology, Beijing Luhe Hospital from December 2017 to December 2018 were collected, RNA-seq was detected and ERBB3 levels were analyzed. The thyroid cancer database of TCGA and the thyroid cancer database of GEO were used to analyze and compare the levels of ERBB3 in patients with recurrent and paracancer, T and N stages. Gene enrichment analysis was used to analyze the relationship between ERBB3 level and EGFR, PI3K and ERK1/2 signaling pathways, as well as the relationship between tumor proliferation and metastasis. Results ERBB3 mRNA was increased in thyroid cancer compared with benign thyroid nodules (P ＜ 0.001). Compared with paracancer, ERBB3 mRNA was elevated in thyroid cancer tissues (TCGA source, P ＜ 0.0001; GEO source, P ＜ 0.0001). In thyroid cancer patients, EGFR, PI3K and ERK1/2 gene sets were significantly enriched in patients with high ERBB3 expression. ERBB3 levels increased with the increase of T staging (P ＜ 0.0001), and the gene sets associated with proliferation were significantly enriched in patients with high ERBB3 expression. Compared with the N0 group, the level of ERBB3 in patients with stage N1 was significantly increased (P ＜ 0.0001). The gene sets associated with metastasis were significantly enriched in patients with high ERBB3 expression. ERBB3 levels were elevated in patients with recurrent thyroid cancer (P = 0.0124). Conclusion ERBB3 may be involved in the proliferation, metastasis and recurrence of thyroid cancer and is expected to be a new target for the treatment of thyroid cancer.
2020 Vol. 17 (5): 18-22 [Abstract] ( 215 ) HTML (1 KB)  PDF (999 KB)  ( 61 )
23 Advances in molecular mechanism of milkvetch root and Chinese angelica to improve myelosuppression after chemotherapy
DING Huan1 WU Chengjie2 PAN Yalan1 XU Guihua1 YANG Min1 SHI Xuqin3 WANG Qing1▲
Myelosuppression is a common toxic and side effect after chemotherapy, mainly related to injury of hematopoietic stem cells and hemopoietic microenvironment. Milkvetch root and Chinese angelica have the functions of benefiting qi and blood, strengthening and supplementing deficiency, and are often used to improve myelosuppression. Pharmacological studies have found that the effective components of the two drugs can improve the myelosuppression after chemotherapy by promoting the proliferation and differentiation of hemopoietic stem cells. The specific mechanism is related to multiple pathways, but it has not been clarified yet, affecting further clinical application and promotion. This paper summarizes the molecular mechanism of milkvetch root and Chinese angelica to improve the microenvironment of bone marrow, so as to expand the research idea of the molecular mechanism of traditional Chinese medicine benefiting qi and blood to improve myelosuppression, and lays a foundation for the promotion of milkvetch root and Chinese angelica to improve the clinical application of myelosuppression.
2020 Vol. 17 (5): 23-26 [Abstract] ( 206 ) HTML (1 KB)  PDF (627 KB)  ( 261 )
27 Advances in the application of rs-fMRI in the study of migraine in traditional Chinese medicine
ZHANG Jiwei1 WU Hongyun2▲
Migraine is a common primary headache, characterized by moderate and severe throbbing headache, which seriously affects patients′ quality of life and brings heavy economic burden to social medical system. Resting-state functional magnetic resonance (rs-fMRI) is a fMRI technology based on the blood-oxygen level dependent mechanism, which can reflect the living brain function without any trauma, especially suitable for the objective study of traditional Chinese medicine. This paper reviewes the research on rs-fMRI in pathogenesis, syndrome and treatment of traditional Chinese medicine migraine in recent years, and build up a theoritic basis for the application of rs-fMRI as an objective biomarker in the exploration of pathogenesis of migraine, in order to explore the syndrome diagnosis, differential diagnosis, therapeutic mechanism and other studies in traditional Chinese medicine.
2020 Vol. 17 (5): 27-30 [Abstract] ( 199 ) HTML (1 KB)  PDF (622 KB)  ( 77 )
31 Advances in oxidative stress and oxidative markers in polycystic ovary syndrome
ZHANG Han WU Linling YAN Ying
Polycystic ovary syndrome(PCOS) is one of the most common hormonal disorders, occurring in 5%-10% women in reproductive ages. Although there are many researches on PCOS in recent years, its etiology is still unclear. Oxidative stress  plays an important role in the pathophysiology of PCOS. Intracellular reactive oxygen species production in patients with PCOS is controlled by highly complex antioxidant enzymatic and non-enzyme systems. Therefore, understanding the mechanism of oxidative stress is of great significance for the prevention and treatment of PCOS. The oxidative stress mechanism and related markers of PCOS are discussed in this paper.
2020 Vol. 17 (5): 31-34 [Abstract] ( 329 ) HTML (1 KB)  PDF (631 KB)  ( 46 )
35 Progress on the application of neutrophil/lymphocyte ratio in bacterial pneumonia
LU Shuihuan1 LIU Xueyuan1 ZHU Zhongquan2
The neutrophil/lymphocyte ratio (NLR) has become one of the recognized effective indicators of systemic inflammatory response. More and more evidence shows that NLR is a simple and practical index which can accurately diagnose bacterial pneumonia and evaluate the severity and prognosis of patients. It is also valuable to distinguish different pathogens. So it especially has universal clinical significance for primary hospitals. This article reviews the role of NLR in the diagnosis, condition and prognosis evaluation of bacterial pneumonia, aiming to provide evidence and reference for the clinical application of NLR.
2020 Vol. 17 (5): 35-37,45 [Abstract] ( 238 ) HTML (1 KB)  PDF (648 KB)  ( 64 )
38 Non-inflammatory factors affecting rheumatoid arthritis pain
HE Jiali1 WANG Xiaoxia2 CHEN Huifang1 LIU Dan1
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by symmetry and polyarthritis. “Pain” is the most common symptom of rheumatoid arthritis. Rheumatoid arthritis pain is caused by a variety of factors, in addition to inflammatory factors, non-inflammatory factors including central nervous system regulatory pathway abnormalities, damage to the surrounding joints, fibromyalgia and chronic generalized pain can cause pain, In addition, other factors including psychological factors such as sleep disorders, anxiety and depression, cognitive responses such as pain disaster and self-efficacy, positive and negative behavioral responses, diet and obesity, and comprehensive nursing care may also affect pain perception in RA patients. Patients and physicians must recognize that not all pain is inflammatory, and that non-inflammatory treatment strategies need to be considered in addition to antirheumatic medications.
2020 Vol. 17 (5): 38-40,58 [Abstract] ( 303 ) HTML (1 KB)  PDF (905 KB)  ( 109 )
41 Research progress of metabolomics in ophthalmology
ZHAO Li LI Qingsong MIAO Wanhong
Metabonomics is a part of system biology. It is of great significance to explain gene function and to understand the overall view of life. It relies on nuclear magnetic resonance spectroscopy, mass spectrometry, chromatography, spectroscopy and other analytical chemistry techniques to obtain data. The examination specimens are usually plasma, urine, body fluid or tissue. It has been widely used in basic life science, clinical science, drug research and development, traditional Chinese medicine and other disciplines. The research in ophthalmology is also gradually increasing. This article reviews the basic principles of metabonomics and its achievements in dry eye, corneal diseases, crystal diseases, glaucoma, fundus diseases and optic nerve diseases.
2020 Vol. 17 (5): 41-45 [Abstract] ( 162 ) HTML (1 KB)  PDF (629 KB)  ( 211 )
46 Application progress of transcranial Doppler ultrasound in stent assisted angioplasty for middle cerebral artery stenosis
SUI Xiaowen1 LI Furong1 ZHANG Meiyan1 PAN Xin1 ZHAO Hongling1 LIU Jinjie2 ZHAO Hong1
Middle cerebral artery(MCA) stenosis is a common cause of cerebral infarction and can affect important functional areas. At present, stent assisted angioplasty have been widely used in the treatment of MCA stenosis. Based on the advantages of transcranial Doppler ultrasound, such as non-invasive, painless and cheap, it has been widely used in surveillance and follow-up before and after stent assisted angioplasty. This article reviews the application of TCD in preoperative and post-operative evaluation parameters, intraoperative microembolic monitoring, identification of hyperperfusion syndrome, vasospasm and restenosis, in order to identify surgical complications by TCD as early as possible and better serve the clinic.
