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| Effect of laparoscopic total mesorectal excision on postoperative serum levels of GAS, bFGF and MOT and quality of life in patients with low rectal cancer |
| CHEN Tenggao LI Lijun LU Yifang ZHANG Lei |
| Department of Anus & Intestine Surgery, Dongyang People′s Hospital, Zhejiang Province, Dongyang 322100, China |
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Abstract Objective To investigate the effect of laparoscopic total mesorectal excision on postoperative serum levels of gastrin (GAS), basic fibroblast growth factor (bFGF) and motilin (MOT) and quality of life in patients with low rectal cancer. Methods Total of 92 cases with low rectal cancer treated in Dongyang People′s Hospital were selected as research objects, and randomly divided into the control group and the observation group, with 46 cases in each group. The observation group was treated with laparoscopic total mesorectal excision, the control group was treated with conventional open surgery. The surgery situation, postoperative recovery of gastrointestinal motility and anal function recovery, improvement of life quality after operation were compared between the two groups. Results The surgical time of the observation group was longer than that of the control group, while the length of incision, intraoperative blood loss, postoperative anal exhaust time, time of taking food and hospitalization time were shorter or less than those of the control group (P < 0.05). The incidence of anastomotic fistula and the total incidence of complications in the observation group were lower than those in the control group (P < 0.05). Three days after surgery, levels of GAS and MOT in the observation group were higher than those in the control group (P < 0.05). Three months after surgery, RMTV in the observation group was higher than that in the control group, while the Wexner score was lower than that in the control group (P < 0.05). Quality of life scores of the observation group were higher than those in the control group at different time points after surgery (P < 0.05). Conclusion Laparoscopic total mesorectal excision has little effect on GAS and MOT in patients with low rectal cancer, and it can improve the quality of life of patients.
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