益气除痞汤联合西药治疗初诊脾虚郁滞型反流性食管炎的临床效果

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Abstract Objective To explore the clinical effect of Yiqi Chupi Decoction combined with Western medicine in the treatment of newly diagnosed reflux esophagitis (RE) of spleen deficiency and stagnation type. Methods A total of 129 newly diagnosed RE patients admitted to Zhangjiagang Hospital of Traditional Chinese Medicine from September 2018 to September 2020 were selected and they were divided into two groups by random number table method. The control group (64 cases) was treated with conventional Western medicine, and the study group (65 cases) was treated with Yiqi Chupi Decoction on the basis of the control group. The therapeutic effect, traditional Chinese medicine syndrome score, serum indexes (motilin [MOT], gastrin [GAS], tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]) and adverse reactions were compared between the two groups. Results After eight weeks of treatment, the total effective rate of the study group was higher than that of the control group (P ＜ 0.05). After eight weeks of treatment, the symptom scores of acid regurgitation, belching, epigastric distension, anorexia, heartburn and burnout in the two groups decreased compared with before treatment, and the symptom scores of the study group were lower than those of the control group (P ＜ 0.05); the levels of MOT and GAS increased than before treatment, and those of the study group were higher than those of the control group (P ＜ 0.05); the levels of TNF-α and IL-6 decreased than before treatment, and those of the study group were lower than those of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Yiqi Chupi Decoction combined with Western medicine in the treatment of RE with significant curative effect and good safety. Its mechanism of action may be related to the regulation of inflammatory indicators and gastrointestinal hormones.

Key words： Yiqi Chupi Decoction Western medicine Reflux esophagitis Curative effect

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	WANG Libing WANG Xiaoyu JI Xiaoyu

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WANG Libing WANG Xiaoyu JI Xiaoyu. Clinical effect of Yiqi Chupi Decoction combined with Western medicine in the treatment of newly diagnosed reflux esophagitis of spleen deficiency and stagnation type#br#[J]. 中国医药导报, 2021, 18(30): 125-128,140.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I30/125

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