2020 Vol. 17 (5): 46-49 [Abstract] ( 176 ) HTML (1 KB)  PDF (623 KB)  ( 117 )
50 Effect of mobile video education based on quick record code scanning on perioperative knowledge and behavioral compliance among percutaneous coronary intervention patients
HU Jingwen LIU Meili LIU Tingting LI Zhijian
Objective To explore the application effect of mobile video education based on quick record code scanning in perioperative health education of patients undergoing percutaneous coronary intervention. Methods One hundred and eighty-two patients who underwent percutaneous coronary intervention were hospitalized in the Department of Cardiology of the First Affiliated Hospital of Xi′an Jiaotong University from May 2018 to January 2019 were recruited in the study. Among them, 89 patients admitted from May to September 2018 were served as the control group, and 93 patients admitted from October 2018 to January 2019 were served as the observation group. The control group received a concentrated perioperative video education, while the observation group used a smartphone or tablet to scan the quick record code to watch the educational videos. The knowledge acquisition, behavioral compliance and the satisfaction of video education in the two groups were evaluated. Results The knowledge acquisition, behavioral compliance and satisfaction of video education in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The average number of videos watched by the observation group was (3.17±0.54) times, and more than 93% of patients watched the video at least 2 times. Conclusion Scanning the quick record code to watch the perioperative education video can effectively improve the perioperative knowledge levels and behavioral compliance among the patients undergoing percutaneous coronary intervention during perioperative period. The mobile video education based on quick record code scanning is a simple method with good patient satisfaction and acceptance.
2020 Vol. 17 (5): 50-53 [Abstract] ( 168 ) HTML (1 KB)  PDF (467 KB)  ( 46 )
59 Analysis of clinical features in patients with myocardial infarction with non-obstructive coronary artery
LUO Qunhua LI Mingjiang WANG Xin YANG Zheng
Objective To analyze the clinical features of myocardial infarction with non-obstructive coronary artery (MINOCA) and myocardial infarction with obstructive coronary artery (MIOCA). Methods A total of 445 patients with acute myocardial infarction admitted to Renmin Hospital of Wuhan University from January 2017 to January 2019 were randomly selected. According to the results of coronary angiography, they were divided into MINOCA group (89 cases) and MIOCA group (356 cases). The general data, the characteristics of the main complaints, and the electrocardiogram were compared between two groups. Results There were significant differences in age, sex, history of coronary heart disease, troponin I, creatine kinase isoenzyme, myoglobin, pro amino terminal brain natriuretic peptide, left ventricular ejection fraction and high-density lipoprotein cholesterol between two groups (P ＜ 0.05). There was no significant difference in BMI, hypertension, diabetes, hyperlipidemia, smoking, family history, triacylglycerol, total cholesterol, LDL cholesterol, free fatty acids, fasting blood glucose and creatinine between two groups (P ＞ 0.05). The incidence of chest pain and radiation pain in MINOCA group was lower than that in MIOCA group, and the effective rate of nitroglycerin in MINOCA group was higher than that in MIOCA group, the differences were statistically significant (P ＜ 0.05). There was no significant difference between two groups in occurrence time of chest distress, chest pain and symptoms < 3 d (P ＞ 0.05). The incidence of normal and T wave changes in MINOCA group was lower than that in MIOCA group, and the incidence of ST segment elevation, pathological Q wave formation and complete left bundle branch block in MINOCA group was higher than that in MIOCA group, the differences were statistically significant (P ＜ 0.05). There was no significant difference between two groups in the incidence of ST segment depression ≥ 0.05 mV, ventricular premature beat, short array ventricular tachycardia, ventricular tachycardia and ventricular fibrillation (P ＞ 0.05). Conclusion Clinically, MINOCA myocardial enzyme index, cardiac function, chest pain symptoms, and electrocardiogram performance are lighter than MIOCA, and there is no significant difference between two groups in terms of high risk factors except age.
2020 Vol. 17 (5): 59-62 [Abstract] ( 230 ) HTML (1 KB)  PDF (477 KB)  ( 62 )
63 Effects of self-made Yangxin Drink assisted with Western medicine in the treatment of angina pectoris of coronary atherosclerotic heart disease
WANG Haitao HUANG Chunli ZHAI Yaoyao
Objective To explore the effects of self-made Yangxin Drink assisted with Western medicine in the treatment of angina pectoris of coronary heart disease (CHD) and the influence on angina pectoris symptoms, peripheral blood lipids, apolipoprotein B/A1 (ApoB/A1) ratio, N-terminal pro-brain natriuretic peptide (NT-pro-BNP), thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α). Methods A total of 140 patients with angina pectoris of CHD in Qinhuangdao Muncipality Traditional Chinese Medicine Hospital of Hebei Province from February 2016 to April 2017 were selected and divided into traditional Western medicine group and Yangxin Drink group according to the random number table method by 1∶1 ratio, with 70 cases in each group. Traditional Western medicine group was given symptomatic treatment with traditional Western medicine, and Yangxin Drink group was given oral therapy of self-made Yangxin Drink based on the above treatment. After 1 month of treatment, traditional Chinese medicine syndrome scores and efficacy of traditional Chinese medicine syndrome were evaluated before and after treatment, and the angina pectoris attack, cardiac function indexes, ApoB/A1 and plasma NT-pro-BNP, TXB2 and 6-keto-PGF1α were compared before and after treatment. Results After treatment, traditional Chinese medicine syndrome score of two groups was significantly lower than that before treatment, and Yangxin Drink group was lower than that traditional Western medicine group (P < 0.05). Total effective rate of traditional Chinese medicine syndrome in Yangxin Drink group was significantly higher than that in traditional Western medicine group (P < 0.05). After treatment, the number of angina pectoris attacks and myocardial oxygen consumption in two groups were significantly reduced, the duration of angina pectoris attack was significantly shorter than before treatment, and LVDD and LVEF were significantly lower than before treatment (P < 0.05), the changes of the above indexes in Yangxin Drink group were significantly larger than those in traditional Western medicine group (P < 0.05). After treatment, the levels of ApoB/A1, NT-pro-BNP and TXB2 in two groups were significantly lower than before treatment, and the level of 6-keto-PGF1α was significantly higher than before treatment (P < 0.05), change range of Yangxin Drink group was significantly larger than that of traditional Western medicine group (P < 0.05). Conclusion Self-made Yangxin Drink assisted with Western medicine has exact efficacy in the treatment of patients with angina pectoris of CHD, and it can significantly alleviate the angina pectoris-related symptoms, improve the angina pectoris attack, cardiac function damage and vascular endothelial dysfunction, and reduce the risk of atherosclerosis.
2020 Vol. 17 (5): 63-66 [Abstract] ( 212 ) HTML (1 KB)  PDF (479 KB)  ( 36 )
67 Effect of Yangxin Dingji Capsules on To-Tp interval and Tp-Te interval in patients with ventricular premature beat accompanying acute coronary syndrome
LIU Dongsheng1 HAN Haili2 LI Bin1
Objective To discuss the effect of Yangxin Dingji Capsules on T onset-T peak (To-Tp) interval and T peak-T end (Tp-Te) interval in patients with ventricular premature beat accompanying acute coronary syndrome. Methods From January 2016 to January 2018, 122 patients with ventricular premature beat accompanying acute coronary syndrome treated in the Cangzhou People′s Hospital of Hebei Province were divided into control group and observation group by random number table, with 61 cases in each group. Patients in control group received conventional treatment, patients in observation group were treated with Yangxin Dingji Capsules, treatment lasts for 8 weeks. Before and after treatment, clinical effects were compared between two groups, the number of premature ventricular beats was recorded in 24 hours, To-Tp interphase and Tp-Te interphase were measured, the adverse reactions were recorded. Results Total effective rate of observation group was higher than that of control group, the difference was statistically significant (P < 0.05). There was no significant difference in the frequency of ventricular premature beat between two groups 24 hours before treatment (P > 0.05). 24 hours after treatment, the frequency of ventricular premature beat in two groups was significantly reduced compared with that before treatment, and the number of ventricular premature beat in observation group was less than that in control group, the difference was statistically significant (P < 0.05). There was no significant difference in To-Tp interphase and Tp-Te interphase between two groups before treatment (P > 0.05). To-Tp interphase and Tp-Te interphase of two groups were shorter than those before treatment, and observation group was shorter than that control group, the difference was statistically significant (P < 0.05). There was no obvious adverse reactions occurred in two groups. Conclusion Yangxin Dingji Capsules is effective in the treatment of acute coronary syndrome patients with premature ventricular beats, can reduce the number of premature ventricular beats, shorten the To-Tp interphase and Tp-Te interphase.
