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| Analysis of GDF-15 gene polymorphism and acute myocardial infarction |
| LIANG Rongzhen WANG Taicheng |
| Department of Geriatrics, the Second Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou 570311, China |
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Abstract Objective To investigate the relationship between rs1058587 polymorphism of GDF-15 gene and acute myocardial infarction (AMI). Methods From January 2016 to January 2017, 120 patients with AMI of Cardiovascular Medicine Department in the Second Affiliated Hospital of Hainan Medical University were selected as AMI group. In the same period, 120 healthy subjects were selected as health group. The two groups were used by polymerase chain reaction PCR GDF-15 gene rs1058587 locus genotypes, allele frequencies, and explore its relationship with patients with concurrent AMI. Results The genotypes of CC, CG and GG at rs1058587 of GDF-15 gene in AMI group were compared with health group, the difference was statistically significant (P < 0.05). The frequency of G allele of rs1058587 in GDF-15 gene in AMI group was higher than health group (P < 0.05). The results of Logistic multifactor regression analysis showed that the decrease of high-density lipoprotein cholesterol and the rise of Low density lipoprotein cholesterol, serum lipoprotein (a), minim white egg, the allele G at rs1058587 in GDF-15 gene were the independent risk factor for concurrent AMI (P < 0.05). Conclusion Rs1058587 polymorphism of GDF-15 gene is closely related to AMI occurrence in population.
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