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| Research progress on gene polymorphism in osteoporosis |
| ZHANG Fan1 XIONG Yanhong2 HAN Chao1 LIANG Qingyang1 LIU Jia1 TANG Yujin1 |
| 1.Department of Orthopedics, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000, China; 2.Department of Gynecology, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000, China |
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Abstract This paper summarizes the effects of gene polymorphism in osteoporosis. Mutations in the vitamin D receptor gene alter mineral metabolism and lead to lower bone density. The effects of the same locus of estrogen receptor gene on different races and genders may be different. Collagen typeⅠgene can aggravate osteoporosis in patients with cardiovascular disease. Different loci of the Gremlin-2 gene may have opposite effects on osteoporosis. The combined gene-gene effect of tumor necrosis factor-α gene and osteoprotegerin gene may increase the risk of osteoporosis. These results suggest that gene polymorphism plays a unique role in osteoporosis, and may provide targeted treatment to avoid bone degeneration.
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