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| Predictive value of the ratio of mean platelet volume to platelet count in the prognosis of community-acquired pneumonia |
| YUAN Xiaoyu ZHANG Tieshuan |
| Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Zhengzhou University, Henan Province, Zhengzhou 450014, China |
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Abstract Objective To explore the predictive value of the ratio of mean platelet volume to platelet count (MPV/PLT) in the prognosis of community acquired pneumonia (CAP). Methods A total of 223 CAP patients who were hospitalized in the Second Affiliated Hospital of Zhengzhou University from January 2018 to July 2020 were selected. According to the prognosis of hospitalized 28 days patients were divided into survival group and death group, including 169 cases in the survival group and 54 cases in the death group. The clinical data of the two groups were compared, the correlation between MPV/PLT and procalcihonin (PCT) and C-reactive protein (CRP) was analyzed, logistic regression was used to analyze independent risk factors that affect the prognosis of CAP. The receiver operating characteristic curve (ROC) was drawn to evaluate the prognostic value of MPV/PLT, the Kaplan-Meier survival analysis curve was drawn according to the best cut-off value. Results There were no significant differences in age, sex and white blood cell count between the two groups (P ＞ 0.05); compared with the death group, the percentage of neutrophils, PCT, CRP, MPV and MPV/PLT were lower, and PLT was higher (P ＜ 0.05). There was a positive correlation between MPV/PLT and PCT and CRP (r = 0.483, 0.489, P ＜ 0.05). The logistic regression analysis showed that MPV/PLT was an independent risk factor affecting the prognosis of patients. The area under curve of MPV/PLT was 0.773, the sensitivity was 85.2%, the specificity was 62.1%, the best cut-off value was 0.0645, and the 95% CI: 0.703-0.842 (P ＜ 0.05). There were 110 patients in the MPV/PLT≥0.0645 group, and 113 patients in the other group. The PCT, CRP and mortality rates in the MPV/PLT≥0.0645 group were higher than the other group (P ＜ 0.05). The cumulative survival rate of MPV/PLT≥0.0645 group was lower than that of MPV/PLT < 0.0645 group (Log-rank=37.974, P ＜ 0.05). Conclusion MPV/PLT may be an independent risk factor affecting the prognosis of CAP and has good clinical value in predicting the prognosis of patients.
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