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Analysis of pathogen distribution and drug resistance of urinary tract infection in senile diabetics |
HAN Shuxia NI Wei |
Department of Clinical Laboratory, Hubei Province Academy of Traditional Chinese Medicine Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China |
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Abstract Objective To discuss the pathogen distribution and drug resistance of urinary tract infection in senile diabetics, in order to offer evidence for reasonable use of antibiotics. Methods The urine culture and drug sensitivity results were analyzed among senile diabetics with urinary tract infection from 2014 to 2016 in Hubei Provincial Hospital of Traditional Chinese Medicine. Results Among the 331 strains of pathogenic bacteria, the first three were Escherichia coli (194 strains, 58.6%), Enterococcus faecalis (30 strains, 9.1%) and Pseudomonas aeruginosa (27 strains, 8.2%). The detection rate of ESBLS-producing strains was 55.2%(107/194) of Escherichia coli, which of Klebsiella pneumoniae was 66.7% (16/24). Resistant rate of Gram-negative bacteria on Amikacin and Imipenem was low, but the rates of that on Ampicillin/Sulbatam, Levofloxacin, Ciprofloxacin and Ceftriaxone were all greater than 50%. The resistant rate of Enterococcus faecalis and Enterococcus faecium were greater than 50% to Clindamycin, high concentration Gentamycin and high concentration Streptomycin, but were highly sensitive to Vancomycin and Linezolid. Conclusion Urinary tract infection in senile diabetics is mainly caused by Escherichia coli and Enterococcus, which are highly resistant to routine antibiotics. Clinicians should attach great importance to drug sensitivity results and select antibiotics according to the result of urine culture and drug sensitive test.
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