曲妥珠单抗联合TC方案治疗HER-2过度表达乳腺癌的效果及安全性

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Abstract Objective To investigate the efficacy and safety of Trastuzumab combined with Docetaxel and Cyclophosphamide chemotherapy in the treatment of HER-2 overexpression breast cancer. Methods From October 2015 to October 2016, 79 cases of breast cancer patients in Cancer Hospital Affiliated to Xinjiang Medical University were selected. The patients were divided into the study group (38 cases) and the control group (41 cases) according to the random number table method. The control group was treated with TC combined chemotherapy before radical mastectomy. The study group was treated with Trastuzumab on the basis of control group. After 18 weeks of treatment, the curative effect and adverse reaction rate of the two groups were compared. The results of HER-2 protein, B7-H1 and IL-2 expression before and after treatment were compared. Results After treatment, the total effective rate (RR) of the study group was significantly higher than that of the control group (P < 0.05). After treatment, HER-2 overexpression rates of the two groups were significantly reduced than before treatment (P < 0.05), and the overexpression rate of the study group was significantly lower than that of the control group (P < 0.05). The positive expression rates of B7-H1 and IL-2 in the study group after treatment were significantly lower than those before treatment (P < 0.05). Adverse reactions occurred in both groups after treatment had no significant difference (P > 0.05). Conclusion Trastuzumab combined with TC regimen in the treatment of patients with HER-2 overexpression breast cancer can effectively reduce the expression of HER-2 protein, B7-H1 and IL-2, improve the clinical curative effect, which can not increase the risk of medication.

Key words： Trastuzumab HER-2 overexpression Breast cancer

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	WANG Xiaomei1 WANG Songzhi1 OU Jianghua2

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WANG Xiaomei1 WANG Songzhi1 OU Jianghua2. The efficacy and safety of Trastuzumab combined with TC regimen in the treatment of HER-2 overexpressing breast cancer[J]. 中国医药导报, 2018, 15(11): 104-107.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I11/104

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