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| Correlation analysis between asymmetric dimethylarginine and symmetric dimethylarginine and coronary artery disease of kawasaki disease |
| LI Xiandong LV Jun HU Xiuxue |
| Department of Laboratory Medicine, Taihe Hospital (Affiliated Hospital of Hubei University of Medicine), Hubei Province, Shiyan 442000, China |
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Abstract Objective To study the three biomarkers of L-arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are used to predict the prognosis of children patients with kawasaki disease (KD). Methods From January 2012 to December 2013, 39 children with KD in Department of Pediatric in Taihe Hospital were selected as the case group, venous blood was collected, and at the same time, the plasma of 27 children patients matched with age was collected as control group, which of respiratory infection was accompanied by fever and exclusion of involvement of myocardium. The plasma levels of L-arginine, ADMA and SDMA were measured in the case group and control group. Results The plasma levels of L-arginine, ADMA and SDMA before intravenous immunoglobulin (IVIG) treatment of children in the case group KD1 were lower than those of control group (P < 0.05 or P < 0.01). After IVIG treatment, the L-arginine, ADMA, L-arginine/ADMA ratio (AAR) and arginine methylation composite index (AMI) of different treatment time in case group were compared, the differences were highly statistically significant (P < 0.01). The plasma levels of SDMA of children in case group KD1, case group KD2, case group KD3, case group KD4 were all lower than the control group (P < 0.01), but comparison of before and after IVIG treatment, the difference were not statistically significant (P > 0.05). The AMDA/SMDA ratio (ASR) of children in case group KD2, case group KD3, case group KD4 were all higher than control group and case group KD1 (P < 0.01). In the case group KD1, the L-arginine level of children with coronary artery dilation was higher than that in children without coronary artery dilatation (P < 0.01), while in the case group KD2 and the case group KD3, the children patients with coronary artery dilation was lower than that in children without coronary artery dilatation (P < 0.01). Conclusion The levels of L-arginine, ADMA and SDMA may be related to KD. Low level of L-arginine and ASR of after IVIG treatment are associated with children patients with abnormal coronary artery KD.
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