LncRNA PANDAR、miR-637表达与甲状腺癌临床病理参数及预后的关系

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Abstract Objective To explore the expression levels of long non-coding RNA (LncRNA) PANDAR and microRNA-637 (miR-637) in thyroid cancer tissues, and to analyze their relationship with clinicopathological parameters and prognosis. Methods A total of 82 patients with thyroid cancer admitted to the Third Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2015 to February 2017 were selected. The relative expression levels of LncRNA PANDAR and miR-637 in thyroid cancer tissues and adjacent tissues (more than 5 cm from the edge of the tumor tissues) were detected, while the relationship between the two indicators and the clinicopathological characteristics and prognosis of patients were analyzed. Results The relative expression of LncRNA PANDAR in thyroid cancer tissues was higher than that of adjacent tissues, and the relative expression of miR-637 was lower than that of adjacent tissues (P ＜ 0.05). The expression of LncRNA PANDAR was negatively correlated with miR-637 (r = -0.634, P ＜ 0.05). The expression of LncRNA PANDAR and miR-637 in thyroid cancer tissue were related to tumor TNM stage, cell differentiation degree, and lymphatic metastasis (P ＜ 0.05). The 3-year overall survival rate of the LncRNA PANDAR high expression group was lower than that of the LncRNA PANDAR low expression group (P ＜ 0.05). There was no significant difference in the 3-year overall survival rate between the miR-637 high expression group and the low expression group (P ＞ 0.05). Conclusion The relative expression of LncRNA PANDAR in thyroid cancer tissues is higher than that in adjacent tissues, and the relative expression of miR-637 is lower than that in adjacent tissues. It is closely related to tumor TNM staging, cell differentiation and lymphatic metastasis. It is expected to become a new biological indicators in diagnosis, treatment and prognosis assessment of thyroid cance.

Key words： Thyroid carcinoma Long-chain non-coding RNA PANDAR MicroRNA-637 Prognosis

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	AO Xueren LIAO Cong MA Kaimin SHEN Guoxi

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AO Xueren LIAO Cong MA Kaimin SHEN Guoxi. Relationship between the expression of LncRNA PANDAR, miR-637 and clinicopathological parameters and prognosis of thyroid cancer[J]. 中国医药导报, 2021, 18(19): 44-47,67.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I19/44

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