生长分化因子-15与N末端-B型利钠肽原及超敏C反应蛋白在急性心力衰竭中的诊断价值

Abstract
Figure/Table
References (22)
Related Citation (8)

Download: PDF (594 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the expression level and diagnostic value of serum growth differentiation factor-15 (GDF-15), N-terminal B-type natriuretic peptide prosoma (NT-proBNP) and high-sensitivity C-reactive protein (CRP) in patients with acute heart failure (AHF) and patients with different severity of AHF. Methods A total of 77 patients with AHF (AHF group) and 60 cases of healthy examined people (control group) from April 2014 to April 2016 in the Second Hospital of Yanbian were selected. The expression level of serum GDF-15 and NT-proBNP were detected by ELISA, the expression of hs-CRP was detected by immunochromatography, routine electrocardiogram and echocardiography were performed to examine the left ventricular ejection fraction (LVEF) and chest X-ray examination. The correlation between GDF-15, NT-proBNP, hs-CRP expression level and the three factors were analyzed. Results Compared with the control group, the expression of GDF-15, NT-proBNP and hs-CRP were significantly increased and the left ventricular ejection fraction (LVEF) was significantly reduced in AHF group, the difference was statistically significant (P ＜ 0.05). The levels of NT-proBNP, hs-CRP among clinical grades Ⅰto Ⅳ had increased trend, the difference was not statistically significant (P ＞ 0.05). GDF-15 and hs-CRP were positively correlated to NT-proBNP, hs-CRP was positivly correlated to NT-proBNP, LVEF and GDF-15 were negatively correlated to NT-proBNP (P ＜ 0.01). The ROC curve analysis showed that the areas under the curve of NT-proBNP, GDF-15 and hs-CRP had statistical significance in diagnosing AHF (P ＜ 0.05), the diagnostic ability was NT-proBNP ＞ GDF-15 ＞ hs-CRP. Conclusion The serum levels of GDF-15, NT-proBNP and hs-CRP are significantly elevated in patients with AHF, and increasd as the clinical severity. The serum GDF-15 can be used as a new index for diagnosis, treatment and estimating prognosis of patients with AHF. GDF-15 combined with the detection of NT-proBNP and hs-CRP has great significance in diagnosing and treating, distinguishing risk stratification and judging prognosis AHF.

Key words： Acute heart failure Left ventricular ejection fraction Growth differentiation factor-15 N-terminal B-type natriuretic peptide prosoma High-sensitivity-C-reactive protein

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HUANG Haiyan1 CUI Ying2 HONG Yunyu1 LI Yulan1 WANG Xingjun1 ZHONG Wenxiu1 LI Meifeng1

Cite this article:

HUANG Haiyan1 CUI Ying2 HONG Yunyu1 LI Yulan1 WANG Xingjun1 ZHONG Wenxiu1 LI Meifeng1. The diagnostic value of growth differentiation factor-15 and N-terminal B-type natriuretic peptide prosoma and high-sensitivity C-reactive protein in patients with acute heart failure[J]. 中国医药导报, 2018, 15(11): 54-58.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I11/54

