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| Research progress of PET/CT and PET/MRI imaging in the diagnosis of lymph node metastasis of cervical cancer |
| WANG Yuanjing WU Yumei |
| Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China |
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Abstract As novel multi-modal molecular functional imaging techniques, positron emission tomography （PET）/CT and PET/MRI have integrated the advantages of PET and CT/MRI imaging techniques, which have been widely used in the diagnosis and treatment of gynecological malignancies. Lymph node metastasis is an independent risk factor for the prognosis of cervical cancer. Functional imaging examination plays an important role in evaluating pelvic or abdominal para-aortic lymph node metastasis, which can not only accurately locate the anatomical location of lymph nodes, but also provide metabolic information, improving the accuracy of diagnosis for lymph node metastasis. This article reviews the application of PET/CT and PET/MRI in the diagnosis of lymph node metastasis of cervical cancer by summarizing the results of related researches at home and abroad in recent years. Finally, PET/CT and PET/MRI, as representatives of novel functional imaging techniques, are expected to be important methods for the development of individualized precise treatment plans for cervical cancer.
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[1] Ward ZJ，Grover S，Scott AM，et al. The role and contribution of treatment and imaging modalities in global cervical cancer management：survival estimates from a simulation-based analysis [J]. Lancet Oncol，2020，21（8）：1089-1098.
[2] Jeong SY，Park H，Kim MS，et al. Pretreatment lymph node metastasis as a prognostic significance in cervical cancer：comparison between Disease Status [J]. Cancer Res Treat，2019，52（2）：516-523.
[3] Du R，Li L，Ma S，et al. Lymph nodes metastasis in cervical cancer：Incidences，risk factors，consequences and imaging evaluations [J]. Asia Pac J Clin Oncol，2018，14（5）：e380-e385.
[4] Meva J，Chaudhary RK，Bhaduri D，et al. Lacunae in International Federation of Gynecology and Obstetrics（FIGO）classifcation for cervical carcinoma：observational study using TNM classifcation as comparator [J]. Int J Gynecol Cancer 2013，23（6）：1071-1077.
[5] Cho WK，Kim YJ，Kim H，et al. Significance of para-aortic lymph node evaluation in patients with FIGO ⅢC1 cervical cancer [J]. Jpn J Clin Oncol，2020，50（10）：1150-1156.
[6] Bloomstein JD，von Eyben R，Chan A，et al. Validated limited gene predictor for cervical cancer lymph node metastases [J]. Oncotarget，2020，11（24）：2302-2309.
[7] Saleh M，Virarkar M，Javadi S，et al. Cervical Cancer：2018 Revised International Federation of Gynecology and Obstetrics Staging System and the Role of Imaging [J]. AJR Am J Roentgenol，2020，214（5）：1182-1195.
[8] Kemppainen J，Hynninen J，Virtanen J，et al. PET/CT for evaluation of ovarian cancer [J]. Semin Nucl Med，2019， 49（6）：484-492.
[9] Devine C，Viswanathan C，Faria S，et al. Imaging and Staging of Cervical Cancer [J]. Semin Ultrasound CT MR，2019，40（4）：280-286.
[10] Mansoori B，Khatri G，Rivera-Colón G，et al. Multimodality imaging of uterine cervical malignancies [J]. AJR Am J Roentgenol，2020，215（2）：292-304.
[11] Papadia A，Gasparri ML，Genoud S，et al. The combination of preoperative PET/CT and sentinel lymph node biopsy in the surgical management of early-stage cervical cancer [J]. J Cancer Res Clin Oncol，2017，143（11）：2275-2281.
[12] Goense L，Meziani J，van Rossum PSN，et al. Limited additional value of cervical ultrasonography over a negative 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with esophageal cancer：a systematic review and meta-analysis [J]. Nucl Med Commun，2018，39（7）：645-651.
[13] Adam JA，van Diepen PR，Mom CH，et al. [18F]FDG-PET or PET/CT in the evaluation of pelvic and para-aortic lymph nodes in patients with locally advanced cervical cancer：A systematic review of the literature [J]. Gynecol Oncol，2020，159（2）：588-596.
[14] Kitajima K，Murakami K，Yamasaki E，et al. Accuracy of integrated FDG-PET/contrast-enhanced CT in detecting pelvic and para-aortic lymph node metastasis in patients with uterine cancer [J]. Eur Radiol，2009，19（6）：1529-1536.
[15] 傅立平，程爱萍，孙美玲，等.PET-CT诊断ⅠA2~ⅡA期宫颈癌原发灶和盆腔淋巴结转移的价值[J].浙江大学学报：医学部，2017，46（5）：517-522.