2020 Vol. 17 (5): 67-70 [Abstract] ( 139 ) HTML (1 KB)  PDF (474 KB)  ( 88 )
71 Effect of different dialysis methods on the inflammatory factors and endothelial function in hemodialysis patients
SHENG Danhong QI Ling
Objective To observe the effect of different dialysis methods on the inflammatory factors and endothelial function in hemodialysis patients. Methods From June 2017 to December 2018, 44 cases with maintenance hemodialysis (MHD) in the First People′s Hospital of Fuyang District were selected. According to the random number table method, they were divided into the observation group and the control group, with 22 cases in each group. The observation group was treated with ordinary hemodialysis (HD) 2 times + hemodialysis filtration (HDF) 1 time per week. The control group was treated with ordinary HD 3 times per week. Treatment for 6 months. Serum levels of interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), vascular willebrand factor (vWF) and soluble intercellular adhesion molecule 1 (sICAM-1) were compared between the two groups before hemodialysis and 6 months after hemodialysis. Correlation analysis of serum IL-6 and hs-CRP levels with vWF and sICAM-1 levels was conducted by Pearson correlation analysis. Results There were no significant differences in serum levels of IL-6 and hs-CRP between the two groups before hemodialysis (P > 0.05). Six months after hemodialysis, Serum IL-6 and hs-CRP in the control group showed no statistically significant differences compared with those before hemodialysis (P > 0.05). Serum IL-6 and hs-CRP levels in the observation group were lower than those before hemodialysis, and those in the observation group were lower than the control group, with statistically significant differences (all P < 0.05). There were no significant differences in serum levels of vWF and sICAM-1 between the two groups before hemodialysis (P > 0.05). Six months after hemodialysis, serum vWF and sICAM-1 levels in the control group showed no statistically significant differences compared with those before hemodialysis (P > 0.05). The serum vWF and sICAM-1 levels in the observation group were lower than those before hemodialysis, and those in the observation group were lower than the control group, with statistically significant differences (all P < 0.05). Serum IL-6 levels were positively correlated with vWF and sICAM-1 levels (r = 0.463, 0.457, P < 0.05). Serum hs-CRP levels were positively correlated with vWF and sICAM-1 levels (r = 0.482, 0.423, P < 0.05). Conclusion Compared with ordinary HD 3 times per week, ordinary HD 2 times + HDF 1 time per week can reduce the state of micro-inflammation in MHD patients, reduce the levels of serum vWF and sICAM-1, and reduce the occurrence of vascular endothelial dysfunction and cardiovascular disease in MHD patients.
2020 Vol. 17 (5): 71-74 [Abstract] ( 186 ) HTML (1 KB)  PDF (392 KB)  ( 89 )
75 Application of continuous intracranial pressure monitoring after standard decompression and microhematoma removal in patients with severe craniocerebral injury and cerebral hemorrhage complicated with cerebral hernia
WANG Zhong ZHANG Ruijian HAN Zhitong WANG Junqing WU Rile ZHANG Xiaojun LIU Baiyu YANG Weiran
Objective To analyze the clinical value of continuous intracranial pressure monitoring, standard decompressive craniectomy with mega-bone flap and microscopic hematoma evacuation in the treatment of severe craniocerebral injury and severe massive cerebral hemorrhage with cerebral hernia. Methods From May 2016 to May 2019, 116 patients with severe craniocerebral injury and massive hypertensive intracerebral hemorrhage with cerebral hernia underwent standard decompressive craniectomy with mega-bone flap, microscopic hematoma evacuation and intraoperative implantation of intracranial pressure monitoring probe, in Department of Neurosurgery, Inner Mongolian People′s Hospital were selected. The intracranial pressure monitoring changes, clinical significance and prognosis (Glasgow outcome scale score) at 6 months after treatment were analyzed. Results There were 116 patients were monitored by continuous dynamic intracranial pressure monitoring. Among them, 19 patients had an intracranial pressure over 40 mmHg (1 mmHg=0.133 kPa), 8 patients suffered from re-bleeding after operation and underwent additional hematoma evacuation, and 3 patients died, the other 8 patients recovered with medical management under intracranial pressure monitoring; the other 97 patients experienced a transient intracranial hypertension which was lower than 40 mmHg during 2-7 days after surgery. All of their intracranial pressure decreased after treatment and fluctuated within a narrow range. The Glasgow outcome scale score of 116 patients showed that, 67 cases with grade 5, 34 cases with grade 4, 9 cases with grade 3, 3 cases with grade 2 and 3 cases with grade 1. Conclusion Microscopic hematoma evacuation and standard decompressive craniectomy with mega-bone flap could remove hematoma quickly and alleviate intracranial hypertension in patients with severe craniocerebral injury and massive cerebral hemorrhage associated with brain herniation. Intracranial pressure monitoring probe implantation during surgery and continuous intracranial pressure monitoring after operation could timely detect intracranial pressure changes, guide a reasonable clinical use of dehydration drugs and discover intracranial complications early, which is of practical importance to improve the prognosis of patients with severe traumatic brain injury and massive cerebral hemorrhage combined with cerebral hernia after standard decompressive craniectomy with mega-bone flap.
2020 Vol. 17 (5): 75-78,82 [Abstract] ( 172 ) HTML (1 KB)  PDF (744 KB)  ( 223 )
79 The changes of disease spectrum, therapeutic drugs and expenses in psychiatric hospitals
CAO Xue1 CHEN Lixia2
Mental disease pathogenesis, clinical manifestations and therapeutic rehabilitation have unique complexity, which makes psychiatry get rid of the shackles of biomedical thinking mode earlier. Psychiatry is an early discipline that deeply implements the bio-psycho-social medical model in disease mechanism research and clinical practice. As human society has developed to today, mental and psychological diseases have become a major chronic disease affecting human health. The following is a review of the development of disease spectrum, clinical treatment medication and medical insurance reimbursement expenses in psychiatric hospitals. In order to understand the treatment and rationality of mental illness, with a view to providing reference for the diagnosis and treatment of mental health workers and the development of community mental health.
2020 Vol. 17 (5): 79-82 [Abstract] ( 184 ) HTML (1 KB)  PDF (471 KB)  ( 79 )
83 Application effect of mindfulness cognitive therapy in hospitalized patients with mental disorders
LIN Zhenghua1 ZHANG Lin2 WANG Jiyao2
Objective To study the application effect of mindfulness cognitive therapy in hospitalized patients with mental disorders. Methods From December 2014 to August 2017, 60 patients with mental disorders admitted to the Department of Psychiatry of the Fourth People′s Hospital of Liaocheng City in Shandong Province were randomly divided into the control group and the righteous thought group. Patients in the control group were treated with conventional therapy. On this basis, patients in the righteous thought group were treated with mindfulness cognitive therapy. After 8 weeks, the righteousness evaluation, positive and negative symptoms, depressive symptoms and anxiety symptoms were compared between the two groups. Results Before treatment, the positive symptoms, negative symptoms, general psychopathology, and total scores of the two groups were not significantly different (P > 0.05). After 8 weeks of treatment, the positive symptoms, negative symptoms, general psychopathology, and total scores of the two groups were improved compared with those before treatment (P < 0.05). After 8 weeks of treatment, there was no statistically significant difference in positive and negative symptoms between the two groups (P > 0.05), the general psychopathology and total scores of the patients in the righteous group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Before treatment, there was no significant difference in FFMQ, HAMD-17, and HAMA between the two groups (P > 0.05). After 8 weeks of treatment, the score of five facet mindfulness questionnaire (FFMQ), Hamilton depression scale (HAMD)-17 and Hamilton anxiety scale (HAMA) of the two groups were improved compared with those before treatment, and the differences were statistically significant (P < 0.05). After 8 weeks of treatment, the FFMQ of the patients in the righteous thought group was higher than that of the control group, the HAMD-17 and HAMA of the patients in the righteous thought group were lower than the control group, and the differences were statistically significant (P < 0.05). Conclusion Mindfulness cognitive therapy can effectively improve the cognitive level of patients with mental disorders and alleviate the negative psychological emotions of patients, which is worth promoting.
