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| Research progress on SIRT5 as deacylase |
| ZHENG Chunlei1,2 LU Wenqing1,2 CHE Xiaofang1,2 LIU Yunpeng1,2▲ |
1.Department of Medical Oncology, the First Hospital of China Medical University, Liaoning Province, Shenyang, 110001, China;
2.Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Liaoning Province, Shenyang, 110001, China |
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Abstract Sirtuin 5, also called SIRT5, is a member of Sirtuins family. Besides its deacetylation activity, SIRT5 also has strong desuccinylation, demalonylation and deglutarylation activities. Therefore, SIRT5 has been attracted much attention in recent years. Currently, about more than tenproteins were identified as substrates of SIRT5. SIRT5 is involved in the regulation of glucose oxidation, ROS metabolism and fatty acid oxidation, ammonia removal, detoxification, anti apoptosis, inflammation and so on, by playing the same enzymatic activity on different substrates, or playing different enzymatic activity on the same substrate. The abnormal expression of SIRT5 is closely related to the occurrence and development of tumor, though its function is not clarified yet. SIRT5 can play the role of oncogene to promote tumor proliferation, metastasis, drug resistance and metabolic reprogramming. On the other hand, SIRT5 also play the role of tumor suppressor gene to inhibit tumor cell growth and apoptosis. In addition, SIRT5 abnormalities are also closely related to hypertrophic cardiomyopathy, myocardial infarction and other cardiovascular diseases, such as Parkinson′s disease and Alzheimer′s disease. In order to have a good comprehensive on the research progress of SIRT5, this paper reviews the structure and regulation, enzyme activity and biological function of SIRT5, and the relationship between SIRT5 and desease in details here.
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