实验性家兔颈动脉粥样硬化模型中颈动脉I/M值与肾动脉粥样硬化的相关性研究

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Abstract Objective To analyze the correlation between the change in carotid intima / media membrane (I/M) ratio and renal atherosclerosis in experimental rabbit carotid atherosclerosis models. Methods Forty-eight rabbits were randomly divided into the blank group, the control group and the model group by the random number table method, with 16 rabbits in each group. The blank group was not given any intervention, which was given basal feed. The control group was given high-fat diet of 120 g/d. The model group was given 7 d of high-fat diet and then the rabbits were changed into bilateral carotid atherosclerosis models through carotid intima air drying after 12 h of fasting (without fasting water). The bilateral operative carotid arteries and renal artery specimens of all rabbits were obtained to analyze the I/M ratio after routine paraffin embedding, sectioning and HE staining. Serum levels of triglyceride (TG), total cholesterol (TC) and C-reactive protein (CRP) were determined at the end of the experiment. Urinary microalbumin / urine creatinine (UACR) was analyzed and correlation analysis was performed. Results HE staining under light microscope was normal in the carotid artery and renal artery of rabbits in the blank group. In the control group, there was slight intimal hyperplasia in the carotid artery and slight hyperplasia and stenosis in the renal artery, without obvious lipid deposition. In the model group, there was obviously proliferated and thickened carotid intima, a large number of foam cells accumulated in the intima, extensively proliferated intima of the renal artery and seriously narrowed vessels, and thickened intima was accumulated foam cells at high magnification. Compared with the blank group, the carotid artery, renal artery I/M ratio in the control group and model group were significantly increased, serum TG, TC, CRP and UACR were significantly increased, and the carotid artery, renal artery I/M ratio and serum TG, TC, CRP and UACR in the model group were significantly higher than those of control group, the differences were statistically significant (P ＜ 0.05). The I/M ratio of carotid artery in rabbit carotid atherosclerosis models was positively correlated with the I/M ratio of renal artery, CRP and UACR (P ＜ 0.05), but there was no significant correlation with TG or TC (P ＞ 0.05). Conclusion Carotid atherosclerosis can promote the occurrence of renal atherosclerosis, which may be related to inflammatory reactions, vascular endothelial cell injury and renal vascular diseases.

Key words： Rabbit Carotid atherosclerosis Intima / media membrane ratio Renal atherosclerosis Correlation

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[1] 赵鹏鸣，王俭勤，梁耀军.糖尿病患者颈动脉内中膜厚度与肾功能的相关性[J].中华肾脏病杂志，2016，32（6）：406-411.
[2] 丁延辉，丁俊丽，周青，等.全反式维甲酸对实验性动脉粥样硬化兔动脉血管内皮依赖性舒张功能的影响[J].安徽医科大学学报，2017，52（1）：7-12.
[3] 杨卉.住院老年2型糖尿病患者尿白蛋白/肌酐比值与颈动脉内膜中层厚度的相关性[J].实用医学杂志，2015，31（10）：1645-1647.
[4] Yilmaz MI，Sonmez A，Saglam M，et al. A Longitudinal Study of Inflammation，CKD-Mineral Bone Disorder，and Carotid Atherosclerosis after Renal Transplantation [J]. Clin J Am Soc Nephrol，2015，10（3）：471-479.
[5] 金彪，王永杰，邹明，等.1.5TMRI评价颈动脉粥样硬化与脑梗死的相关性研究[J].中国医学计算机成像杂志，2016，22（4）：297-300.
[6] 田春鸥，张鑫，袁媛，等.家兔脑动脉粥样硬化性狭窄模型的建立[J].中国临床医学，2016，23（4）：444-448.
[7] 唐曦，杨松，苟博，等.高脂喂养联合免疫损伤建立兔动脉粥样硬化模型及评价[J].中国医药导报，2016，13（18）：21-24.
[8] 王显利，廉秋芳，牟建军，等.原发性高血压合并2型糖尿病患者日间及夜间血压变异性与颈动脉硬化的关系[J].中华高血压杂志，2015，23（10）：940-945.
[9] 孟胜喜，霍清萍，梁芳，等.稳消Ⅲ号方对颈动脉粥样硬化患者不稳定斑块、脂质代谢及踝臂指数的作用[J].中华中医药杂志，2016，33（12）：5366-5369.
[10] 印荻.晚期氧化蛋白产物与慢性肾脏病患者动脉粥样硬化的相关性[J].中国中西医结合肾病杂志，2016，17（9）：845-846.
[11] 张若青，杨春燕，王紫韫.颈动脉粥样硬化与冠状动脉、肾动脉狭窄的相关性研究[J].河北医药，2014，36（17）：2583-2585.
[12] 周叶，毛亮，张景旭，等.颈动脉粥样硬化及主动脉瓣钙化与动脉粥样硬化性肾动脉狭窄的关系[J].现代生物医学进展，2015，15（20）：3858-3861.
[13] Ueno H，Koyama H，Fukumoto S，et al. Advanced glycation end products，carotid atherosclerosis，and circulating endothelial progenitor cells in patients with end-stage renal disease [J]. Metabolism，2011，60（4）：453-459.
[14] Hoke M，Pernicka E，Niessner A，et al. Renal function and long-term mortality in patients with asymptomatic carotid atherosclerosis.[J]. Thromb Haemost，2012，107（1）：150-157.
[15] Geraci G，Mulè G，Costanza G，et al. Relationship Between Carotid Atherosclerosis and Pulse Pressure with Renal Hemodynamics in Hypertensive Patients [J]. Am J Hypertens，2016，29（4）：519-527.
[16] 于伟，周风云，刘青，等.心绞痛患者血清hs-CRP水平与动脉粥样硬化斑块稳定性的关系[J].山东医药，2015， 55（42）：81-82.
[17] 朱英标，官常荣，叶祖森，等.阿加曲班联合氯吡格雷治疗大动脉粥样硬化性脑梗死的临床效果分析[J].中国现代医生，2017，55（1）：64-67.
[18] 王雪梅，魏琴，张春，等.重组腺病毒介导脂联素基因对ApoE-/-小鼠动脉粥样硬化的作用机制[J].中国实验动物学报，2016，24（2）：175-183.
[19] 易琼，李雅，郭志华，等.心痛泰通过降低Lp-PLA2、IL-6、hs-CRP、LOX-1水平减轻兔动脉粥样硬化炎症反应[J].中国动脉硬化杂志，2017，25（8）：796-799.
[20] 宋筱靓，王帅，王凤荣.祛浊化痰中药干预食饵性动脉粥样硬化模型兔血脂及相关炎性因子的变化[J].中国组织工程研究，2016，20（5）：677-682.
[21] 曹文钦，唐菲.尿微量白蛋白/肌酐比值与2型糖尿病患者颈动脉内膜中膜厚度及颈动脉僵硬度的关系研究[J].实用心脑肺血管病杂志，2017，25（3）：38-41.
[22] 董春萍，乔媛，张艳，等.肾功能正常2型糖尿病患者血清胱抑素C与颈动脉粥样硬化相关性探讨[J].陕西医学杂志，2015，44（10）：1371-1372.
[23] 李立辉.动脉粥样硬化相关炎性因子的研究进展[J].中国现代医生，2017，55（1）：157-161.