2020 Vol. 17 (5): 83-86 [Abstract] ( 240 ) HTML (1 KB)  PDF (474 KB)  ( 75 )
87 Predictive value of third trimester of pregnancy serum 25(OH)D3 and environmental risk factors for infantile eczema
LI Xiaorui1 WANG Xinchun1 ZHU Lihong2
Objective To explore the predictive value of 25 hydroxyvitamin D3 [25(OH)D3] and environmental risk factors for infantile eczema. Methods From January to December 2016, 528 pregnant women who gave birth regularly in the obstetrical clinic of the People′s Hospital of Xinjiang Uygur Autonomous Region were selected as a cohort. Serums 25(OH)D3 levels of pregnant women were measured, and infants were followed up for 6 months to observe the occurrence of infant eczema, the predictive value of 25(OH)D3 for infants eczema was analyzed. Results Finally, 505 pairs of mothers and infants completed, 243 cases (48.1%) of the infants were diagnosed with eczema, of which eczema of 56.4% (137/243) infants occurred from 2 to 3 months after birth. According to the occurrence of eczema, the infants were divided into eczema group (n = 243) and control group (n = 262). The maternal 25(OH)D3 in eczema group was lower than control group (P < 0.05). The results of ROC analysis showed that the area under curve was 0.584, the sensitivity was 90.70%, the specificity was 14.17%, the positive predictive value was 50.18%, the negative predictive value was 61.52%. Therefore, the diagnostic value of maternal 25(OH)D3 in the third trimester of pregnancy was low. Logistic regression analysis showed that the positive maternal allergy history (OR = 8.308, 95%CI: 5.131-13.45), cesarean section delivery (OR = 1.494, 95%CI: 0.977-2.286), frequent passive smoking during pregnancy (OR = 1.386, 95%CI: 0.680-4.826) were the risk factors of infant eczema (P < 0.05); but compared with 25(OH)D3 deficiency, low 25(OH)D3 (OR = 0.233, 95%CI: 0.138-0.392) and high 25(OH)D3 (OR = 0.459, 95%CI: 0.270-0.779) in late pregnancy were the protect factors of infant eczema (P < 0.05). Conclusion There is a low predictive value of serum 25(OH)D3 in infantile eczema.
2020 Vol. 17 (5): 87-90,94 [Abstract] ( 248 ) HTML (1 KB)  PDF (532 KB)  ( 176 )
95 Clinical effect of Cetuximab combined with FOLFOXIRI regimen in the treatment of liver metastasis of unresectable colorectal cancer
LU Ruimin1,2 LIU Tao2 WANG Xinji2 LI Jianguo2 LIANG Yao3 LUO Lijie1
Objective To investigate the clinical effect of Cetuximab combined with FOLFOXIRI regimen in the treatment of liver metastasis of unresectable colorectal cancer. Methods From January 2013 to May 2016, 105 patients with liver metastasis of unresectable colorectal cancer admitted to the Second Affiliated Hospital of Guangzhou University of Chinese Medicine were divided into the control group (52 cases) and the observation group (53 cases) according to the random number table method. The control group was treated with FOLFOXIRI regimen, while the observation group was treated with Cetuximab combined with FOLFOXIRI regimen. 14 days were one chemotherapy cycle. Both groups were given continuous treatment for 4 chemotherapy cycles. The clinical effect was evaluated after treatment. The number and size of lesions and the levels of peripheral blood CD4+, CD8+, CD4+/CD8+, serum glycoantigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) of patients in two groups were compared between before and after treatment. Survival rates of patients at 6 months, 1 year, and 3 years after treatment were calculated and compared between the two groups. Results The effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The number and size of lesions of patients in both groups after treatment were significantly smaller than before treatment, and those in the observation group were significantly smaller than those in the control group, with statistically significant differences (all P ＜ 0.05). The levels of CD4+, CD8+ and CD4+/CD8+ in peripheral blood of patients in the two groups after treatment were significantly higher than those before treatment, and those in the observation group were significantly higher than those in the control group, with statistically significant differences (all P ＜ 0.05). Serum CA19-9 and CEA levels of patients in both groups after treatment were significantly lower than those before treatment, and those in the observation group were significantly lower than those in the control group, with statistically significant differences (all  P ＜ 0.05). There was no significant difference in survival rate of patients between the two groups at 6 months after treatment (P ＞ 0.05). The 1 year and 3 year survival rates in the observation group after treatment were significantly higher than those in the control group, with statistically significant differences (all P ＜ 0.05). Conclusion Cetuximab combined with FOLFOXIRI regimen has a significant clinical effect in the treatment of liver metastasis of unresectable colorectal cancer, which can improve the immune function of the body, reduce serum CA19-9 and CEA levels, and prolong the survival time of patients.
2020 Vol. 17 (5): 95-98,103 [Abstract] ( 254 ) HTML (1 KB)  PDF (480 KB)  ( 126 )
99 Study on the application of hospital-basic-family three-level traditional Chinese medicine management model in patients with advanced cancer
ZHANG Lan1 ZHAO Yongchen1▲ SONG Lei1 LI Dexu1 LIU Yawei1 TANG Min2
Objective To study the influence of the hospital-basic-family three-level traditional Chinese medicine management mode on the mental resilience and quality of life of patients with advanced cancer. Methods From August 2017 to August 2018, 122 patients with advanced cancer who were discharged from the Department of Integrated Chinese and Western Medicine, Affiliated Hospital of Hebei University were selected as the study objects. They were divided into the intervention group and the control group by the random number table method. During the study, 2 cases died and 4 cases were lost to follow-up. Finally, 116 patients with advanced cancer were included as the study objects, including 59 in the intervention group and 57 in the control group. After discharge, the intervention group was given the hospital-basic-family traditional Chinese medicine management mode, while the control group was given the conventional discharge management mode. Mental resilience and quality of life of parents at discharge and nine months after discharge were compared between the two groups. Results At the time of discharge, there was no statistically significant difference in the total score of mental resilience and scores of each dimension between the two groups (P ＞ 0.05). Nine months after discharge, the total score of mental resilience and scores of each dimension in the control group showed no statistically significant difference compared with those at discharge (P ＞ 0.05). The total score of mental resilience and scores of each dimension in the intervention group were significantly higher than those at discharge, and those in the intervention group were higher than those in the control group, with statistically significant differences (all P ＜ 0.05). At the time of discharge, there was no statistically significant difference in the total score of quality of life and scores of each dimension between the two groups (P ＞ 0.05). Nine months after discharge, there was no significant difference in the total score of quality of life and scores of each dimension between the two groups compared with those at discharge (P ＞ 0.05). Nine months after discharge, the total score of quality of life and scores of each dimension in the intervention group were significantly higher than that in the control group, with statistically significant differences (P ＜ 0.05). Conclusion Carrying out the hospital-basic-family traditional Chinese medicine management mode can ensure the continuation and complete medical services for patients with cancer in the middle and advanced stages. Patients can maintain good compliance with the treatment and nursing measures in the hospital, improve their mental resilience after cancer, enhance their quality of life, and facilitate their long-term survival with cancer.
2020 Vol. 17 (5): 99-103 [Abstract] ( 181 ) HTML (1 KB)  PDF (496 KB)  ( 70 )
104 A meta-analysis of treatment of mixed hemorrhoids with external hemorrhoid resection combined with internal hemorrhoids automatic elastic wire-sheathing
GUO Shiqi1,2 LI Huashan2
Objective To analysis the results of a randomized controlled trial of external hemorrhoidectomy combined with internal hemorrhoid bandaging in the treatment of mixed hemorrhoids by meta-analysis, and to evaluate the effects of external hemorrhoidectomy combined with internal hemorrhoid bandaging and traditional external stripping in the treatment of mixed hemorrhoids. Methods The literatures of CNKI and Wanfang database from June 1966 to June 2019 were searched. A total of 8 articles were included in this study, and the obeservation was given external hemorrhoidectomy combined with automatic elastic wire-sheathing, the control group was given traditional external strippin. The surgical effect, operation time, intraoperative blood loss, pain score at 1 d after operation and postoperative complications were compared by meta-analysis. Results Comparison of surgical effects of patients between the two groups, the difference was not statistically significant (RR = 0.00, 95%CI: -0.03, 0.03, P ＞ 0.05). The operation time of the observation group was significantly shorter than that of the control group (MD = -7.73, 95%CI: -10.75, 4.70), while the intraoperative blood loss was less than that of the control group (MD = -13.06, 95%CI: -13.64, -12.47), and the differences were statistically significant (P ＜ 0.05). There were no significant differences in 1 d after surgery (MD = -0.93, 95%CI: -1.99, 0.14) and postoperative complications (RR = -0.16, 95%CI: -0.70, 0.37) of patients between the two groups (P ＞ 0.05). Conclusion The curative effect of external hemorrhoidectomy combined with automatic elastic wire-sheathing of internal hemorrhoids is better than that of traditional external stripping, and it is worthy of clinical promotion.
