|
|
|
| Clinical effect of Yougui Pills combined with ginger moxibustion in the treatment of knee osteoarthritis with syndrome of yang deficiency and coagulated cold |
| SHAO Jieqi ZENG Zhijiang YANG Min LU Xiangran ZHONG Qiusheng |
| Internal Medicine Department of Traditional Chinese Medicine, the Third People's Hospital of Dongguan City, Guangdong Province, Dongguan 523326, China |
|
|
|
Abstract Objective To explore the clinical curative effect of Yougui Pills combined with ginger moxibustion in the treatment of knee osteoarthritis with syndrome of yang deficiency and coagulated cold. Methods One hundred and ten cases of knee osteoarthritis patients with syndrome of yang deficiency and coagulated cold treated in the Third People's Hospital of Dongguan City form June 2013 to June 2017 were selected and randomly divided into control group and experimental group by random number table method, with 55 cases in each group. The control group was given oral Yougui Pills, the experimental group was given Yougui Pills combined with ginger moxibustion. The serum inflammatory activity indicators, serum immunological indices, and the scores of Lequesne index and yang deficiency syndrome of the two groups before and after treatment were compared. Results After treatment, the serum inflammatory activity indicators of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and 28 human body joint function assessment (DAS28), the serum immunological indices of interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and the scores of Lequesne index and yang deficiency syndrome in the two groups were significantly lower than those before treatment (P ＜ 0.05), and the serum inflammatory activity indicators, serum immunological indices, the scores of Lequesne index and yang deficiency syndrome in the experimental group after treatment were all significantly lower than those of control group at the same period, the differences were all statistically significant (P ＜ 0.05). Conclusion Yougui Pills combined with ginger moxibustion in the treatment of knee osteoarthritis with syndrome of yang deficiency and coagulated cold has remarkable curative effects, which can significantly improve the inflammatory symptoms and immunity, relieve pain, with high safety.
|
|
|
|
|
|
[1] 中华中医药学会.骨性关节炎[J].风湿病与关节炎，2013， 2（2）：71-72.
[2] 吴节，田策.足三里烧山火针法为主治疗阳虚寒凝型膝骨关节炎64例[J].中国中医药现代远程教育，2014，12（10）：61-62.
[3] Brandt KD，Mankin HJ，Shulman LE. Workshop on etiopathogenesis of osteoarthritis [J]. J Rheumatol，1986，13：1126-1130.
[4] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：67-68.
[5] 姚血明，马武开，唐芳，等.类风湿关节炎患者DAS28积分与疾病活动指标的相关性分析[J].中国慢性病预防与控制，2013，21（1）：79-81.
[6] 黄伟军，潘雅丽，李志民，等.抗骨增生胶囊口服联合玻璃酸钠关节腔注射治疗膝骨关节炎[J].中医正骨，2017， 29（4）：67-68.
[7] 柳璇，王琦.《中医体质分类与判定》标准修改建议及分析[J].北京中医药大学学报，2013，36（5）：300-304.
[8] 谢秀俊，焦琳，付勇，等.不同方案温和灸治疗阳虚寒凝型膝骨性关节炎临床疗效观察[J].针刺研究，2014，39（6）：496-499.
[9] 李盛华，周明旺，潘文，等.阳虚质膝骨性关节炎软骨组织Sox9、Col2al基因表达的研究[J].西部中医药，2016， 29（12）：1-4.
[10] 梁桂洪，梁祖建，林勇凯，等.补肾活血中药对比塞来昔布治疗膝骨性关节炎疗效与安全性的Meta分析[J].中国药房，2016，27（27）：3810-3814.
[11] 聂斌，钟旭敏，林湖广，等.扶阳火艾灸对亚健康人群阳虚证调养作用研究[J].针灸临床杂志，2014，30（2）：22-24.
[12] 任景，李涛，于苗，等.针灸联合独活寄生汤治疗膝关节骨性关节炎疗效观察及对微炎性反应指标的影响[J].世界中医药，2016，11（10）：2113-2115，2119.
[13] 徐亚红，魏小利，王社平，等.温针灸联合超短波治疗膝骨性关节炎54例[J].环球中医药，2016，9（7）：878-880.
[14] 聂斌，谭媛，孙正平，等.扶阳火艾灸治疗阳虚寒凝型膝骨关节炎临床观察[J].风湿病与关节炎，2017，6（3）：22-23.
[15] 吴节，田策.足三里烧山火针法为主治疗阳虚寒凝型膝骨关节炎64例[J].中国中医药现代远程教育，2014，12（10）：61-62.
[16] 蒋海鹰，林俊山.隔姜灸结合手法治疗膝骨关节炎80例[J].光明中医，2013，28（1）：128-129.
[17] 周文娟，章薇，娄必丹，等.温针灸治疗阳虚寒凝型膝骨性关节炎32例疗效观察[J].湖南中医杂志，2014，30（4）：90-93.
[18] 周明旺，柳海平，李盛华，等.阳虚质膝骨性关节炎关节软骨中PKC的表达研究[J].西部中医药，2017，30（10）：1-3.
[19] 李建，樊炜骏，孙鹏，等.独活寄生汤联合硫酸氨基葡萄糖治疗膝骨性关节炎的临床观察[J].中国药房，2017， 28（14）：1955-1958.
[20] 黄明辉，宋进良，陈彦军，等.膝骨性关节炎（骨痹）患者中医体质与临床证型的调查研究[J].世界中医药，2017， 12（7）：1580-1582，1586.
[21] 马小娟.温针灸加蜡疗治疗阳虚寒凝型膝骨关节炎40例[J].湖南中医杂志，2014，30（2）：75-76.
[22] 张金柱.温针灸联合中药外敷治疗阳虚寒凝型膝关节骨性关节炎疗效观察[J].山西中医，2014，30（3）：24-25. |
|
|
|
