非糖尿病急性缺血性脑卒中患者血浆ApoB/ApoA1比值的检测及其临床意义

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Abstract Objective To observe the clinical significance of the ratio of plasma apolipoprotein B to apolipoprotein A1 (ApoB/ApoA1) in non-diabetic acute ischemic stroke. Methods A total of 78 cases of non-diabetic acute ischemic stroke patients hospitalized in Wuxi Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from July 2017 to July 2019 were selected as the stroke group, and 55 healthy subjects with physical examination results in our hospital during the same period were selected as the control group. The ratio of ApoB/ApoA1 in the two groups was compared, and the risk factors of non-diabetic acute ischemic stroke were analyzed by logistic regression, and the receiver operating characteristic (ROC) curve of the value of ApoB/ApoA1 in the diagnosis of non-diabetic acute ischemic stroke was drawn. Results The ApoA1 level in the stroke group was lower than that in the control group, and the ApoB/ApoA1 ratio in the stroke group was higher than that in the control group, with statistical significance (all P ＜ 0.05). Multivariate logistic regression analysis showed that the increase of ApoB/ApoA1 ratio and the decrease of ApoA1 level were independent risk factors for non-diabetic acute ischemic stroke (P ＜ 0.05). ROC curve analysis showed that the area under the curve of ApoB/ApoA1 ratio in the diagnosis of non-diabetic acute ischemic stroke was 0.876, 95%CI: 0.714-0.922, the sensitivity was 69.1%, the specificity was 95.2% and the best cutoff value was 0.853. Conclusion The increase of ApoB/ApoA1 ratio is a risk factor for patients with non-diabetic acute ischemic stroke. When the ratio of ApoB/ApoA1 in peripheral blood is higher than 0.853, the risk of non-diabetic acute ischemic stroke is greatly increased.

Key words： Apolipoprotein B Apolipoprotein A1 Acute ischemic stroke Arteriosclerosis

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YI Xiaojing LI Lejun. Detection and clinical significance of plasma ApoB/ApoA1 ratio in non-diabetic patients with acute ischemic stroke[J]. 中国医药导报, 2021, 18(19): 98-101.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I19/98

[1] O’Donnell MJ，Chin SL，Rangarajan S，et al. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries（INTERSTROKE）：a case-control study [J]. Lancet，2016，388（10046）：761-775.
[2] 黎建乐，王莹，冯慧宇，等.广东省脑卒中流行病学调查[J].中国神经精神疾病杂志，2020，46（1）：1-7.
[3] 王永华，王春玉.河南豫东地区乡镇居民脑卒中的流行病学特征及高危因素分析[J].卒中与神经疾病，2020，27（4）：466-469，478.
[4] 施德，刘振国，王文安，等.老年急性轻型脑卒中患者中陈旧性腔隙性脑梗死的流行病学调查[J].河北医药，2020，42（20）：3166-3169.
[5] 温伟谊，张舒媚，刘晓剑，等.hsCRP、apoB/apoA1、血脂表达与早发冠心病急性冠脉综合征的关系[J].中国循证心血管医学杂志，2019，11（3）：344-348.
[6] 杨蓬勃，黄桂玉，王艳.血清ApoB/ApoA1比值对动脉粥样硬化临床诊断的价值[J].解放军医学院学报，2019，40（6）：544-547.
[7] 陈严，吕晶，董艾艾，等.载脂蛋白B/载脂蛋白A1比值在糖尿病合并冠心病患者冠状动脉病变评估中的作用[J].心脑血管病防治，2018，18（5）：376-378，384.
[8] 田婷，余江毅.依折麦布联合阿托伐他汀对2型糖尿病患者ApoB/ApoA1的影响[J].南京医科大学学报：自然科学版，2016，36（10）：1222-1225.
[10] Beheshtian A，Shitole SG，Segal AZ，et al. Lipoprotein（a） level，apolipoprotein（a）size，and risk of unexplained ischemic stroke in young and middle-aged adults [J]. Atherosclerosis，2016，253：47-53.
[11] Tamburus NY，Verlengia R，Kunz VC，et al. Apolipoprotein B and angiotensin-converting enzyme polymorphisms and aerobic interval training：randomized controlled trial in coronary artery disease patients [J]. Braz J Med Biol Res，2018，51（8）：e6944.
[12] 李宓儿，王菊，杜旭东，等.缺血性脑卒中幸存者的相对生存率及其影响因素分析[J].四川大学学报：医学版，2018，49（4）：594-598.
[13] 王晓旭，徐丹.apoB/apoA1比值与冠心病患者冠脉病变及预后相关性的研究[J].重庆医科大学学报，2018，43（8）：1041-1046.
[14] 刘晓媛.载脂蛋白B/载脂蛋白A1及相关血脂指标对冠心病经皮冠状动脉介入治疗术预后的预测价值[J].中华老年病研究电子杂志，2019，6（4）：13-17.
[15] 孙亚茹，吴振永，孙璐，等.老年高血压并发脑梗死患者Hcy、ApoB/ApoA1与颈动脉内膜中层厚度的相关性研究[J].现代中西医结合杂志，2018，27（24）：2672-2676.
[16] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志，2015，48（4）：246-257.
[17] Albers JJ，Slee A，O’Brien KD，et al. Relationship of apolipoproteins A-1 and B，and lipoprotein（a） to cardiovascular outcomes： the AIM-HIGH trial（Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes）[J]. J Am Coll Cardiol，2013，62（17）：1575-1579.
[18] 陈继群，董吉云，王锋.老年H型高血压患者同型半胱氨酸与ApoB/ApoA1相关性[J].安徽医学，2018，39（8）：940-944.
[19] 罗群华，黎明江，王鑫，等.首诊胸痛患者血清载脂蛋白B与冠状动脉病变的相关性分析[J].疑难病杂志，2019， 18（11）：1081-1085.
[20] 陈海慧，蔡安利，郭海飞，等.多囊卵巢综合征合并代谢综合征患者血清ApoB/ApoA1比值测定的临床意义[J].中华内分泌外科杂志，2018，12（1）：65-69.
[21] 李琳，宋婷婷.冠心病冠脉病变程度与Apo AI/Apo B、同型半胱氨酸、血脂指标的相关性[J].中国医药导报，2019，16（17）：35-38.
[22] 李源源，高莹，曹蕾，等.血清PDGF、ApoB/ApoA1与原发性胆汁性肝硬化的相关性分析[J].肝脏，2019，24（11）：1248-1250.
[23] Kostapanos MS，Christogiannis LG，Bika E，et al. Apoli-poprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects [J]. Stroke Cerebrovasc Dis，2010，19（6）：497-502.
[24] Park JH，Hong KS，Lee EJ，et al. High levels of apolipo-protein B/AI ratio are associated with intracranial atherosclerotic stenosis [J]. Stroke，2011，42（11）：3040-3046.
[25] Tastet L，Capoulade R，Shen M，et al. ApoB/ApoA-I Ratio is Associated With Faster Hemodynamic Progression of Aortic Stenosis：Results From the PROGRESSA （Met-abolic Determinants of the Progression of Aortic Stenosis）Study [J]. J Am Heart Assoc，2018，7（4）：e007980.
[26] 李旭，张飚，曹沁梅.急性缺血性脑卒中患者血清ApoB/ApoA1与NIHSS评分的相关性[J].山东医药，2015，55（10）：11-13.
[27] Sierra-Johnson J，Fisher RM，Romero-Corral A，et al. Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-Ⅰ ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality： findings from a multi-ethnic US population [J]. Eur Heart J，2009，30（6）：710-717.