2020 Vol. 17 (5): 104-108 [Abstract] ( 392 ) HTML (1 KB)  PDF (1469 KB)  ( 109 )
109 Study on risk factors and predictive model of incontinence-associated dermatitis in surgical ICU patients
ZHONG Lixia WANG Xinran▲
Objective To investigate the risk factors of incontinence-associated dermatitis (IAD) in patients in surgical intensive care unit (ICU) and to establish a prediction model. Methods A total of 116 patients were collected by continuous sampling from July 2018 to April 2019 in ICU of Xuanwu Hospital Capital Medical University. They were divided into non-IAD group (93 cases) and IAD group (23 cases) according to the presence or absence of IAD. The influencing factors of IAD were analyzed by logistic stepwise regression analysis, while construct a prediction model, and evaluate the effect. Results The incidence of IAD in surgical ICU patients was 19.83%. The main influencing factors included PAT risk stratification, Barthel index, acute physiology and chronic health evaluation (APACHEⅡ), Braden score and age (P ＜ 0.05). Braden score (OR = 0.593, 95%CI: 0.415-0.846, P ＜ 0.01), PAT risk stratification (OR = 8.755, 95%CI: 1.038-73.821, P ＜ 0.05), age＞70 years (OR = 4.474, 95%CI: 1.112-17.993, P ＜ 0.05) were independent risk factors. A risk prediction equation was established based on multivariate logistic regression: logit(P) = -1.848-0.523X1+2.170X2+1.498X3, and the Hosmer-Lemeshow was used to test the goodness of fit of the regression equation (P = 0.237). The area under the ROC curve was 0.810 (95%CI: 0.704-0.916, P ＜ 0.01). Conclusion Low Braden score, high risk of PAT assessment, and age＞70 years old are independent risk factors for IAD in surgical ICU patients. Establishing a predictive model of IAD is helpful for early identification of high-risk patients with IAD.
2020 Vol. 17 (5): 109-112 [Abstract] ( 266 ) HTML (1 KB)  PDF (687 KB)  ( 34 )
113 Correlation between serum level of GDF-15 and pulmonary artery pressure in patients with chronic obstructive pulmonary disease
ZHANG Juan1 YANG Heyin2 HU Yuying2 WANG Huaizhen1
Objective To investigate the correlation between serum level of growth differentiation factor-15 (GDF-15) and pulmonary artery pressure in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 112 patients with COPD admitted to First People′s Hospital of Kashgar (“our hospital” for short) from January 2016 to January 2019 were selected as the study group. According to whether have hypertension or not, the patients were divided into non-pulmonary hypertension group (36 cases) and combined pulmonary hypertension group (76 cases). The patients combined pulmonary hypertension were divided into mild group (24 cases), moderate group (31 cases) and severe group (21 cases) according to pulmonary systolic pressure (sPAP). A total of 60 healthy people from our hospital during the same period were selected as the control group. The serum levels of GDF-15 and brain natriuretic peptide (BNP) were detected, while the correlation between serum levels GDF-15 and sPAP and BNP were analyzed. Results Serum GDF-15 and BNP levels in the non-pulmonary hypertension group and the combined pulmonary hypertension group were significantly higher than those in the control group, and the combined pulmonary hypertension group was significantly higher than the non-pulmonary hypertension group (P ＜ 0.05). The levels of serum sPAP, GDF-15 and BNP in the moderate and severe groups were significantly higher than those in the mild group, and the severe group was higher than the moderate group (P ＜ 0.05). The serum GDF-15 levels were positively correlated with sPAP and BNP in COPD patients (r = 0.507, 0.350, P = 0.001, 0.029). Conclusion GDF-15 is significantly increased in the serum of COPD patients combined pulmonary hypertension, and it is positively correlated with sPAP and BNP.
2020 Vol. 17 (5): 113-116 [Abstract] ( 193 ) HTML (1 KB)  PDF (731 KB)  ( 112 )
117 A case-control study on the risk factors of cervical spondylosis associated with emotional disorders
LIU Yamei1 TAN Liduan2 LIN Lin3 LIU Yan4 ZHANG Linna5 WANG Shujuan1
Objective To explore the risk factors of cervical spondylotic with emotional disorders and provide the basis for prevention and treatment strategy. Methods A total of 240 patients with cervical spondylosis who were admitted to the Department of Rehabilitation Medicine of Affiliated Hospital of Chengde Medical University from January 2016 to May 2018 were selected. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used for evaluation, and the patients were divided into emotional disorder group (172 cases) and non-emotional disorder group (68 cases) by SAS and SDS. Univariate logistic regression analysis and multivariate logistic regression analysis were performed to analyze the influencing factors of cervical spondylosis accompanied by mood disorders. Results Univariate analysis showed that gender, age, education level, marital status, family per capita monthly income, neck pain, headache, limb numbness, limb movement disorder and disease course were all related to mood disorder (P ＜ 0.05). Multivariate logistic regression analysis showed that neck pain (OR = 16.862, 95%CI = 1.511-188.228, P = 0.022), limb movement disorders (OR = 0.386, 95%CI = 0.162-0.938, P = 0.032), education level (OR = 3.989, 95%CI = 1.712-7.294, P = 0.001), and disease course (OR = 2.017, 95%CI = 1.173-3.469, P = 0.011). Neck pain, dyspepsia, education level and course of disease are risk factors for mood disorders associated with cervical spondylosis. Conclusion The neck pain, dyskinesia of limbs, educational level, course of disease and type of cervical spondylosis are the main factors for the cervical spondylosis with emotional disorders.
2020 Vol. 17 (5): 117-120,124 [Abstract] ( 225 ) HTML (1 KB)  PDF (669 KB)  ( 136 )
121 Expression and clinical significance of mucoprotein MUC5AC in respiratory tract of patients with ventilator associated pneumonia disease
CHU Yimiao FANG Changtai HONG Changxing ZHA Junjing HUANG Lijuan CHENG Gaoxiang
Objective To observe the expression of mucoprotein MUC5AC in respiratory tract of patients with ventilator-associated pneumonia (VAP) and the clinical value. Methods A total of 63 patients received mechanical ventilation in the intensive care unit (ICU) of Anqing Hospital Affiliated to Anhui Medical University from April 2018 to March 2019 were selected as study subjects. The subjects were divided into experimental group (VAP group) and control group (non-VAP group) according to the diagnostic criteria of VAP formulated by the Chinese society of critical care medicine. After endotracheal intubation at 1 h and 48 h, alveolar lavage fluid was collected by fiberoptic bronchoscopy, and MUC5AC content of mucin in lavage fluid was determined by enzyme linked immunosorbent assay, and a simplified clinical pulmonary infection score (CPIS) was calculated. MUC5AC level and CPIS score were compared between the two groups, and the correlation between MUC5AC expression level and CPIS score was analyzed. MUC5AC level and CPIS score of the two groups had no significant difference after 1 h of intubation (P ＞ 0.05). MUC5AC level and CPIS score in the experimental group were higher than those in the control group (P ＜ 0.05). The expression level of MUC5AC mucin and CPIS score in the experimental group were significantly higher than that in the experimental group at 48 h after intubation (P ＜ 0.01). The expression level of MUC5AC in the control group was also higher than that in the control group at 48 h after intubation (P ＜ 0.05), while CPIS score had no significant difference between 48 h and 1 h after intubation (P ＞ 0.05). MUC5AC expression level was positively correlated with CPIS score in all patients (r = 0.782, P ＜ 0.05). Conclusion MUC5AC is highly expressed in respiratory tract of ventilator-associated pneumonia patients. Mechanical ventilation also plays an important role in MUC5AC oversecretion.
