多囊卵巢综合征患者甘油三酯葡萄糖乘积指数与非酒精性脂肪性肝病患病风险的关系

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Abstract Objective To investigate the relationship between triglyceride-glucose index (TyG) and the risk of non-alcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). Methods A total of 350 PCOS patients admitted to the Department of Endocrinology and Metabolism, Renji Hospital, Shanghai Jiao Tong University School of Medicine from January 2017 to December 2020 were selected. According to whether they had NAFLD or not, they were divided into NAFLD group (201 cases) and non-NAFLD group (149 cases). TyG, lipid accumulation index (LAP) and visceral adiposity index (VAI) were calculated. Spearman correlation coefficient was used to analyze the correlation between TyG and liver function, glucolipid metabolism and reproductive indexes. Logistic univariate and multivariate analysis was used to analyze the correlation between TyG, LAP, VAI, and NAFLD in PCOS patients. Results There were statistically significant differences in clinical indicators, TyG, LAP, and VAI between the two groups (P ＜ 0.05). Correlation analysis showed that TyG was positively correlated with glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase, γ-glutamyl transpeptidase, total cholesterol, low density lipoprotein cholesterol, area under insulin curve and free androgen index (rs ＞ 0, P ＜ 0.05). And it was negatively correlated with high density lipoprotein cholesterol, sex hormone-binding globulin, and anti-Müllerian hormone (rs ＜ 0, P ＜ 0.05). Univariate logistic regression analysis showed that age, body mass index, homeostasis model assessment-IR, free androgen index, glutamic-pyruvic transaminase, TyG, LAP, and VAI were all risk factors for NAFLD in PCOS patients (OR ＞ 1, P ＜ 0.05). In order to compare the relationship between TyG, LAP, VAI, and NAFLD in PCOS patients and avoid the interaction between the indexes, they were stratified by quartile, and the subjects were included in four subgroups of every index, respectively. Multivariate logistic regression was performed to correct confounding factors. The results showed that TyG ＞ 7.95, LAP ＞ 15.85, and VAI ＞ 1.91 were independent risk factors for NAFLD in PCOS patients (OR ＞ 1, P ＜ 0.05). Conclusion TyG index has certain value for the auxiliary diagnosis of NAFLD in PCOS patients.

Key words： Polycystic ovary syndrome Non-alcoholic fatty liver disease Triglyceride-glucose index Insulin resistance

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	FU Jiarong ZHU Yuchen YU Jie LIU Wei TAO Tao

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FU Jiarong ZHU Yuchen YU Jie LIU Wei TAO Tao. Association of triglyceride-glucose index with risk of non-alcoholic fatty liver disease in patients with polycystic ovary syndrome[J]. 中国医药导报, 2021, 18(28): 98-102.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I28/98

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