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| Discussion on the mechanism of peach seed-safflower in the treatment of retinal vein occlusion based on network pharmacology#br# |
| JIN Qi HAO Xiaofeng XIE Like SUN Mei |
| Department of Ophthalmology and Ocular Trauma, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China |
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Abstract Objective To explore the mechanism of peach seed-safflower in the treatment of retinal vein occlusion (RVO) by network pharmacology. Methods The composition and target of peach seed-safflower were predicted by traditional Chinese medicine systems pharmacology database and analysis platform, the target of RVO was predicted by GeneCards database, and the intersection target was obtained by Jvenn. Metascape database was used for GO analysis and KEGG pathway enrichment analysis of intersection targets, and AutoDock software was used for molecular docking verification of components and targets. Results A total of 35 components and 178 targets of peach seed-safflower were obtained, and 96 intersection targets were obtained by intersection of peach seed-safflower with 853 RVO targets. GO analysis obtained 246 biological processes, 61 cell components and 111 molecular functions, including apoptotic signaling pathways, response to oxidative stress and other biological processes. A total of 150 pathways were obtained by KEGG analysis, including AGE-RAGE signaling pathway, IL-17 signaling pathway, PI3K-Akt signaling pathway, etc. Molecular docking results showed that the compounds could stably combine with the target and exert therapeutic effect after entering the body. Conclusion The treatment of RVO by peach seed-safflower is characterized by multiple components, multiple targets and multiple pathways. It is speculated that the specific mechanism may be related to improving hemodynamics, regulating the expression of inflammatory factors and regulating the generation of oxygen free radicals.
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