2020 Vol. 17 (5): 121-124 [Abstract] ( 238 ) HTML (1 KB)  PDF (645 KB)  ( 104 )
125 Relationship between fine particulate matter pollution and airway inflammation and oxidative stress in chronic obstructive pulmonary disease
ZHOU Wei1,2 JIANG Shujuan3
Objective To investigate the relationship between air fine particulate matter (PM2.5) pollution and airway inflammation and oxidative stress in patients with chronic obstructive pulmonary disease (COPD). Methods Eighty patients with chronic obstructive pulmonary disease who admitted to the Jiyang People′s Hospital of Ji′nan City Shandong Province (“our hospital” for short from) May 2018 to May 2019 were divided into the urban group (40 cases) and the suburban group (40 cases) according to the living area of the patients. In the same period, 40 patients who were included in our hospital for healthy physical examination were established as the control group. The real-time monitoring data of PM2.5 in the living environment of the subjects were continuously monitored for 12 weeks, and the forced expiratory volume in the first second (FEV1), the proportion of forced expiratory volume in the first second (FEV1/FVC%), serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels of the subjects in the three groups were compared and analyzed. Results PM2.5 particles monitored in the urban group for 12 weeks were significantly higher than those in the suburban group, and the differences were statistically significant (P ＜ 0.05). FEV1 and FEV1/FVC% in the urban group and the suburban group were lower than those in the control group (P ＜ 0.05). There was no significant difference in FEV1, FEV1/FVC%, MDA and SOD between the urban group and the suburban group (P > 0.05). MDA concentration in the suburban group was lower than that in the urban group and was higher than that in the control group (P ＜ 0.05). There was no significant difference in SOD level between the three groups (P ＞ 0.05). PM2.5 was negatively correlated with FEV1, FEV1/FVC% in COPD patients (r = -0.428, -0.807, P ＜ 0.05). PM2.5 was positively correlated with SOD and MDA in COPD patients (r = 0.543, 0.502, P ＜ 0.05). Conclusion High levels of PM2.5 exposure may reduce lung function in patients with COPD, increase airway inflammation and oxidative stress, and aggravate the disease. In this regard, the prevention of haze weather should be done to protect the health of the residents and avoid the adverse effects of PM2.5 on the human body.
2020 Vol. 17 (5): 125-128 [Abstract] ( 188 ) HTML (1 KB)  PDF (599 KB)  ( 91 )
129 Clinical study on self-made Yiqi Huoxue Quyu Decoction in the treatment of postoperative syndrome of lumbar disc herniation
GONG Jian1 GAO Yingqing1 GONG Yanhong2
Objective To explore clinical effect of self-made Yiqi Huoxue Quyu Decoction in the treatment of postoperative syndrome of lumbar disc herniation (LDH). Methods One hundred and three patients with  postoperative syndrome of LDH admitted to Tieling Central Hospital from January 2017 to March 2019 were selected, they were divided into control group (51 cases) and study group (52 cases) according to random number table method. Control group was given routine treatment, and study group was given self-made Yiqi Huoxue Quyu Decoction on the basis of control group, two groups were treated for 4 weeks. Clinical efficacy, inflammatory factors, pain visual analogue scale (VAS), Oswestry dysfunction index (ODI), Chinese medicine symptom score and adverse reactions were compared between two groups. Results Total clinical effective rate in study group was significantly higher than that in control group after 4 weeks of treatment (P < 0.05). The serum levels of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α in two groups were lower than those before treatment, and the levels in study group were lower than those in control group (P < 0.05). After treatment, the scores of VAS, ODI and Chinese medicine symptoms in two groups were lower than those before treatment, and those in study group were lower than those in control group (P < 0.05). No serious adverse reactions occurred in both groups. Conclusion Self-made Yiqi Huoxue Quyu Decoction can effectively improve clinical symptoms and reduce the level of inflammatory factors in the treatment of postoperative syndrome of LDH. It has good safety and high clinical application value.
2020 Vol. 17 (5): 129-132 [Abstract] ( 307 ) HTML (1 KB)  PDF (703 KB)  ( 28 )
133 Treatment based on manifestation and root cause of disease of patients with non-transfusion dependent thalassemia
LEI Yu ZENG Qing CHENG Weimin
Non-transfusion dependent thalassemia is a chronic hemolytic disease. During the acute attack, hemolysis and blood transfusion should be controlled, and iron removal should be paid attention to at ordinary times. After summing up the treatment based on syndrome differentiation of traditional Chinese medicine of doctors of all dynasties and combining the modern medical theory to clarify the relationship between kidney deficiency and blood stasis, modern Chinese medicine scholars take treatment based on syndrome differentiation and refining for the non-transfusion dependent thalassemia patients and put forward the sequential therapy of treating the tip at the acute condition, treating both manifestation and root cause of disease at stable period and further improve the patient′s hemoglobin to reduce the frequency of blood transfusion and iron deposition, so as to achieve the goal of improving the therapeutic effect of traditional Chinese medicine and the quality of life of patients.
2020 Vol. 17 (5): 133-136 [Abstract] ( 279 ) HTML (1 KB)  PDF (747 KB)  ( 60 )
137 Clinical study of Xuefu Zhuyu Decoction combined with acupuncture in the treatment of hemiplegia after ischemic stroke
LI Xinyang1 LIU Suping1 WANG Jialiang1 ZHANG Yueqi2
Objective To explore clinical effect of Xuefu Zhuyu Decoction combined with acupuncture in the treatment of hemiplegia after ischemic stroke. Methods One hundred patients with hemiplegia due to ischemic stroke admitted to Weifang People′s Hospital of Shandong Province were selected from April 2018 to April 2019. The patients were randomly divided into control group (50 cases) and observation group (50 cases), in which, control group was given rehabilitation training on the basis of routine symptomatic intervention, while observation group was treated with Xuefu Zhuyu Decoction combined with acupuncture on the basis of control group. The clinical efficacy, Chinese medicine symptom score, intracranial artery blood flow, lower limb motor function and quality of life were compared between two groups, and adverse reactions during treatment were recorded. Results After treatment, total effective rate of observation group was significantly higher than that of control group (P < 0.05). After treatment, the average blood flow velocity of anterior cerebral artery, middle cerebral artery and posterior cerebral artery in two groups was faster than that before treatment, and that in observation group was faster than that in control group (P < 0.05). After treatment, the scores of Chinese medicine symptoms in two groups were lower than those before treatment, and the scores in observation group were lower than those in control group (P < 0.05). The scores of Fugl-Meyer assessment and stroke specific quality of life in two groups were higher than those before treatment, and those in observation group were higher than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Xuefu Zhuyu Decoction combined with acupuncture can rapidly improve the clinical symptoms, intracranial blood flow, lower limb motor function and quality of life of patients with hemiplegia after ischemic stroke. The curative effect is remarkable, without increasing the incidence of adverse reactions, and the clinical application value is high.
2020 Vol. 17 (5): 137-140 [Abstract] ( 296 ) HTML (1 KB)  PDF (703 KB)  ( 107 )
141 Examples of experience in Xie Xinke′s treatment for hyperbilirubinemia and coagulation disorders
LI Yumin1 XIE Xinke2 BIAN Qian2
Hyperbilirubinemia is equivalent to the category of “jaundice” in traditional Chinese medicine. The effect of Western medicine on jaundice is not ideal. However, the understanding of jaundice in traditional Chinese medicine has a long history. On the basis of summing up the experience of predecessors, combined with the characteristics of modern jaundice, the chief physician of Xie Xinke thinks that dampness, heat, blood stasis and stagnation are the key to the onset of jaundice, and he makes Jianghuang Mixture by himself. The main symptom of yellow body and eyes urination is accompanied by hypochondriac pain, bitter mouth, greasiness, pruritus and a small amount of bleeding in the mouth and nose (or gums). The syndrome differentiation is damp heat type with remarkable clinical effect. The clinical experience is analyzed in this case.
2020 Vol. 17 (5): 141-144 [Abstract] ( 341 ) HTML (1 KB)  PDF (702 KB)  ( 210 )
145 Effect of self-made Tongluo Xieding Powder fire therapy on lumbar disc herniation of qi stagnation and blood stasis type
XU Xingxing WANG Baoyu HAN Lu
Objective To observe the effects of self-made Tongluo Xieding Powder fire therapy on lumbar disc herniation of qi stagnation and blood stasis type. Methods Sixty-six cases of patients with lumbar disc herniation of qi stagnation and blood stasis type from August 2018 to May 2019 in Tuina Department of Hangzhou Chinese Medical Hospital were divided into control group and treatment group according to the random number table method, with 33 cases in each group. Control group received routine massage treatment, while treatment group received massage and Tongluo Xieding Powder fire therapy. The pain visual analogue score, JOA function score and clinical effect of two groups were compared. Results After treatment, visual analogue score of pain in two groups was lower than that before treatment, and that in treatment group was lower than that in control group, the difference was statistically significant (P < 0.05). After treatment, JOA score of lumbago in two groups was higher than that before treatment, and that in treatment group was higher than that in control group, the difference was statistically significant (P < 0.05). Total effective rate of clinical treatment in treatment group was higher than that in control group, the difference was statistically significant (P < 0.05). Conclusion Self-made Tongluo Xieding Powder fire therapy can relive the pain and improve total effective rate of patients with qi stagnation and blood stasis lumbar disc herniation.
