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| Application effect of anti-D immunoglobulin on Rh negative blood pregnant women |
| Zhang Jing LU Xin SUN Xuan PAN Li CHEN Lidong |
| Clinical Laboratory, Haidian District Maternal And Child Health Care Hospital, Beijing 100081, China |
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Abstract Objective To dicuss the application effect of anti-D immunoglobulin on Rh negative blood pregnant women. Methods From January 2016 to November 2017, in Haidian District Maternal and Child Health Care Hospital, 119 pregnant women with Rh negative blood were selected, 33 pregnant women injected with anti-D immunoglobulin by themselves at 28 weeks of pregnancy were as the injected anti-D immunoglobulin group (experiment group), and 33 randomly selected from 86 pregnant women not received anti-D immunoglobulin were as the control group. The anti-human globulin detection card of Diana microcolumn gel was applied to test the anti-D antibody of the Rh negative blood pregnant women, and the RhD blood type was tested by test tube method, and the difference of two groups were statistically analyzed. Results The postpartum hemorrhage, neonatal infection, premature birth, stillbirth and neonatal anemia of experiment group and control group were compared, the differences were not statistically significant (P > 0.05). The mode of delivery, proportion of Rh-negative newborns, neonatal hyperbilirubinemia of two groups were compared, the differences were statistically significant (P < 0.05) Conclusion Injecting anti-D immunoglobulin is an effective way to avoid alloimmunization to produce anti-D antibody, it can reduce incidence of Rh immunosuppression, the management of anti-D immunoglobulin in our country needs to be improved.
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[1] Rebecca AR，Dunsmoor S. Cost-benefit analysis of indirect antiglobulin screening in Rh（D）-negative women at 28 weeks of gestation [J]. Obstetrics and Gynecology，2014，123（5）：938-945.
[2] Stamatoyannopoulos G，Majerus PW，Perlmutter RM，et al. The molecular basis of blood diseases [M].3版.北京：人民卫生出版社，2001：316.
[3] 王宇宏，刘冰.用微柱凝胶法诊断新生儿溶血病的实验研究[J].中国实验诊断学，2011，12（15）：2018-2020.
[4] 尹力扬，赵莉.成分血换血早期治疗新生儿Rh溶血病临床评价[J].徐州医学院学报，2012，32（12）：855-857.
[5] Savithrisownya S，Singh M，Kriplani A. Assessment of fetomaterrnal hemorrhage by fiow eytometry and Kleihauer-Betke test in Rh-negative pregnancies [J]. Gynecol Obstet Invest，2007，65（2）：84-88.
[6] 赵桐茂.人类血型遗传学[M].北京：科学出版社，1987：104.
[7] 马印图，刘芳.母婴Rh血型不合新生儿溶血病的治疗进展[J].医学研究杂志，2011，1（40）：151-153.
[8] Qureashi H，Massey E，Kirwan D，et al. BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn [J]. Transfus Med，2014，24（1）：8-20.
[9] Sandier SG，Gottschall JL. Postpartum Rh hnnmnoprophylaxis [J]. Obstetrics and Gynecology，2012，120（6）：1428-1438.
[10] 李彤彤，刘晗.抗-D免疫球蛋白与Rh新生儿溶血病2例[J].临床输血与检验，2012，14（4）：355-356.
[11] 任少敏，刘献成.英国预防新生儿溶血病抗-D免疫球蛋白应用指南解读[J].中国输血杂志，2014，27（6）：673-678.
[12] 李杏，黄文青.抗D免疫球蛋白的安全注射[J].护理与康复，2014，1（39）：866-867.
[13] 宋月花.产后出血原因及相关因素临床分析[J]中国实用医药，2010，6（5）：87-88.
[14] 孙媛.Rh阴性血型孕妇输产前储备自体血液5例心理护理[J]齐鲁护理杂志，2012，18（27）：94-95.
[15] Debbia M，Braossard Y，Lambin P. Measurement of the affinity of anti-D in the serum of immunized mothers and in immunoglobulin preparations with unlabeled antibodies [J]. Transfusion，2005，45（11）：975-983.
[16] 陈步云，胡品佳，黄焕馨.第三产程时间与产后出血的关系[J].国际医药卫生导报，2012，18（1）：113-115.
[17] 王志勤，陈正平.高效价抗D致多胎胎儿死亡的原因探讨[J].中外健康文摘，2011，1，（8）：3188-3189.
[18] 刘舒鑫，姚若进.50例Rh阴性血型孕妇的妊娠结局分析[J].实用妇产科杂志，2008，24（11）：685-686.
[19] 张杨，梁梅英.血浆置换治疗母儿Rh血型不合并成功妊娠二例报告及分析[J]中华妇产科杂志，2013，48（1）：51-53.
[20] 周春波，叶松.Rh（D）阴性血型病人剖宫产术中成分式自体输血的安全性[J].中华麻醉学杂志，2011，31（2）：226-229. |
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