肝动脉化疗栓塞联合超声引导下微波消融治疗原发性肝癌的效果分析

Abstract
Figure/Table
References (25)
Related Citation (5)

Download: PDF (602 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To analyze the effect of transcatheter arterial chemoembolization combined with ultrasound guided microwave ablation in the treatment of primary liver cancer. Methods 98 patients with primary hepatocellular carcinoma treated in Dalian Central Hospital from January 2014 to December 2016 were selected as the study subjects. According to different treatment methods, patients were divided into observation group (50 cases) and control group (48 cases). The patients in the control group were treated with hepatic artery chemoembolization, and the patients in the observation group were treated with transcatheter arterial chemoembolization combined with ultrasound guided microwave ablation. The treatment outcomes was compared between the two groups; before treatment and 3 months after treatment, the levels of alpha fetal protein (AFP), glutamate aminotransferase (ALT) and glutamate transaminase (AST) of the patients in the two groups were tested; the adverse reactions in the two groups during and after treatment were observed. Results The total effective rate and disease control rate in the observation group were higher than those in the control group, with statistically significant difference（P < 0.05）; after treatment, levels of AFP, ALT and AST of the two groups were significantly lower than those before treatment, and the observation group was lower than that of the control group, with statistically significant difference (P < 0.05). During treatment complications such as nausea, vomiting, diarrhea, skin rash, bone marrow suppression, fever, and pain happened in both groups, while the incidence of complications in the two group was not statistically different (P > 0.05). Conclusion Compared with hepatic artery embolization chemotherapy alone, transcatheter arterial chemoembolization combined with ultrasound-guided percutaneous microwave ablation therapy can provide obvious therapeutic effect, and do not increase the occurrence of adverse reactions, which is worthy of clinical promotion.

Key words： Transcatheter arterial chemoembolization Microwave ablation Primary liver cancer Effect

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Meng GAO Zhong TAN Guifang LIU Zhigang QIAN Yong ZHANG Yi

Cite this article:

ZHANG Meng GAO Zhong TAN Guifang LIU Zhigang QIAN Yong ZHANG Yi. Effect of transcatheter arterial chemoembolization combined with ultrasound-guided microwave ablation in the treatment of primary hepatocellular carcinoma[J]. 中国医药导报, 2017, 14(29): 103-106.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I29/103

[1] 王珂，汪爱勤，尹文等.原发性肝癌的治疗进展[J].山东医药，2014，54（43）：88-90.
[2] 姚冬雪，秦成勇.原发性肝癌非手术治疗的研究进展[J].医学综述，2015，21（20）：3708-3709，3710.
[3] 范卫君.射频、微波、冷冻消融治疗肿瘤的临床应用及优势对比[J].实用医学杂志，2013，29（21）：3447-3448.
[4] 邓兴，胡鸿，游箭，等.TACE联合微波消融治疗原发性肝癌的效果分析[J].西部医学，2016，28（4）：524-527.
[5] 范晓英.超声引导下经皮微波消融治疗复发性肝癌12例回顾性分析[J].母婴世界，2015（6）：94-95.
[6] 杨秉辉，任正刚.原发性肝癌诊断标准[J].中华肝脏病杂志，2000，8（3）:135-135.
[7] 周霞译，刘鸿凌.《2015年EASL肝移植临床实践指南》摘译[J].实用肝脏病杂志，2016，19（3）：385-388.
[8] 包长斌，刘明涛，蒋林，等.肝动脉化疗栓塞术治疗中晚期原发性肝癌的疗效分析[J].重庆医学，2012，41（32）：3424-3425.
[9] 任翰淼.TACE治疗晚期原发性肝癌30例效果观察[J].山东医药，2011，51（46）：77-78.
[10] 俞武生，王在国，卢星照，等.肝癌合并门脉癌栓术后行肝动脉栓塞化疗联合门静脉化疗的临床疗效分析[J].中外医疗，2014（28）：20-23.
[11] 冯鹏.超声引导经皮射频消融与微波消融治疗肝脏肿瘤对比分析[J].医学理论与实践，2017，30（8）：1158-1159.
[12] 滕藤，杜宏伟.一种用于肝癌微波消融空间定位的优化算法[J].北京生物医学工程，2015（4）：340-344，426.
[13] 张涛.肿瘤局部消融治疗进展述评[J].西部医学，2016， 28（9）：1185-1190.
[14] 董宝玮，梁萍，于晓玲，等.超声引导经皮微波消融治疗早期原发性肝癌的远期疗效[J].中华医学杂志，2006， 86（12）：797-800.
[15] 张丽英，李开艳，张婷婷，等.原发性肝癌直接微波消融的疗效分析[J].华中科技大学学报：医学版，2013，42（6）：707-711.
[16] Itamoto T，Katayama K，Fukuda S，et al. Percutaneous microwave coagulation therapy for primary or recurrent hepatocellular carcinoma：long-term results. [J]. Hepato?鄄gastroenterology，2001，48（41）：1401-1405.
[17] 王洪武.肿瘤微创治疗技术[M].北京：北京科学技术出版社，2007.
[18] 黄书明，陈圣开，张涛，等.巨大肝癌肝动脉栓塞化疗联合微波消融的临床分析[J].重庆医学，2015（36）：5149-5152.
[19] 黄森渺，张天奇，黄职妹，等.肝动脉化疗栓塞同步联合多源微波消融治疗大肝癌的初步临床应用[J].肿瘤预防与治疗，2017，30（2）：96-101.
[20] 张世杰.微波消融治疗肝癌的现状[J].中国癌症防治杂志，2012，4（4）：373-376.
[21] 张慧贤，马向明，付庆江，等.经肝动脉化疗栓塞联合经皮微波消融序贯治疗中晚期肝癌的疗效及预后分析[J].肝脏，2017，22（5）：431-434.
[22] 王晓维，付守忠，戴锋，等.肝动脉栓塞化疗联合射频消融与联合微波消融治疗原发性肝癌的疗效和安全性比较[J].介入放射学杂志，2016，25（8）：673-676.
[23] 马文静.肝动脉化疗栓塞联合微波消融治疗肝癌的临床研究[D].泰山：泰山医学院，2012.
[24] Lee S，Rhim H，Kim YS，et al. Percutaneous radiofrequency ablation of hepatocellular carcinomas：factors related to intraprocedural and postprocedural pain [J]. AJR Am J Roent Genol，2009，192（4）：1064-1070.
[25] 李京华，崔石昌，孙健，等.原发性肝癌患者CT引导下经皮微波消融术中肿瘤位置与疼痛程度的关系[J].临床肝胆病杂志，2015，31（6）：903-906.