核医学及分子成像在肺栓塞诊断中的现状及进展

Abstract
Figure/Table
References (28)
Related Citation (1)

Download: PDF (646 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract In recent years, with the renewal and comprehensive application of imaging diagnostic techniques, the diagnostic rate of pulmonary embolism has been greatly improved, but common pulmonary embolism (PE) still have some limitations. Since the prospective study of pulmonary embolism diagnosis (PIOPED) since its establishment, imaging equipment and radiopharmaceuticals have developed rapidly and further improved pulmonary ventilation perfusion (V/Q) imaging techniques. Single photon emission computed tomography (SPECT) combination of SPECT and low dose CT (SPECT/CT) has been widely used in daily practice. Positron emission computed tomography has recently been proposed (PET) lung perfusion/ventilation imaging, however, has not yet been clearly confirmed in large-scale prospective studies. In this paper, we will discuss various imaging methods such as V/Q SPECT, SPECT/CT and V/Q PET/CT, and summarize the present situation and development trend of molecular imaging in the study of in vivo characteristics of venous thromboembolism.

Key words： Pulmonary embolism Ventilation/perfusion imaging Molecular imaging

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Jie CHEN Diansen PENG Nan

Cite this article:

LI Jie CHEN Diansen PENG Nan. Current status and progress of nuclear medicine and molecular imaging in the diagnosis of pulmonary embolism[J]. 中国医药导报, 2018, 15(11): 41-44.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I11/41

[1] 刘娜.肺栓塞抗凝治疗解析[J].继续医学教育，2016，30（7）：102-104.
[2] 郭宵峰，刘建忠.CT及核医学技术在肺栓塞诊断中的应用价值[J].国际医学放射学杂志，2015，38（2）：122-125.
[3] Mullins MD，Becker DM，Hagspiel KD，et al. The role of spiralvolumetric computed tomography in the diagnosis of pulmonary embolism [J]. Arch Intern Med，2000，160（3）：293-298.
[4] Rathbun SW，Raskob GE，Whitsett TL. Sensitivity and specificityof helical computed tomography in the diagnosis of pulmonary embolism：a systematic review [J]. Ann Intern Med，2000，132（3）：227-232.
[5] 李永刚.SPECT肺灌注显像对肺血栓栓塞症诊断的临床价值[J].医学理论与实践，2015，28（22）：3118-3119.
[6] Stein PD，Fowler SE，Goodman LR，et al. Multidetector computed tomography for acute pulmonary embolism [J]. N Engl J Med，2006，354（22）：2317-2327.
[7] Zhou HT，Yan WY，Zhao DL，et al. CT pulmonary angiogram for assessing the treatment outcome of acute pulmonary embolism [J]. Echocardiography，2018，35（3）：396-400.
[8] Yumoto T，Naito H，Yamakawa Y，et al. Venous thromboembolism in major trauma patients：a single-center retrospective cohort study of the epidemiology and utility of D-dimer for screening [J]. Acute Med Surg，2017，4（4）：394-400.
[9] Li W，Huang B，Tian L，et al. Admission D-dimer testing for differentiating acute aortic dissection from other causes of acute chest pain [J]. Arch Med Sci，2017，13（3）：591-596.
[10] Simanek M，Koranda P. The benefit of personalized hybrid SPECT/CT pulmonary imaging [J]. Am J Nucl Med Mol Imaging，2016，6（4）：215-222.
[11] Leblanc M，Leveillee F，Turcotte E. Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-Technegas [J]. Nucl Med Commun，2007，28（8）：667-672.
[12] Le Roux PY，Robin P，Delluc A，et al. Additional value of combining low-dose computed tomography to V/Q SPECT on a hybrid SPECT-CT camera for pulmonary embolism diagnosis [J]. Nucl Med Commun，2015，36（9）：922-930.
[13] Kumar N，Xie K，Mar W，et al. Software-Based Hybrid Perfusion SPECT/CT Provides Diagnostic Accuracy When Other Pulmonary Embolism Imaging Is Indeterminate [J]. Nuclear Medicine & Molecular Imaging，2015， 49（4）：1-9.
[14] Kearon C，Ak EA，Comerota AJ，et al. Antithrombotic therapy for VTE disease：Antithrombotic Therapy and Prevention of Thrombosis，9th ed：American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J]. Chest，2012，141（2 Suppl）：e419S-e496S.
[15] 张明，刘玉婷，金刚，等.SPECT肺灌注/低剂量CT融合显像技术在肺栓塞中的诊断价值[J].标记免疫分析与临床，2016，23（4）：375-378.
[16] Kotzerke J，Andreeff M，Wunderlich G，et al. Ventilation-perfusion-lungscintigraphy using PET and 68Ga-labeled radiopharmaceuticals [J]. Nuklearmedizin，2010；49（6）：203-208.
[17] Rahmim A，Zaidi H. PET versus SPECT：strengths，limitations and challenges [J]. Nucl Med Commun，2008，29（3）：193-207.
[18] Bailey DL，Eslick EM，Schembri GP，et al.（68）Ga PET Ventilation and Perfusion Lung Imaging-Current Status and Future Challenges [J]. SeminNucl Med，2016，46（5）：428-435.
[19] Le Roux PY，Siva S，Steinfort DP， et al. Correlation of 68Ga Ventilation-Perfusion PET/CT with Pulmonary Function Test Indices for Assessing Lung Function [J]. J Nucl Med，2015，56（11）：1718-1723.
[20] Siva S，Thomas R，Callahan J，et al. High-resolution pulmonary ventilation and perfusion PET/CT allows for functionally adapted intensity modulated radiotherapy in lung cancer [J]. Radiother Oncol，2015，115（2）：157-162.
[21] Le Roux PY，Leong TL，Barnett SA，et al. Gallium-68 perfusion positron emission tomography/computed tomography to assess pulmonary function in lung cancer patients undergoing surgery [J]. Cancer Imaging，2016，16（1）：24.
[22] Perrier A. Labeling the thrombus：the future of nuclear medicine for venous thromboembolism? [J]. Am J Respir Crit Care Med，2004，169（9）：977-978.
[23] Walton BL，Byrnes JR，Wolberg AS. Fibrinogen，red blood cells，and factor XIII in venous thrombosis [J]. J Thromb Haemost，2015，13 Suppl 1：S208-215.
[24] Le Roux PY，Robin P，Delluc A，et al. Performance of 18F fluoro-2-désoxy-D-glucose positron emission tomography/computed tomography for the diagnosis of venous thromboembolism [J]. Thromb Res，2015，135（1）：31-35.
[25] Sharma P，Kumar R，Jeph S，et al. 18F-FDG PET-CT in the diagnosis of tumor thrombus：can it be differentiated from benign thrombus? [J]. Nucl Med Commun，2011，32（9）：782-788.
[26] Miceli M，Atoui R，Walker R，et al. Diagnosis of deep septic thrombophlebitis in cancer patients by fluorine-18 fluorodeoxyglucose positron emission tomography scanning：a preliminary report [J]. J ClinOncol，2004，22（10）：1949-1956.
[27] Houshmand S，Salavati A，Hess S，et al. The role of molecular imaging in diagnosis of deep vein thrombosis [J]. Am J Nucl Med Mol Imaging，2014，4（5）：406-425.
[28] Morris TA，Gerometta M，Smart RC，et al. Pulmonary emboli imaging with（99m）Tc-labelled anti-D-dimer（DI-80B3） Fab' followed by SPECT [J]. Heart Lung Circ，2011， 20（8）：503-511.