IGF-1、hs-CRP、NT-proBNP与老年2型糖尿病患者左心室肥厚的临床关系

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Abstract Objective To investigate the clinical relationships between islet growth factor 1 (IGF-1), high sensitivity C reactive protein (hs-CRP) and N-terminal B type natriuretic peptide (NT-proBNP) and left ventricular hypertrophy in elderly patients with type 2 diabetes. Methods From June 2015 to February 2017, 163 elderly patients with type 2 diabetes were selected in the Second Hospital of Xingtai (“our hospital” for short), including 74 patients with left ventricular hypertrophy (hypertrophy group) and 89 patients without any complications (diabetes group). During the same period, 79 healthy persons in our hospital were selected (control group). The left ventricular end diastolic diameter (LVIDd), systolic diameter (LVIDs), end diastolic posterior wall thickness (LVPWD), end diastolic ventricular septal thickness (IVST), left ventricular mass indexes (LVMI) and the levels of serum IGF-1, hs-CRP and NT-proBNP were compared, then the relationships between serum indexes and left ventricular hypertrophy of hypertrophy group were analyzed. Results The LVIDd, LVIDs, LVPWD, IVST, LVMI and the serum levels of hs-CRP and NT-proBNP of the hypertrophy group and diabetes group were significantly higher than those of the control group (P < 0.05), of which the hypertrophy group were significantly higher than those of the diabetes group (P < 0.05). The serum levels of IGF-1 of the hypertrophy group and the control group were significantly higher than those of the diabetes group (P < 0.05), of which the hypertrophy group was significantly higher than that of the control group (P < 0.05). The levels of IGF-1, hs-CRP and NT-proBNP were positively related to LVIDd, LVIDs, LVPWD, IVST and LVMI (P < 0.05). Conclusion The serum levels of IGF-1, hs-CRP and NT-proBNP in left ventricular hypertrophy in elderly patients with type 2 diabetes mellitus are significantly increased, which have closed relationships with left ventricular hypertrophy.

Key words： Islet like growth factor 1 Hypersensitive C reactive protein Nitrogen terminal B brain natriuretic peptide Type 2 diabetes Left ventricular hypertrophy

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	GUO Chunxia FU Likun LI Mo LI Jiaxiu WANG Yafei SONG Hua

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GUO Chunxia FU Likun LI Mo LI Jiaxiu WANG Yafei SONG Hua. Clinical relationships between IGF-1，hs-CRP，NT-proBNP and left ventricular hypertrophy in elderly patients with type 2 diabetes[J]. 中国医药导报, 2018, 15(11): 120-122,142.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I11/120

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