药学干预抗菌药物使用在骨科Ⅰ类切口围术期的效果评估

Abstract
Figure/Table
References (23)
Related Citation (7)

Download: PDF (450 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the effect on pharmaceutical intervention of the perioperative antimicrobial drugs use in typeⅠincision in Orthopedic Department. Methods Through the DIS system of hospital, electronic medical records of perioperative antibacterial drugs used in typeⅠincision in Sichuan Orthopedic Hospital from January to June 2016 (before intervention, 127 cases in control group) and from January to June 2017 (after intervention, 133 cases in intervention group) were selected. The time of administration, drug varieties, usage and dosage, medication treatment, and so on of perioperative antibacterial drugs used in typeⅠincision in orthopedic department before and after the intervention were retrospectively analyzed. Results After intervention, the reasonable proportion of the time of administration of perioperative antibacterial drugs varieties used in intervention group was significantly increased to 84.2%, and it compared with the control group (51.2%), the difference was highly statistically significant (χ2=32.81, P=0.000). The rational proportion of perioperative antibacterial drugs used in intervention group was compared with the control group, the difference was highly statistically significant (χ2=46.27, P=0.000). Administration route of antimicrobial drugs before and after the intervention were intravenous drip, and the two groups were compared on the route of administration, the difference was not statistically significant (P > 0.05), but the dosage and frequency of medication in intervention group were higher than those of the control group (χ2=23.11, P=0.000, χ2=36.32, P=0.000). The antibacterial drug of treatment in the operation of < 24 h in the two groups were compared, the difference was not statistically significant (P > 0.05). The medication treatment in the operation of 24-48 h in the intervention group was higher than the control group (χ2=23.78, P=0.000). The medication treatment in the operation of > 48 h in the intervention group was lower than the control group (χ2=18.42, P=0.000). Conclusion The effect of pharmaceutical intervention of the perioperative antimicrobial drugs use in typeⅠincision in Orthopedic Department is definite, and can effectively improve the rational utility ratio of antibacterial drugs, reduce the occurrence of non-standard drugs use, which is worth promoting.

Key words： Pharmaceutical intervention Antibiotics TypeⅠincision perioperative period Orthopaedic Department

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WU Chuanhong CHEN Yunbei WANG Xiaoling WEI Tingsen

Cite this article:

WU Chuanhong CHEN Yunbei WANG Xiaoling WEI Tingsen. Effectiveness evaluation on pharmaceutical intervention of the perioperative antimicrobial drugs use in typeⅠincision in Orthopedic Department[J]. 中国医药导报, 2018, 15(11): 139-142.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I11/139

[1] 唐志立，唐捷，王丽，等.合理用药处方点评体系的构建及实施效果分析[J].中国药业，2015，24（23）：106-108.
[2] 张镭，谭玲，陆进，等.超说明书用药专家共识[J].药物不良反应杂志，2015，（2）：101-103.
[3] 方水凉，邱杏桃，黄水湖，等.抗菌药物规范化管理对Ⅰ、Ⅱ类切口中抗菌药物预防应用情况的影响[J].中国生化药物杂志，2015，（9）：85-87，90.
[4] 国家卫生计生委，国家中医药管理局，总后卫生部药品器材局.关于印发《抗菌药物临床应用指导原则（2015年版）》的通知[S].国卫办医发〔2015〕43号.2015-07-24.
[5] 黄娟，唐晓铃，柯昌毅，等.我院时间依赖性抗菌药物输注间隔时间不规范的原因及对策分析[J].中国药房，2017， 28（2）：273-275.
[6] 颜铭，滕韦卫，崔岚，等.某综合医院骨科住院患者盐酸克林霉素注射剂使用合理性评价[J].中国药房，2017，28（29）：4053-4056.
[7] 周殿友，贾晋生.我院抗肿瘤药物合理应用评价体系的建立及实施效果评价[J].中国药房，2017，28（29）：4157-4160.
[8] 国家卫生计生委.关于开展2017年抗菌药物临床合理应用督导工作的通知[EB/OL].（2017-9-1）[2018-1-9] http：//www.qhwst.gov.cn/ywgl/yzhengc/tzgg/2017/09/04/150449383 9858.html.
[9] 王志英.我院2014年骨科Ⅰ类切口手术围手术期预防使用抗菌药物分析[J].中国执业药师，2015，（11）：3-5，15.
[10] 陶敏，张月笙.临床药师干预Ⅰ类切口手术抗菌药物预防性使用的效果评价[J].中国感染控制杂志，2016，15（4）：269-271，276.
[11] 董嘉，杨雪松，袁晓宁，等.脊柱手术围手术期抗菌药物预防应用干预效果评价[J].中国医院管理，2016，36（4）：49-51.
[12] 金育忠，宋建民，雷旭东，等.风险分层法规范骨与软组织科Ⅰ类切口手术抗菌药物预防使用[J].中国药房，2015，（32）：4493-4494，4495.
[13] 台磊.898张门诊抗菌药物处方点评与分析[J].中国医院用药评价与分析，2017，17（11）：1580-1581，1584.
[14] Wyatt RWB，Maletis GB，Lyon LL，et al. Efficacy of prophylactic antibiotics in simple knee arthroscopy [J]. Arthroscopy，2017，33（1）：157-162.
[15] Mercuri LG，Psutka D. Perioperative，postoperative，and prophylactic use of antibiotics in alloplastic total temporomandibular joint replacement surgery：a survey and preliminary guidelines [J]. J Oral Maxillofac Surg，2011，69（8）：2106-2111.
[16] 张增珠，李刚，徐劲松，等.临床药师对呼吸内科吸入用药患者的宣教[J].医药导报，2016，35（6）：660-662，663.
[17] 李京向，何青，王春红，等.清洁切口手术预防应用抗菌药物的干预与评价[J].中国感染控制杂志，2016，15（7）：527-529.
[18] Gustin MP，Ohannessian R，Giard M，et al. Use of surveillance data to calculate the sample size and the statistical power of randomized clinical trials testing staphy?鄄lococcus aureus vaccine efficacy in orthopedic surgery [J]. Vaccine，2017，35（50）：6934-6937.
[19] Gottschalk F，Wilke T，Mueller S，et al. Staphylococcus aureus infections in German patients with type 2 diabetes Mellitus after orthopedic surgery：incidence，risk factors，and clinical and health-economic outcomes [J]. Surg Infect （Larchmt），2017，18（8）：915-923.
[20] 谢朝云，熊永发，闫飞，等.手术切口多药耐药菌感染危险因素logistic回归分析[J].中华医院感染学杂志，2016， 26（23）：5440-5443.
[21] 黎海燕.药剂师参与处方管理对促进医院抗菌药物合理应用的影响[J].中国药物经济学，2016，11（2）：191-192.
[22] 朱振宇.2016年我院住院患者抗菌药物使用情况汇总分析[J].中西医结合心血管病电子杂志，2017，5（7）：73-74.
[23] 王梅.临床药师参与抗菌药物管理前后的临床应用情况调查分析[J].中国药事，2017，31（6）：679-683.