右美托咪定联合利多卡因静脉输注对腹腔镜全子宫切除术患者氧化应激水平及炎性反应的影响

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Abstract Objective To expiore the effects of Dexmedetomidine combined with Lidocaine on oxidative stress and inflammatory response in patients with laparoscopic total hysterectomy. Methods One hundred and twenty patients with laparoscopic total hysterectomy in gynaecology of the First People′s Hospital of Yibin from September 2014 to October 2017 were selected as the subjects. According to the random digital table method,120 patients were divided into group A, B, C and control group, 30 cases in each group. Group A was treated with dexmedetomidin combined with Lidocaine by intravenous pump. Group B was treated with Dexmedetomidine by intravenous pump. Group C was treated with Lidocaine by intravenous pump. The control group treated with normal saline by intravenous pump. The inflammatory factors (IL-6, TNF-α) and oxidative stress indexes (H2O2, MDA and TAS) were monitored before administration (T1), at the end of operation (T2), 2 h after operation (T3) and 24 h after operation (T4). The incidence of postoperative adverse reactions was compared between the four groups. Results At T2, T3 and T4, levels of serum H2O2 and MDA, group A < group B< group C< control group, the difference between groups was statistically significant (P < 0.05). Levels of serum IL-6, TNF-α in group A < group B< group C< control group, and the TAS leves, group A> group B> group C> control group, the difference between groups was statistically significant (P < 0.05). The incidence of nausea and vomiting in group A was lower than that in group B and control group, the difference was statistically significant (P < 0.05). The incidence of somnolence and bradycardia in group A and B was higher than that in group C and control group, the difference was statistically significant (P < 0.05). Conclusion Dexmedetomidine combined with Lidocaine can alleviate the oxidative stress response and inflammatory response in patients with laparoscopic total hysterectomy. However, the incidence of somnolence and bradycardia increased after operation.

Key words： Dexmedetomidine Lidocaine Laparoscopic hysterectomy Oxidative stress Inflammatory response

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ZHANG Nu XU Liansheng. Effects of Dexmedetomidine combined with Lidocaine on oxidative stress and inflammatory response in laparoscopic hysterectomy patients[J]. 中国医药导报, 2018, 15(10): 95-98,134.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I10/95

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