2020 Vol. 17 (5): 145-147,151 [Abstract] ( 206 ) HTML (1 KB)  PDF (767 KB)  ( 89 )
148 Application of principle-method-recipe-medicine of heat invading blood chamber in female patient with recurrent urinary tract infection
LIU Xianli1 ZHAO Kaiwei2 LIU Baoli1，3▲
Heat invading blood chamber is a common clinical syndrome. At present, the research on heat invading blood chamber mainly focuses on the specific parts of “blood chamber”, which is controversial. However, the research on heat invading blood chamber is relatively less, and the existing research has many theoretical levels. For the specific clinical application of heat invading blood chamber, the normative indications are not clear enough, and there is no corresponding medical record or clinical research support. In this paper, the heat invading blood chamber formula and drug system as the research object, from the heat invading blood chamber theory source, high incidence population and the characteristics of the onset time, clinical characteristics, etiology and pathogenesis, treatment principles, specific treatment and prognosis judgment six aspects, the heat invading blood chamber formula and drug system analysis, clear its theoretical characteristics, standardize its clinical application indications, and high incidence in young and middle-aged women based on the clinical characteristics and treatment status of recurrent urinary tract infection in women. This paper discusses the correlation between the two, and expounds the key points of diagnosis and treatment of recurrent urinary tract infection in women by using the heat invading blood chamber, and standardizes its clinical application.
2020 Vol. 17 (5): 148-151 [Abstract] ( 256 ) HTML (1 KB)  PDF (701 KB)  ( 67 )
152 Discussion on the path of traditional Chinese medicine cultural heritage and intellectual property protection under the background of independent innovation in the new era
LI Xiuming1 ZHANG Jing1 HAN Guixiang2
Since the founding of people′s Republic of China 70 years ago, with the promulgation of The Chinese Medicine Law of the People′s Republic of China, the concept of “healthy China” has been put forward, and traditional Chinese medicine has ushered in unprecedented opportunities for development. The inheritance and development of traditional Chinese medicine has become an important policy and strategy of the party and the state, and the inheritance of traditional Chinese medicine culture and the protection of intellectual property rights of traditional Chinese medicine are the key links. They promote each other and complement each other. Based on the background of independent innovation in the new era, this paper attempts to explore the path of traditional Chinese medicine cultural heritage and intellectual property protection of traditional Chinese medicine, and puts forward countermeasures and suggestions.
2020 Vol. 17 (5): 152-155 [Abstract] ( 204 ) HTML (1 KB)  PDF (741 KB)  ( 150 )
156 Effect of Sargentodoxae Caulis combined with Maitong Powder exteral application on hemorheology and thrombolytic elasticity of lung cancer patients with lower extremity deep venous thrombosis
CHEN Hong WANG Wei LI Peifu XIAO Caizhi
Objective To investigate the effect of Sargentodoxae Caulis combined with Maitong Powder exteral application on hemorheology and thromboelastic elasticity of lung cancer patients with lower extremity deep venous thrombosis. Methods From July 2016 to July 2018, a total of 52 cases with lung cancer patients with lower extremity deep venous thrombosis were admitted to Chongqing University Cancer Hospital. According to the random number table method, they were divided into the treatment group and the control group, with 26 cases in each group. The control group was treated with Low Molecular Weight Heparin Calcium. The treatment group was treated with Sargentodoxae Caulis combined with Maitong Powder on the basis of the control group for 2 courses of treatment. Clinical efficacy, circumference diameter of affected limb difference, high blood viscosity (HBV), low blood viscosity (LBV), fibrinogen (FIB) and K value of thrombolytic elasticity were compared between the two groups. Results The total effective rate of the treatment group was significantly higher than that of the control group，and the difference was statistically significant (P < 0.05). The difference of 15 cm circumference between the upper and lower edges of the patella in the treatment group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Before treatment, there was no significant difference with HBV, LBV and FIB levels in the two groups (P > 0.05). After treatment, the levels of HBV, LBV and FIB in the two groups were all lower than those before treatment, and the treatment group were lower than the control group, with statistically significant differences (P < 0.05). Before treatment, there was no significant difference in the K value of thrombolytic elasticity between the two groups (P > 0.05). After treatment, the K value of thrombolytic elasticity was higher than that before treatment, and the treatment group was higher than the control group, with statistically significant differences (all P < 0.05). Conclusion Sargentodoxae Caulis combined with Maitong Powder external application have a definite effect on patients with lung cancer with deep vein thrombosis of lower extremities, which can significantly improve hemorheology indexes and K value of thrombolytic elasticity, and it is worthy of clinical application.
2020 Vol. 17 (5): 156-159 [Abstract] ( 213 ) HTML (1 KB)  PDF (411 KB)  ( 121 )
160 Metrology and visualization analysis of gynecological tumor nursing in China in recent 20 years
DAI Yu1 ZHOU Lihua1 CHEN Qin2
Objective To analyze the research status of gynecological tumor nursing in recent 20 years in China, and provide references for related research in the future. Methods The words “gynecological tumor” “gynecological cancer” and “nursing” were used as search terms, and the retrieval time was from January 2000 to June 2019. Bibliometrics was used to analyze the annual publication volume, regional distribution, periodical distribution, author cooperation and high-frequency keyword co-word. Results After retrieval and screening, 1586 articles were included. The statistical results show that the total number of publications is on the rise. There are 21 core regional journals; the core author group has been formed, but the degree of cooperation and co-writing rate is not high. The regional distribution of literature is obviously different. The research topics are diversified. In the past 20 years, the research focuses include “chemotherapy” “nursing intervention” “quality of life” “high-quality nursing” and “psychological nursing”. Conclusion The research on gynecological tumor nursing in China has made some progress, but the literature quality is not high, and the research breadth and depth are not enough. Therefore, in the future development, we need to pay more attention and investment in this field, so as to better promote the continuous improvement of the quality of gynecological tumor nursing in China.
2020 Vol. 17 (5): 160-163,168 [Abstract] ( 246 ) HTML (1 KB)  PDF (1168 KB)  ( 93 )
164 Effect of psychological intervention combined with family intervention mode based on the theory of King compliance on postoperative recovery, GQOLI-74 and IPSS score of BPH patients undergoing PKEP
JIANG Wenhua SHI Xiaoping HUANG Jing LI Jieming GUO Xiao▲
Objective To investigate the effect of psychological intervention combined with family intervention mode based on the King theory of compliance on the postoperative recovery, generic quality of life inventory questionnaire (GQOLI-74) and international prostate symptom score (IPSS) in patients with benign prostatic hyperplasia (BPH) after transurethral bipolar plasma kinetic enucleation of prostate(PKEP). Methods From August 2017 to February 2019, 120 male patients with BPH were treated at the Second Hospital of Jiaxing City, Zhejiang Province. They were divided into control group and observation group by random number table method, with 60 cases in each group. Both groups were treated with PKEP. After surgical treatment, patients in the control group took routine nursing measures, while patients in the observation group took psychological intervention based on the theory of King standards combined with the family intervention mode. The nursing duration of patients in both groups was 4 weeks. The perioperative indicators, symptom improvement, complications, quality of life and compliance of the two groups were compared. Results IPSS score, maximum urine flow rate (Qmax) and residual urine volume (RUV) of the two groups were compared before and after treatment, and the differences were statistically significant (all P ＜ 0.05). After treatment, there was no significant difference between the two groups in operation time, intraoperative blood loss, excised tissue volume, IPSS score, Qmax and RUV (P ＞ 0.05). After treatment, the quality of life score of patients of the two groups increased, and the quality of life score of the observation group was significantly higher than that of the control group, the difference was statistically significant (P ＜ 0.05). The patients′ behaviors of taking medicine as directed by the doctor and taking medicine badly, the total scores of tobacco and alcohol addiction management behavior and compliance of two groups were higher than before treatment. All scores in the observation group were higher than those in the control group, with statistically significant differences (P ＜ 0.05). Conclusion Through the combination of psychological intervention based on King standard theory and family intervention mode nursing for BPH patients, GQOLI-74 and IPSS scores of patients are significantly improved, and the complications of patients are significantly decreased, which is of positive significance for the treatment of patients.
