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| Correlation between cerebral glucose metabolism and cognitive function in Alzheimer’s disease patients based on PET/CT |
| WANG Yanyan1 LI Xiaoxia2 XIA Huan3 LUO Qin4 |
1.Department of Leader Neurology, Gansu Provincial People’s Hospital, Gansu Province, Lanzhou 730000, China;
2.Department of Neurology, Leshan People’s Hospital, Sichuan Province, Leshan 614100, China;
3.Department of Nuclear Medicine, Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China; 4.Department of Respiratory and Neurology, Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China |
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Abstract Objective To explore the correlation between cerebral glucose metabolism and cognitive function in Alzheimer’s disease patients based on positron emission tomography / computed tomography (PET/CT). Methods Clinical data of 31 patients with primary AD in Gansu Provincial People’s Hospital (hereinafter referred to as “our hospital”) from September 2016 to October 2019 were analyzed. According to the mini-mental state examination (MMSE), the patients were divided into mild to moderate AD group (22 cases, 12≤MMSE< 24 points) and severe AD group (9 cases, MMSE< 12 points). The control group was 57 healthy people who underwent physical examination in our hospital during the same period. In PET/CT examination, the imaging agent was fluorodeoxy glucose (18F-FDG), the image fusion and reconstruction were processed by PHILIPS Syntegra software, and SUVavg (Br/Bl) value was obtained after the correction of interest area. At the same time, the correlation between brain glucose metabolism and cognitive function in AD patients was analyzed. Results There was a positive correlation between SUVavg (Br/Bl) value in bilateral temporal lobe and recall power score in MMSE score in AD patients (r = 0.516, P ＜ 0.05). SUVavg (Br/Bl) value of right parietal lobe in mild to moderate AD group was lower than that in control group (P < 0.05). Conclusion The progressive decrease of 18F-FDG glucose metabolism in temporal lobe of AD patients is consistent with the decline of the ability to memorize score in MMSE, and PET/CT can earlier reflect the functional damage of right parietal lobe in mild to moderate AD patients.
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