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Analysis of the research hotspots of sjogren syndrome based on CNKI database literature |
BAI Xuejiao1 BAI Zhiyi1 WANG Haiyu1 KANG Tianlun1 ZHU Yuelan2 HOU Xiujuan2 |
1.Beijing University of Chinese Medicine,Beijing 100029, China;
2.Department of Rheumatology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China |
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Abstract Objective To search the literatures on sjogren syndrome in China national knowledge infrastructure (CNKI) database in recent five years, and to analyze the recent research hotspots of Western medicine on sjogren syndrome. Methods With “sjogren syndrome” as the main topic, the literature of Western medicine related to the study of sjogren syndrome published in CNKI database from January 2015 to August 2020 was searched. The bibliographic co-occurrence analysis system (Bicomb2) was used to calculate the frequency of the occurrence of keywords, and the high-frequency keywords with the occurrence frequency greater or equal to ten times were intercepted to generate the co-occurrence matrix. After the co-occurrence matrix was converted into the dissimilarity matrix, the cluster analysis was carried out with SPSS 25.0 software to discuss the research hotspots of Western medicine on sjogren syndrome in the past five years. Results A total of 501 literatures were selected, and 1032 keywords were extracted, including 26 high-frequency keywords, accounting for 40.6301% of all keywords. Clustering analysis showed that the cellular immunology pathogenesis, diagnostic indicators, clinical complications of sjogren syndrome, clinical study of Eramod and Hydroxychloroquine in the treatment of sjogren syndorme, the value of ultrasound diagnosis and evaluation of sjogren syndrome were the recent research hotspots. Conclusion The hot issues of sjogren syndrome in Western medicine mainly focus on the pathogenesis, diagnosis, clinical complications and treatment. In recent years, there are few studies on the epidemiological characteristics of sjogren syndrome and the application of biological agents, which suggest the direction for further research.
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