[16] Choi HJ，Ju W，Myung SK，et al. Diagnostic performance of computer tomography，magnetic resonance imaging，and positron emission tomography or positron emission tomography/computer tomography for detection of metastatic lymph nodes in patients with cervical cancer：Meta-analysis [J]. Cancer Science，2010，101（6）：1471-1479.
[17] Liu B，Gao S，Li S. A comprehensive comparison of CT，MRI，positron emission tomography or positron emission tomography/CT，and diffusion weighted imaging-MRI for detecting the lymph nodes metastases in patients with cervical cancer：a meta-analysis based on 67 studies [J]. Gynecol Obstet Invest，2017，82（3）：209-222.
[18] De Cuypere M，Lovinfosse P，Goffin F，et al. Added value of para-aortic surgical staging compared to（18）F-FDG PET/CT on the external beam radiation field for patients with locally advanced cervical cancer：an ONCO-GF study [J]. Eur J Surg Oncol，2019，46（5）：883-887.
[19] Martinez A，Voglimacci M，Lusque A，et al. Tumour and pelvic lymph node metabolic activity on FDG-PET/CT to stratifypatients for para-aortic surgical staging in locally advanced cervical cancer [J]. Eur J Nucl Med Mol Imaging，2020，47（5）：1252-1260.
[20] Lin AJ，Wright JD，Dehdashti F，et al. Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with 18F-fluorodeoxyglucose-positron emission tomography in stage IB cervical cancer [J]. Int J Gynecol Cancer，2019，29（9）：1351-1354.
[21] Nguyen NC，Beriwal S，Moon CH，et al. Diagnostic Value of FDG PET/MRI in Females With Pelvic Malignancy-A Systematic Review of the Literature [J]. Front Oncol，2020，10：519440.
[22] Forte E，Fiorenza D，Torino E，et al. Radiolabeled PET/MRI Nanoparticles for Tumor Imaging [J]. J Clin Med，2019，9（1）：89.
[23] Sher AC，Seghers V，Paldino MJ，et al. Assessment of sequential PET/MRI in comparison with PET/CT of pediatric lymphoma：a prospective study [J]. AJR Am J Roentgenol，2016，206（3）：623-631.
[24] Lund KV，Simonsen TG，Hompland T，et al. Short term pretreatment DCE MRI in predictionof outcome in locally advanced cervical cancer [J]. Radio Oncol，2015， 115（3）：379-385.
[25] Kiselev VG. Microstructure with diffusion MRI：what scale we are sensitive to ? [J]. J Neurosci Methods，2021，347：108910.
[26] Patel-Lippmann K，Robbins JB，Barroilhet L，et al. MR imaging of cervical cancer [J]. Magn Reson Imaging Clin N Am，2017，25（3）：635-649.
[27] Xu C，Li X，Shi Y，et al. Combinative evaluation of primary tumor and lymph nodes to predict pelvic lymphatic metastasis in cervical cancer：an integrated PET-IVIM MRI study [J]. Cancer Imaging，2020，20（1）：21.
[28] Sarabhai T，Schaarschmidt BM，Wetter A，et al. Comparison of（18）F-FDG PET/MRI and MRI for pre-therapeutic tumor staging of patients with primary cancer of the uterine cervix [J]. Eur J Nucl Med Mol Imaging，2018，45（1）：67-76.
[29] Stecco A，Buemi F，Cassarà A，et al. Comparison of retrospective PET and MRI-DWI （PET/MRI-DWI） image fusion with PET/CT and MRI-DWI in detection of cervical and endometrial cancer lymph node metastases [J]. Radiol Med，2016，121（7）：537-545.
[30] Kim SK，Choi HJ，Park SY，et al. Additional value of MR/PET fusion compared with PET/CT in the detection of lymph node metastases in cervical cancer patients [J]. Eur J Cancer，2009，45（12）：2103-2109.
[31] 尚靳，孙洪赞，辛军，等.PET/MRI在宫颈癌分期及盆腔淋巴结转移评价中的临床应用研究[J].中国临床医学影像杂志，2019，30（5）：337-341.
[32] Kirchner J，Sawicki LM，Suntharalingam S，et al. Whole-body staging of female patients with recurrent pelvic malignancies：ultra-fast 18F-FDG PET/MRI compared to 18F-FDG PET/CT and CT [J]. PLoS One，2017，12（2）：e0172553.
[33] Schramm G，Ladefoged CN. Metal artifact correction strategies in MRI-based attenuation correction in PET/MRI [J]. BJR Open，2019，1（1）：20190033. |
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