2020 Vol. 17 (5): 164-168 [Abstract] ( 218 ) HTML (1 KB)  PDF (633 KB)  ( 137 )
169 Effect of super early intervention on aphasia after glioma operation
HU Juan WANG Aifeng▲ WANG Weijie
Objective To explore the effect of super early intervention on aphasia after glioma operation. Methods From December 2016 to December 2018, 100 patients with aphasia after glioma operation admitted to neurosurgery Department of Huai′an First People′s Hospital were selected, they were divided into control group and observation group according to the random number table method, with 50 cases in each group. The control group received routine intervention, and the observation group received super early intervention. Results The score of language function in the two groups after 3 months of intervention was higher than that before intervention, and the differences were statistically significant (all P ＜ 0.05). After 3 months of intervention, the score of language function in the observation group was higher than that in the control group, with statistically significant difference (P ＜ 0.05). After 3 months of intervention, the self-rating anxiety scale (SAS), self-rating depression scale (SDS) scores of the two groups were lower than before intervention, and the differences were statistically significant (P ＜ 0.05). After 3 months of intervention, the SAS and SDS scores of the observation group were lower than the control group, with statistically significant differences (all P ＜ 0.05). After 3 months of intervention, the incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of super early intervention in aphasia patients after glioma surgery can significantly improve their language function changes, alleviate their negative emotions, and effectively reduce the incidence of postoperative complications, which is worthy of promotion.
2020 Vol. 17 (5): 169-172 [Abstract] ( 258 ) HTML (1 KB)  PDF (625 KB)  ( 40 )
173 Analysis of the feasibility and acceptability of dance intervention in elderly patients with cognitive impairment who need long-term care
HAN Qing LU Shuang▲
Objective To explore the feasibility, acceptability and initial effect of dance intervention in elderly patients with cognitive impairment who need long-term care. Methods Twenty geriatrics patients who met the inclusion criteria and were admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January to April 2019 were selected to provide dance courses. At the same time, the method of repeated measurement design was adopted to collect and record the participation rate and attrition rate of patients in the whole experiment process, as well as the general physical condition, cognitive impairment degree and psychological test results of all participants. At the end of each dance, the participation rate of the patients, the degree of completion of the dance program, and the evaluation of the dance course were recorded. Results The completion rate of the study was 93% (13/14). The overall mean participation rate of the patients was 1.82 (1.75, 1.97) points, and the overall evaluation of dance intervention was 2.05 (1.85, 2.35) points. The overall acceptability of the caregiver for dance intervention was (2.37±0.72) points. Conclusion The high completion rate and participation rate in this study support the feasibility of dance intervention, and both patients′ evaluation of dance intervention and caretakers′ acceptance of dance intervention are high. Therefore, dance intervention has a broad application prospect and is worthy of further study to determine its effectiveness in a larger sample.
2020 Vol. 17 (5): 173-176 [Abstract] ( 160 ) HTML (1 KB)  PDF (817 KB)  ( 80 )
177 Application of umbilical vein intubation with indwelling needle in neonatal asphyxia resuscitation
ZHOU Xiulian1 HE Haochen2 FU Xiaohui1 GAO Xiaowei3
Objective To explore the application of umbilical vein intubation with indwelling needle in neonatal asphyxia resuscitation. Methods From January 2017 to December 2018, a total of 58 cases of critically ill neonates delivered in Beijing Shangdi Hospital and needed to establish venous route were selected. The patients in the experimental group were randomly divided into two groups by coin toss, 28 patients in the experimental group were intubated with indwelling needle and 30 patients in the control group were intubated with umbilical vein catheter. The primary operation success rate, operation time, catheter-related infection rate and rescue success rate of umbilical vein intubation with two different catheters were compared. Results There was no significant difference in the success rate of primary intubation between the two groups (P ＞ 0.05). The operation time of the experimental group was significantly shorter than that of the control group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in catheter-related infection rate between the two groups (P ＞ 0.05). There was no significant difference in the success rate of rescue between the two groups (P ＞ 0.05). Conclusion In neonatal asphyxia resuscitation, medical staff use indwelling needle to conduct umbilical vein intubation to establish venous route faster, which can meet the demand of intravenous medication in neonatal asphyxia resuscitation.
2020 Vol. 17 (5): 177-180 [Abstract] ( 208 ) HTML (1 KB)  PDF (621 KB)  ( 101 )
181 Treatment of 2 cases of pregnancy induced hypertension with traditional Chinese medicine
HAN Yanhua1 SUN Meina2 HAN Yaguang3 ZHU Xiaolin4
Pregnancy induced hypertension is a common complication of pregnant women and the incidence is high, which is the main cause of maternal and perinatal morbidity and mortality. Pregnancy induced hypertension has been the focus of experts in the field of obstetrics and gynecology at home and abroad. The motherland medicine has long-term effective observation of the etiology and pathogenesis of this disease through the theory of traditional Chinese medicine. At the same time, the application of traditional Chinese medicine to regulate the function of the organs has been used to treat this disease. The clinical 2 cases of traditional Chinese medicine for treating pregnancy induced hypertension are retrospectively analyzed to explore its etiology, pathogenesis, diagnosis and treatment.
2020 Vol. 17 (5): 181-183,196 [Abstract] ( 366 ) HTML (1 KB)  PDF (728 KB)  ( 54 )
184 Analysis of hot points of angiogenesis research in China based on co-word analysis
CUI Herong1* ZHAO Ya2* ZHANG Wenxi1 LI Lei1 CHEN Hongshan1 WANG Penglong1 SU Jin1 LEI Haimin1
Objective To co-word analyze the key words of related literature on angiogenesis, and explore the research hotspots. Methods The data sources were “EI journals” “core journals” “CSSCI” or “CSCD” in CNKI academic journals, the field was limited as “medical, health science and technology”, with “angiogenesis” as the key word and “subject” as the search type, and the search time was from 1992 to June 2019. Pajek and SPSS 22.0 were used for literature metrological analysis. Results of co-word analysis was obtained by high frequency word statistics, keywords cluster analysis based on co-word matrix, and network graph. Results A total of 2586 research papers were obtained. The co-word network graph showed that five main aspects exist: intervention mode, research model/technology, mechanism, evaluation index and disease. Conclusion Among these hotspots on angiogenesis in China, the main direction of inhibiting angiogenesis is tumor. The main direction of promoting angiogenesis is endometriosis, myocardial ischemia and others. The main experimental animal is chick embryo allantoic membrane. These provide references for relevant clinical and research.
2020 Vol. 17 (5): 184-187 [Abstract] ( 193 ) HTML (1 KB)  PDF (983 KB)  ( 121 )
188 Countermeasure research on the training of Chinese medicine talents at the grassroots level in higher Chinese medicine colleges based on “healthy China”
BAI Yu1 ZHOU Donglei2 LIU Hongyu3 ZHANG Rongxing4 LIU Chuming1 WANG He5
With the promotion of the “healthy China” strategy, the grassroots Chinese medicine medical treatment has ushered in a leap forward, and the basic hardware facilities are improving, but the shortage of grassroots Chinese medicine talents has become the key to limit the development of grassroots health care. This research analyzes the development of grassroots Chinese medicine under the background of “healthy China”, combines the advantages of Chinese medicine service grassroots medicine, discusses the current situation and countermeasures of the training of Chinese medicine talents at the grassroots level, and puts forward that higher Chinese medicine institutions should strengthen the policy propaganda of grassroots Chinese medicine and establish a market-oriented way of training the grassroots talents. Improve students′ recognition of grassroots Chinese medicine medical services, enhance students′ own clinical comprehensive diagnosis and treatment skills and enhance medical service awareness.
2020 Vol. 17 (5): 188-191 [Abstract] ( 186 ) HTML (1 KB)  PDF (534 KB)  ( 42 )
192 Discussion on diagnosis and treatment of pulmonary nodules in Chinese and Western medicine
ZHAO Yuanchen LIU Shigang
As the rate of examination of pulmonary nodules increased recent years, the method to deal with or treat pulmonary nodules is coming to a controversial and challenging question. There is incrementally progresses in radiography and non-operative biopsy in Western medicine last several years, which provides an important reference on the differentiation of benign and malignant nodules. Meanwhile, the traditional Chinese medicine, which already has good clinical efficacy in the lung cancer prevention and treatment, is gradually beginning to treat pulmonary nodules patients, and has made good therapeutic effect. Chinese herbs can improve the organism′s microenvironment with its integrality and multi-targets features, in order to make a healthy lung microenvironment so that pulmonary nodules won′t grow. Therefore, according to the writer′s theory of resolving phlegm and softening hardness to dissipate stagnation used in Chinese herbs, plenty of pulmonary nodules patients were treated effectively. With the theory of “preventive treatment of disease” in traditional Chinese medicine, pulmonary nodules, known as precancerous lesions, if could be early detection and intervention, which can be helpful for the early prevention and treatment of lung cancer.
2020 Vol. 17 (5): 192-196 [Abstract] ( 297 ) HTML (1 KB)  PDF (803 KB)  ( 98 )
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