[1] Wang FF，Chen BX，Yu HY，et al. Correlation between growth dif ferentiation factor-15 and collagen metabolism indicators in patients with myocardial infarction and heart failure [J]. J Geriatr Cardiol，2016，13（1）：88-93.
[2] 颜毅.探讨冠状动脉扩张发生的相关机制及生长分化因子-15的内皮保护作用[D].北京：中国协和医科大学，2010.
[3] Gaggin HK，Szymonifka J，Bhardwaj A，et al. Head-to-head comparison of serial soluble ST2，growth differentiation factor-15，and highly-sensitive troponin T measurements in patients with chronic heart failure [J]. JACC Heart Fail，2014，2（1）：65-72.
[4] Fuernau G，Poenisch C，Eitel I，et al. Growth differentiate on factor 15 and osteoprotegerin in acute myocardial infarction complicated by cardiogenic shock：a biomarker substudy of the IABP-SHOCK II-trial [J]. Eur J Heart Fail，2014，16（8）：880-887.
[5] Damman P，Kempf T，Windhausen F，et al. Growth differentiation factor 15 for long-term prognostication in pa tients with non-ST-elevation acute coronary syndrome：anInvasive versus Conservative Treatment in Unstable coronary Syndromes （ICTUS） substudy [J]. Int J Cardiol，2014， 172（2）：356-363.
[6] Wollert KC，Kempf T，Peter T，et al. Prognostic value of growth differentiation factor-15 in patients with non-ST elevation acute coronary syndrome [J]. Circulation 2007， 115（8）：962-971.
[7] 武德梅，周琪，陈超.急性心肌梗死患者生长分化因子-15、心肌梗死标志物水平表达及其相关性研究[J].疑难病杂志，2014，（8）：790-792.
[8] Melvin G，Amrita J，Varsha S，et al. GDF 15-A Novel Bio?鄄marker in the Offing for Heart Failure [J]. Curr Cardiol Rev，2016，12（1），37-46.
[9] 中华医学会心血管病血分会，中华心血管病杂志编辑委员会.急性心力衰竭诊断和治疗指南[J].中华心血管病杂志，2010，38（3）：195-208．
[10] Kempf T，Eden M，Strelau J ，et al. The transforming growth factor-beta superfamily member growth defferentiation factor-15 protecters the heart from ischemia/reperfusion injury [J]. Cire Res，2006，98（3）：351-360.
[11] Maisel A. Biomarkers in heart failure：Does prognostic utility translate to clinical futilure? [J]. J Am Coll Cardiol，2007，50（11）：1054-1060.
[12] Gil M，Zarebiske M，Adamus J，et al. Plasma fibrinogen and troponin I in acute coronary syndrome and stable angina [J]. Int J Cardiol，2007，83（6）：43-46.
[13] Bron DA，Breit SN，Buring J，et al. Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women：a nested case control study [J]. Lancet，2012，359（9）：159-163.
[14] 蔡宗群，钟斌，李爱群，等.血浆生长分化因子-15水平检测对左心衰竭的临床意义[J].临床心血管病杂志，2012， 28（4）：252-255.
[15] 王大正，蔡力，陶剑虹，等.心力衰竭患者血浆生长分化因子-15水平、超敏C反应蛋白和氮末端-前体脑钠肽表达水平及其相关性的研究[J].实用医院临床杂志，2013， 10（2）：39-42.
[16] Friedl W，mair J，Thomas S，et al. Relatlonship between natriuretic peptide and hemodynamics in patients heart failure at rest and after ergometrie exercise [J]. Clin Chim Acta，2009，281（12）：121-126.
[17] Kempf T，Hom-wichmann R，Brabant G，et al. Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly indivdduals and atients with chronic heart failure as assessad by a new inmunoradimetric sandwich assay [J]. Clin Chem，2007，53（2）：284-291.
[18] 赵玉清，袁桂莉，张进顺，等.和肽素联合N末端B型利钠肽原评估慢性心力衰竭患者预后的价值[J].中国循环杂志，2014，29（4）：275-278.
[19] 周阳贞，李艳.急性心肌梗死患者PCI手术前后CRP、NT-proBNP、CK-MB、cTnT水平测定及临床意义[J].海南医学院学报，2016，22（13）：1357-1360.
[20] 陈都，徐峰，陆士奇，等.急性心肌梗死早期血清超敏C反应蛋白和前白蛋白与并发急性心力衰竭的关系[J].海南医学院学报，2016，22（13）：1357-1360.
[21] Corrado E，Rizzo M，Coppola G，el al，An update on the role of markers of inflammation in atherosclerosis [J]. J Atheroscler Thromb，2010，17（1）：1-11.
[22] Nozari Y，Geraiely B. Correlation between the serum levels of uric acid and HS—CRP with the occurrence of early systolic failure of 1eft ventricle following acute myocardial infarction [J]. Acta Med Iran，2011，49（8）：531-535.